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Protein kinase domain-containing protein

 A0A2I3MTU5_PAPAN        Unreviewed;       385 AA.
A0A2I3MTU5;
28-FEB-2018, integrated into UniProtKB/TrEMBL.
28-FEB-2018, sequence version 1.
11-DEC-2019, entry version 12.
SubName: Full=Mitogen-activated protein kinase kinase 2 {ECO:0000313|Ensembl:ENSPANP00000039137};
Name=MAP2K2 {ECO:0000313|Ensembl:ENSPANP00000039137};
Papio anubis (Olive baboon).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
Cercopithecidae; Cercopithecinae; Papio.
NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000039137, ECO:0000313|Proteomes:UP000028761};
[1] {ECO:0000313|Ensembl:ENSPANP00000039137, ECO:0000313|Proteomes:UP000028761}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., Aqrawi P.A.,
Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., Bandaranaike D.B.,
Battles P.B., Bell A.B., Beltran B.B., Berhane-Mersha D.B., Bess C.B.,
Bickham C.B., Bolden T.B., Carter K.C., Chau D.C., Chavez A.C.,
Clerc-Blankenburg K.C., Coyle M.C., Dao M.D., Davila M.L.D.,
Davy-Carroll L.D., Denson S.D., Dinh H.D., Fernandez S.F., Fernando P.F.,
Forbes L.F., Francis C.F., Francisco L.F., Fu Q.F., Garcia-Iii R.G.,
Garrett T.G., Gross S.G., Gubbala S.G., Hirani K.H., Hogues M.H.,
Hollins B.H., Jackson L.J., Javaid M.J., Jhangiani S.J., Johnson A.J.,
Johnson B.J., Jones J.J., Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K.,
Kovar C.K., Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., Perez Y.P.,
Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., Rouhana J.R., Ruiz M.R.,
Ruiz S.-J.R., Saada N.S., Santibanez J.S., Scheel M.S., Schneider B.S.,
Simmons D.S., Sisson I.S., Tang L.-Y.T., Thornton R.T., Tisius J.T.,
Toledanes G.T., Trejos Z.T., Usmani K.U., Varghese R.V., Vattathil S.V.,
Vee V.V., Walker D.W., Weissenberger G.W., White C.W., Williams A.W.,
Woodworth J.W., Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N.,
Nazareth L.N., Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
"Whole Genome Assembly of Papio anubis.";
Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSPANP00000039137}
IDENTIFICATION.
Ensembl;
Submitted (JAN-2018) to UniProtKB.
-!- SIMILARITY: Belongs to the protein kinase superfamily.
{ECO:0000256|RuleBase:RU000304}.
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EMBL; AHZZ02013236; -; NOT_ANNOTATED_CDS; Genomic_DNA.
Ensembl; ENSPANT00000034839; ENSPANP00000039137; ENSPANG00000008882.
GeneTree; ENSGT00940000153487; -.
Proteomes; UP000028761; Chromosome 19.
ExpressionAtlas; A0A2I3MTU5; baseline.
GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
GO; GO:0009898; C:cytoplasmic side of plasma membrane; IEA:Ensembl.
GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
GO; GO:0005874; C:microtubule; IEA:Ensembl.
GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004708; F:MAP kinase kinase activity; IEA:Ensembl.
GO; GO:0060090; F:molecular adaptor activity; IEA:Ensembl.
GO; GO:0030165; F:PDZ domain binding; IEA:Ensembl.
GO; GO:0043539; F:protein serine/threonine kinase activator activity; IEA:Ensembl.
GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO; GO:0097110; F:scaffold protein binding; IEA:Ensembl.
GO; GO:0060502; P:epithelial cell proliferation involved in lung morphogenesis; IEA:Ensembl.
GO; GO:0070371; P:ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0060324; P:face development; IEA:Ensembl.
GO; GO:0007507; P:heart development; IEA:Ensembl.
GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
GO; GO:0036289; P:peptidyl-serine autophosphorylation; IEA:Ensembl.
GO; GO:0050772; P:positive regulation of axonogenesis; IEA:Ensembl.
GO; GO:2000147; P:positive regulation of cell motility; IEA:Ensembl.
GO; GO:1903800; P:positive regulation of production of miRNAs involved in gene silencing by miRNA; IEA:Ensembl.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:Ensembl.
GO; GO:0048679; P:regulation of axon regeneration; IEA:Ensembl.
GO; GO:0043497; P:regulation of protein heterodimerization activity; IEA:Ensembl.
GO; GO:0048538; P:thymus development; IEA:Ensembl.
GO; GO:0030878; P:thyroid gland development; IEA:Ensembl.
GO; GO:0060440; P:trachea formation; IEA:Ensembl.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR008271; Ser/Thr_kinase_AS.
Pfam; PF00069; Pkinase; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
3: Inferred from homology;
ATP-binding {ECO:0000256|RuleBase:RU000304};
Coiled coil {ECO:0000256|SAM:Coils};
Kinase {ECO:0000256|RuleBase:RU000304};
Nucleotide-binding {ECO:0000256|RuleBase:RU000304};
Reference proteome {ECO:0000313|Proteomes:UP000028761};
Serine/threonine-protein kinase {ECO:0000256|RuleBase:RU000304};
Transferase {ECO:0000256|RuleBase:RU000304}.
DOMAIN 72..354
/note="Protein kinase"
/evidence="ECO:0000259|PROSITE:PS50011"
COILED 27..57
/evidence="ECO:0000256|SAM:Coils"
SEQUENCE 385 AA; 42558 MW; 24DE5C6C160C7457 CRC64;
MLARRKPVLP ALTINPTIAE GPSPTSEGAS EANLVDLQKK LEELELDEQQ KKRLEAFLTQ
KAKVGELKDD DFERISELGA GNGGVVTKVQ HRPSGLIMAR KLIHLEIKPA IRNQIIRELQ
VLHECNSPYI VGFYGAFYSD GEISICMEHM DGGSLDQVLK EAKRIPEEIL GKVSIAVLRG
LAYLREKHQI MHRDVKPSNI LVNSRGEIKL CDFGVSGQLI DSMANSFVGT RSYMAPERLQ
GTHYSVQSDV WSMGLSLVEL AIGRYPIPPP DAKELEAIFG RPVVDGEEGE PHSISPRPRP
PGRPISGTVP WGHQLTALSC LPYCFPVLPL GTPSLIKNPA ERADLKMLTN HTFIKRSEVE
EVDFAGWLCK TLRLNQPGTP TRTAV


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Pathways :
WP1689: Porphyrin and chlorophyll metabolism
WP1493: Carbon assimilation C4 pathway
WP1049: G Protein Signaling Pathways
WP1692: Protein export
WP73: G Protein Signaling Pathways
WP211: BMP signaling pathway
WP1659: Glycine, serine and threonine metabolism
WP2218: sGC
WP1438: Influenza A virus infection
WP1700: Selenoamino acid metabolism
WP931: G Protein Signaling Pathways
WP1531: Vitamin D synthesis
WP1713: Two-component system
WP1665: Limonene and pinene degradation
WP232: G Protein Signaling Pathways
WP1675: Nitrogen metabolism
WP1613: 1,4-Dichlorobenzene degradation
WP1888: Post-translational protein modification
WP1624: Bacterial secretion system
WP1939: Unfolded Protein Response
WP1690: Propanoate metabolism
WP525: Mitochondrial Unfolded-Protein Response
WP1650: Fluorobenzoate degradation
WP210: Cytoplasmic Ribosomal Proteins
WP1657: Glycerolipid metabolism

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Bibliography :
[31961032] Jumonji domain-containing protein 6 protein and its role in cancer.
[31954080] A common signaling pathway leading to degranulation in mast cells and its regulation by CCR1-ligand.
[31944172] Metabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithelial cells.
[31943712] Resveratrol protects human bronchial epithelial cells against nickel-induced toxicity via suppressing p38 MAPK, NF-κB signaling, and NLRP3 inflammasome activation.
[31932472] The Kidney Contains Ontogenetically Distinct Dendritic Cell and Macrophage Subtypes throughout Development That Differ in Their Inflammatory Properties.
[31917201] Inhibition of TRIM8 restrains ischaemia-reperfusion-mediated cerebral injury by regulation of NF-κB activation associated inflammation and apoptosis.
[31903827] Toll-like receptor-4 pathway as a possible molecular mechanism for brain injuries after subarachnoid hemorrhage.
[31903135] ANKRD22, a novel tumor microenvironment-induced mitochondrial protein promotes metabolic reprogramming of colorectal cancer cells.
[31902237] S-Nitrosylation of Muscle LIM Protein Facilitates Myocardial Hypertrophy Through Toll-Like Receptor 3-Mediated Receptor-Interacting Protein Kinase 3 and NLRP3 Inflammasome Activation.