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Protein CBR-CUL-1

 A8XSK6_CAEBR            Unreviewed;       768 AA.
A8XSK6;
15-JAN-2008, integrated into UniProtKB/TrEMBL.
16-DEC-2008, sequence version 2.
07-APR-2021, entry version 84.
SubName: Full=Protein CBR-CUL-1 {ECO:0000313|EMBL:CAP35848.2};
Name=cul-1 {ECO:0000313|WormBase:CBG18382};
Synonyms=Cbr-cul-1 {ECO:0000313|EMBL:CAP35848.2};
ORFNames=CBG18382 {ECO:0000313|WormBase:CBG18382},
CBG_18382 {ECO:0000313|EMBL:CAP35848.2};
Caenorhabditis briggsae.
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
Caenorhabditis.
NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP35848.2, ECO:0000313|Proteomes:UP000008549};
[1] {ECO:0000313|EMBL:CAP35848.2, ECO:0000313|Proteomes:UP000008549}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=AF16 {ECO:0000313|EMBL:CAP35848.2,
ECO:0000313|Proteomes:UP000008549};
PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
Durbin R., Waterston R.H.;
"The genome sequence of Caenorhabditis briggsae: a platform for comparative
genomics.";
PLoS Biol. 1:166-192(2003).
-!- SIMILARITY: Belongs to the cullin family.
{ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
ECO:0000256|RuleBase:RU003829}.
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EMBL; HE600936; CAP35848.2; -; Genomic_DNA.
STRING; 6238.CBG18382; -.
WormBase; CBG18382; CBP10829; WBGene00037818; Cbr-cul-1.
eggNOG; KOG2166; Eukaryota.
HOGENOM; CLU_004747_6_1_1; -.
InParanoid; A8XSK6; -.
OMA; WLWHLCK; -.
OrthoDB; 1040292at2759; -.
Proteomes; UP000008549; Chromosome III.
GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IBA:GO_Central.
GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
GO; GO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central.
GO; GO:0004842; F:ubiquitin-protein transferase activity; IBA:GO_Central.
GO; GO:0008340; P:determination of adult lifespan; IEA:EnsemblMetazoa.
GO; GO:0009792; P:embryo development ending in birth or egg hatching; IEA:EnsemblMetazoa.
GO; GO:0043066; P:negative regulation of apoptotic process; IEA:EnsemblMetazoa.
GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:EnsemblMetazoa.
GO; GO:0010826; P:negative regulation of centrosome duplication; IEA:EnsemblMetazoa.
GO; GO:0043518; P:negative regulation of DNA damage response, signal transduction by p53 class mediator; IEA:EnsemblMetazoa.
GO; GO:0045930; P:negative regulation of mitotic cell cycle; IEA:EnsemblMetazoa.
GO; GO:0002119; P:nematode larval development; IEA:EnsemblMetazoa.
GO; GO:0043065; P:positive regulation of apoptotic process; IEA:EnsemblMetazoa.
GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
GO; GO:0008361; P:regulation of cell size; IEA:EnsemblMetazoa.
GO; GO:0031647; P:regulation of protein stability; IEA:EnsemblMetazoa.
GO; GO:0000003; P:reproduction; IEA:EnsemblMetazoa.
GO; GO:0042594; P:response to starvation; IEA:EnsemblMetazoa.
GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
Gene3D; 1.10.10.10; -; 1.
InterPro; IPR016157; Cullin_CS.
InterPro; IPR016158; Cullin_homology.
InterPro; IPR036317; Cullin_homology_sf.
InterPro; IPR001373; Cullin_N.
InterPro; IPR019559; Cullin_neddylation_domain.
InterPro; IPR016159; Cullin_repeat-like_dom_sf.
InterPro; IPR036388; WH-like_DNA-bd_sf.
InterPro; IPR036390; WH_DNA-bd_sf.
Pfam; PF00888; Cullin; 1.
Pfam; PF10557; Cullin_Nedd8; 1.
SMART; SM00182; CULLIN; 1.
SMART; SM00884; Cullin_Nedd8; 1.
SUPFAM; SSF46785; SSF46785; 1.
SUPFAM; SSF74788; SSF74788; 1.
SUPFAM; SSF75632; SSF75632; 1.
PROSITE; PS01256; CULLIN_1; 1.
PROSITE; PS50069; CULLIN_2; 1.
3: Inferred from homology;
Reference proteome {ECO:0000313|Proteomes:UP000008549};
Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
DOMAIN 398..638
/note="CULLIN_2"
/evidence="ECO:0000259|PROSITE:PS50069"
SEQUENCE 768 AA; 87784 MW; 8A56D93F0FE30A3C CRC64;
MDRRAPVDSQ DRTLTISRYV YDYCTSITLS TSRREGDERI NANETVNPNR VTGADFVGHE
MYQKVEEYVS AYVTAVREKG AELSGEDLLK FYTTEWENFR ISSKVMDGIF AYLNRHWIRR
ELDEGHENIF MVYTLALVVW KRNLFNELRD KVIDAMLELI RAERTGSTIT SRYISGVVEC
LVELGIDDTE GENKKNAEAK KLMVYKECFE ARFLEATREF YAQEAANFLG NEGTVTDYMI
KVETRLQQED DRCALYLNSS TKQTLAGCVE SVLIANQLEF FQSHFGHLLV EKQDDDLSRM
FKLCDRVPNG LDQLRLSLER HITKEGHDAL ERVAQEASND AKLYVKTLLE VHQRYQVLVN
RSFKNEPGFM QSLDKAATAF INANAVTSRA PPNAQLTKSA ELLARYCDQL LRKSSKNPDE
AELEDLLTKV MIVFKYIEDK DVFSKFYTKM FSKRLITDLS ASDESEASFI SKLKSMCGYE
YTARLSKMVN DTQVSKDLTA EFKEKKSHLL GEKPIEFNVL VLSSGSWPTF PNSTLTLPHQ
LSSTIDVFGQ YYNEKFNGRR LTWVYSQSRG EVTSSAFSKK YVFTNIWQNL KYADFQVTTA
QMCTLLLFNE QASFTVQQIS EATGLEGKTC AGIAGSLIKN LVLKSDAPLE GEEIPMTAAV
SLNNSYTNKK VRVDLSKMSL KQEAVRDTEV VQKNAEEDRK SLISACIVRI MKTRKRVPHT
QLMSEVITQL TGRFKPKVDV IKRCIGSLIE KEYMLRVEGQ KDVYDYMA


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Related Genes :
[DCAF1 At4g31160 F6E21_80] DDB1- and CUL4-associated factor homolog 1 (Protein DDB1-CUL4 ASSOCIATED FACTOR 1) (Protein DCAF1)
[CUL9 H7AP1 KIAA0708 PARC] Cullin-9 (CUL-9) (UbcH7-associated protein 1) (p53-associated parkin-like cytoplasmic protein)
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[CUL1] Cullin-1 (CUL-1)
[Cbr1 Cbr] Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.196) (EC 1.1.1.197) (20-beta-hydroxysteroid dehydrogenase) (NADPH-dependent carbonyl reductase 1) (Prostaglandin 9-ketoreductase) (PG-9-KR) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189)
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[CUL5 VACM1] Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
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[WDR26 CDW2 MIP2 PRO0852] WD repeat-containing protein 26 (CUL4- and DDB1-associated WDR protein 2) (Myocardial ischemic preconditioning up-regulated protein 2)

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