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Prolactin regulatory element-binding protein (Mammalian guanine nucleotide exchange factor mSec12)

 PREB_MOUSE              Reviewed;         417 AA.
Q9WUQ2; Q9QZ99;
24-OCT-2001, integrated into UniProtKB/Swiss-Prot.
01-NOV-1999, sequence version 1.
13-FEB-2019, entry version 150.
RecName: Full=Prolactin regulatory element-binding protein;
AltName: Full=Mammalian guanine nucleotide exchange factor mSec12;
Name=Preb; Synonyms=Sec12;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Lung;
Edgar A.J., Polak J.M.;
"The human and mouse homologues of rat prolactin regulatory element
binding protein.";
Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
STRAIN=BALB/cJ; TISSUE=Brain;
PubMed=10704286; DOI=10.1006/geno.1999.6089;
Taylor Clelland C.L., Craciun L., Bancroft C., Lufkin T.;
"Mapping and developmental expression analysis of the WD-repeat gene
Preb.";
Genomics 63:391-399(2000).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N; TISSUE=Salivary gland;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
FUNCTION, AND INTERACTION WITH SAR1B.
PubMed=11422940; DOI=10.1034/j.1600-0854.2001.20704.x;
Weissman J.T., Plutner H., Balch W.E.;
"The mammalian guanine nucleotide exchange factor mSec12 is essential
for activation of the Sar1 GTPase directing endoplasmic reticulum
export.";
Traffic 2:465-475(2001).
[5]
NITRATION [LARGE SCALE ANALYSIS] AT TYR-10, AND IDENTIFICATION BY MASS
SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain;
PubMed=16800626; DOI=10.1021/bi060474w;
Sacksteder C.A., Qian W.-J., Knyushko T.V., Wang H., Chin M.H.,
Lacan G., Melega W.P., Camp D.G. II, Smith R.D., Smith D.J.,
Squier T.C., Bigelow D.J.;
"Endogenously nitrated proteins in mouse brain: links to
neurodegenerative disease.";
Biochemistry 45:8009-8022(2006).
[6]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
Spleen, and Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Guanine nucleotide exchange factor that specifically
activates the small GTPase SAR1B. Mediates the recruitement of
SAR1B and other COPII coat components to endoplasmic reticulum
membranes and is therefore required for the formation of COPII
transport vesicles from the ER. {ECO:0000269|PubMed:11422940}.
-!- FUNCTION: Was first identified based on its probable role in the
regulation of pituitary gene transcription. Binds to the prolactin
gene (PRL) promoter and seems to activate transcription.
{ECO:0000250|UniProtKB:Q9WTV0}.
-!- SUBUNIT: Interacts with SAR1B (GDP-bound form) (PubMed:11422940).
Interacts with MIA2; recruits PREB to endoplasmic reticulum exit
sites (By similarity). {ECO:0000250|UniProtKB:Q9HCU5,
ECO:0000269|PubMed:11422940}.
-!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
{ECO:0000250|UniProtKB:Q9WTV0}; Single-pass membrane protein
{ECO:0000250|UniProtKB:Q9WTV0}. Nucleus
{ECO:0000250|UniProtKB:Q9WTV0}. Note=Concentrates at endoplasmic
reticulum exit sites (ERES), also known as transitional
endoplasmic reticulum (tER). {ECO:0000250|UniProtKB:Q9HCU5}.
-!- DEVELOPMENTAL STAGE: Detected starting at 10.5 dpc in the ectoderm
and superficial mesoderm surrounding the caudal part of the tail
region. At 12.5 dpc detected in dorsal root ganglia, surface
ectoderm surrounding the caudal part of the tail, the inferior
wall of the genital tubercle, developing liver, in Rathke pouch
and in condensing mesenchyme forming the roof of the skull. At
14.5 dpc detected in the perichondrial region of the craniofacial,
axial, and appendicular skeleton. By 16.5 dpc expression is much
lower throughout the embryo, and is not detectable by 18.5 dpc.
{ECO:0000269|PubMed:10704286}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AF150808; AAD31722.1; -; mRNA.
EMBL; AF193017; AAF07954.1; -; mRNA.
EMBL; BC017527; AAH17527.1; -; mRNA.
CCDS; CCDS39051.1; -.
RefSeq; NP_057912.2; NM_016703.3.
UniGene; Mm.272414; -.
ProteinModelPortal; Q9WUQ2; -.
SMR; Q9WUQ2; -.
BioGrid; 206147; 5.
IntAct; Q9WUQ2; 2.
MINT; Q9WUQ2; -.
STRING; 10090.ENSMUSP00000074387; -.
iPTMnet; Q9WUQ2; -.
PhosphoSitePlus; Q9WUQ2; -.
SwissPalm; Q9WUQ2; -.
EPD; Q9WUQ2; -.
jPOST; Q9WUQ2; -.
MaxQB; Q9WUQ2; -.
PaxDb; Q9WUQ2; -.
PRIDE; Q9WUQ2; -.
Ensembl; ENSMUST00000074840; ENSMUSP00000074387; ENSMUSG00000045302.
GeneID; 50907; -.
KEGG; mmu:50907; -.
UCSC; uc012dui.2; mouse.
CTD; 10113; -.
MGI; MGI:1355326; Preb.
eggNOG; KOG0771; Eukaryota.
eggNOG; ENOG410XRQK; LUCA.
GeneTree; ENSGT00390000018031; -.
HOGENOM; HOG000045302; -.
HOVERGEN; HBG002027; -.
InParanoid; Q9WUQ2; -.
KO; K14003; -.
OMA; AHSMFVT; -.
OrthoDB; 828247at2759; -.
PhylomeDB; Q9WUQ2; -.
TreeFam; TF314383; -.
Reactome; R-MMU-204005; COPII-mediated vesicle transport.
Reactome; R-MMU-5694530; Cargo concentration in the ER.
ChiTaRS; Preb; mouse.
PRO; PR:Q9WUQ2; -.
Proteomes; UP000000589; Chromosome 5.
Bgee; ENSMUSG00000045302; Expressed in 285 organ(s), highest expression level in bone fossa.
ExpressionAtlas; Q9WUQ2; baseline and differential.
Genevisible; Q9WUQ2; MM.
GO; GO:0070971; C:endoplasmic reticulum exit site; ISS:UniProtKB.
GO; GO:0000139; C:Golgi membrane; IEA:GOC.
GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; ISO:MGI.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI.
GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:MGI.
GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
GO; GO:0051020; F:GTPase binding; IPI:UniProtKB.
GO; GO:0005090; F:Sar guanyl-nucleotide exchange factor activity; IDA:UniProtKB.
GO; GO:0048208; P:COPII vesicle coating; ISS:UniProtKB.
GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; ISS:UniProtKB.
GO; GO:0032527; P:protein exit from endoplasmic reticulum; ISS:UniProtKB.
GO; GO:0009306; P:protein secretion; IBA:GO_Central.
GO; GO:0003400; P:regulation of COPII vesicle coating; IBA:GO_Central.
GO; GO:0006355; P:regulation of transcription, DNA-templated; ISO:MGI.
InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
InterPro; IPR001680; WD40_repeat.
InterPro; IPR017986; WD40_repeat_dom.
Pfam; PF00400; WD40; 1.
SMART; SM00320; WD40; 3.
SUPFAM; SSF50998; SSF50998; 1.
PROSITE; PS50082; WD_REPEATS_2; 1.
PROSITE; PS50294; WD_REPEATS_REGION; 1.
1: Evidence at protein level;
Activator; Complete proteome; DNA-binding; Endoplasmic reticulum;
ER-Golgi transport; Membrane; Nitration; Nucleus; Protein transport;
Reference proteome; Repeat; Transcription; Transcription regulation;
Transmembrane; Transmembrane helix; Transport; WD repeat.
CHAIN 1 417 Prolactin regulatory element-binding
protein.
/FTId=PRO_0000051155.
TOPO_DOM 1 388 Cytoplasmic. {ECO:0000255}.
TRANSMEM 389 409 Helical. {ECO:0000255}.
TOPO_DOM 410 417 Lumenal. {ECO:0000255}.
REPEAT 152 191 WD 1.
REPEAT 194 232 WD 2.
REPEAT 298 337 WD 3.
MOD_RES 10 10 Nitrated tyrosine.
{ECO:0000244|PubMed:16800626}.
CONFLICT 136 136 Missing (in Ref. 2; AAF07954).
{ECO:0000305}.
SEQUENCE 417 AA; 45437 MW; 89F8B24F9A7684FA CRC64;
MGRRRGVELY RAPFPLYALR IDPKTGLLIA AGGGGAAKTG IKNGVHFLQL ELINGCLSAS
LLHSHDTETR ATMNLALAGD ILAAGQDAQC QLLRFQVHQQ KGSKAEKSGS KEQGPRQRKG
APPAEKKSGA QVHPEGVELK VKNLEAVQTD FSNEPLQKVV CFNHDNTLLA TGGTDGHVRV
WKVPSLEKVL EFKAHEGEIG DLTLGPDGKL VTVGWDFKAS VWQKDQLVTQ LQWQENGPAS
SNTPYRYQAC RFGQVPDQLG GLRLFTVQIP HKRLRQPPPC YLTAWDSSTF LPLRTRSCGH
EVISCLSVSD SGTFLGLGTV TGSVAIYIAF SLQRLYYVKE AHGIVVTDVT FLPEKGCGPK
LLGPHETALF SVAVDSRCQL HLLPSRRSVP VWLLLLLCVG LIIVTILLLQ TAFPGFL


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Pathways :
WP2292: Chemokine signaling pathway
WP731: Sterol regulatory element binding protein related
WP1493: Carbon assimilation C4 pathway
WP1531: Vitamin D synthesis
WP1616: ABC transporters
WP1678: Nucleotide excision repair
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP1899: Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WP1909: Signal regulatory protein (SIRP) family interactions
WP1042: Nucleotide GPCRs
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1049: G Protein Signaling Pathways
WP1158: Nucleotide GPCRs
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP1165: G Protein Signaling Pathways
WP1191: Nucleotide Metabolism
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP1364: Nucleotide GPCRs
WP1371: G Protein Signaling Pathways
WP1438: Influenza A virus infection
WP146: Nucleotide Metabolism
WP1502: Mitochondrial biogenesis
WP1566: Citrate cycle (TCA cycle)
WP1574: Catalytic cycle of mammalian FMOs

Related Genes :
[RAPGEF3 CGEF1 EPAC EPAC1] Rap guanine nucleotide exchange factor 3 (Exchange factor directly activated by cAMP 1) (Exchange protein directly activated by cAMP 1) (EPAC 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP) (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI)
[Rapgef2 Pdzgef1] Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1)
[ARFGEF1 ARFGEP1 BIG1] Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (ADP-ribosylation factor guanine nucleotide-exchange factor 1) (p200 ARF guanine nucleotide exchange factor) (p200 ARF-GEP1)
[RAPGEF2 KIAA0313 NRAPGEP PDZGEF1] Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1)
[AKAP13 BRX HT31 LBC] A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47)
[Arhgef2 Kiaa0651 Lbcl1 Lfc] Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (LBC'S first cousin) (Lymphoid blast crisis-like 1) (Oncogene LFC) (Rhobin)
[Rapgef3 Epac Epac1] Rap guanine nucleotide exchange factor 3 (Exchange factor directly activated by cAMP 1) (Exchange protein directly activated by cAMP 1) (EPAC 1) (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI)
[SERGEF DELGEF GNEFR] Secretion-regulating guanine nucleotide exchange factor (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF) (Guanine nucleotide exchange factor-related protein)
[Arfgef2 Arfgep2 Big2] Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) (ADP-ribosylation factor guanine nucleotide-exchange factor 2)
[Rapgef2 Kiaa0313 Pdzgef1] Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1)
[ARFGEF2 ARFGEP2 BIG2] Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) (ADP-ribosylation factor guanine nucleotide-exchange factor 2)
[ARHGEF2] Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Tight junction-associated guanine nucleotide exchange factor isoform A)
[RAPGEF2 NRAPGEP PDZGEF1] Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1)
[RAPGEF2 NRAPGEP PDZGEF1] Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1)
[Rapgef3 Epac Epac1] Rap guanine nucleotide exchange factor 3 (Exchange factor directly activated by cAMP 1) (Exchange protein directly activated by cAMP 1) (EPAC 1) (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI)
[ARHGEF18 KIAA0521] Rho guanine nucleotide exchange factor 18 (114 kDa Rho-specific guanine nucleotide exchange factor) (p114-Rho-GEF) (p114RhoGEF) (Septin-associated RhoGEF) (SA-RhoGEF)
[ARHGEF2 KIAA0651 LFP40] Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40)
[Arfgef1] Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) (Brefeldin A-inhibited GEP 1) (ADP-ribosylation factor guanine nucleotide-exchange factor 1)
[Arfgef2 Arfgep2 Big2] Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) (ADP-ribosylation factor guanine nucleotide-exchange factor 2)
[ARHGEF5 TIM] Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM)
[ARFGEF1 ARFGEP1 BIG1] Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (ADP-ribosylation factor guanine nucleotide-exchange factor 1) (p200 ARF guanine nucleotide exchange factor) (p200 ARF-GEP1)
[ARHGEF1] Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5)
[Arhgef2] Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1)
[ARHGEF9 ARHDH9 KIAA0424] Rho guanine nucleotide exchange factor 9 (Collybistin) (PEM-2 homolog) (Rac/Cdc42 guanine nucleotide exchange factor 9)
[Arfgef1] Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) (Brefeldin A-inhibited GEP 1) (ADP-ribosylation factor guanine nucleotide-exchange factor 1)
[Srebf1 Srebp1] Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1) [Cleaved into: Processed sterol regulatory element-binding protein 1]
[ARHGEF2] Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1)
[ROPGEF1 At4g38430 F22I13.200] Rop guanine nucleotide exchange factor 1 (AtRopGEF1) (Kinase partner protein-like) (KPP-like) (Rho of plants guanine nucleotide exchange factor 1)
[GCD6 TIF225 YDR211W YD8142.12 YD8142B.03] Translation initiation factor eIF-2B subunit epsilon (GCD complex subunit GCD6) (Guanine nucleotide exchange factor subunit GCD6) (eIF-2B GDP-GTP exchange factor subunit epsilon)
[RACK1 GNB2L1 HLC7 PIG21] Receptor of activated protein C kinase 1 (Cell proliferation-inducing gene 21 protein) (Guanine nucleotide-binding protein subunit beta-2-like 1) (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Human lung cancer oncogene 7 protein) (HLC-7) (Receptor for activated C kinase) (Small ribosomal subunit protein RACK1) [Cleaved into: Receptor of activated protein C kinase 1, N-terminally processed (Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed)]

Bibliography :
[11422940] The mammalian guanine nucleotide exchange factor mSec12 is essential for activation of the Sar1 GTPase directing endoplasmic reticulum export.
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