GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

Protein-tyrosine kinase 2-beta (EC 2 7 10 2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2)

 FAK2_RAT                Reviewed;        1009 AA.
P70600; O88489; Q3T1H4; Q63201;
15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
01-FEB-1997, sequence version 1.
17-JUN-2020, entry version 193.
RecName: Full=Protein-tyrosine kinase 2-beta;
EC=2.7.10.2;
AltName: Full=Calcium-dependent tyrosine kinase;
Short=CADTK;
AltName: Full=Calcium-regulated non-receptor proline-rich tyrosine kinase;
AltName: Full=Cell adhesion kinase beta;
Short=CAK-beta;
Short=CAKB;
AltName: Full=Focal adhesion kinase 2;
Short=FADK 2;
AltName: Full=Proline-rich tyrosine kinase 2;
Name=Ptk2b; Synonyms=Fak2, Pyk2;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND PROTEIN SEQUENCE OF 310-334;
553-572; 672-687 AND 989-998.
TISSUE=Liver epithelium;
PubMed=8939945; DOI=10.1074/jbc.271.47.29993;
Yu H., Li X., Marchetto G.S., Dy R., Hunter D., Calvo B., Dawson T.L.,
Wilm M., Anderegg R.J., Graves L.M., Earp H.S.;
"Activation of a novel calcium-dependent protein-tyrosine kinase.
Correlation with c-Jun N-terminal kinase but not mitogen-activated protein
kinase activation.";
J. Biol. Chem. 271:29993-29998(1996).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
STRAIN=Sprague-Dawley; TISSUE=Brain;
PubMed=7673154; DOI=10.1074/jbc.270.36.21206;
Sasaki H., Nagura K., Ishino M., Tobioka H., Kotani K., Sasaki T.;
"Cloning and characterization of cell adhesion kinase beta, a novel
protein-tyrosine kinase of the focal adhesion kinase subfamily.";
J. Biol. Chem. 270:21206-21219(1995).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), SUBCELLULAR LOCATION, AND
DOMAIN FAT.
TISSUE=Hippocampus;
PubMed=9645946;
Xiong W.-C., Macklem M., Parsons J.T.;
"Expression and characterization of splice variants of PYK2, a focal
adhesion kinase-related protein.";
J. Cell Sci. 111:1981-1991(1998).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Prostate;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
FUNCTION, AND PHOSPHORYLATION.
PubMed=7544443; DOI=10.1038/376737a0;
Lev S., Moreno H., Martinez R., Canoll P., Peles E., Musacchio J.M.,
Plowman G.D., Rudy B., Schlessinger J.;
"Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion
channel and MAP kinase functions.";
Nature 376:737-745(1995).
[6]
FUNCTION IN G-PROTEIN COUPLED RECEPTOR SIGNALING AND PHOSPHORYLATION OF
SRC, INTERACTION WITH SRC, AND PHOSPHORYLATION.
PubMed=8849729; DOI=10.1038/383547a0;
Dikic I., Tokiwa G., Lev S., Courtneidge S.A., Schlessinger J.;
"A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP
kinase activation.";
Nature 383:547-550(1996).
[7]
INTERACTION WITH TGFB1I1.
PubMed=9422762; DOI=10.1074/jbc.273.2.1003;
Matsuya M., Sasaki H., Aoto H., Mitaka T., Nagura K., Ohba T., Ishino M.,
Takahashi S., Suzuki R., Sasaki T.;
"Cell adhesion kinase beta forms a complex with a new member, Hic-5, of
proteins localized at focal adhesions.";
J. Biol. Chem. 273:1003-1014(1998).
[8]
FUNCTION IN ANGIOGENESIS; CELL MIGRATION; CELL SPREADING AND REORGANIZATION
OF THE ACTIN CYTOSKELETON, AND TISSUE SPECIFICITY.
PubMed=11739395; DOI=10.1074/jbc.m110673200;
Tang H., Hao Q., Fitzgerald T., Sasaki T., Landon E.J., Inagami T.;
"Pyk2/CAKbeta tyrosine kinase activity-mediated angiogenesis of pulmonary
vascular endothelial cells.";
J. Biol. Chem. 277:5441-5447(2002).
[9]
INTERACTION WITH KCNA2.
PubMed=11739373; DOI=10.1074/jbc.m104726200;
Byron K.L., Lucchesi P.A.;
"Signal transduction of physiological concentrations of vasopressin in A7r5
vascular smooth muscle cells. A role for PYK2 and tyrosine phosphorylation
of K+ channels in the stimulation of Ca2+ spiking.";
J. Biol. Chem. 277:7298-7307(2002).
[10]
FUNCTION IN SRC-MEDIATED PHOSPHORYLATION OF NMDA RECEPTORS AND REGULATION
OF NMDA RECEPTOR CHANNEL ACTIVITY.
PubMed=12097497; DOI=10.1523/jneurosci.22-13-05452.2002;
Heidinger V., Manzerra P., Wang X.Q., Strasser U., Yu S.P., Choi D.W.,
Behrens M.M.;
"Metabotropic glutamate receptor 1-induced upregulation of NMDA receptor
current: mediation through the Pyk2/Src-family kinase pathway in cortical
neurons.";
J. Neurosci. 22:5452-5461(2002).
[11]
FUNCTION, PHOSPHORYLATION AT TYR-402 AND TYR-580, AND CATALYTIC ACTIVITY.
PubMed=16574377; DOI=10.1016/j.cellsig.2006.02.013;
Wu S.S., Jacamo R.O., Vong S.K., Rozengurt E.;
"Differential regulation of Pyk2 phosphorylation at Tyr-402 and Tyr-580 in
intestinal epithelial cells: roles of calcium, Src, Rho kinase, and the
cytoskeleton.";
Cell. Signal. 18:1932-1940(2006).
[12]
AUTOPHOSPHORYLATION, AND INTERACTION WITH DLG4.
PubMed=20071509; DOI=10.1523/jneurosci.4992-08.2010;
Bartos J.A., Ulrich J.D., Li H., Beazely M.A., Chen Y., Macdonald J.F.,
Hell J.W.;
"Postsynaptic clustering and activation of Pyk2 by PSD-95.";
J. Neurosci. 30:449-463(2010).
[13]
FUNCTION.
PubMed=21451101; DOI=10.1152/ajpcell.00315.2010;
Perez J., Torres R.A., Rocic P., Cismowski M.J., Weber D.S.,
Darley-Usmar V.M., Lucchesi P.A.;
"PYK2 signaling is required for PDGF-dependent vascular smooth muscle cell
proliferation.";
Am. J. Physiol. 301:C242-C251(2011).
[14]
PHOSPHORYLATION AT TYR-402; TYR-579 AND TYR-580, AND SUBUNIT.
PubMed=20849950; DOI=10.1016/j.cellsig.2010.09.015;
Riggs D., Yang Z., Kloss J., Loftus J.C.;
"The Pyk2 FERM regulates Pyk2 complex formation and phosphorylation.";
Cell. Signal. 23:288-296(2011).
[15]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-375, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22673903; DOI=10.1038/ncomms1871;
Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
Olsen J.V.;
"Quantitative maps of protein phosphorylation sites across 14 different rat
organs and tissues.";
Nat. Commun. 3:876-876(2012).
-!- FUNCTION: Non-receptor protein-tyrosine kinase that regulates
reorganization of the actin cytoskeleton, cell polarization, cell
migration, adhesion, spreading and bone remodeling. Plays a role in the
regulation of the humoral immune response, and is required for normal
levels of marginal B-cells in the spleen and normal migration of
splenic B-cells. Required for normal macrophage polarization and
migration towards sites of inflammation. Regulates cytoskeleton
rearrangement and cell spreading in T-cells, and contributes to the
regulation of T-cell responses. Promotes osteoclastic bone resorption;
this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and
activity of osteoprogenitor cells. Functions in signaling downstream of
integrin and collagen receptors, immune receptors, G-protein coupled
receptors (GPCR), cytokine, chemokine and growth factor receptors, and
mediates responses to cellular stress. Forms multisubunit signaling
complexes with SRC and SRC family members upon activation; this leads
to the phosphorylation of additional tyrosine residues, creating
binding sites for scaffold proteins, effectors and substrates.
Regulates numerous signaling pathways. Promotes activation of
phosphatidylinositol 3-kinase and of the AKT1 signaling cascade.
Promotes activation of NOS3. Regulates production of the cellular
messenger cGMP. Promotes activation of the MAP kinase signaling
cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1.
Promotes activation of Rho family GTPases, such as RHOA and RAC1.
Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and
thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and
proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and
SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373',
and 'Tyr-376' (By similarity). Promotes phosphorylation of NMDA
receptors by SRC family members, and thereby contributes to the
regulation of NMDA receptor ion channel activity and intracellular
Ca(2+) levels. May also regulate potassium ion transport by
phosphorylation of potassium channel subunits. Phosphorylates SRC; this
increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and
SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires
both SRC and PTK2/PYK2 (By similarity). {ECO:0000250,
ECO:0000269|PubMed:7544443}.
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2;
Evidence={ECO:0000255|PROSITE-ProRule:PRU10028,
ECO:0000269|PubMed:16574377};
-!- ACTIVITY REGULATION: Activated in response to stimuli that lead to
increased intracellular Ca(2+) levels; this activation is indirect and
may be mediated by calcium-mediated production of reactive oxygen
species (ROS). Activated by autophosphorylation at Tyr-402; this
creates a binding site for SRC family kinases and leads to
phosphorylation at additional tyrosine residues. Phosphorylation at
Tyr-402, Tyr-579 and Tyr-580 is required for optimal kinase activity
(By similarity). {ECO:0000250}.
-!- SUBUNIT: Homodimer, or homooligomer. Interacts with NPHP1, ASAP1,
ASAP2, ARHGAP26, SKAP2 and TGFB1I1. The Tyr-402 phosphorylated form
interacts with SRC (via SH2 domain) and SRC family members. Forms a
signaling complex with EPHA1, LCK and phosphatidylinositol 3-kinase;
upon activation by EFNA1. Interacts with GRB2 (via SH2 domain).
Interacts with P53/TP53 and MDM2. Interacts with MYLK. Interacts with
BCAR1. Interacts with RB1CC1. Interacts with RHOU. Interacts with VAV1.
Interacts with PDPK1. Interacts with LPXN and PTPN12 (By similarity).
Interacts with SIRPA and SH2D3C. Interacts (hypophosphorylated) with
PXN. Interacts with ARHGAP10. Interacts with KCNA2 (PubMed:11739373).
{ECO:0000250, ECO:0000269|PubMed:11739373, ECO:0000269|PubMed:20071509,
ECO:0000269|PubMed:20849950, ECO:0000269|PubMed:8849729,
ECO:0000269|PubMed:9422762}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9645946}.
Cytoplasm, perinuclear region {ECO:0000250}. Cell membrane
{ECO:0000269|PubMed:9645946}; Peripheral membrane protein
{ECO:0000269|PubMed:9645946}; Cytoplasmic side
{ECO:0000269|PubMed:9645946}. Cell projection, lamellipodium
{ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Nucleus
{ECO:0000250}. Note=Colocalizes with integrins at the cell periphery.
Interaction with NPHP1 induces the membrane-association of the kinase.
Colocalizes with PXN at the microtubule-organizing center. The tyrosine
phosphorylated form is detected at cell-cell contacts (By similarity).
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: [Isoform 2]: Cell junction, focal adhesion.
Note=Localizes to focal adhesions, but not isoform 1 and isoform 3.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=3;
Name=1;
IsoId=P70600-1; Sequence=Displayed;
Name=2; Synonyms=PRNK;
IsoId=P70600-2; Sequence=VSP_004982, VSP_004983;
Name=3; Synonyms=PYK2s;
IsoId=P70600-3; Sequence=VSP_004984;
-!- TISSUE SPECIFICITY: Highly expressed in pulmonary vein endothelial
cells, lung and brain (at protein level). Isoform 1 is expressed at
high levels in the brain (hippocampus, cerebral cortex and olfactory
bulb) and poorly in the spleen and other tissues, whereas isoforms 2
and 3 are expressed in the spleen and brain (highest in cerebellum).
{ECO:0000269|PubMed:11739395}.
-!- PTM: Phosphorylated on tyrosine residues in response to various stimuli
that elevate the intracellular calcium concentration; this activation
is indirect and may be mediated by production of reactive oxygen
species (ROS). Tyr-402 is the major autophosphorylation site, but other
kinases can also phosphorylate Tyr-402. Autophosphorylation occurs in
trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine
residues on the other subunit. Phosphorylation at Tyr-402 promotes
interaction with SRC and SRC family members, leading to phosphorylation
at Tyr-579; Tyr-580 and Tyr-881. Phosphorylation at Tyr-881 is
important for interaction with GRB2. Phosphorylated on tyrosine
residues upon activation of FGR and PKC. Recruitment by NPHP1 to cell
matrix adhesions initiates Tyr-402 phosphorylation. In monocytes,
adherence to substrata is required for tyrosine phosphorylation and
kinase activation. Angiotensin II, thapsigargin and L-alpha-
lysophosphatidic acid (LPA) also induce autophosphorylation and
increase kinase activity. Phosphorylation by MYLK promotes ITGB2
activation and is thus essential to trigger neutrophil transmigration
during lung injury. Dephosphorylated by PTPN12 (By similarity).
{ECO:0000250}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
kinase family. FAK subfamily. {ECO:0000255|PROSITE-ProRule:PRU00159}.
---------------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
---------------------------------------------------------------------------
EMBL; U69109; AAC52895.1; -; mRNA.
EMBL; D45854; BAA08290.1; -; mRNA.
EMBL; AF063890; AAC28340.1; -; mRNA.
EMBL; BC101921; AAI01922.1; -; mRNA.
PIR; A57434; A57434.
RefSeq; NP_059014.2; NM_017318.2. [P70600-1]
RefSeq; XP_006252205.1; XM_006252143.3. [P70600-1]
RefSeq; XP_006252206.1; XM_006252144.3. [P70600-1]
RefSeq; XP_006252207.1; XM_006252145.3. [P70600-3]
RefSeq; XP_008768995.1; XM_008770773.2. [P70600-1]
RefSeq; XP_008768996.1; XM_008770774.2. [P70600-1]
SMR; P70600; -.
BioGRID; 248405; 4.
CORUM; P70600; -.
IntAct; P70600; 1.
MINT; P70600; -.
STRING; 10116.ENSRNOP00000031615; -.
ChEMBL; CHEMBL1075222; -.
iPTMnet; P70600; -.
PhosphoSitePlus; P70600; -.
jPOST; P70600; -.
PaxDb; P70600; -.
PRIDE; P70600; -.
Ensembl; ENSRNOT00000030007; ENSRNOP00000031615; ENSRNOG00000027839. [P70600-1]
Ensembl; ENSRNOT00000030036; ENSRNOP00000036813; ENSRNOG00000027839. [P70600-1]
GeneID; 50646; -.
KEGG; rno:50646; -.
UCSC; RGD:628758; rat. [P70600-1]
CTD; 2185; -.
RGD; 628758; Ptk2b.
eggNOG; KOG4257; Eukaryota.
eggNOG; ENOG410ZH9Y; LUCA.
GeneTree; ENSGT00940000157269; -.
HOGENOM; CLU_002646_0_1_1; -.
InParanoid; P70600; -.
KO; K05871; -.
OMA; IMELYSY; -.
OrthoDB; 43729at2759; -.
PhylomeDB; P70600; -.
TreeFam; TF316643; -.
BRENDA; 2.7.10.2; 5301.
Reactome; R-RNO-391160; Signal regulatory protein family interactions.
Reactome; R-RNO-4420097; VEGFA-VEGFR2 Pathway.
Reactome; R-RNO-9020558; Interleukin-2 signaling.
PRO; PR:P70600; -.
Proteomes; UP000002494; Chromosome 15.
Bgee; ENSRNOG00000027839; Expressed in brain and 9 other tissues.
Genevisible; P70600; RN.
GO; GO:0097440; C:apical dendrite; IDA:Alzheimers_University_of_Toronto.
GO; GO:0030424; C:axon; IDA:RGD.
GO; GO:0005623; C:cell; IEA:GOC.
GO; GO:0044297; C:cell body; IDA:UniProtKB.
GO; GO:0005938; C:cell cortex; IDA:RGD.
GO; GO:0042995; C:cell projection; IDA:UniProtKB.
GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
GO; GO:0030425; C:dendrite; IDA:Alzheimers_University_of_Toronto.
GO; GO:0043197; C:dendritic spine; IDA:SynGO.
GO; GO:0031234; C:extrinsic component of cytoplasmic side of plasma membrane; IEA:InterPro.
GO; GO:0005925; C:focal adhesion; IDA:RGD.
GO; GO:0098978; C:glutamatergic synapse; IDA:SynGO.
GO; GO:0030426; C:growth cone; IDA:Alzheimers_University_of_Toronto.
GO; GO:0030027; C:lamellipodium; ISS:UniProtKB.
GO; GO:0045121; C:membrane raft; IDA:RGD.
GO; GO:0043025; C:neuronal cell body; IDA:Alzheimers_University_of_Toronto.
GO; GO:0017146; C:NMDA selective glutamate receptor complex; IDA:Alzheimers_University_of_Toronto.
GO; GO:0005634; C:nucleus; IDA:RGD.
GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.
GO; GO:0098794; C:postsynapse; IDA:SynGO.
GO; GO:0014069; C:postsynaptic density; IDA:Alzheimers_University_of_Toronto.
GO; GO:0043423; F:3-phosphoinositide-dependent protein kinase binding; IDA:RGD.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004683; F:calmodulin-dependent protein kinase activity; IDA:Alzheimers_University_of_Toronto.
GO; GO:0019899; F:enzyme binding; IPI:RGD.
GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; ISS:UniProtKB.
GO; GO:0008022; F:protein C-terminus binding; ISO:RGD.
GO; GO:0004672; F:protein kinase activity; ISO:RGD.
GO; GO:0044877; F:protein-containing complex binding; IPI:RGD.
GO; GO:0031625; F:ubiquitin protein ligase binding; IPI:RGD.
GO; GO:0007015; P:actin filament organization; IMP:RGD.
GO; GO:0090630; P:activation of GTPase activity; IMP:RGD.
GO; GO:0042976; P:activation of Janus kinase activity; IMP:RGD.
GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
GO; GO:0001525; P:angiogenesis; IMP:RGD.
GO; GO:0043534; P:blood vessel endothelial cell migration; IMP:RGD.
GO; GO:0045453; P:bone resorption; ISS:UniProtKB.
GO; GO:0007155; P:cell adhesion; IMP:RGD.
GO; GO:0030154; P:cell differentiation; IEP:RGD.
GO; GO:0007166; P:cell surface receptor signaling pathway; ISS:UniProtKB.
GO; GO:0006968; P:cellular defense response; IMP:Alzheimers_University_of_Toronto.
GO; GO:0071498; P:cellular response to fluid shear stress; ISO:RGD.
GO; GO:0071300; P:cellular response to retinoic acid; ISO:RGD.
GO; GO:0070098; P:chemokine-mediated signaling pathway; ISS:UniProtKB.
GO; GO:0086100; P:endothelin receptor signaling pathway; ISS:UniProtKB.
GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IMP:RGD.
GO; GO:0048041; P:focal adhesion assembly; IMP:RGD.
GO; GO:0014009; P:glial cell proliferation; IEP:RGD.
GO; GO:0007229; P:integrin-mediated signaling pathway; ISS:UniProtKB.
GO; GO:0035235; P:ionotropic glutamate receptor signaling pathway; IMP:Alzheimers_University_of_Toronto.
GO; GO:0060292; P:long-term synaptic depression; IMP:RGD.
GO; GO:0060291; P:long-term synaptic potentiation; IMP:Alzheimers_University_of_Toronto.
GO; GO:0000165; P:MAPK cascade; IMP:RGD.
GO; GO:0002315; P:marginal zone B cell differentiation; ISS:UniProtKB.
GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
GO; GO:0030502; P:negative regulation of bone mineralization; ISS:UniProtKB.
GO; GO:0008285; P:negative regulation of cell population proliferation; ISS:UniProtKB.
GO; GO:0010656; P:negative regulation of muscle cell apoptotic process; IMP:RGD.
GO; GO:0045638; P:negative regulation of myeloid cell differentiation; ISO:RGD.
GO; GO:0043524; P:negative regulation of neuron apoptotic process; IMP:Alzheimers_University_of_Toronto.
GO; GO:0030279; P:negative regulation of ossification; IMP:RGD.
GO; GO:0043267; P:negative regulation of potassium ion transport; ISO:RGD.
GO; GO:0031175; P:neuron projection development; IMP:RGD.
GO; GO:0001556; P:oocyte maturation; IMP:RGD.
GO; GO:0038083; P:peptidyl-tyrosine autophosphorylation; IDA:Alzheimers_University_of_Toronto.
GO; GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:RGD.
GO; GO:0030838; P:positive regulation of actin filament polymerization; ISS:UniProtKB.
GO; GO:0045766; P:positive regulation of angiogenesis; ISO:RGD.
GO; GO:2000538; P:positive regulation of B cell chemotaxis; ISS:UniProtKB.
GO; GO:0030307; P:positive regulation of cell growth; IMP:RGD.
GO; GO:0030335; P:positive regulation of cell migration; IMP:RGD.
GO; GO:0008284; P:positive regulation of cell population proliferation; IEP:RGD.
GO; GO:0001954; P:positive regulation of cell-matrix adhesion; ISS:UniProtKB.
GO; GO:0032270; P:positive regulation of cellular protein metabolic process; IMP:RGD.
GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IMP:RGD.
GO; GO:2000573; P:positive regulation of DNA biosynthetic process; IMP:RGD.
GO; GO:0010595; P:positive regulation of endothelial cell migration; ISO:RGD.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.
GO; GO:2000463; P:positive regulation of excitatory postsynaptic potential; IMP:Alzheimers_University_of_Toronto.
GO; GO:0046330; P:positive regulation of JNK cascade; ISS:UniProtKB.
GO; GO:0043507; P:positive regulation of JUN kinase activity; IMP:RGD.
GO; GO:0010976; P:positive regulation of neuron projection development; ISO:RGD.
GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IMP:RGD.
GO; GO:0051000; P:positive regulation of nitric-oxide synthase activity; IMP:RGD.
GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; ISO:RGD.
GO; GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; ISS:UniProtKB.
GO; GO:0045860; P:positive regulation of protein kinase activity; ISS:UniProtKB.
GO; GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IMP:RGD.
GO; GO:0051968; P:positive regulation of synaptic transmission, glutamatergic; IMP:Alzheimers_University_of_Toronto.
GO; GO:0045727; P:positive regulation of translation; IMP:RGD.
GO; GO:2000060; P:positive regulation of ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
GO; GO:0006468; P:protein phosphorylation; ISO:RGD.
GO; GO:2000249; P:regulation of actin cytoskeleton reorganization; ISS:UniProtKB.
GO; GO:0050848; P:regulation of calcium-mediated signaling; ISO:RGD.
GO; GO:0030155; P:regulation of cell adhesion; ISS:UniProtKB.
GO; GO:0008360; P:regulation of cell shape; ISS:UniProtKB.
GO; GO:0010752; P:regulation of cGMP-mediated signaling; ISO:RGD.
GO; GO:2000114; P:regulation of establishment of cell polarity; ISS:UniProtKB.
GO; GO:0032960; P:regulation of inositol trisphosphate biosynthetic process; ISS:UniProtKB.
GO; GO:0010758; P:regulation of macrophage chemotaxis; ISS:UniProtKB.
GO; GO:0045428; P:regulation of nitric oxide biosynthetic process; ISO:RGD.
GO; GO:2000310; P:regulation of NMDA receptor activity; IMP:Alzheimers_University_of_Toronto.
GO; GO:0051279; P:regulation of release of sequestered calcium ion into cytosol; ISS:UniProtKB.
GO; GO:2000058; P:regulation of ubiquitin-dependent protein catabolic process; ISO:RGD.
GO; GO:0051592; P:response to calcium ion; IEP:RGD.
GO; GO:0051591; P:response to cAMP; IEP:RGD.
GO; GO:0042220; P:response to cocaine; IEP:RGD.
GO; GO:0042493; P:response to drug; IEP:RGD.
GO; GO:0045471; P:response to ethanol; IEP:RGD.
GO; GO:0009749; P:response to glucose; IEP:RGD.
GO; GO:0009725; P:response to hormone; IEP:RGD.
GO; GO:0042542; P:response to hydrogen peroxide; IPI:RGD.
GO; GO:0001666; P:response to hypoxia; IEP:RGD.
GO; GO:0035902; P:response to immobilization stress; IEP:RGD.
GO; GO:0010226; P:response to lithium ion; IEP:RGD.
GO; GO:0009612; P:response to mechanical stimulus; IEP:RGD.
GO; GO:0010243; P:response to organonitrogen compound; IEP:RGD.
GO; GO:0006970; P:response to osmotic stress; IEP:RGD.
GO; GO:0000302; P:response to reactive oxygen species; IEP:RGD.
GO; GO:0007172; P:signal complex assembly; IEA:InterPro.
GO; GO:0002040; P:sprouting angiogenesis; ISS:UniProtKB.
GO; GO:0043149; P:stress fiber assembly; IMP:RGD.
GO; GO:0033209; P:tumor necrosis factor-mediated signaling pathway; ISO:RGD.
GO; GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; ISO:RGD.
CDD; cd14473; FERM_B-lobe; 1.
CDD; cd13190; FERM_C_FAK1; 1.
Gene3D; 1.20.80.10; -; 1.
Gene3D; 2.30.29.30; -; 1.
InterPro; IPR019749; Band_41_domain.
InterPro; IPR041390; FADK_N.
InterPro; IPR041784; FAK1/PYK2_FERM_C.
InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
InterPro; IPR035963; FERM_2.
InterPro; IPR019748; FERM_central.
InterPro; IPR000299; FERM_domain.
InterPro; IPR036137; Focal_adhe_kin_target_dom_sf.
InterPro; IPR005189; Focal_adhesion_kin_target_dom.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR011993; PH-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR030610; PTK2B.
InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
InterPro; IPR008266; Tyr_kinase_AS.
InterPro; IPR020635; Tyr_kinase_cat_dom.
InterPro; IPR029071; Ubiquitin-like_domsf.
PANTHER; PTHR24418:SF94; PTHR24418:SF94; 1.
Pfam; PF00373; FERM_M; 1.
Pfam; PF18038; FERM_N_2; 1.
Pfam; PF03623; Focal_AT; 1.
Pfam; PF07714; Pkinase_Tyr; 1.
PRINTS; PR00109; TYRKINASE.
SMART; SM00295; B41; 1.
SMART; SM00219; TyrKc; 1.
SUPFAM; SSF47031; SSF47031; 1.
SUPFAM; SSF54236; SSF54236; 1.
SUPFAM; SSF56112; SSF56112; 1.
SUPFAM; SSF68993; SSF68993; 1.
PROSITE; PS50057; FERM_3; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
1: Evidence at protein level;
Adaptive immunity; Alternative splicing; Angiogenesis; ATP-binding;
Cell junction; Cell membrane; Cell projection; Cytoplasm;
Direct protein sequencing; Immunity; Kinase; Membrane; Nucleotide-binding;
Nucleus; Phosphoprotein; Reference proteome; Transferase;
Tyrosine-protein kinase.
CHAIN 1..1009
/note="Protein-tyrosine kinase 2-beta"
/id="PRO_0000088083"
DOMAIN 39..359
/note="FERM"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00084"
DOMAIN 425..683
/note="Protein kinase"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
NP_BIND 431..439
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
NP_BIND 503..509
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
REGION 801..1009
/note="Interaction with TGFB1I1"
/evidence="ECO:0000269|PubMed:9422762"
REGION 868..1009
/note="Focal adhesion targeting (FAT)"
COMPBIAS 701..767
/note="Pro-rich"
COMPBIAS 831..869
/note="Pro-rich"
ACT_SITE 549
/note="Proton acceptor"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
ECO:0000255|PROSITE-ProRule:PRU10028"
BINDING 457
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MOD_RES 361
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q14289"
MOD_RES 375
/note="Phosphoserine"
/evidence="ECO:0000244|PubMed:22673903"
MOD_RES 399
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q14289"
MOD_RES 402
/note="Phosphotyrosine; by autocatalysis"
/evidence="ECO:0000269|PubMed:16574377,
ECO:0000269|PubMed:20849950"
MOD_RES 579
/note="Phosphotyrosine"
/evidence="ECO:0000269|PubMed:20849950"
MOD_RES 580
/note="Phosphotyrosine"
/evidence="ECO:0000269|PubMed:16574377,
ECO:0000269|PubMed:20849950"
MOD_RES 722
/note="Phosphotyrosine"
/evidence="ECO:0000250|UniProtKB:Q14289"
MOD_RES 762
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q14289"
MOD_RES 765
/note="Phosphothreonine"
/evidence="ECO:0000250|UniProtKB:Q14289"
MOD_RES 834
/note="Phosphotyrosine"
/evidence="ECO:0000250|UniProtKB:Q14289"
MOD_RES 839
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q14289"
MOD_RES 842
/note="Phosphothreonine"
/evidence="ECO:0000250|UniProtKB:Q14289"
MOD_RES 849
/note="Phosphotyrosine"
/evidence="ECO:0000250|UniProtKB:Q14289"
MOD_RES 866
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q14289"
MOD_RES 881
/note="Phosphotyrosine"
/evidence="ECO:0000250|UniProtKB:Q14289"
VAR_SEQ 1..771
/note="Missing (in isoform 2)"
/evidence="ECO:0000303|PubMed:9645946"
/id="VSP_004982"
VAR_SEQ 739..780
/note="Missing (in isoform 3)"
/evidence="ECO:0000303|PubMed:9645946"
/id="VSP_004984"
VAR_SEQ 772..780
/note="NVFKRHSMR -> MGLIVLSSQ (in isoform 2)"
/evidence="ECO:0000303|PubMed:9645946"
/id="VSP_004983"
CONFLICT 205
/note="E -> A (in Ref. 2; BAA08290)"
/evidence="ECO:0000305"
CONFLICT 807
/note="V -> F (in Ref. 3; AAC28340)"
/evidence="ECO:0000305"
SEQUENCE 1009 AA; 115784 MW; D435A475BCA49E9B CRC64;
MSGVSEPLSR VKVGTLRPPE GPPEPMVVVP VDVEKEDVRI LKVCFYSNSF NPGKNFKLVK
CTVQTEIQEI ITSILLSGRI GPNIQLAECY GLRLKHMKSD EIHWLHPQMT VGEVQDKYEC
LHVEAEWRYD LQIRYLPEDF MESLKEDRTT LLYFYQQLRN DYMQRYASKV SEGMALQLGC
LELRRFFKDM PHNALDKKSN FELLEKEVGL DLFFPKQMQE NLKPKQFRKM IQQTFQQYAS
LREEECVMKF FNTLAGFANI DQETYRCELI QGWNITVDLV IGPKGIRQLT SQDTKPTCLA
EFKQIRSIRC LPLEETQAVL QLGIEGAPQS LSIKTSSLAE AENMADLIDG YCRLQGEHKG
SLIIHAKKDG EKRNSLPQIP TLNLESRRSH LSESCSIESD IYAEIPDETL RRPGGPQYGV
AREDVVLNRI LGEGFFGEVY EGVYTNHKGE KINVAVKTCK KDCTLDNKEK FMSEAVIMKN
LDHPHIVKLI GIIEEEPTWI VMELYPYGEL GHYLERNKNS LKVPTLVLYA LQICKAMAYL
ESINCVHRDI AVRNILVASP ECVKLGDFGL SRYIEDEDYY KASVTRLPIK WMSPESINFR
RFTTASDVWM FAVCMWEILS FGKQPFFWLE NKDVIGVLEK GDRLPKPELC PPVLYTLMTR
CWDYDPSDRP RFTELVCSLS DIYQMERDIA IEQERNARYR PPKILEPTAF QEPPPKPSRP
KYKHPPQTNL LAPKLQFQVP EGLCASSPTL TSPMEYPSPV NSLHTPPLHR HNVFKRHSMR
EEDFIRPSSR EEAQQLWEAE KIKMRQVLDR QQKQMVEDSQ WLRREERCLD PMVYMNDKSP
LTPEKEAGYT EFTGPPQKPP RLGAQSIQPT ANLDRTDDLV YHNVMTLVEA VLELKNKLSQ
LPPEEYVVVV KNVGLNLRKL IGSVDDLLPS LPASSRTEIE GTQKLLNKDL AELINKMRLA
QQNAVTSLSE DCKRQMLTAS HTLAVDAKNL LDAVDQAKVV ANLAHPPAE


Related products :

Catalog number Product name Quantity
EIAAB14369 CADTK,CAK-beta,Calcium-dependent tyrosine kinase,Cell adhesion kinase beta,FADK 2,Fak2,Focal adhesion kinase 2,Proline-rich tyrosine kinase 2,Protein-tyrosine kinase 2-beta,Ptk2b,Pyk2,Rat,Rattus norve
EIAAB14370 CADTK,CAK-beta,Calcium-dependent tyrosine kinase,Cell adhesion kinase beta,FADK 2,FAK2,Focal adhesion kinase 2,Homo sapiens,Human,Proline-rich tyrosine kinase 2,Protein-tyrosine kinase 2-beta,PTK2B,PY
EIAAB14368 CADTK,CAK-beta,Calcium-dependent tyrosine kinase,Cell adhesion kinase beta,FADK 2,Fak2,Focal adhesion kinase 2,Mouse,Mus musculus,Proline-rich tyrosine kinase 2,Protein-tyrosine kinase 2-beta,Ptk2b,Py
18-003-42265 Protein tyrosine kinase 2 beta - EC 2.7.10.2; Focal adhesion kinase 2; FADK 2; Proline-rich tyrosine kinase 2; Cell adhesion kinase beta; CAK beta; Calcium-dependent tyrosine kinase; CADTK; Related ad 0.1 mg Protein A
18-003-42266 Protein tyrosine kinase 2 beta - EC 2.7.10.2; Focal adhesion kinase 2; FADK 2; Proline-rich tyrosine kinase 2; Cell adhesion kinase beta; CAK beta; Calcium-dependent tyrosine kinase; CADTK; Related ad 0.05 mg Aff Pur
18-785-210388 Pyk2 (Phospho-Tyr402) - EC 2.7.10.2; Focal adhesion kinase 2; FADK 2; Proline-rich tyrosine kinase 2; Cell adhesion kinase beta; CAK beta; Calcium-dependent tyrosine kinase; CADTK; Related adhesion fo 0.05 mg
18-785-210388 Pyk2 (Phospho-Tyr402) - EC 2.7.10.2; Focal adhesion kinase 2; FADK 2; Proline-rich tyrosine kinase 2; Cell adhesion kinase beta; CAK beta; Calcium-dependent tyrosine kinase; CADTK; Related adhesion fo 0.1 mg
18-785-210389 Pyk2 (Ab-402) - EC 2.7.10.2; Focal adhesion kinase 2; FADK 2; Proline-rich tyrosine kinase 2; Cell adhesion kinase beta; CAK beta; Calcium-dependent tyrosine kinase; CADTK; Related adhesion focal tyro 0.1 mg
18-785-210389 Pyk2 (Ab-402) - EC 2.7.10.2; Focal adhesion kinase 2; FADK 2; Proline-rich tyrosine kinase 2; Cell adhesion kinase beta; CAK beta; Calcium-dependent tyrosine kinase; CADTK; Related adhesion focal tyro 0.05 mg
EIAAB33008 CCK4,CCK-4,Colon carcinoma kinase 4,Homo sapiens,Human,Inactive tyrosine-protein kinase 7,Protein-tyrosine kinase 7,Pseudo tyrosine kinase receptor 7,PTK7,Tyrosine-protein kinase-like 7
U1915m CLIA Agammaglobulinaemia tyrosine kinase,ATK,B-cell progenitor kinase,BPK,Bpk,Bruton tyrosine kinase,Btk,Kinase EMB,Mouse,Mus musculus,Tyrosine-protein kinase BTK 96T
U1915m CLIA kit Agammaglobulinaemia tyrosine kinase,ATK,B-cell progenitor kinase,BPK,Bpk,Bruton tyrosine kinase,Btk,Kinase EMB,Mouse,Mus musculus,Tyrosine-protein kinase BTK 96T
E1915m ELISA Agammaglobulinaemia tyrosine kinase,ATK,B-cell progenitor kinase,BPK,Bpk,Bruton tyrosine kinase,Btk,Kinase EMB,Mouse,Mus musculus,Tyrosine-protein kinase BTK 96T
E1915m ELISA kit Agammaglobulinaemia tyrosine kinase,ATK,B-cell progenitor kinase,BPK,Bpk,Bruton tyrosine kinase,Btk,Kinase EMB,Mouse,Mus musculus,Tyrosine-protein kinase BTK 96T
E1178m ELISA Fadk,FADK 1,Fak,Fak1,Focal adhesion kinase 1,Kiaa4203,Mouse,Mus musculus,pp125FAK,Protein-tyrosine kinase 2,Ptk2 96T
U1178m CLIA Fadk,FADK 1,Fak,Fak1,Focal adhesion kinase 1,Kiaa4203,Mouse,Mus musculus,pp125FAK,Protein-tyrosine kinase 2,Ptk2 96T
E1178m ELISA kit Fadk,FADK 1,Fak,Fak1,Focal adhesion kinase 1,Kiaa4203,Mouse,Mus musculus,pp125FAK,Protein-tyrosine kinase 2,Ptk2 96T
E1915h ELISA Agammaglobulinaemia tyrosine kinase,AGMX1,ATK,ATK,B-cell progenitor kinase,BPK,BPK,Bruton tyrosine kinase,BTK,Homo sapiens,Human,Tyrosine-protein kinase BTK 96T
U1915h CLIA kit Agammaglobulinaemia tyrosine kinase,AGMX1,ATK,ATK,B-cell progenitor kinase,BPK,BPK,Bruton tyrosine kinase,BTK,Homo sapiens,Human,Tyrosine-protein kinase BTK 96T
E1915h ELISA kit Agammaglobulinaemia tyrosine kinase,AGMX1,ATK,ATK,B-cell progenitor kinase,BPK,BPK,Bruton tyrosine kinase,BTK,Homo sapiens,Human,Tyrosine-protein kinase BTK 96T
U1915h CLIA Agammaglobulinaemia tyrosine kinase,AGMX1,ATK,ATK,B-cell progenitor kinase,BPK,BPK,Bruton tyrosine kinase,BTK,Homo sapiens,Human,Tyrosine-protein kinase BTK 96T
10-663-45555 Active Focal Adhesion Kinase (FAK) Human - EC 2.7.10.2; FADK 1; pp125FAK; Protein-tyrosine kinase 2 N_A 1 mg
10-663-45555 Active Focal Adhesion Kinase (FAK) Human - EC 2.7.10.2; FADK 1; pp125FAK; Protein-tyrosine kinase 2 N_A 0.002 mg
10-663-45555 Active Focal Adhesion Kinase (FAK) Human - EC 2.7.10.2; FADK 1; pp125FAK; Protein-tyrosine kinase 2 N_A 0.01 mg
E1178r ELISA kit FADK 1,Fak,Fak1,Focal adhesion kinase 1,pp125FAK,Protein-tyrosine kinase 2,Ptk2,Rat,Rattus norvegicus 96T
Pathways :
WP32: Translation Factors
WP1493: Carbon assimilation C4 pathway
WP1619: Amino sugar and nucleotide sugar metabolism
WP1946: Cori Cycle
WP2341: vitamin B1 (thiamin) biosynthesis and salvage pathway
WP1703: Streptomycin biosynthesis
WP253: Glycolysis
WP2340: Thiamine (vitamin B1) biosynthesis and salvage
WP1567: Glycolysis and Gluconeogenesis
WP1701: Starch and sucrose metabolism
WP1844: MAP kinase cascade
WP1681: Pantothenate and CoA biosynthesis
WP1653: Galactose metabolism
WP1714: Tyrosine metabolism
WP809: TGF-beta Receptor Signaling Pathway
WP258: TGF-beta Receptor Signaling Pathway
WP27: Phenylalanine, Tyrosine, Tryptophan biosynthesis
WP210: Cytoplasmic Ribosomal Proteins
WP926: TGF-beta Receptor Signaling Pathway
WP362: TGF-beta Receptor Signaling Pathway
WP538: Tyrosine Biosynthesis
WP120: Phenylalanine and Tyrosine Biosynthesis
WP1687: Phenylalanine, tyrosine and tryptophan biosynthesi
WP1897: Regulation of beta-cell development
WP2218: sGC

Related Genes :
[Ptk2b Fak2 Pyk2 Raftk] Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK)
[PTK2B FAK2 PYK2 RAFTK] Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK)
[Ptk2b Fak2 Pyk2] Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2)
[Ptk2 Fadk Fak Fak1 Kiaa4203] Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK)
[PTK2 FAK FAK1] Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK)
[DDR1 CAK EDDR1 NEP NTRK4 PTK3A RTK6 TRKE] Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (HGK2) (Mammary carcinoma kinase 10) (MCK-10) (Protein-tyrosine kinase 3A) (Protein-tyrosine kinase RTK-6) (TRK E) (Tyrosine kinase DDR) (Tyrosine-protein kinase CAK) (CD antigen CD167a)
[PTK2 FAK FAK1] Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (p41/p43FRNK) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK)
[Ptk2 Fak Fak1] Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK)
[Abl1 Abl] Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
[Lyn] Tyrosine-protein kinase Lyn (EC 2.7.10.2) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
[TEK TIE2 VMCM VMCM1] Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (p140 TEK) (CD antigen CD202b)
[ABL1 ABL JTK7] Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
[EPHB2 DRT EPHT3 EPTH3 ERK HEK5 TYRO5] Ephrin type-B receptor 2 (EC 2.7.10.1) (Developmentally-regulated Eph-related tyrosine kinase) (ELK-related tyrosine kinase) (EPH tyrosine kinase 3) (EPH-like kinase 5) (EK5) (hEK5) (Renal carcinoma antigen NY-REN-47) (Tyrosine-protein kinase TYRO5) (Tyrosine-protein kinase receptor EPH-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2]
[Epha2 Eck Myk2 Sek2] Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK) (Tyrosine-protein kinase receptor MPK-5) (Tyrosine-protein kinase receptor SEK-2)
[EPHA2 ECK] Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
[RET CDHF12 CDHR16 PTC RET51] Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
[BTK AGMX1 ATK BPK] Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase)
[LYN JTK8] Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
[ITK EMT LYK] Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (Interleukin-2-inducible T-cell kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk)
[EPHB1 ELK EPHT2 HEK6 NET] Ephrin type-B receptor 1 (EC 2.7.10.1) (ELK) (EPH tyrosine kinase 2) (EPH-like kinase 6) (EK6) (hEK6) (Neuronally-expressed EPH-related tyrosine kinase) (NET) (Tyrosine-protein kinase receptor EPH-2)
[Ephb2 Epth3 Nuk Sek3] Ephrin type-B receptor 2 (EC 2.7.10.1) (Neural kinase) (Nuk receptor tyrosine kinase) (Tyrosine-protein kinase receptor EPH-3) (Tyrosine-protein kinase receptor SEK-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2]
[Eif2ak2 Pkr Prkr Tik] Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (P1/eIF-2A protein kinase) (Protein kinase RNA-activated) (PKR) (Protein kinase R) (Serine/threonine-protein kinase TIK) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2) (p68 kinase)
[LCK] Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
[Tek Hyk Tie-2 Tie2] Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (HYK) (STK1) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (p140 TEK) (CD antigen CD202b)
[KDR FLK1 VEGFR2] Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309)
[NTRK1 MTC TRK TRKA] High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
[ptk2 fak1] Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Protein-tyrosine kinase 2) (pp125FAK)
[ABL2 ABLL ARG] Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG)
[EGFR ERBB ERBB1 HER1] Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
[FLT1 FLT FRT VEGFR1] Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeability factor receptor)

Bibliography :