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Protein BEX3 (Brain-expressed X-linked protein 3) (Nerve growth factor receptor-associated protein 1) (Ovarian granulosa cell 13.0 kDa protein HGR74) (p75NTR-associated cell death executor)

 BEX3_HUMAN              Reviewed;         111 AA.
Q00994; B2RD17; D3DXA3; Q5JQT4; Q5JQT5;
01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
01-JUN-1994, sequence version 1.
02-JUN-2021, entry version 177.
RecName: Full=Protein BEX3 {ECO:0000305};
AltName: Full=Brain-expressed X-linked protein 3 {ECO:0000312|HGNC:HGNC:13388};
AltName: Full=Nerve growth factor receptor-associated protein 1;
AltName: Full=Ovarian granulosa cell 13.0 kDa protein HGR74;
AltName: Full=p75NTR-associated cell death executor;
Name=BEX3 {ECO:0000312|HGNC:HGNC:13388}; Synonyms=DXS6984E, NADE, NGFRAP1;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Ovary;
PubMed=2171551; DOI=10.1089/dna.1990.9.479;
Rapp G., Freudenstein J., Klaudiny J., Mucha J., Wempe F., Zimmer M.,
Scheit K.H.;
"Characterization of three abundant mRNAs from human ovarian granulosa
cells.";
DNA Cell Biol. 9:479-485(1990).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND CHARACTERIZATION.
PubMed=10764727; DOI=10.1074/jbc.c000140200;
Mukai J., Hachiya T., Shoji-Hoshino S., Kimura M.T., Nadano D., Suvanto P.,
Hanaoka T., Li Y., Irie S., Greene L.A., Sato T.-A.;
"NADE, a p75NTR-associated cell death executor, is involved in signal
transduction mediated by the common neurotrophin receptor p75NTR.";
J. Biol. Chem. 275:17566-17570(2000).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
PubMed=15958283; DOI=10.1016/j.gene.2005.05.012;
Alvarez E., Zhou W., Witta S.E., Freed C.R.;
"Characterization of the Bex gene family in humans, mice, and rats.";
Gene 357:18-28(2005).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Cerebellum;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Eye;
Zhou X., Wang W., Lu F., Hu S., Jiang L., Yan D., Zhang X., Yu X., Yu J.,
Qu J.;
"A comparative gene expression profile of the whole eye from human, mouse,
and guinea pig.";
Mol. Vis. 13:2214-2221(2007).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15772651; DOI=10.1038/nature03440;
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
Rogers J., Bentley D.R.;
"The DNA sequence of the human X chromosome.";
Nature 434:325-337(2005).
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
Hunkapiller M.W., Myers E.W., Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Eye;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[9]
3D-STRUCTURE MODELING OF 1-111.
Arunkumar S.;
"Theoretical model for p75NTR-associated cell death executor.";
Submitted (JAN-2005) to the PDB data bank.
-!- FUNCTION: May be a signaling adapter molecule involved in p75NTR-
mediated apoptosis induced by NGF. Plays a role in zinc-triggered
neuronal death (By similarity). May play an important role in the
pathogenesis of neurogenetic diseases. {ECO:0000250}.
-!- SUBUNIT: Self-associates. Binds to the DEATH domain of p75NTR/NGFR.
Interacts with 14-3-3 epsilon (YWHAE). Interacts with DIABLO/SMAC.
{ECO:0000250|UniProtKB:Q9WTZ9}.
-!- INTERACTION:
Q00994; Q00994: BEX3; NbExp=4; IntAct=EBI-741753, EBI-741753;
Q00994; Q13515: BFSP2; NbExp=3; IntAct=EBI-741753, EBI-10229433;
Q00994; Q8NA61-2: CBY2; NbExp=3; IntAct=EBI-741753, EBI-11524851;
Q00994; Q8IYX3: CCDC116; NbExp=4; IntAct=EBI-741753, EBI-744311;
Q00994; Q8WYA6: CTNNBL1; NbExp=3; IntAct=EBI-741753, EBI-748128;
Q00994; G5E9A7: DMWD; NbExp=3; IntAct=EBI-741753, EBI-10976677;
Q00994; P26378-2: ELAVL4; NbExp=3; IntAct=EBI-741753, EBI-21603100;
Q00994; Q9Y6C2: EMILIN1; NbExp=3; IntAct=EBI-741753, EBI-744586;
Q00994; Q9Y6C2-2: EMILIN1; NbExp=6; IntAct=EBI-741753, EBI-11748557;
Q00994; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-741753, EBI-744099;
Q00994; P22607: FGFR3; NbExp=3; IntAct=EBI-741753, EBI-348399;
Q00994; A1L4K1: FSD2; NbExp=6; IntAct=EBI-741753, EBI-5661036;
Q00994; Q53GS7: GLE1; NbExp=3; IntAct=EBI-741753, EBI-1955541;
Q00994; Q0D2H9: GOLGA8DP; NbExp=3; IntAct=EBI-741753, EBI-10181276;
Q00994; Q08AF8: GOLGA8G; NbExp=3; IntAct=EBI-741753, EBI-10181260;
Q00994; P01112: HRAS; NbExp=3; IntAct=EBI-741753, EBI-350145;
Q00994; P42858: HTT; NbExp=6; IntAct=EBI-741753, EBI-466029;
Q00994; Q9UNL4: ING4; NbExp=3; IntAct=EBI-741753, EBI-2866661;
Q00994; Q8WYH8: ING5; NbExp=3; IntAct=EBI-741753, EBI-488533;
Q00994; O76011: KRT34; NbExp=3; IntAct=EBI-741753, EBI-1047093;
Q00994; P59942: MCCD1; NbExp=3; IntAct=EBI-741753, EBI-11987923;
Q00994; Q99750: MDFI; NbExp=3; IntAct=EBI-741753, EBI-724076;
Q00994; Q7Z6G3-2: NECAB2; NbExp=6; IntAct=EBI-741753, EBI-10172876;
Q00994; P23297: S100A1; NbExp=3; IntAct=EBI-741753, EBI-743686;
Q00994; Q8WXG8: S100Z; NbExp=5; IntAct=EBI-741753, EBI-12198403;
Q00994; Q96GM5: SMARCD1; NbExp=3; IntAct=EBI-741753, EBI-358489;
Q00994; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-741753, EBI-5235340;
Q00994; Q9Y6A5: TACC3; NbExp=3; IntAct=EBI-741753, EBI-2554984;
Q00994; Q92574: TSC1; NbExp=5; IntAct=EBI-741753, EBI-1047085;
Q00994; Q99598: TSNAX; NbExp=3; IntAct=EBI-741753, EBI-742638;
Q00994; Q8N6Y0: USHBP1; NbExp=6; IntAct=EBI-741753, EBI-739895;
Q00994; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-741753, EBI-740727;
-!- SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Shuttles between the
cytoplasm and the nucleus. Associates with replicating mitochondria (By
similarity). {ECO:0000250}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q00994-1; Sequence=Displayed;
Name=2;
IsoId=Q00994-2; Sequence=VSP_046343;
-!- TISSUE SPECIFICITY: Found in ovarian granulosa cells, testis, prostate
and seminal vesicle tissue. High levels also detected in liver.
{ECO:0000269|PubMed:15958283}.
-!- DOMAIN: The nuclear export signal is required for export from the
nucleus and the interactions with itself and p75NTR/NGFR.
{ECO:0000250}.
-!- PTM: Ubiquitinated. Degraded by the proteasome (By similarity).
{ECO:0000250}.
-!- MISCELLANEOUS: Binds transition metals. {ECO:0000250}.
-!- SIMILARITY: Belongs to the BEX family. {ECO:0000305}.
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EMBL; M38188; AAA63232.1; -; mRNA.
EMBL; AF187064; AAF75129.1; -; mRNA.
EMBL; AY833562; AAX40680.1; -; mRNA.
EMBL; AK315371; BAG37764.1; -; mRNA.
EMBL; EL953547; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AL606763; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH471190; EAW54710.1; -; Genomic_DNA.
EMBL; CH471190; EAW54712.1; -; Genomic_DNA.
EMBL; BC003190; AAH03190.1; -; mRNA.
CCDS; CCDS14508.1; -. [Q00994-1]
CCDS; CCDS14509.1; -. [Q00994-2]
PIR; C35826; C35826.
RefSeq; NP_055195.1; NM_014380.2. [Q00994-1]
RefSeq; NP_996798.1; NM_206915.2. [Q00994-1]
RefSeq; NP_996800.1; NM_206917.2. [Q00994-2]
PDB; 1SA6; Model; -; A=1-111.
PDBsum; 1SA6; -.
SMR; Q00994; -.
BioGRID; 117956; 32.
IntAct; Q00994; 45.
MINT; Q00994; -.
STRING; 9606.ENSP00000361728; -.
iPTMnet; Q00994; -.
BioMuta; BEX3; -.
DMDM; 547642; -.
MassIVE; Q00994; -.
PaxDb; Q00994; -.
PeptideAtlas; Q00994; -.
PRIDE; Q00994; -.
ProteomicsDB; 57900; -. [Q00994-1]
Antibodypedia; 540; 260 antibodies.
DNASU; 27018; -.
Ensembl; ENST00000361298; ENSP00000354843; ENSG00000166681. [Q00994-2]
Ensembl; ENST00000372634; ENSP00000361717; ENSG00000166681. [Q00994-2]
Ensembl; ENST00000372635; ENSP00000361718; ENSG00000166681. [Q00994-1]
Ensembl; ENST00000372645; ENSP00000361728; ENSG00000166681. [Q00994-1]
GeneID; 27018; -.
KEGG; hsa:27018; -.
UCSC; uc004ekh.5; human. [Q00994-1]
CTD; 27018; -.
DisGeNET; 27018; -.
GeneCards; BEX3; -.
HGNC; HGNC:13388; BEX3.
HPA; ENSG00000166681; Low tissue specificity.
MIM; 300361; gene.
neXtProt; NX_Q00994; -.
OpenTargets; ENSG00000166681; -.
PharmGKB; PA31616; -.
VEuPathDB; HostDB:ENSG00000166681.13; -.
eggNOG; ENOG502TF4N; Eukaryota.
GeneTree; ENSGT00940000153412; -.
HOGENOM; CLU_123122_0_0_1; -.
InParanoid; Q00994; -.
OMA; PMQNREE; -.
OrthoDB; 1340122at2759; -.
PhylomeDB; Q00994; -.
TreeFam; TF337909; -.
PathwayCommons; Q00994; -.
Reactome; R-HSA-205025; NADE modulates death signalling.
BioGRID-ORCS; 27018; 7 hits in 592 CRISPR screens.
ChiTaRS; BEX3; human.
GeneWiki; NGFRAP1; -.
GenomeRNAi; 27018; -.
Pharos; Q00994; Tbio.
PRO; PR:Q00994; -.
Proteomes; UP000005640; Chromosome X.
RNAct; Q00994; protein.
Bgee; ENSG00000166681; Expressed in cerebellar vermis and 252 other tissues.
Genevisible; Q00994; HS.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0005829; C:cytosol; IDA:HPA.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0042802; F:identical protein binding; IPI:IntAct.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0005163; F:nerve growth factor receptor binding; IEA:Ensembl.
GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; TAS:Reactome.
GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO; GO:0007275; P:multicellular organism development; TAS:ProtInc.
GO; GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; TAS:Reactome.
GO; GO:0043281; P:regulation of cysteine-type endopeptidase activity involved in apoptotic process; TAS:Reactome.
GO; GO:0007165; P:signal transduction; IBA:GO_Central.
InterPro; IPR007623; BEX.
InterPro; IPR021156; TF_A-like/BEX.
PANTHER; PTHR19430; PTHR19430; 1.
Pfam; PF04538; BEX; 1.
PIRSF; PIRSF008633; BEX; 1.
1: Evidence at protein level;
3D-structure; Alternative splicing; Apoptosis; Cytoplasm; Metal-binding;
Nucleus; Reference proteome; Ubl conjugation.
CHAIN 1..111
/note="Protein BEX3"
/id="PRO_0000096688"
REGION 1..63
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 68..111
/note="Interaction with 14-3-3 epsilon"
/evidence="ECO:0000250"
REGION 68..93
/note="Interaction with p75NTR/NGFR"
/evidence="ECO:0000250"
MOTIF 77..87
/note="Nuclear export signal"
/evidence="ECO:0000250"
VAR_SEQ 1..10
/note="Missing (in isoform 2)"
/evidence="ECO:0000303|Ref.5"
/id="VSP_046343"
SEQUENCE 111 AA; 12959 MW; 29AA0573282C933E CRC64;
MANIHQENEE MEQPMQNGEE DRPLGGGEGH QPAGNRRGQA RRLAPNFRWA IPNRQINDGM
GGDGDDMEIF MEEMREIRRK LRELQLRNCL RILMGELSNH HDHHDEFCLM P


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EIAAB11411 Dlk2,DLK-2,Egfl9,EGF-like protein 9,Endothelial cell-specific protein S-1,Epidermal growth factor-like protein 9,Mouse,Mus musculus,Protein delta homolog 2
EIAAB07403 Cell death activator CIDE-3,Cell death-inducing DFFA-like effector protein C,CIDEC,Fat-specific protein FSP27 homolog,FSP27,Homo sapiens,Human
EIAAB07404 Cell death activator CIDE-3,Cell death-inducing DFFA-like effector protein C,Cidec,Fat-specific protein FSP27,Fsp27,Mouse,Mus musculus
30-218 NELL2 is a cytoplasmic protein that contains epidermal growth factor (EGF) -like repeats. Heterotrimeric protein may be involved in cell growth regulation and differentiation. A similar protein in rod 0.1 mg
E0416r ELISA kit Early growth response protein 1,Egr1,EGR-1,Nerve growth factor-induced protein A,NGFI-A,Rat,Rattus norvegicus,Transcription factor Zif268,Zinc finger protein Krox-24 96T
E0416r ELISA Early growth response protein 1,Egr1,EGR-1,Nerve growth factor-induced protein A,NGFI-A,Rat,Rattus norvegicus,Transcription factor Zif268,Zinc finger protein Krox-24 96T
U0416r CLIA Early growth response protein 1,Egr1,EGR-1,Nerve growth factor-induced protein A,NGFI-A,Rat,Rattus norvegicus,Transcription factor Zif268,Zinc finger protein Krox-24 96T
EIAAB30264 Homo sapiens,Human,PDCD5,Programmed cell death protein 5,Protein TFAR19,TF-1 cell apoptosis-related protein 19,TFAR19
EIAAB30263 Mouse,Mus musculus,Pdcd5,Programmed cell death protein 5,Protein TFAR19,TF-1 cell apoptosis-related protein 19,Tfar19
27-526 Early Growth Response Protein 1 (EGR1, Krox-24 protein, nerve growth factor-induced protein A, Transcription factor ETR103, Zinc finger protein 225) belongs to the EGR family of C2H2-type zinc-finger 0.05 mg
28-572 Early Growth Response Protein 1 (EGR1, Krox-24 protein, nerve growth factor-induced protein A, Transcription factor ETR103, Zinc finger protein 225) belongs to the EGR family of C2H2-type zinc-finger 0.1 mg
18-272-197131 RIP - Rabbit polyclonal to RIP; EC 2.7.11.1; Serine_threonine-protein kinase RIP; Cell death protein RIP; Receptor-interacting protein Polyclonal 0.05 mg
18-272-195083 RIP - Rabbit polyclonal to RIP; EC 2.7.11.1; Serine_threonine-protein kinase RIP; Cell death protein RIP; Receptor-interacting protein Polyclonal 0.1 ml
EIAAB32922 Gpcr25,Gpr65,G-protein coupled receptor 65,Mouse,Mus musculus,Psychosine receptor,T-cell death-associated gene 8 protein,Tdag8
EIAAB32921 GPR65,G-protein coupled receptor 65,Homo sapiens,Human,Psychosine receptor,T-cell death-associated gene 8 protein,TDAG8
U0416h CLIA AT225,Early growth response protein 1,EGR1,EGR-1,Homo sapiens,Human,KROX24,Nerve growth factor-induced protein A,NGFI-A,Transcription factor ETR103,Transcription factor Zif268,Zinc finger protein 96T
Pathways :
WP2272: Pathogenic Escherichia coli infection
WP2292: Chemokine signaling pathway
WP232: G Protein Signaling Pathways
WP1625: Base excision repair
WP1690: Propanoate metabolism
WP1694: Pyrimidine metabolism
WP1654: gamma-Hexachlorocyclohexane degradation
WP1661: Glyoxylate and dicarboxylate metabolism
WP1892: Protein folding
WP2203: TSLP Signaling Pathway
WP1438: Influenza A virus infection
WP1714: Tyrosine metabolism
WP35: G Protein Signaling Pathways
WP1493: Carbon assimilation C4 pathway
WP1672: Mismatch repair
WP1676: Non-homologous end-joining
WP1566: Citrate cycle (TCA cycle)
WP210: Cytoplasmic Ribosomal Proteins
WP1624: Bacterial secretion system
WP211: BMP signaling pathway
WP1689: Porphyrin and chlorophyll metabolism
WP1939: Unfolded Protein Response
WP731: Sterol regulatory element binding protein related
WP1693: Purine metabolism
WP1650: Fluorobenzoate degradation

Related Genes :
[Bex3 Nade Ngfrap1] Protein BEX3 (Brain-expressed X-linked protein 3 homolog) (rBex3) (Nerve growth factor receptor-associated protein 1) (p75NTR-associated cell death executor)
[NGFR TNFRSF16] Tumor necrosis factor receptor superfamily member 16 (Gp80-LNGFR) (Low affinity neurotrophin receptor p75NTR) (Low-affinity nerve growth factor receptor) (NGF receptor) (p75 ICD) (CD antigen CD271)
[NTRK1 MTC TRK TRKA] High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
[NGF NGFB] Beta-nerve growth factor (Beta-NGF)
[Ngf Ngfb] Beta-nerve growth factor (Beta-NGF)
[SORT1] Sortilin (100 kDa NT receptor) (Glycoprotein 95) (Gp95) (Neurotensin receptor 3) (NT3) (NTR3)
[Traf6] TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (RING-type E3 ubiquitin transferase TRAF6)
[Ngf Ngfb] Beta-nerve growth factor (Beta-NGF)
[Kitlg Kitl Mgf Sl Slf] Kit ligand (Hematopoietic growth factor KL) (Mast cell growth factor) (MGF) (Steel factor) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Soluble KIT ligand (sKITLG)]
[SQSTM1 ORCA OSIL] Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62)
[RIPK1 RIP RIP1] Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1)
[Ripk1 Rinp Rip] Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1)
[Ntrk1 Trk Trka] High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (Slow nerve growth factor receptor) (p140-TrkA) (Trk-A)
[TRAF6 RNF85] TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
[KIT SCFR] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
[FGFR3 JTK4] Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333)
[Ntrk2 Trkb] BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Trk-B)
[Maged1 Nrage] Melanoma-associated antigen D1 (MAGE-D1 antigen) (Neurotrophin receptor-interacting MAGE homolog) (Sertoli cell necdin-related gene protein 1) (SNERG-1)
[Kit Sl] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
[Ntrk1] High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1)
[FGFR2 BEK KGFR KSAM] Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332)
[Ptprn] Receptor-type tyrosine-protein phosphatase-like N (R-PTP-N) (105 kDa islet cell antigen) (BEM-3) (Brain-enriched membrane-associated protein tyrosine phosphatase) (ICA105) (ICA512) (PTP IA-2) (PTPLP) [Cleaved into: ICA512-N-terminal fragment (ICA512-NTF); ICA512-transmembrane fragment (ICA512-TMF); ICA512-cleaved cytosolic fragment (ICA512-CCF)]
[KIT] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit)
[NRG1 GGF HGL HRGA NDF SMDF] Pro-neuregulin-1, membrane-bound isoform (Pro-NRG1) [Cleaved into: Neuregulin-1 (Acetylcholine receptor-inducing activity) (ARIA) (Breast cancer cell differentiation factor p45) (Glial growth factor) (Heregulin) (HRG) (Neu differentiation factor) (Sensory and motor neuron-derived factor)]
[RIPK2 CARDIAK RICK RIP2 UNQ277/PRO314/PRO34092] Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containing IL-1 beta ICE-kinase) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (Tyrosine-protein kinase RIPK2) (EC 2.7.10.2)
[Cxcr4 Cmkar4 Lestr Sdf1r] C-X-C chemokine receptor type 4 (CXC-R4) (CXCR-4) (Fusin) (Leukocyte-derived seven transmembrane domain receptor) (LESTR) (Pre-B-cell-derived chemokine receptor) (PB-CKR) (Stromal cell-derived factor 1 receptor) (SDF-1 receptor) (CD antigen CD184)
[TNFRSF21 DR6 UNQ437/PRO868] Tumor necrosis factor receptor superfamily member 21 (Death receptor 6) (CD antigen CD358)
[Tnfrsf21 Dr6] Tumor necrosis factor receptor superfamily member 21 (Death receptor 6) (CD antigen CD358)
[Cxcl12 Sdf1] Stromal cell-derived factor 1 (SDF-1) (12-O-tetradecanoylphorbol 13-acetate repressed protein 1) (TPAR1) (C-X-C motif chemokine 12) (Pre-B cell growth-stimulating factor) (PBSF) (Thymic lymphoma cell-stimulating factor) (TLSF)
[Bcl2l11 Bim Bod] Bcl-2-like protein 11 (Bcl2-L-11) (Bcl-2-related ovarian death protein) (Bcl2-interacting mediator of cell death)

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