GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

Protein fem-1 homolog B (FEM1b) (FEM1-beta) (Fem-1-like death receptor-binding protein alpha) (Fem-1-like in apoptotic pathway protein alpha) (F1A-alpha)

 FEM1B_HUMAN             Reviewed;         627 AA.
Q9UK73; O43146;
18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
18-SEP-2019, entry version 162.
RecName: Full=Protein fem-1 homolog B;
Short=FEM1b;
AltName: Full=FEM1-beta;
AltName: Full=Fem-1-like death receptor-binding protein alpha;
AltName: Full=Fem-1-like in apoptotic pathway protein alpha;
Short=F1A-alpha;
Name=FEM1B; Synonyms=F1AA, KIAA0396;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CLEAVAGE, TISSUE SPECIFICITY,
INTERACTION WITH FAS AND TNFRSF1A, AND MUTAGENESIS OF ASP-342 AND
ASP-356.
PubMed=10542291; DOI=10.1074/jbc.274.45.32461;
Chan S.-L., Tan K.-O., Zhang L., Yee K.S.Y., Ronca F., Chan M.-Y.,
Yu V.C.;
"F1Aalpha, a death receptor-binding protein homologous to the
Caenorhabditis elegans sex-determining protein, FEM-1, is a caspase
substrate that mediates apoptosis.";
J. Biol. Chem. 274:32461-32468(1999).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=10623617; DOI=10.1006/bbrc.1999.1942;
Ventura-Holman T., Maher J.F.;
"Sequence, organization, and expression of the human FEM1B gene.";
Biochem. Biophys. Res. Commun. 267:317-320(2000).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
PubMed=9455477; DOI=10.1093/dnares/4.5.307;
Ishikawa K., Nagase T., Nakajima D., Seki N., Ohira M., Miyajima N.,
Tanaka A., Kotani H., Nomura N., Ohara O.;
"Prediction of the coding sequences of unidentified human genes. VIII.
78 new cDNA clones from brain which code for large proteins in
vitro.";
DNA Res. 4:307-313(1997).
[4]
SEQUENCE REVISION.
PubMed=12168954; DOI=10.1093/dnares/9.3.99;
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.;
"Construction of expression-ready cDNA clones for KIAA genes: manual
curation of 330 KIAA cDNA clones.";
DNA Res. 9:99-106(2002).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Thalamus;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16572171; DOI=10.1038/nature04601;
Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R.,
Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G.,
Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A.,
Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W.,
Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X.,
Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K.,
Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S.,
Nusbaum C.;
"Analysis of the DNA sequence and duplication history of human
chromosome 15.";
Nature 440:671-675(2006).
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Placenta;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[9]
INTERACTION WITH PPM1F.
PubMed=11559703; DOI=10.1074/jbc.m105880200;
Tan K.M.L., Chan S.-L., Tan K.O., Yu V.C.;
"The Caenorhabditis elegans sex-determining protein fem-2 and its
human homologue, hFEM-2, are Ca2+/calmodulin-dependent protein kinase
phosphatases that promote apoptosis.";
J. Biol. Chem. 276:44193-44202(2001).
[10]
IDENTIFICATION IN E3 UBIQUITIN-PROTEIN LIGASE COMPLEX WITH CUL2.
PubMed=15601820; DOI=10.1101/gad.1252404;
Kamura T., Maenaka K., Kotoshiba S., Matsumoto M., Kohda D.,
Conaway R.C., Conaway J.W., Nakayama K.I.;
"VHL-box and SOCS-box domains determine binding specificity for Cul2-
Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases.";
Genes Dev. 18:3055-3065(2004).
[11]
FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH CHEK1.
PubMed=19330022; DOI=10.1038/onc.2009.58;
Sun T.P., Shieh S.Y.;
"Human FEM1B is required for Rad9 recruitment and CHK1 activation in
response to replication stress.";
Oncogene 28:1971-1981(2009).
-!- FUNCTION: Component of an E3 ubiquitin-protein ligase complex, in
which it may act as a substrate recognition subunit. Involved in
apoptosis by acting as a death receptor-associated protein that
mediates apoptosis. Also involved in glucose homeostasis in
pancreatic islet. Functions as an adapter/mediator in replication
stress-induced signaling that leads to the activation of CHEK1.
{ECO:0000269|PubMed:10542291, ECO:0000269|PubMed:19330022}.
-!- PATHWAY: Protein modification; protein ubiquitination.
-!- SUBUNIT: Homooligomer. Component of a probable ECS E3 ubiquitin-
protein ligase complex containing CUL2, RBX1, ELOB, ELOC and
FEM1B. Interacts with PPM1F and PHTF1. Interacts with the death
domain of FAS/TNFRSF6 and TNFRSF1A. Interacts with CHEK1.
{ECO:0000269|PubMed:10542291, ECO:0000269|PubMed:11559703,
ECO:0000269|PubMed:15601820, ECO:0000269|PubMed:19330022}.
-!- INTERACTION:
Q9NWT6:HIF1AN; NbExp=3; IntAct=EBI-310482, EBI-745632;
P49593:PPM1F; NbExp=2; IntAct=EBI-310482, EBI-719945;
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19330022}.
Nucleus {ECO:0000269|PubMed:19330022}. Note=In the nucleus, the
protein level increased slightly after camptothecin (CPT)
treatment. Associated with chromatin.
-!- TISSUE SPECIFICITY: Widely expressed. Highly expressed in testis.
Weakly expressed in other tissues. {ECO:0000269|PubMed:10542291}.
-!- SIMILARITY: Belongs to the fem-1 family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AF178632; AAF05314.1; -; mRNA.
EMBL; AF204883; AAF69303.1; -; mRNA.
EMBL; AB007856; BAA23692.2; -; mRNA.
EMBL; AK290167; BAF82856.1; -; mRNA.
EMBL; AC021553; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AC107871; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH471082; EAW77818.1; -; Genomic_DNA.
EMBL; BC010122; AAH10122.1; -; mRNA.
EMBL; BC014558; AAH14558.1; -; mRNA.
CCDS; CCDS10228.1; -.
RefSeq; NP_056137.1; NM_015322.4.
BioGrid; 115421; 62.
DIP; DIP-31663N; -.
IntAct; Q9UK73; 47.
MINT; Q9UK73; -.
STRING; 9606.ENSP00000307298; -.
iPTMnet; Q9UK73; -.
PhosphoSitePlus; Q9UK73; -.
BioMuta; FEM1B; -.
DMDM; 74753369; -.
EPD; Q9UK73; -.
jPOST; Q9UK73; -.
MassIVE; Q9UK73; -.
MaxQB; Q9UK73; -.
PaxDb; Q9UK73; -.
PeptideAtlas; Q9UK73; -.
PRIDE; Q9UK73; -.
ProteomicsDB; 84733; -.
DNASU; 10116; -.
Ensembl; ENST00000306917; ENSP00000307298; ENSG00000169018.
GeneID; 10116; -.
KEGG; hsa:10116; -.
UCSC; uc002arg.4; human.
CTD; 10116; -.
DisGeNET; 10116; -.
GeneCards; FEM1B; -.
HGNC; HGNC:3649; FEM1B.
HPA; HPA041920; -.
HPA; HPA042192; -.
MIM; 613539; gene.
neXtProt; NX_Q9UK73; -.
OpenTargets; ENSG00000169018; -.
PharmGKB; PA28089; -.
eggNOG; KOG0508; Eukaryota.
eggNOG; COG0666; LUCA.
GeneTree; ENSGT00940000161115; -.
HOGENOM; HOG000008180; -.
InParanoid; Q9UK73; -.
KO; K10349; -.
OMA; YRTRKRW; -.
OrthoDB; 252380at2759; -.
PhylomeDB; Q9UK73; -.
TreeFam; TF351376; -.
Reactome; R-HSA-8951664; Neddylation.
UniPathway; UPA00143; -.
ChiTaRS; FEM1B; human.
GenomeRNAi; 10116; -.
Pharos; Q9UK73; -.
PMAP-CutDB; Q9UK73; -.
PRO; PR:Q9UK73; -.
Proteomes; UP000005640; Chromosome 15.
Bgee; ENSG00000169018; Expressed in 235