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Protein kinase domain-containing protein

 I3M097_ICTTR            Unreviewed;       498 AA.
I3M097;
11-JUL-2012, integrated into UniProtKB/TrEMBL.
22-NOV-2017, sequence version 2.
17-JUN-2020, entry version 47.
SubName: Full=Mitogen-activated protein kinase kinase 2 {ECO:0000313|Ensembl:ENSSTOP00000002113};
Name=MAP2K2 {ECO:0000313|Ensembl:ENSSTOP00000002113};
Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
tridecemlineatus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
Xerinae; Marmotini; Ictidomys.
NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000002113, ECO:0000313|Proteomes:UP000005215};
[1] {ECO:0000313|Ensembl:ENSSTOP00000002113, ECO:0000313|Proteomes:UP000005215}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
The Broad Institute Genome Assembly & Analysis Group;
Computational R&D Group;
and Sequencing Platform;
Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
"The Draft Genome of Spermophilus tridecemlineatus.";
Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSSTOP00000002113}
IDENTIFICATION.
Ensembl;
Submitted (MAY-2012) to UniProtKB.
-!- SIMILARITY: Belongs to the protein kinase superfamily.
{ECO:0000256|RuleBase:RU000304}.
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EMBL; AGTP01068850; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AGTP01068851; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AGTP01068852; -; NOT_ANNOTATED_CDS; Genomic_DNA.
STRING; 43179.ENSSTOP00000002113; -.
Ensembl; ENSSTOT00000002362; ENSSTOP00000002113; ENSSTOG00000002366.
eggNOG; KOG0581; Eukaryota.
eggNOG; ENOG410XQ5A; LUCA.
GeneTree; ENSGT00940000153487; -.
HOGENOM; CLU_000288_63_23_1; -.
InParanoid; I3M097; -.
TreeFam; TF105137; -.
Proteomes; UP000005215; Unassembled WGS sequence.
GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0060090; F:molecular adaptor activity; IEA:Ensembl.
GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO; GO:0060502; P:epithelial cell proliferation involved in lung morphogenesis; IEA:Ensembl.
GO; GO:0070371; P:ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0060324; P:face development; IEA:Ensembl.
GO; GO:0007507; P:heart development; IEA:Ensembl.
GO; GO:0050772; P:positive regulation of axonogenesis; IEA:Ensembl.
GO; GO:2000147; P:positive regulation of cell motility; IEA:Ensembl.
GO; GO:0048679; P:regulation of axon regeneration; IEA:Ensembl.
GO; GO:0048538; P:thymus development; IEA:Ensembl.
GO; GO:0030878; P:thyroid gland development; IEA:Ensembl.
GO; GO:0060440; P:trachea formation; IEA:Ensembl.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR008271; Ser/Thr_kinase_AS.
Pfam; PF00069; Pkinase; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
3: Inferred from homology;
ATP-binding {ECO:0000256|RuleBase:RU000304};
Coiled coil {ECO:0000256|SAM:Coils};
Kinase {ECO:0000256|RuleBase:RU000304};
Nucleotide-binding {ECO:0000256|RuleBase:RU000304};
Reference proteome {ECO:0000313|Proteomes:UP000005215};
Serine/threonine-protein kinase {ECO:0000256|RuleBase:RU000304};
Transferase {ECO:0000256|RuleBase:RU000304}.
DOMAIN 170..467
/note="Protein kinase"
/evidence="ECO:0000259|PROSITE:PS50011"
REGION 1..46
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 380..408
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COILED 125..155
/evidence="ECO:0000256|SAM:Coils"
COMPBIAS 13..31
/note="Polyampholyte"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 498 AA; 55105 MW; BCC6327B24FC4906 CRC64;
MSDNLSWGDR RGRWSNSLDE FGEDEGHLAK GPRRTATPSQ GGDLPRQRRL SQLLAQLTLR
GSDAASLLGA VPGLYPEDGS RGYVKLLPAE KGALESPGRR GRAGEAQRVE SSCHLSTCPL
LICALELHRA NLVDLQKKLE ELELDEQQKK RLEAFLTQKA KVGELKDDDF ERISELGAGN
GGVVTKVQHR PSGLIMARKL IHLEIKPAIR NQIIRELQVL HECNSPYIVG FYGAFYSDGE
ISICMEHMDG GSLDQVLKEA KRIPEEILGK VSIAVLRGLA YLREKHQIMH RDVKPSNILV
NSRGEIKLCD FGVSGQLIDS MANSFVGTRS YMSPERLQGT HYSVQSDIWS MGLSLVELSI
GRYPIPPPDA KELEAIFGRP VGNGAEGEPH STSPRPRPPG RPISGHGMDS RPAMAIFELL
DYIVNEPPPK LPSGVFSPHF QEFVHKCLIK NPAERADLKM LMGHAFIKRS EAEEVDFAGW
LCRTLRLNQP STPTRTAV


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Pathways :
WP1689: Porphyrin and chlorophyll metabolism
WP1493: Carbon assimilation C4 pathway
WP211: BMP signaling pathway
WP1049: G Protein Signaling Pathways
WP1692: Protein export
WP73: G Protein Signaling Pathways
WP931: G Protein Signaling Pathways
WP1659: Glycine, serine and threonine metabolism
WP2218: sGC
WP1438: Influenza A virus infection
WP1700: Selenoamino acid metabolism
WP1531: Vitamin D synthesis
WP1713: Two-component system
WP1665: Limonene and pinene degradation
WP232: G Protein Signaling Pathways
WP1675: Nitrogen metabolism
WP1613: 1,4-Dichlorobenzene degradation
WP1888: Post-translational protein modification
WP1624: Bacterial secretion system
WP1939: Unfolded Protein Response
WP1690: Propanoate metabolism
WP525: Mitochondrial Unfolded-Protein Response
WP1650: Fluorobenzoate degradation
WP210: Cytoplasmic Ribosomal Proteins
WP1657: Glycerolipid metabolism

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[32697358] The Hippo in the room: Targeting the Hippo signalling pathway for osteosarcoma therapies.
[32682012] The long noncoding RNA OTUD6B-AS1 enhances cell proliferation and the invasion of hepatocellular carcinoma cells through modulating GSKIP/Wnt/β-catenin signalling via the sequestration of miR-664b-3p.
[32681351] EPAS1 promotes peritoneal carcinomatosis of non-small-cell lung cancer by enhancing mesothelial-mesenchymal transition.