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Prostaglandin D2 receptor 2 (Chemoattractant receptor-homologous molecule expressed on Th2 cells) (G-protein coupled receptor 44) (CD antigen CD294)

 PD2R2_HUMAN             Reviewed;         395 AA.
Q9Y5Y4; O94765; Q4QRI6;
11-JUL-2001, integrated into UniProtKB/Swiss-Prot.
18-MAY-2010, sequence version 3.
02-JUN-2021, entry version 161.
RecName: Full=Prostaglandin D2 receptor 2;
AltName: Full=Chemoattractant receptor-homologous molecule expressed on Th2 cells;
AltName: Full=G-protein coupled receptor 44;
AltName: CD_antigen=CD294;
Name=PTGDR2; Synonyms=CRTH2, DL1R, GPR44;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ALA-204.
PubMed=10036181; DOI=10.1006/geno.1998.5655;
Marchese A., Sawzdargo M., Nguyen T., Cheng R., Heng H.H.Q., Nowak T.,
Im D.-S., Lynch K.R., George S.R., O'Dowd B.F.;
"Discovery of three novel orphan G-protein-coupled receptors.";
Genomics 56:12-21(1999).
[2]
NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND VARIANT ALA-204.
TISSUE=Blood;
PubMed=9973380;
Nagata K., Tanaka K., Ogawa K., Kemmotsu K., Imai T., Yoshie O., Abe H.,
Tada K., Nakamura M., Sugamura K., Takano S.;
"Selective expression of a novel surface molecule by human Th2 cells in
vivo.";
J. Immunol. 162:1278-1286(1999).
[3]
NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ALA-204.
TISSUE=Placenta;
Methner A., Schroeder S.;
"Tissue expression and chromosomal organization of a novel G protein-
coupled receptor.";
Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-204.
TISSUE=Placenta;
King M.M., Aronstam R.S., Sharma S.V.;
"cDNA clones of human proteins involved in signal transduction sequenced by
the Guthrie cDNA resource center (www.cdna.org).";
Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16554811; DOI=10.1038/nature04632;
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
Hattori M., Rogers J., Lander E.S., Sakaki Y.;
"Human chromosome 11 DNA sequence and analysis including novel gene
identification.";
Nature 440:497-500(2006).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-204.
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
FUNCTION AS RECEPTOR FOR PGD2.
PubMed=11535533; DOI=10.1182/blood.v98.6.1942;
Monneret G., Gravel S., Diamond M., Rokach J., Powell W.S.;
"Prostaglandin D2 is a potent chemoattractant for human eosinophils that
acts via a novel DP receptor.";
Blood 98:1942-1948(2001).
[8]
TISSUE SPECIFICITY.
PubMed=11168006; DOI=10.1046/j.1365-2249.2001.01422.x;
Tsuda H., Michimata T., Sakai M., Nagata K., Nakamura M., Saito S.;
"A novel surface molecule of Th2- and Tc2-type cells, CRTH2 expression on
human peripheral and decidual CD4+ and CD8+ T cells during the early stage
of pregnancy.";
Clin. Exp. Immunol. 123:105-111(2001).
[9]
FUNCTION AS RECEPTOR FOR PGD2, AND TISSUE SPECIFICITY.
PubMed=11208866; DOI=10.1084/jem.193.2.255;
Hirai H., Tanaka K., Yoshie O., Ogawa K., Kenmotsu K., Takamori Y.,
Ichimasa M., Sugamura K., Nakamura M., Takano S., Nagata K.;
"Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells,
eosinophils, and basophils via seven-transmembrane receptor CRTH2.";
J. Exp. Med. 193:255-261(2001).
[10]
TISSUE SPECIFICITY, AND CHARACTERIZATION.
PubMed=12466225; DOI=10.1038/sj.bjp.0704973;
Sawyer N., Cauchon E., Chateauneuf A., Cruz R.P., Nicholson D.W.,
Metters K.M., O'Neill G.P., Gervais F.G.;
"Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2.";
Br. J. Pharmacol. 137:1163-1172(2002).
[11]
FUNCTION AS PGD2 RECEPTOR, AND FUNCTION IN PI3K SIGNALING.
PubMed=17196174; DOI=10.1016/j.bcp.2006.11.021;
Xue L., Gyles S.L., Barrow A., Pettipher R.;
"Inhibition of PI3K and calcineurin suppresses chemoattractant receptor-
homologous molecule expressed on Th2 cells (CRTH2)-dependent responses of
Th2 lymphocytes to prostaglandin D(2).";
Biochem. Pharmacol. 73:843-853(2007).
[12]
SUBCELLULAR LOCATION, AND PHOSPHORYLATION.
PubMed=17207480; DOI=10.1016/j.ejphar.2006.11.058;
Gallant M.A., Slipetz D., Hamelin E., Rochdi M.D., Talbot S.,
de Brum-Fernandes A.J., Parent J.L.;
"Differential regulation of the signaling and trafficking of the two
prostaglandin D2 receptors, prostanoid DP receptor and CRTH2.";
Eur. J. Pharmacol. 557:115-123(2007).
[13]
MUTAGENESIS OF ASP-330; SER-331; GLU-332; LEU-333 AND THR-347, AND
IDENTIFICATION OF A RECYCLING MOTIF.
PubMed=20035740; DOI=10.1016/j.ejphar.2009.12.022;
Roy S.J., Parent A., Gallant M.A., de Brum-Fernandes A.J., Stankova J.,
Parent J.L.;
"Characterization of C-terminal tail determinants involved in CRTH2
receptor trafficking: identification of a recycling motif.";
Eur. J. Pharmacol. 630:10-18(2010).
-!- FUNCTION: Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-
protein. Receptor activation may result in pertussis toxin-sensitive
decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is
also implicated in mediating PTGDR2 effects. PGD2 induced receptor
internalization. CRTH2 internalization can be regulated by diverse
kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor
activation is responsible, at least in part, in immune regulation and
allergic/inflammation responses. {ECO:0000269|PubMed:11208866,
ECO:0000269|PubMed:11535533, ECO:0000269|PubMed:17196174}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
protein {ECO:0000305}. Note=Internalized receptors colocalized with
RAB11A. {ECO:0000269|PubMed:17207480}.
-!- TISSUE SPECIFICITY: Widespread expression. High expression in stomach,
small intestine, heart and thymus. Intermediate expression in colon,
spinal cord and peripheral blood and low expression in brain, skeletal
muscle and spleen. Expressed also on Th2- and Tc2- type cells,
eosinophils and basophils. {ECO:0000269|PubMed:11168006,
ECO:0000269|PubMed:11208866, ECO:0000269|PubMed:12466225,
ECO:0000269|PubMed:9973380}.
-!- DOMAIN: The 330-DSEL-333 motif is involved in the recycling of PTGDR2
to the cell surface after agonist-induced internalization. This motif
seems to be required for GRK2 and GPRK5/GRK5 to promote agonist-induced
internalization. Thr-347 is a major site for PKC-induced
internalization of the receptor.
-!- PTM: Phosphorylated. {ECO:0000269|PubMed:17207480}.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
-!- SEQUENCE CAUTION:
Sequence=AAD21055.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Sequence=AAD21055.1; Type=Frameshift; Evidence={ECO:0000305};
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EMBL; AF118265; AAD21055.1; ALT_SEQ; Genomic_DNA.
EMBL; AB008535; BAA74518.1; -; mRNA.
EMBL; AF144308; AAD34539.1; -; mRNA.
EMBL; AY507142; AAR92484.1; -; mRNA.
EMBL; AP000777; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC096841; AAH96841.1; -; mRNA.
CCDS; CCDS7994.1; -.
RefSeq; NP_004769.2; NM_004778.2.
PDB; 6D26; X-ray; 2.80 A; A=1-339.
PDB; 6D27; X-ray; 2.74 A; A=1-339.
PDBsum; 6D26; -.
PDBsum; 6D27; -.
SMR; Q9Y5Y4; -.
BioGRID; 116412; 5.
STRING; 9606.ENSP00000332812; -.
BindingDB; Q9Y5Y4; -.
ChEMBL; CHEMBL5071; -.
DrugBank; DB00770; Alprostadil.
DrugBank; DB12789; Dinoprost.
DrugBank; DB00917; Dinoprostone.
DrugBank; DB01088; Iloprost.
DrugBank; DB00328; Indomethacin.
DrugBank; DB02056; Prostaglandin D2.
DrugBank; DB13036; Ramatroban.
DrugBank; DB00605; Sulindac.
DrugBank; DB04828; Zomepirac.
DrugCentral; Q9Y5Y4; -.
GuidetoPHARMACOLOGY; 339; -.
SwissLipids; SLP:000001575; -.
GlyGen; Q9Y5Y4; 2 sites.
iPTMnet; Q9Y5Y4; -.
PhosphoSitePlus; Q9Y5Y4; -.
BioMuta; PTGDR2; -.
DMDM; 296439334; -.
MassIVE; Q9Y5Y4; -.
PaxDb; Q9Y5Y4; -.
PeptideAtlas; Q9Y5Y4; -.
PRIDE; Q9Y5Y4; -.
ProteomicsDB; 86540; -.
Antibodypedia; 2960; 645 antibodies.
DNASU; 11251; -.
Ensembl; ENST00000332539; ENSP00000332812; ENSG00000183134.
GeneID; 11251; -.
KEGG; hsa:11251; -.
UCSC; uc001nqc.3; human.
CTD; 11251; -.
DisGeNET; 11251; -.
GeneCards; PTGDR2; -.
HGNC; HGNC:4502; PTGDR2.
HPA; ENSG00000183134; Tissue enhanced (blood, lymphoid tissue).
MIM; 604837; gene.
neXtProt; NX_Q9Y5Y4; -.
OpenTargets; ENSG00000183134; -.
PharmGKB; PA28891; -.
VEuPathDB; HostDB:ENSG00000183134.4; -.
eggNOG; ENOG502QTYS; Eukaryota.
GeneTree; ENSGT00940000162009; -.
HOGENOM; CLU_009579_8_0_1; -.
InParanoid; Q9Y5Y4; -.
OMA; FRDTIPR; -.
OrthoDB; 1102944at2759; -.
PhylomeDB; Q9Y5Y4; -.
TreeFam; TF330976; -.
PathwayCommons; Q9Y5Y4; -.
Reactome; R-HSA-391908; Prostanoid ligand receptors.
Reactome; R-HSA-418594; G alpha (i) signalling events.
BioGRID-ORCS; 11251; 4 hits in 992 CRISPR screens.
GeneWiki; GPR44; -.
GenomeRNAi; 11251; -.
Pharos; Q9Y5Y4; Tchem.
PRO; PR:Q9Y5Y4; -.
Proteomes; UP000005640; Chromosome 11.
RNAct; Q9Y5Y4; protein.
Bgee; ENSG00000183134; Expressed in mucosa of transverse colon and 93 other tissues.
Genevisible; Q9Y5Y4; HS.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0043005; C:neuron projection; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0004930; F:G protein-coupled receptor activity; IDA:UniProtKB.
GO; GO:0042923; F:neuropeptide binding; IBA:GO_Central.
GO; GO:0042277; F:peptide binding; IBA:GO_Central.
GO; GO:0004956; F:prostaglandin D receptor activity; IDA:UniProtKB.
GO; GO:0004958; F:prostaglandin F receptor activity; IEA:Ensembl.
GO; GO:0001785; F:prostaglandin J receptor activity; IEA:Ensembl.
GO; GO:0007193; P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; IEA:Ensembl.
GO; GO:0019722; P:calcium-mediated signaling; IDA:UniProtKB.
GO; GO:0006935; P:chemotaxis; IDA:UniProtKB.
GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IDA:UniProtKB.
GO; GO:0006955; P:immune response; TAS:ProtInc.
GO; GO:2000255; P:negative regulation of male germ cell proliferation; IEA:Ensembl.
GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
GO; GO:0045745; P:positive regulation of G protein-coupled receptor signaling pathway; IEA:Ensembl.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
Pfam; PF00001; 7tm_1; 1.
PRINTS; PR00237; GPCRRHODOPSN.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
1: Evidence at protein level;
3D-structure; Cell membrane; Disulfide bond; G-protein coupled receptor;
Glycoprotein; Membrane; Phosphoprotein; Receptor; Reference proteome;
Transducer; Transmembrane; Transmembrane helix.
CHAIN 1..395
/note="Prostaglandin D2 receptor 2"
/id="PRO_0000069572"
TOPO_DOM 1..33
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 34..56
/note="Helical; Name=1"
/evidence="ECO:0000255"
TOPO_DOM 57..67
/note="Cytoplasmic"
/evidence="ECO:0000255"
TRANSMEM 68..89
/note="Helical; Name=2"
/evidence="ECO:0000255"
TOPO_DOM 90..106
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 107..127
/note="Helical; Name=3"
/evidence="ECO:0000255"
TOPO_DOM 128..146
/note="Cytoplasmic"
/evidence="ECO:0000255"
TRANSMEM 147..168
/note="Helical; Name=4"
/evidence="ECO:0000255"
TOPO_DOM 169..210
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 211..231
/note="Helical; Name=5"
/evidence="ECO:0000255"
TOPO_DOM 232..247
/note="Cytoplasmic"
/evidence="ECO:0000255"
TRANSMEM 248..269
/note="Helical; Name=6"
/evidence="ECO:0000255"
TOPO_DOM 270..288
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 289..308
/note="Helical; Name=7"
/evidence="ECO:0000255"
TOPO_DOM 309..395
/note="Cytoplasmic"
/evidence="ECO:0000255"
REGION 333..363
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
MOTIF 330..333
/note="Involved in the recycling of CRTH2"
COMPBIAS 338..353
/note="Polar residues"
/evidence="ECO:0000256|SAM:MobiDB-lite"
MOD_RES 331
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q6XKD3"
MOD_RES 345
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q9Z2J6"
CARBOHYD 4
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 25
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 104..182
/evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
VARIANT 204
/note="V -> A (in dbSNP:rs2467642)"
/evidence="ECO:0000269|PubMed:10036181,
ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:9973380,
ECO:0000269|Ref.3, ECO:0000269|Ref.4"
/id="VAR_063131"
MUTAGEN 330
/note="D->A: 45% increases internalization of PTGDR2."
/evidence="ECO:0000269|PubMed:20035740"
MUTAGEN 331
/note="S->A: 45% increases internalization of PTGDR2."
/evidence="ECO:0000269|PubMed:20035740"
MUTAGEN 332
/note="E->A: 45% increases internalization of PTGDR2."
/evidence="ECO:0000269|PubMed:20035740"
MUTAGEN 333
/note="L->A: 45% increase in internalization of PTGDR2."
/evidence="ECO:0000269|PubMed:20035740"
MUTAGEN 347
/note="T->A: Decreases in PKC-induced internalization of
PTGDR2."
/evidence="ECO:0000269|PubMed:20035740"
HELIX 12..17
/evidence="ECO:0007829|PDB:6D27"
STRAND 22..25
/evidence="ECO:0007829|PDB:6D26"
HELIX 33..59
/evidence="ECO:0007829|PDB:6D27"
HELIX 66..92
/evidence="ECO:0007829|PDB:6D27"
HELIX 102..134
/evidence="ECO:0007829|PDB:6D27"
HELIX 136..142
/evidence="ECO:0007829|PDB:6D27"
HELIX 145..162
/evidence="ECO:0007829|PDB:6D27"
HELIX 164..168
/evidence="ECO:0007829|PDB:6D27"
STRAND 170..174
/evidence="ECO:0007829|PDB:6D27"
STRAND 176..178
/evidence="ECO:0007829|PDB:6D27"
STRAND 180..184
/evidence="ECO:0007829|PDB:6D27"
HELIX 186..188
/evidence="ECO:0007829|PDB:6D26"
HELIX 195..213
/evidence="ECO:0007829|PDB:6D27"
HELIX 216..236
/evidence="ECO:0007829|PDB:6D27"
HELIX 245..258
/evidence="ECO:0007829|PDB:6D27"
HELIX 260..271
/evidence="ECO:0007829|PDB:6D27"
TURN 272..274
/evidence="ECO:0007829|PDB:6D27"
HELIX 276..278
/evidence="ECO:0007829|PDB:6D27"
HELIX 279..294
/evidence="ECO:0007829|PDB:6D27"
HELIX 296..306
/evidence="ECO:0007829|PDB:6D27"
HELIX 309..326
/evidence="ECO:0007829|PDB:6D27"
SEQUENCE 395 AA; 43268 MW; 99A63CBDA418DEC9 CRC64;
MSANATLKPL CPILEQMSRL QSHSNTSIRY IDHAAVLLHG LASLLGLVEN GVILFVVGCR
MRQTVVTTWV LHLALSDLLA SASLPFFTYF LAVGHSWELG TTFCKLHSSI FFLNMFASGF
LLSAISLDRC LQVVRPVWAQ NHRTVAAAHK VCLVLWALAV LNTVPYFVFR DTISRLDGRI
MCYYNVLLLN PGPDRDATCN SRQVALAVSK FLLAFLVPLA IIASSHAAVS LRLQHRGRRR
PGRFVRLVAA VVAAFALCWG PYHVFSLLEA RAHANPGLRP LVWRGLPFVT SLAFFNSVAN
PVLYVLTCPD MLRKLRRSLR TVLESVLVDD SELGGAGSSR RRRTSSTARS ASPLALCSRP
EEPRGPARLL GWLLGSCAAS PQTGPLNRAL SSTSS


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WP886: Kit Receptor Signaling Pathway
WP1781: Advanced glycosylation endproduct receptor signaling
WP252: Androgen Receptor Signaling Pathway
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1336: EPO Receptor Signaling
WP274: B Cell Receptor Signaling Pathway
WP774: Kit Receptor Signaling Pathway
WP1348: Androgen Receptor Signaling Pathway
WP2197: Endothelin
WP566: canonical wnt - zebrafish
WP908: B Cell Receptor Signaling Pathway
WP590: Cardiovascular Signaling

Related Genes :
[CD300LF CD300F CLM1 IGSF13 IREM1 NKIR UNQ3105/PRO10111] CMRF35-like molecule 1 (CLM-1) (CD300 antigen-like family member F) (Immune receptor expressed on myeloid cells 1) (IREM-1) (Immunoglobulin superfamily member 13) (IgSF13) (NK inhibitory receptor) (CD antigen CD300f)
[SIRPA BIT MFR MYD1 PTPNS1 SHPS1 SIRP] Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (Macrophage fusion receptor) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (Signal-regulatory protein alpha-2) (Sirp-alpha-2) (Signal-regulatory protein alpha-3) (Sirp-alpha-3) (p84) (CD antigen CD172a)
[OR1D2 OLFR1] Olfactory receptor 1D2 (Olfactory receptor 17-4) (OR17-4) (Olfactory receptor OR17-6) (Olfactory receptor-like protein HGMP07E)
[Ceacam1 Bgp Bgp1] Carcinoembryonic antigen-related cell adhesion molecule 1 (Biliary glycoprotein 1) (BGP-1) (Biliary glycoprotein D) (MHVR1) (Murine hepatitis virus receptor) (MHV-R) (CD antigen CD66a)
[CD44 LHR MDU2 MDU3 MIC4] CD44 antigen (CDw44) (Epican) (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44)
[LTB4R BLT BLT1 BLTR CMKRL1 GPR16 P2RY7] Leukotriene B4 receptor 1 (LTB4-R 1) (LTB4-R1) (Chemoattractant receptor-like 1) (G-protein coupled receptor 16) (P2Y purinoceptor 7) (P2Y7)
[Ccrl2 Ccr11 Lccr] C-C chemokine receptor-like 2 (Chemokine receptor CCR11) (G-protein coupled beta chemokine receptor) (Lipopolysaccharide-inducible C-C chemokine receptor) (L-CCR)
[GPER1 CEPR CMKRL2 DRY12 GPER GPR30] G-protein coupled estrogen receptor 1 (Chemoattractant receptor-like 2) (Flow-induced endothelial G-protein coupled receptor 1) (FEG-1) (G protein-coupled estrogen receptor 1) (G-protein coupled receptor 30) (GPCR-Br) (IL8-related receptor DRY12) (Lymphocyte-derived G-protein coupled receptor) (LYGPR) (Membrane estrogen receptor) (mER)
[Sirpa Bit Mfr Ptpns1 Shps1 Sirp] Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (Macrophage fusion receptor) (Macrophage membrane protein MFP150) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (CD antigen CD172a)
[Sirpa Bit Myd1 Ptpns1 Shps1 Sirp] Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (mSIRP-alpha1) (p84) (CD antigen CD172a)
[CCR7 CMKBR7 EBI1 EVI1] C-C chemokine receptor type 7 (C-C CKR-7) (CC-CKR-7) (CCR-7) (BLR2) (CDw197) (Epstein-Barr virus-induced G-protein coupled receptor 1) (EBI1) (EBV-induced G-protein coupled receptor 1) (MIP-3 beta receptor) (CD antigen CD197)
[Gper1 Cmkrl2 Gper Gpr30 Gpr41] G-protein coupled estrogen receptor 1 (Chemoattractant receptor-like 2) (G protein-coupled estrogen receptor 1) (G-protein coupled receptor 30) (G-protein coupled receptor 41) (Membrane estrogen receptor) (mER)
[Cd44 Ly-24] CD44 antigen (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Hermes antigen) (Hyaluronate receptor) (Lymphocyte antigen 24) (Ly-24) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44)
[Gper1 Cmkrl2 Gper Gpr30] G-protein coupled estrogen receptor 1 (Chemoattractant receptor-like 2) (G protein-coupled estrogen receptor 1) (G-protein coupled receptor 30) (Membrane estrogen receptor) (mER)
[Trem2 Trem2a Trem2b Trem2c] Triggering receptor expressed on myeloid cells 2 (TREM-2) (Triggering receptor expressed on monocytes 2)
[TREM2] Triggering receptor expressed on myeloid cells 2 (TREM-2) (Triggering receptor expressed on monocytes 2)
[Havcr2 Tim3 Timd3] Hepatitis A virus cellular receptor 2 homolog (HAVcr-2) (T-cell immunoglobulin and mucin domain-containing protein 3) (TIMD-3) (T-cell immunoglobulin mucin receptor 3) (TIM-3) (T-cell membrane protein 3) (CD antigen CD366)
[TREM1] Triggering receptor expressed on myeloid cells 1 (TREM-1) (Triggering receptor expressed on monocytes 1) (CD antigen CD354)
[KLRD1 CD94] Natural killer cells antigen CD94 (KP43) (Killer cell lectin-like receptor subfamily D member 1) (NK cell receptor) (CD antigen CD94)
[CXCR3 GPR9] C-X-C chemokine receptor type 3 (CXC-R3) (CXCR-3) (CKR-L2) (G protein-coupled receptor 9) (Interferon-inducible protein 10 receptor) (IP-10 receptor) (CD antigen CD183)
[Treml4 TLT4 Treml3] Trem-like transcript 4 protein (TLT-4) (Triggering receptor expressed on myeloid cells-like protein 3) (Triggering receptor expressed on myeloid cells-like protein 4)
[Fcgr2 Fcgr2b Ly-17] Low affinity immunoglobulin gamma Fc region receptor II (Fc gamma receptor IIB) (Fc-gamma RII) (Fc-gamma-RIIB) (FcRII) (IgG Fc receptor II beta) (Lymphocyte antigen 17) (Ly-17) (CD antigen CD32)
[Cd244 2b4 Nmrk] Natural killer cell receptor 2B4 (NK cell type I receptor protein 2B4) (NKR2B4) (Non-MHC restricted killing associated) (SLAM family member 4) (SLAMF4) (Signaling lymphocytic activation molecule 4) (CD antigen CD244)
[CD300A CMRF35H IGSF12 HSPC083] CMRF35-like molecule 8 (CLM-8) (CD300 antigen-like family member A) (CMRF-35-H9) (CMRF35-H9) (CMRF35-H) (IRC1/IRC2) (Immunoglobulin superfamily member 12) (IgSF12) (Inhibitory receptor protein 60) (IRp60) (NK inhibitory receptor) (CD antigen CD300a)
[EBAG9 RCAS1] Receptor-binding cancer antigen expressed on SiSo cells (Cancer-associated surface antigen RCAS1) (Estrogen receptor-binding fragment-associated gene 9 protein)
[Cd300c2 Cd300c Clm4 Igsf7 Lmir2] CMRF-35-like molecule 4 (CLM-4) (CD300C molecule 2) (Dendritic cell-derived Ig-like receptor 1) (DIgR1) (Immunoglobulin superfamily member 7) (IgSF7) (Leukocyte mono-Ig-like receptor 2) (Myeloid-associated immunoglobulin-like receptor 2) (MAIR-2) (MAIR-II)
[Havcr2 Tim3 Timd3] Hepatitis A virus cellular receptor 2 homolog (HAVcr-2) (T-cell immunoglobulin and mucin domain-containing protein 3) (TIMD-3) (T-cell immunoglobulin mucin receptor 3) (TIM-3) (T-cell membrane protein 3) (CD antigen CD366)
[Cd300lf Clm1 Lmir3] CMRF35-like molecule 1 (CLM-1) (CD300 antigen-like family member F) (Leukocyte mono-Ig-like receptor 3) (Myeloid-associated immunoglobulin-like receptor 5) (MAIR-5) (MAIR-V) (CD antigen CD300f)
[FCRLA FCRL FCRL1 FCRLM1 FCRX FREB UNQ291/PRO329] Fc receptor-like A (Fc receptor homolog expressed in B-cells) (Fc receptor-like and mucin-like protein 1) (Fc receptor-like protein) (Fc receptor-related protein X) (FcRX)
[LILRB1 ILT2 LIR1 MIR7] Leukocyte immunoglobulin-like receptor subfamily B member 1 (LIR-1) (Leukocyte immunoglobulin-like receptor 1) (CD85 antigen-like family member J) (Immunoglobulin-like transcript 2) (ILT-2) (Monocyte/macrophage immunoglobulin-like receptor 7) (MIR-7) (CD antigen CD85j)

Bibliography :
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