GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

Protein turtle homolog B (Immunoglobulin superfamily member 9B)

 TUTLB_MOUSE             Reviewed;        1328 AA.
E9PZ19; Q5DU06;
11-MAY-2016, integrated into UniProtKB/Swiss-Prot.
05-APR-2011, sequence version 1.
25-MAY-2022, entry version 86.
RecName: Full=Protein turtle homolog B;
AltName: Full=Immunoglobulin superfamily member 9B {ECO:0000312|MGI:MGI:2685354};
Flags: Precursor;
Name=Igsf9b {ECO:0000312|MGI:MGI:2685354}; Synonyms=Kiaa1030;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Mus; Mus.
NCBI_TaxID=10090 {ECO:0000312|Proteomes:UP000000589};
[1] {ECO:0000312|Proteomes:UP000000589}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J {ECO:0000312|Proteomes:UP000000589};
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of the
mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[2] {ECO:0000312|EMBL:BAD90425.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 576-1328.
TISSUE=Brain {ECO:0000312|EMBL:BAD90425.1};
Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O.,
Koga H.;
"Prediction of the coding sequences of mouse homologues of KIAA gene. The
complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by
screening of terminal sequences of cDNA clones randomly sampled from size-
fractionated libraries.";
Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
[3]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain;
PubMed=16452087; DOI=10.1074/mcp.t500041-mcp200;
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.;
"Comprehensive identification of phosphorylation sites in postsynaptic
density preparations.";
Mol. Cell. Proteomics 5:914-922(2006).
[4]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-783; SER-794 AND SER-1215,
AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and expression.";
Cell 143:1174-1189(2010).
[5] {ECO:0000305}
FUNCTION, IDENTIFICATION IN A COMPLEX WITH MAGI2 AND NLGN2, SUBCELLULAR
LOCATION, AND TISSUE SPECIFICITY.
PubMed=23751499; DOI=10.1083/jcb.201209132;
Woo J., Kwon S.K., Nam J., Choi S., Takahashi H., Krueger D., Park J.,
Lee Y., Bae J.Y., Lee D., Ko J., Kim H., Kim M.H., Bae Y.C., Chang S.,
Craig A.M., Kim E.;
"The adhesion protein IgSF9b is coupled to neuroligin 2 via S-SCAM to
promote inhibitory synapse development.";
J. Cell Biol. 201:929-944(2013).
[6]
METHYLATION [LARGE SCALE ANALYSIS] AT ARG-1136, AND IDENTIFICATION BY MASS
SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain;
PubMed=24129315; DOI=10.1074/mcp.o113.027870;
Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
Bedford M.T., Comb M.J.;
"Immunoaffinity enrichment and mass spectrometry analysis of protein
methylation.";
Mol. Cell. Proteomics 13:372-387(2014).
-!- FUNCTION: Transmembrane protein which is abundantly expressed in
interneurons, where it may regulate inhibitory synapse development (By
similarity). May mediate homophilic cell adhesion (PubMed:23751499).
{ECO:0000250|UniProtKB:D3ZB51, ECO:0000269|PubMed:23751499}.
-!- SUBUNIT: Found in a complex with MAGI2 and NLGN2, where it interacts
with MAGI2 (via PDZ 5 and PDZ 6 domains).
{ECO:0000269|PubMed:23751499}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23751499};
Single-pass type I membrane protein {ECO:0000255}. Cell junction,
synapse, postsynaptic cell membrane {ECO:0000250|UniProtKB:D3ZB51};
Single-pass type I membrane protein {ECO:0000255}. Cell junction,
synapse, postsynaptic density {ECO:0000250|UniProtKB:D3ZB51}.
-!- TISSUE SPECIFICITY: Detected in brain. {ECO:0000269|PubMed:23751499}.
-!- PTM: N-glycosylated and sialylated. Not significantly O-glycosylated.
{ECO:0000250|UniProtKB:D3ZB51}.
-!- SIMILARITY: Belongs to the immunoglobulin superfamily. Turtle family.
{ECO:0000305}.
---------------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
---------------------------------------------------------------------------
EMBL; AC117198; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AC154374; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AK220364; BAD90425.1; -; mRNA.
RefSeq; NP_001123259.1; NM_001129787.1.
AlphaFoldDB; E9PZ19; -.
SMR; E9PZ19; -.
IntAct; E9PZ19; 2.
MINT; E9PZ19; -.
STRING; 10090.ENSMUSP00000117017; -.
GlyGen; E9PZ19; 3 sites.
iPTMnet; E9PZ19; -.
PhosphoSitePlus; E9PZ19; -.
MaxQB; E9PZ19; -.
PaxDb; E9PZ19; -.
PRIDE; E9PZ19; -.
ProteomicsDB; 298388; -.
Antibodypedia; 2253; 29 antibodies from 12 providers.
Ensembl; ENSMUST00000133213; ENSMUSP00000117017; ENSMUSG00000034275.
GeneID; 235086; -.
UCSC; uc009oqm.2; mouse.
CTD; 22997; -.
MGI; MGI:2685354; Igsf9b.
VEuPathDB; HostDB:ENSMUSG00000034275; -.
eggNOG; KOG2408; Eukaryota.
eggNOG; KOG3510; Eukaryota.
GeneTree; ENSGT00940000155900; -.
HOGENOM; CLU_008169_0_0_1; -.
InParanoid; E9PZ19; -.
OrthoDB; 291729at2759; -.
PhylomeDB; E9PZ19; -.
TreeFam; TF326128; -.
BioGRID-ORCS; 235086; 1 hit in 72 CRISPR screens.
PRO; PR:E9PZ19; -.
Proteomes; UP000000589; Chromosome 9.
RNAct; E9PZ19; protein.
Bgee; ENSMUSG00000034275; Expressed in hindbrain and 67 other tissues.
ExpressionAtlas; E9PZ19; baseline and differential.
GO; GO:0030425; C:dendrite; IDA:MGI.
GO; GO:0098982; C:GABA-ergic synapse; IDA:SynGO.
GO; GO:0060077; C:inhibitory synapse; IDA:MGI.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0043005; C:neuron projection; IBA:GO_Central.
GO; GO:0043025; C:neuronal cell body; IDA:MGI.
GO; GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
GO; GO:0099629; C:postsynaptic specialization of symmetric synapse; ISO:MGI.
GO; GO:0019900; F:kinase binding; IDA:MGI.
GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IDA:MGI.
GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
GO; GO:0097151; P:positive regulation of inhibitory postsynaptic potential; IMP:MGI.
GO; GO:0099560; P:synaptic membrane adhesion; IDA:SynGO.
CDD; cd00063; FN3; 2.
Gene3D; 2.60.40.10; -; 7.
InterPro; IPR003961; FN3_dom.
InterPro; IPR036116; FN3_sf.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003599; Ig_sub.
InterPro; IPR003598; Ig_sub2.
Pfam; PF00041; fn3; 1.
Pfam; PF13895; Ig_2; 1.
SMART; SM00060; FN3; 3.
SMART; SM00409; IG; 5.
SMART; SM00408; IGc2; 5.
SUPFAM; SSF48726; SSF48726; 5.
SUPFAM; SSF49265; SSF49265; 1.
PROSITE; PS50853; FN3; 2.
PROSITE; PS50835; IG_LIKE; 5.
1: Evidence at protein level;
Cell adhesion; Cell junction; Cell membrane; Disulfide bond; Glycoprotein;
Immunoglobulin domain; Membrane; Methylation; Neurogenesis; Phosphoprotein;
Postsynaptic cell membrane; Reference proteome; Repeat; Signal; Synapse;
Transmembrane; Transmembrane helix.
SIGNAL 1..17
/evidence="ECO:0000255"
CHAIN 18..1328
/note="Protein turtle homolog B"
/id="PRO_5003245544"
TOPO_DOM 18..722
/note="Extracellular"
/evidence="ECO:0000305"
TRANSMEM 723..743
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 744..1328
/note="Cytoplasmic"
/evidence="ECO:0000305"
DOMAIN 30..115
/note="Ig-like 1"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
DOMAIN 139..226
/note="Ig-like 2"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
DOMAIN 228..320
/note="Ig-like 3"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
DOMAIN 324..415
/note="Ig-like 4"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
DOMAIN 420..504
/note="Ig-like 5"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
DOMAIN 512..604
/note="Fibronectin type-III 1"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
DOMAIN 614..708
/note="Fibronectin type-III 2"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
REGION 758..817
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 914..1040
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 1106..1328
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 771..803
/note="Polar residues"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1015..1035
/note="Polar residues"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1125..1139
/note="Polar residues"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1195..1214
/note="Polar residues"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1233..1280
/note="Polar residues"
/evidence="ECO:0000256|SAM:MobiDB-lite"
MOD_RES 775
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:D3ZB51"
MOD_RES 783
/note="Phosphoserine"
/evidence="ECO:0007744|PubMed:21183079"
MOD_RES 794
/note="Phosphoserine"
/evidence="ECO:0007744|PubMed:21183079"
MOD_RES 1136
/note="Omega-N-methylarginine"
/evidence="ECO:0007744|PubMed:24129315"
MOD_RES 1207
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:D3ZB51"
MOD_RES 1215
/note="Phosphoserine"
/evidence="ECO:0007744|PubMed:21183079"
CARBOHYD 241
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 258
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 624
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 45..113
/evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
DISULFID 161..208
/evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
DISULFID 250..303
/evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
DISULFID 346..397
/evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
DISULFID 442..488
/evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SEQUENCE 1328 AA; 144951 MW; 686913AB14AB2D3D CRC64;
MIWYVATLIA SVISTRGLVA QGAHGLREEP EFVTARAGEG VVLRCDVIHP VTGQPPPYVV
EWFKFGVPIP IFIKFGYYPP HVDPEYAGRA SLHDKASLRL EQVRSEDQGW YECKVLMLDQ
QYDTFHNGSW VHLTINAPPT FTETPPQYIE AKEGGSITMT CTAFGNPKPI VTWLKEGTLL
GASAKYQVSD GSLTVTSVSR EDRGAYTCRA YSIQGEAVHT THLLVQGPPF IVSPPENITV
NISQDALLTC RAEAYPGNLT YTWYWQDENV YFQNDLKLRV RILIDGTLII FRVKPEDAGK
YTCVPSNSLG RSPSASAYLT VQYPARVLNM PPVIYVPVGI HGYIRCPVDA EPPATVVKWN
KDGRPLQVEK NLGWTLMEDG SIRIEEATEE ALGTYTCVPY NTLGTMGQSA PARLVLKDPP
YFTVLPGWEY RQEAGRELLI PCAAAGDPFP VITWRKVGKP SRSKHNALPS GSLQFRALSK
EDHGEWECVA TNVVTSITAS THLTVIGTSP HAPGSVRVHV SMTTANVSWE PGYDGGYEQT
FSVWMKRAQF GPHDWLSLSV PPGPSWLLVD SLEPETAYQF SVLAQNRLGT SAFSEVVTVN
TLAFPVTTPE PLVLVTPPRC LTANRTQQGV LLSWLPPANH SFPIDRYIME FRVGERWEML
DDAIPGTDGD FFAKDLSQDT WYEFRVLAVM QDLISEPSNI AGVSSTDIFP QPDLTDDGLA
RPVLAGIVAT ICFLAAAILF STLAACFVNK QRKRKLKRKK DPPLSITHCR KSLESPLSSG
KVSPESIRTL RAPSESSDDQ GQPAAKRMLS PTREKELSLY KKTKRAISSR KYSVAKAEAE
AEATTPIELI SRGPDGRFVM GPSEMEPSVK GRRIEGFPFA EETDMYPEFR QSDEENEDPL
VPTSVAALKP QLTPMSSSQD SYLPPPAYSP RFQPRGLEGP SGLGGRLQAT GQARPPAPRP
FQHGQYYGYL SSSSPGEVEP PPFYMPEVGS PLSSVMSSPP LHTEGPFGHP TIPEENGENA
SNSTLPLTQT PTGGRSPEPW GRPEFPFGGL ETPAMMFPHQ LHPCDVAESL QPKACLPRGL
PPAPLQVPAA YPGMLSLEAP KGWVGKSPGR GPIPAPPATK WQERPMQPLV SQGQLRHTSQ
GMGIPVLPYP EPAEPGGHGG PSTFGLDTRW YEPQPRPRPS PRQARRAEPS LHQVVLQPSR
LSPLTQSPLS SRTGSPELAA RARPRPGLLQ QAEMSEITLQ PPAAVSFSRK STPSSTGSPS
QSSRSGSPSY RPTMGFTTLA TGYPSPPPGP APPAPGDTLD VFGQTPSPRR MGEEPLRPEP
PTTLPTSG


Related products :

Catalog number Product name Quantity
EIAAB44564 Homo sapiens,Human,IgSF9B,IGSF9B,Immunoglobulin superfamily member 9B,KIAA1030,Protein turtle homolog B
EIAAB44563 Homo sapiens,Human,IGSF9,IgSF9A,IGSF9A,Immunoglobulin superfamily member 9A,KIAA1355,NRT1,Protein turtle homolog A
EIAAB44562 Dasm1,Dendrite arborization and synapse maturation protein 1,Igsf9,IgSF9A,Igsf9a,Immunoglobulin superfamily member 9A,Protein turtle homolog A,Rat,Rattus norvegicus
EIAAB44561 Dasm1,Dendrite arborization and synapse maturation protein 1,Igsf9,IgSF9A,Igsf9a,Immunoglobulin superfamily member 9A,Mouse,Mus musculus,Nrt1,Protein turtle homolog A
26-421 IGSF9 belongs to the immunoglobulin superfamily, turtle family. It contains 2 fibronectin type-III domains and 5 Ig-like (immunoglobulin-like) domains. It functions in dendrite outgrowth and synapse m 0.05 mg
EIAAB05120 CADM1,Cell adhesion molecule 1,Homo sapiens,Human,IgSF4,IGSF4,IGSF4A,Immunoglobulin superfamily member 4,NECL2,NECL-2,Nectin-like protein 2,SgIgSF,Spermatogenic immunoglobulin superfamily,Synaptic cel
EIAAB05121 Cadm1,Cell adhesion molecule 1,IgSF4,Igsf4,Immunoglobulin superfamily member 4,Mouse,Mus musculus,Necl2,NECL-2,Nectin-like protein 2,Ra175,SgIgSF,Spermatogenic immunoglobulin superfamily,Synaptic cell
E0273h ELISA kit Homo sapiens,Human,IGDC1,IgSF1,IGSF1,Immunoglobulin superfamily member 1,Immunoglobulin-like domain-containing protein 1,InhBP,Inhibin-binding protein,KIAA0364,p120,PGSF2,Pituitary gland-sp 96T
E0273h ELISA Homo sapiens,Human,IGDC1,IgSF1,IGSF1,Immunoglobulin superfamily member 1,Immunoglobulin-like domain-containing protein 1,InhBP,Inhibin-binding protein,KIAA0364,p120,PGSF2,Pituitary gland-specifi 96T
U0273h CLIA Homo sapiens,Human,IGDC1,IgSF1,IGSF1,Immunoglobulin superfamily member 1,Immunoglobulin-like domain-containing protein 1,InhBP,Inhibin-binding protein,KIAA0364,p120,PGSF2,Pituitary gland-specific 96T
G4335 Protein turtle homolog A (IGSF9), Rat, ELISA Kit 96T
APRV1_HUMAN Human ELISA Kit FOR Protein turtle homolog A 96T
E0365b Human ELISA Kit FOR Protein turtle homolog A 96T
GPR19_RAT Human ELISA Kit FOR Protein turtle homolog A 96T
CSB-EL011566RA Rat Protein turtle homolog A(IGSF9) ELISA kit 96T
CSB-EL011566RA Rat Protein turtle homolog A(IGSF9) ELISA kit SpeciesRat 96T
G4336 Protein turtle homolog B (IGSF9B), Human, ELISA Kit 96T
CSB-EL011567HU Human Protein turtle homolog B(IGSF9B) ELISA kit 96T
CSB-EL011566MO Mouse Protein turtle homolog A(IGSF9) ELISA kit 96T
G4333 Protein turtle homolog A (IGSF9), Human, ELISA Kit 96T
G4334 Protein turtle homolog A (IGSF9), Mouse, ELISA Kit 96T
CSB-EL011566HU Human Protein turtle homolog A(IGSF9) ELISA kit 96T
CSB-EL011567HU Human Protein turtle homolog B(IGSF9B) ELISA kit SpeciesHuman 96T
TUTLA_RAT ELISA Kit FOR Protein turtle homolog A; organism: Rat; gene name: Igsf9 96T
CSB-EL011566HU Human Protein turtle homolog A(IGSF9) ELISA kit SpeciesHuman 96T