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Protein kinase domain-containing protein

 F1MIC3_BOVIN            Unreviewed;       492 AA.
F1MIC3;
03-MAY-2011, integrated into UniProtKB/TrEMBL.
10-APR-2019, sequence version 3.
17-JUN-2020, entry version 63.
RecName: Full=Protein kinase domain-containing protein {ECO:0000259|PROSITE:PS50011};
Name=GSK3B {ECO:0000313|Ensembl:ENSBTAP00000051604};
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
Bovinae; Bos.
NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000051604, ECO:0000313|Proteomes:UP000009136};
[1] {ECO:0000313|Ensembl:ENSBTAP00000051604}
IDENTIFICATION.
STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000051604};
Ensembl;
Submitted (MAR-2016) to UniProtKB.
[2] {ECO:0000313|Ensembl:ENSBTAP00000051604, ECO:0000313|Proteomes:UP000009136}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000051604,
ECO:0000313|Proteomes:UP000009136};
Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
"ARS-UCD1.2.";
Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
-!- SIMILARITY: Belongs to the protein kinase superfamily.
{ECO:0000256|RuleBase:RU000304}.
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STRING; 9913.ENSBTAP00000051604; -.
PaxDb; F1MIC3; -.
Ensembl; ENSBTAT00000056446; ENSBTAP00000051604; ENSBTAG00000048057.
eggNOG; KOG0658; Eukaryota.
eggNOG; COG0515; LUCA.
GeneTree; ENSGT00520000055635; -.
HOGENOM; CLU_123597_1_0_1; -.
InParanoid; F1MIC3; -.
Reactome; R-BTA-195253; Degradation of beta-catenin by the destruction complex.
Reactome; R-BTA-196299; Beta-catenin phosphorylation cascade.
Reactome; R-BTA-3371453; Regulation of HSF1-mediated heat shock response.
Reactome; R-BTA-399956; CRMPs in Sema3A signaling.
Reactome; R-BTA-4641262; Disassembly of the destruction complex and recruitment of AXIN to the membrane.
Reactome; R-BTA-5610785; GLI3 is processed to GLI3R by the proteasome.
Proteomes; UP000009136; Chromosome 1.
Bgee; ENSBTAG00000040597; Expressed in prefrontal cortex and 8 other tissues.
ExpressionAtlas; F1MIC3; baseline and differential.
GO; GO:0030424; C:axon; IBA:GO_Central.
GO; GO:0030877; C:beta-catenin destruction complex; IBA:GO_Central.
GO; GO:0005813; C:centrosome; IEA:Ensembl.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0005829; C:cytosol; IBA:GO_Central.
GO; GO:0098978; C:glutamatergic synapse; IBA:GO_Central.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0008013; F:beta-catenin binding; IBA:GO_Central.
GO; GO:0034452; F:dynactin binding; IEA:Ensembl.
GO; GO:0051059; F:NF-kappaB binding; IEA:Ensembl.
GO; GO:0002039; F:p53 binding; IEA:Ensembl.
GO; GO:0002020; F:protease binding; IEA:Ensembl.
GO; GO:0034236; F:protein kinase A catalytic subunit binding; IEA:Ensembl.
GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
GO; GO:0001085; F:RNA polymerase II transcription factor binding; IEA:Ensembl.
GO; GO:0050321; F:tau-protein kinase activity; IBA:GO_Central.
GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
GO; GO:0001837; P:epithelial to mesenchymal transition; IEA:Ensembl.
GO; GO:0006983; P:ER overload response; IEA:Ensembl.
GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IBA:GO_Central.
GO; GO:0005977; P:glycogen metabolic process; IEA:Ensembl.
GO; GO:0021766; P:hippocampus development; IEA:Ensembl.
GO; GO:0008286; P:insulin receptor signaling pathway; IBA:GO_Central.
GO; GO:0035556; P:intracellular signal transduction; IEA:Ensembl.
GO; GO:0070885; P:negative regulation of calcineurin-NFAT signaling cascade; IEA:Ensembl.
GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IBA:GO_Central.
GO; GO:1902042; P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
GO; GO:1901215; P:negative regulation of neuron death; IEA:Ensembl.
GO; GO:0032091; P:negative regulation of protein binding; IEA:Ensembl.
GO; GO:0031333; P:negative regulation of protein-containing complex assembly; IEA:Ensembl.
GO; GO:0031175; P:neuron projection development; IEA:Ensembl.
GO; GO:0018105; P:peptidyl-serine phosphorylation; IEA:Ensembl.
GO; GO:0018107; P:peptidyl-threonine phosphorylation; IEA:Ensembl.
GO; GO:0001954; P:positive regulation of cell-matrix adhesion; IEA:Ensembl.
GO; GO:0043547; P:positive regulation of GTPase activity; IEA:Ensembl.
GO; GO:0010822; P:positive regulation of mitochondrion organization; IEA:Ensembl.
GO; GO:1901216; P:positive regulation of neuron death; IEA:Ensembl.
GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO; GO:0046827; P:positive regulation of protein export from nucleus; IEA:Ensembl.
GO; GO:1904781; P:positive regulation of protein localization to centrosome; IEA:Ensembl.
GO; GO:0031334; P:positive regulation of protein-containing complex assembly; IEA:Ensembl.
GO; GO:0046777; P:protein autophosphorylation; IEA:Ensembl.
GO; GO:0150101; P:regulation of microtubule anchoring at centrosome; IEA:Ensembl.
GO; GO:0070507; P:regulation of microtubule cytoskeleton organization; IBA:GO_Central.
GO; GO:0010975; P:regulation of neuron projection development; IBA:GO_Central.
GO; GO:2000300; P:regulation of synaptic vesicle exocytosis; IEA:Ensembl.
GO; GO:0007165; P:signal transduction; IBA:GO_Central.
GO; GO:0071109; P:superior temporal gyrus development; IEA:Ensembl.
CDD; cd14137; STKc_GSK3; 1.
InterPro; IPR033573; GSK3B.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR008271; Ser/Thr_kinase_AS.
InterPro; IPR039192; STKc_GSK3.
PANTHER; PTHR24057:SF8; PTHR24057:SF8; 1.
Pfam; PF00069; Pkinase; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
3: Inferred from homology;
ATP-binding {ECO:0000256|RuleBase:RU000304};
Kinase {ECO:0000256|RuleBase:RU000304};
Nucleotide-binding {ECO:0000256|RuleBase:RU000304};
Reference proteome {ECO:0000313|Proteomes:UP000009136};
Serine/threonine-protein kinase {ECO:0000256|RuleBase:RU000304};
Transferase {ECO:0000256|RuleBase:RU000304}.
DOMAIN 56..353
/note="Protein kinase"
/evidence="ECO:0000259|PROSITE:PS50011"
REGION 1..53
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 398..428
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1..25
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 400..418
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
ACT_SITE 181
/note="Proton acceptor"
/evidence="ECO:0000256|PIRSR:PIRSR633573-1"
SEQUENCE 492 AA; 55067 MW; 8C3ED4993C010E0B CRC64;
MSGRPRTTSF AESCKPVQQP SAFGSMKVSR DKDGSKVTTV VATPGQGPDR PQEVSYTDTK
VIGNGSFGVV YQAKLCDSGE LVAIKKVLQD KRFKNRELQI MRKLDHCNIV RLRYFFYSSG
EKKDEVYLNL VLDYVPETVY RVARHYSRAK QTLPVIYVKL YMYQLFRSLA YIHSFGICHR
DIKPQNLLLD PDTAVLKLCD FGSAKQLVRG EPNVSYICSR YYRAPELIFG ATDYTSSIDV
WSAGCVLAEL LLGQPIFPGD SGVDQLVEII KVLGTPTREQ IREMNPNYTE FKFPQIKAHP
WTKDSSGTGH FTSGVRVFRP RTPPEAIALC SRLLEYTPTA RLTPLEACAH SFFDELRDPN
VKLPNGRDTP ALFNFTTQEL SSNPPLATIL IPPHARIQAA ASAPSNTTAA SGENVENPSN
RKGNHDKSWT RSMLMLETVD RPIMPLLHQL PTPEQSRAAS YTGTTTSLLE CHSATLVTIG
KKIKKRKKTY SF


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