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Protein odd-skipped-related 1

 OSR1_MOUSE              Reviewed;         266 AA.
Q9WVG7;
24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
01-NOV-1999, sequence version 1.
13-FEB-2019, entry version 132.
RecName: Full=Protein odd-skipped-related 1;
Name=Osr1; Synonyms=Odd1;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=10473132; DOI=10.1016/S0925-4773(99)00058-1;
So P.L., Danielian P.S.;
"Cloning and expression analysis of a mouse gene related to Drosophila
odd-skipped.";
Mech. Dev. 84:157-160(1999).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N; TISSUE=Mammary tumor;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
PubMed=16223478; DOI=10.1016/j.ydbio.2005.09.024;
Wang Q., Lan Y., Cho E.S., Maltby K.M., Jiang R.;
"Odd-skipped related 1 (Odd 1) is an essential regulator of heart and
urogenital development.";
Dev. Biol. 288:582-594(2005).
[4]
INDUCTION.
PubMed=18804520; DOI=10.1016/j.gene.2008.08.015;
Yamauchi M., Kawai S., Kato T., Ooshima T., Amano A.;
"Odd-skipped related 1 gene expression is regulated by Runx2 and Ikzf1
transcription factors.";
Gene 426:81-90(2008).
[5]
METHYLATION [LARGE SCALE ANALYSIS] AT ARG-116, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Embryo;
PubMed=24129315; DOI=10.1074/mcp.O113.027870;
Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V.,
Aguiar M., Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C.,
Vemulapalli V., Bedford M.T., Comb M.J.;
"Immunoaffinity enrichment and mass spectrometry analysis of protein
methylation.";
Mol. Cell. Proteomics 13:372-387(2014).
-!- FUNCTION: Transcription factor that plays a role in the regulation
of embryonic heart and urogenital development.
{ECO:0000269|PubMed:16223478}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
-!- DEVELOPMENTAL STAGE: During early embryogenesis it is expressed in
the intermediate mesoderm and in a dynamic pattern during limb and
branchial arch development. Is expressed from the earliest stage
of intermediate development. Is expressed in the dorsal atrial
wall, including the developing primary atrial septum and the
venous valve. {ECO:0000269|PubMed:16223478}.
-!- INDUCTION: Transcriptionally regulated by Ikzf1 and Runx2.
{ECO:0000269|PubMed:18804520}.
-!- DISRUPTION PHENOTYPE: Mice die prenatally with severe heart
defects including defective atrioventricular junction and venous
valves. They never initiate metanephric kidney formation.
Nephrogenic mesenchyme undergo massive apoptosis, which causes a
disruption of nephric duct elongation and failure of metanephric
induction. {ECO:0000269|PubMed:16223478}.
-!- SIMILARITY: Belongs to the Odd C2H2-type zinc-finger protein
family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AF117814; AAD37115.1; -; mRNA.
EMBL; BC023922; AAH23922.1; -; mRNA.
CCDS; CCDS25809.1; -.
RefSeq; NP_035989.1; NM_011859.3.
UniGene; Mm.45055; -.
ProteinModelPortal; Q9WVG7; -.
SMR; Q9WVG7; -.
BioGrid; 204828; 1.
STRING; 10090.ENSMUSP00000055486; -.
iPTMnet; Q9WVG7; -.
PhosphoSitePlus; Q9WVG7; -.
PaxDb; Q9WVG7; -.
PRIDE; Q9WVG7; -.
Ensembl; ENSMUST00000057021; ENSMUSP00000055486; ENSMUSG00000048387.
GeneID; 23967; -.
KEGG; mmu:23967; -.
UCSC; uc007nao.2; mouse.
CTD; 130497; -.
MGI; MGI:1344424; Osr1.
eggNOG; KOG1721; Eukaryota.
eggNOG; COG5048; LUCA.
GeneTree; ENSGT00940000158993; -.
HOGENOM; HOG000013107; -.
HOVERGEN; HBG054398; -.
InParanoid; Q9WVG7; -.
KO; K09215; -.
OMA; GPALKTK; -.
OrthoDB; 1318335at2759; -.
PhylomeDB; Q9WVG7; -.
TreeFam; TF350876; -.
PRO; PR:Q9WVG7; -.
Proteomes; UP000000589; Chromosome 12.
Bgee; ENSMUSG00000048387; Expressed in 217 organ(s), highest expression level in dorsal pancreas.
ExpressionAtlas; Q9WVG7; baseline and differential.
Genevisible; Q9WVG7; MM.
GO; GO:0005829; C:cytosol; ISO:MGI.
GO; GO:0019898; C:extrinsic component of membrane; ISO:MGI.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IBA:GO_Central.
GO; GO:0030154; P:cell differentiation; IGI:BHF-UCL.
GO; GO:0072111; P:cell proliferation involved in kidney development; IMP:UniProtKB.
GO; GO:0071300; P:cellular response to retinoic acid; IEP:UniProtKB.
GO; GO:0002062; P:chondrocyte differentiation; IGI:BHF-UCL.
GO; GO:0042733; P:embryonic digit morphogenesis; IGI:BHF-UCL.
GO; GO:0035115; P:embryonic forelimb morphogenesis; IGI:BHF-UCL.
GO; GO:0035116; P:embryonic hindlimb morphogenesis; IGI:BHF-UCL.
GO; GO:0072498; P:embryonic skeletal joint development; IGI:BHF-UCL.
GO; GO:0060272; P:embryonic skeletal joint morphogenesis; IGI:BHF-UCL.
GO; GO:0036023; P:embryonic skeletal limb joint morphogenesis; IGI:BHF-UCL.
GO; GO:0008406; P:gonad development; IMP:MGI.
GO; GO:0007507; P:heart development; IMP:UniProtKB.
GO; GO:0048389; P:intermediate mesoderm development; IMP:MGI.
GO; GO:0072143; P:mesangial cell development; IMP:UniProtKB.
GO; GO:0072180; P:mesonephric duct morphogenesis; IMP:UniProtKB.
GO; GO:0001823; P:mesonephros development; IMP:UniProtKB.
GO; GO:0090094; P:metanephric cap mesenchymal cell proliferation involved in metanephros development; IMP:UniProtKB.
GO; GO:0072207; P:metanephric epithelium development; IMP:UniProtKB.
GO; GO:0072239; P:metanephric glomerulus vasculature development; IMP:UniProtKB.
GO; GO:0072259; P:metanephric interstitial fibroblast development; IMP:UniProtKB.
GO; GO:0072162; P:metanephric mesenchymal cell differentiation; IMP:UniProtKB.
GO; GO:0072075; P:metanephric mesenchyme development; IDA:UniProtKB.
GO; GO:0072133; P:metanephric mesenchyme morphogenesis; IMP:UniProtKB.
GO; GO:0072234; P:metanephric nephron tubule development; IMP:UniProtKB.
GO; GO:0072208; P:metanephric smooth muscle tissue development; IMP:UniProtKB.
GO; GO:0001656; P:metanephros development; IMP:MGI.
GO; GO:0042474; P:middle ear morphogenesis; IGI:UniProtKB.
GO; GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.
GO; GO:1905408; P:negative regulation of creatine transmembrane transporter activity; ISO:MGI.
GO; GO:0030857; P:negative regulation of epithelial cell differentiation; IMP:UniProtKB.
GO; GO:0072183; P:negative regulation of nephron tubule epithelial cell differentiation; IMP:UniProtKB.
GO; GO:2000650; P:negative regulation of sodium ion transmembrane transporter activity; ISO:MGI.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IGI:BHF-UCL.
GO; GO:0042476; P:odontogenesis; IGI:UniProtKB.
GO; GO:0072268; P:pattern specification involved in metanephros development; IMP:UniProtKB.
GO; GO:0030501; P:positive regulation of bone mineralization; IGI:BHF-UCL.
GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IGI:UniProtKB.
GO; GO:2000543; P:positive regulation of gastrulation; ISS:UniProtKB.
GO; GO:0010628; P:positive regulation of gene expression; IMP:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
GO; GO:0072166; P:posterior mesonephric tubule development; IMP:UniProtKB.
GO; GO:0048793; P:pronephros development; ISS:UniProtKB.
GO; GO:0072184; P:renal vesicle progenitor cell differentiation; IMP:UniProtKB.
GO; GO:0060021; P:roof of mouth development; IGI:UniProtKB.
GO; GO:0072168; P:specification of anterior mesonephric tubule identity; IMP:UniProtKB.
GO; GO:0072169; P:specification of posterior mesonephric tubule identity; IMP:UniProtKB.
GO; GO:0048863; P:stem cell differentiation; IDA:UniProtKB.
GO; GO:0072190; P:ureter urothelium development; IMP:UniProtKB.
GO; GO:0001657; P:ureteric bud development; IMP:UniProtKB.
GO; GO:0001655; P:urogenital system development; IMP:UniProtKB.
InterPro; IPR036236; Znf_C2H2_sf.
InterPro; IPR013087; Znf_C2H2_type.
Pfam; PF00096; zf-C2H2; 3.
SMART; SM00355; ZnF_C2H2; 3.
SUPFAM; SSF57667; SSF57667; 2.
PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
1: Evidence at protein level;
Complete proteome; Metal-binding; Methylation; Nucleus;
Reference proteome; Repeat; Transcription; Transcription regulation;
Zinc; Zinc-finger.
CHAIN 1 266 Protein odd-skipped-related 1.
/FTId=PRO_0000047005.
ZN_FING 175 197 C2H2-type 1. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 203 225 C2H2-type 2. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 231 253 C2H2-type 3. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
MOD_RES 116 116 Asymmetric dimethylarginine.
{ECO:0000244|PubMed:24129315}.
SEQUENCE 266 AA; 29584 MW; CC9948ACFC90F7A5 CRC64;
MGSKTLPAPV PIHPSLQLTN YSFLQAVNGL PTVPSDHLPN LYGFSALHAV HLHQWTLGYP
AMHLPRSSFS KVPGAVSSLM DARFQLPAFP WFPHVIHPKP EITAGGSGAA LKTKPRFDFA
NLALAATQED PTKLGRGEGP GSPAGGLGAL LDVTKLSPEK KPTRGRLPSK TKKEFVCKFC
GRHFTKSYNL LIHERTHTDE RPYTCDICHK AFRRQDHLRD HRYIHSKEKP FKCQECGKGF
CQSRTLAVHK TLHSQVKELK TSKIKC


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Pathways :
WP2199: Seed Development
WP1371: G Protein Signaling Pathways
WP211: BMP signaling pathway
WP2272: Pathogenic Escherichia coli infection
WP731: Sterol regulatory element binding protein related
WP100: Glutathione metabolism
WP1016: Wnt Signaling Pathway
WP1039: Glutathione metabolism
WP104: Alanine and aspartate metabolism
WP1049: G Protein Signaling Pathways
WP1056: Complement and Coagulation Cascades
WP106: Alanine and aspartate metabolism
WP1126: Tryptophan metabolism
WP1135: Wnt Signaling Pathway
WP1165: G Protein Signaling Pathways
WP1172: Complement and Coagulation Cascades
WP1313: Insulin Signaling
WP1315: IL-5 Signaling Pathway
WP1318: Eicosanoid Synthesis
WP1321: Myometrial Relaxation and Contraction Pathways
WP1323: EGFR1 Signaling Pathway
WP1330: estrogen signalling
WP1331: Adipogenesis
WP1333: Hypothetical Network for Drug Addiction
WP1337: MAPK signaling pathway

Related Genes :
[Osr1 Odd1] Protein odd-skipped-related 1
[osr1 si:dkey-199e17.1 zgc:101674] Protein odd-skipped-related 1 (zOsr1)
[Osr1 Odd1] Protein odd-skipped-related 1
[OSR1 ODD1] Protein odd-skipped-related 1
[OSR1 ODD] Protein odd-skipped-related 1
[Osr2] Protein odd-skipped-related 2
[odd CG3851] Protein odd-skipped
[OSR2] Protein odd-skipped-related 2
[osr1 TGas143j06.1] Protein odd-skipped-related 1 (XOsr1)
[osr2 zgc:111995] Protein odd-skipped-related 2 (zOsr2)
[Osr2] Protein odd-skipped-related 2
[OSR2] Protein odd-skipped-related 2
[OSR1 CK820_G0009699] OSR1 isoform 1 (Odd-skipped related 1) (Odd-skipped related transciption factor 1)
[OSR1 EGK_05079] Odd-skipped related transciption factor 1 (Protein odd-skipped-related 1)
[OSR1] Odd-skipped related transciption factor 1 (Protein odd-skipped-related 1)
[bowl CG10021] Protein bowel (Brother of odd with entrails limited)
[osr1 odd1] Protein odd-skipped-related 1 (XOsr1)
[OSR1 Anapl_04996] Odd-skipped related transciption factor 1 (Protein odd-skipped-related 1) (Fragment)
[odd-1 B0280.4] Protein odd-skipped-related 1
[eve CG2328] Segmentation protein even-skipped
[odd-2 C34H3.2] Protein odd-skipped-related 2
[osr2-a osr2] Protein odd-skipped-related 2-A (XOsr2)
[zic1 opl] Zinc finger protein ZIC 1 (XZic1) (XlZic1) (ODD-paired-like) (Xopl) (ZIC-related protein 1) (ZIC-r1) (Zinc finger protein of the cerebellum 1)
[OSR1] Odd-skipped related transciption factor 1
[OSR1] Odd-skipped related transciption factor 1
[CgPICR_006443 I79_008582] OSR1 (Protein odd-skipped-related 1)
[OSR1] Odd-skipped related transciption factor 1
[OSR1] Odd-skipped related transciption factor 1
[rep 1a-1b] Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor nsp1 (nsp1) (Leader protein); Non-structural protein 2 (nsp2) (p65 homolog); Papain-like proteinase (PL-PRO) (EC 3.4.19.12) (EC 3.4.22.69) (Non-structural protein 3) (nsp3); Non-structural protein 4 (nsp4); 3C-like proteinase (3CL-PRO) (3CLp) (EC 3.4.22.-) (nsp5); Non-structural protein 6 (nsp6); Non-structural protein 7 (nsp7); Non-structural protein 8 (nsp8); Non-structural protein 9 (nsp9); Non-structural protein 10 (nsp10) (Growth factor-like peptide) (GFL); RNA-directed RNA polymerase (Pol) (RdRp) (EC 2.7.7.48) (nsp12); Helicase (Hel) (EC 3.6.4.12) (EC 3.6.4.13) (nsp13); Guanine-N7 methyltransferase (ExoN) (EC 2.1.1.-) (EC 3.1.13.-) (nsp14); Uridylate-specific endoribonuclease (EC 3.1.-.-) (NendoU) (nsp15); 2'-O-methyltransferase (EC 2.1.1.-) (nsp16)]
[OSR1] Odd-skipped related transciption factor 1

Bibliography :
[30244004] Odd-skipped related transcription factor 1 (OSR1) suppresses tongue squamous cell carcinoma migration and invasion through inhibiting NF-κB pathway.
[29660200] Odd-skipped related 1 inhibits lung cancer proliferation and invasion by reducing Wnt signaling through the suppression of SOX9 and β-catenin.
[29234951] Zinc-finger transcription factor Odd-skipped related 1 regulates cranial bone formation.
[29123220] Significance of dopamine D receptor signalling for steroidogenic differentiation of human induced pluripotent stem cells.
[29084951] Odd skipped-related 1 identifies a population of embryonic fibro-adipogenic progenitors regulating myogenesis during limb development.
[28731788] Identification of Osr2 Transcriptional Target Genes in Palate Development.
[28724605] Heterozygous loss-of-function mutation in Odd-skipped related 1 () is associated with vesicoureteric reflux, duplex systems, and hydronephrosis.
[28404905] OSR1 is a novel epigenetic silenced tumor suppressor regulating invasion and proliferation in renal cell carcinoma.
[27805568] Hand2 inhibits kidney specification while promoting vein formation within the posterior mesoderm.
[26436110] Regulatory variant in FZD6 gene contributes to nonsyndromic cleft lip and palate in an African-American family.
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