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Proteinase-activated receptor 1 (PAR-1) (Coagulation factor II receptor) (Thrombin receptor)

 PAR1_HUMAN              Reviewed;         425 AA.
P25116; Q53XV0; Q96RF7; Q9BUN4;
01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
16-APR-2002, sequence version 2.
29-SEP-2021, entry version 220.
RecName: Full=Proteinase-activated receptor 1;
Short=PAR-1;
AltName: Full=Coagulation factor II receptor;
AltName: Full=Thrombin receptor;
Flags: Precursor;
Name=F2R; Synonyms=CF2R, PAR1, TR;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1672265; DOI=10.1016/0092-8674(91)90261-v;
Vu T.-K.H., Hung D.T., Wheaton V.I., Coughlin S.R.;
"Molecular cloning of a functional thrombin receptor reveals a novel
proteolytic mechanism of receptor activation.";
Cell 64:1057-1068(1991).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
SeattleSNPs variation discovery resource;
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-335.
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
Phelan M., Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-335.
TISSUE=Eye;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
PHOSPHORYLATION.
PubMed=8955127; DOI=10.1074/jbc.271.51.32874;
Shapiro M.J., Trejo J., Zeng D., Coughlin S.R.;
"Role of the thrombin receptor's cytoplasmic tail in intracellular
trafficking. Distinct determinants for agonist-triggered versus tonic
internalization and intracellular localization.";
J. Biol. Chem. 271:32874-32880(1996).
[6]
FUNCTION.
PubMed=10079109; DOI=10.1172/jci6042;
Kahn M.L., Nakanishi-Matsui M., Shapiro M.J., Ishihara H., Coughlin S.R.;
"Protease-activated receptors 1 and 4 mediate activation of human platelets
by thrombin.";
J. Clin. Invest. 103:879-887(1999).
[7]
ANGIOGENESIS INHIBITION PROPERTIES OF PARSTATIN.
PubMed=18988770; DOI=10.1124/jpet.108.145664;
Zania P., Gourni D., Aplin A.C., Nicosia R.F., Flordellis C.S.,
Maragoudakis M.E., Tsopanoglou N.E.;
"Parstatin, the cleaved peptide on proteinase-activated receptor 1
activation, is a potent inhibitor of angiogenesis.";
J. Pharmacol. Exp. Ther. 328:378-389(2009).
[8]
SIGNAL SEQUENCE CLEAVAGE SITE.
PubMed=22659187; DOI=10.1016/j.febslet.2012.05.042;
Zampatis D.E., Rutz C., Furkert J., Schmidt A., Wustenhagen D., Kubick S.,
Tsopanoglou N.E., Schulein R.;
"The protease-activated receptor 1 possesses a functional and cleavable
signal peptide which is necessary for receptor expression.";
FEBS Lett. 586:2351-2359(2012).
[9]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-418, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Erythroleukemia;
PubMed=23186163; DOI=10.1021/pr300630k;
Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
Mohammed S.;
"Toward a comprehensive characterization of a human cancer cell
phosphoproteome.";
J. Proteome Res. 12:260-271(2013).
[10]
VARIANT GLY-166.
PubMed=10391209; DOI=10.1038/10290;
Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N.,
Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L.,
Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q.,
Lander E.S.;
"Characterization of single-nucleotide polymorphisms in coding regions of
human genes.";
Nat. Genet. 22:231-238(1999).
[11]
ERRATUM OF PUBMED:10391209.
Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N.,
Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L.,
Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q.,
Lander E.S.;
Nat. Genet. 23:373-373(1999).
[12]
X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 38-64 IN COMPLEX WITH THROMBIN.
PubMed=8136362; DOI=10.1021/bi00177a018;
Mathews I.I., Padmanabhan K.P., Ganesh V., Tulinsky A., Ishii M., Chen J.,
Turck C.W., Coughlin S.R., Fenton J.W. II;
"Crystallographic structures of thrombin complexed with thrombin receptor
peptides: existence of expected and novel binding modes.";
Biochemistry 33:3266-3279(1994).
-!- FUNCTION: High affinity receptor for activated thrombin coupled to G
proteins that stimulate phosphoinositide hydrolysis. May play a role in
platelets activation and in vascular development.
{ECO:0000269|PubMed:10079109}.
-!- INTERACTION:
P25116; Q03135: CAV1; NbExp=3; IntAct=EBI-2803960, EBI-603614;
P25116; Q9UNN8: PROCR; NbExp=5; IntAct=EBI-2803960, EBI-719705;
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- TISSUE SPECIFICITY: Platelets and vascular endothelial cells.
-!- DOMAIN: The cleaved signal peptide may not be degraded and may function
as an intracellular angiogenesis inhibitor peptide known as parstatin.
-!- PTM: A proteolytic cleavage generates a new N-terminus that functions
as a tethered ligand.
-!- PTM: Phosphorylated in the C-terminal tail; probably mediating
desensitization prior to the uncoupling and internalization of the
receptor. {ECO:0000269|PubMed:8955127}.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
-!- WEB RESOURCE: Name=SeattleSNPs;
URL="http://pga.gs.washington.edu/data/f2r/";
---------------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
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EMBL; M62424; AAA36743.1; -; mRNA.
EMBL; AF391809; AAK69768.1; -; Genomic_DNA.
EMBL; BT007279; AAP35943.1; -; mRNA.
EMBL; BC002464; AAH02464.1; -; mRNA.
EMBL; BC051909; AAH51909.1; -; mRNA.
CCDS; CCDS4032.1; -.
PIR; A37912; A37912.
RefSeq; NP_001298242.1; NM_001311313.1.
RefSeq; NP_001983.2; NM_001992.4.
PDB; 1NRN; X-ray; 3.10 A; R=38-60.
PDB; 1NRO; X-ray; 3.10 A; R=38-64.
PDB; 1NRP; X-ray; 3.00 A; R=38-60.
PDB; 1NRQ; X-ray; 3.50 A; R=40-60.
PDB; 1NRR; X-ray; 2.40 A; R=43-60.
PDB; 3BEF; X-ray; 2.20 A; C/F=49-57.
PDB; 3HKI; X-ray; 2.20 A; C/F=42-62.
PDB; 3HKJ; X-ray; 2.60 A; C/F=42-62.
PDB; 3LU9; X-ray; 1.80 A; C/F=33-57.
PDB; 3VW7; X-ray; 2.20 A; A=86-395.
PDBsum; 1NRN; -.
PDBsum; 1NRO; -.
PDBsum; 1NRP; -.
PDBsum; 1NRQ; -.
PDBsum; 1NRR; -.
PDBsum; 3BEF; -.
PDBsum; 3HKI; -.
PDBsum; 3HKJ; -.
PDBsum; 3LU9; -.
PDBsum; 3VW7; -.
SMR; P25116; -.
BioGRID; 108448; 24.
DIP; DIP-29703N; -.
IntAct; P25116; 21.
STRING; 9606.ENSP00000321326; -.
BindingDB; P25116; -.
ChEMBL; CHEMBL3974; -.
DrugBank; DB05361; SR-123781A.
DrugBank; DB00086; Streptokinase.
DrugBank; DB11300; Thrombin.
DrugBank; DB09030; Vorapaxar.
DrugCentral; P25116; -.
GuidetoPHARMACOLOGY; 347; -.
GlyGen; P25116; 5 sites.
iPTMnet; P25116; -.
PhosphoSitePlus; P25116; -.
SwissPalm; P25116; -.
BioMuta; F2R; -.
DMDM; 20178318; -.
jPOST; P25116; -.
MassIVE; P25116; -.
MaxQB; P25116; -.
PaxDb; P25116; -.
PeptideAtlas; P25116; -.
PRIDE; P25116; -.
ProteomicsDB; 54263; -.
Antibodypedia; 4409; 660 antibodies.
DNASU; 2149; -.
Ensembl; ENST00000319211; ENSP00000321326; ENSG00000181104.
GeneID; 2149; -.
KEGG; hsa:2149; -.
UCSC; uc003ken.5; human.
CTD; 2149; -.
DisGeNET; 2149; -.
GeneCards; F2R; -.
HGNC; HGNC:3537; F2R.
HPA; ENSG00000181104; Tissue enhanced (lymphoid).
MIM; 187930; gene.
neXtProt; NX_P25116; -.
OpenTargets; ENSG00000181104; -.
PharmGKB; PA27946; -.
VEuPathDB; HostDB:ENSG00000181104; -.
eggNOG; ENOG502QTR0; Eukaryota.
GeneTree; ENSGT01040000240473; -.
HOGENOM; CLU_009579_8_2_1; -.
InParanoid; P25116; -.
OMA; FGSEMCR; -.
OrthoDB; 763273at2759; -.
PhylomeDB; P25116; -.
TreeFam; TF330775; -.
PathwayCommons; P25116; -.
Reactome; R-HSA-140875; Common Pathway of Fibrin Clot Formation.
Reactome; R-HSA-375276; Peptide ligand-binding receptors.
Reactome; R-HSA-416476; G alpha (q) signalling events.
Reactome; R-HSA-456926; Thrombin signalling through proteinase activated receptors (PARs).
SIGNOR; P25116; -.
BioGRID-ORCS; 2149; 15 hits in 1016 CRISPR screens.
ChiTaRS; F2R; human.
EvolutionaryTrace; P25116; -.
GeneWiki; Coagulation_factor_II_receptor; -.
GenomeRNAi; 2149; -.
Pharos; P25116; Tclin.
PRO; PR:P25116; -.
Proteomes; UP000005640; Chromosome 5.
RNAct; P25116; protein.
Bgee; ENSG00000181104; Expressed in decidua and 194 other tissues.
ExpressionAtlas; P25116; baseline and differential.
Genevisible; P25116; HS.
GO; GO:0005901; C:caveola; IDA:BHF-UCL.
GO; GO:0009986; C:cell surface; IDA:UniProtKB.
GO; GO:0005769; C:early endosome; IDA:UniProtKB.
GO; GO:0005576; C:extracellular region; TAS:Reactome.
GO; GO:0005794; C:Golgi apparatus; TAS:ProtInc.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0005770; C:late endosome; IDA:UniProtKB.
GO; GO:0031594; C:neuromuscular junction; ISS:UniProtKB.
GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO; GO:0031094; C:platelet dense tubular network; IDA:BHF-UCL.
GO; GO:0045211; C:postsynaptic membrane; ISS:UniProtKB.
GO; GO:0004930; F:G protein-coupled receptor activity; ISS:UniProtKB.
GO; GO:0001965; F:G-protein alpha-subunit binding; ISS:UniProtKB.
GO; GO:0031681; F:G-protein beta-subunit binding; ISS:UniProtKB.
GO; GO:0005102; F:signaling receptor binding; IPI:BHF-UCL.
GO; GO:0015057; F:thrombin-activated receptor activity; IDA:BHF-UCL.
GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:BHF-UCL.
GO; GO:0000186; P:activation of MAPKK activity; ISS:UniProtKB.
GO; GO:0009653; P:anatomical structure morphogenesis; TAS:ProtInc.
GO; GO:0045217; P:cell-cell junction maintenance; IMP:UniProtKB.
GO; GO:0002248; P:connective tissue replacement involved in inflammatory response wound healing; IDA:BHF-UCL.
GO; GO:0007529; P:establishment of synaptic specificity at neuromuscular junction; ISS:UniProtKB.
GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:UniProtKB.
GO; GO:0048873; P:homeostasis of number of cells within a tissue; ISS:UniProtKB.
GO; GO:0006954; P:inflammatory response; ISS:UniProtKB.
GO; GO:0008285; P:negative regulation of cell population proliferation; IDA:BHF-UCL.
GO; GO:0003105; P:negative regulation of glomerular filtration; ISS:UniProtKB.
GO; GO:0043524; P:negative regulation of neuron apoptotic process; ISS:UniProtKB.
GO; GO:1900134; P:negative regulation of renin secretion into blood stream; ISS:UniProtKB.
GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; IDA:BHF-UCL.
GO; GO:0030168; P:platelet activation; IDA:BHF-UCL.
GO; GO:0060155; P:platelet dense granule organization; IC:BHF-UCL.
GO; GO:0030194; P:positive regulation of blood coagulation; IDA:BHF-UCL.
GO; GO:0051928; P:positive regulation of calcium ion transport; ISS:UniProtKB.
GO; GO:0030335; P:positive regulation of cell migration; IMP:BHF-UCL.
GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
GO; GO:0032967; P:positive regulation of collagen biosynthetic process; IDA:BHF-UCL.
GO; GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:BHF-UCL.
GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISS:UniProtKB.
GO; GO:0051482; P:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; ISS:UniProtKB.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.
GO; GO:0043547; P:positive regulation of GTPase activity; IMP:UniProtKB.
GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IEP:UniProtKB.
GO; GO:0032755; P:positive regulation of interleukin-6 production; IDA:UniProtKB.
GO; GO:0032757; P:positive regulation of interleukin-8 production; IDA:UniProtKB.
GO; GO:0043410; P:positive regulation of MAPK cascade; IDA:BHF-UCL.
GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; ISS:UniProtKB.
GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; NAS:BHF-UCL.
GO; GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IDA:BHF-UCL.
GO; GO:0035025; P:positive regulation of Rho protein signal transduction; ISS:UniProtKB.
GO; GO:0045987; P:positive regulation of smooth muscle contraction; ISS:UniProtKB.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:BHF-UCL.
GO; GO:0045907; P:positive regulation of vasoconstriction; ISS:UniProtKB.
GO; GO:0007205; P:protein kinase C-activating G protein-coupled receptor signaling pathway; ISS:UniProtKB.
GO; GO:0030193; P:regulation of blood coagulation; IDA:BHF-UCL.
GO; GO:0032651; P:regulation of interleukin-1 beta production; ISS:UniProtKB.
GO; GO:0051930; P:regulation of sensory perception of pain; ISS:UniProtKB.
GO; GO:0051209; P:release of sequestered calcium ion into cytosol; ISS:UniProtKB.
GO; GO:0032496; P:response to lipopolysaccharide; ISS:UniProtKB.
GO; GO:0009611; P:response to wounding; IDA:BHF-UCL.
GO; GO:0099553; P:trans-synaptic signaling by endocannabinoid, modulating synaptic transmission; IEA:Ensembl.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR003912; Protea_act_rcpt.
InterPro; IPR000935; Thrmbn_rcpt.
Pfam; PF00001; 7tm_1; 1.
PRINTS; PR00237; GPCRRHODOPSN.
PRINTS; PR01428; PROTEASEAR.
PRINTS; PR00908; THROMBINR.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
1: Evidence at protein level;
3D-structure; Blood coagulation; Cell membrane; Disulfide bond;
G-protein coupled receptor; Glycoprotein; Hemostasis; Membrane;
Phosphoprotein; Receptor; Reference proteome; Signal; Transducer;
Transmembrane; Transmembrane helix.
SIGNAL 1..21
/evidence="ECO:0000269|PubMed:22659187"
PROPEP 22..41
/id="PRO_0000012740"
CHAIN 42..425
/note="Proteinase-activated receptor 1"
/id="PRO_0000012741"
TOPO_DOM 42..102
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 103..128
/note="Helical; Name=1"
/evidence="ECO:0000255"
TOPO_DOM 129..137
/note="Cytoplasmic"
/evidence="ECO:0000255"
TRANSMEM 138..157
/note="Helical; Name=2"
/evidence="ECO:0000255"
TOPO_DOM 158..176
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 177..198
/note="Helical; Name=3"
/evidence="ECO:0000255"
TOPO_DOM 199..218
/note="Cytoplasmic"
/evidence="ECO:0000255"
TRANSMEM 219..239
/note="Helical; Name=4"
/evidence="ECO:0000255"
TOPO_DOM 240..268
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 269..288
/note="Helical; Name=5"
/evidence="ECO:0000255"
TOPO_DOM 289..311
/note="Cytoplasmic"
/evidence="ECO:0000255"
TRANSMEM 312..334
/note="Helical; Name=6"
/evidence="ECO:0000255"
TOPO_DOM 335..350
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 351..374
/note="Helical; Name=7"
/evidence="ECO:0000255"
TOPO_DOM 375..425
/note="Cytoplasmic"
/evidence="ECO:0000255"
SITE 41..42
/note="Cleavage; by thrombin"
MOD_RES 418
/note="Phosphoserine"
/evidence="ECO:0007744|PubMed:23186163"
CARBOHYD 35
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 62
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 75
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 250
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 259
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 175..254
/evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
VARIANT 166
/note="S -> G (in dbSNP:rs5893)"
/evidence="ECO:0000269|PubMed:10391209"
/id="VAR_014167"
VARIANT 187
/note="Y -> N (in dbSNP:rs2230849)"
/id="VAR_049432"
VARIANT 257
/note="V -> L (in dbSNP:rs2227832)"
/id="VAR_049433"
VARIANT 268
/note="A -> P (in dbSNP:rs1055103)"
/id="VAR_060680"
VARIANT 335
/note="A -> V (in dbSNP:rs17849599)"
/evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.3"
/id="VAR_060681"
VARIANT 412
/note="S -> Y (in dbSNP:rs2227799)"
/id="VAR_049434"
CONFLICT 238
/note="L -> V (in Ref. 1; AAA36743)"
/evidence="ECO:0000305"
CONFLICT 364
/note="C -> S (in Ref. 1; AAA36743)"
/evidence="ECO:0000305"
STRAND 39..41
/evidence="ECO:0007829|PDB:3LU9"
TURN 47..50
/evidence="ECO:0007829|PDB:3LU9"
HELIX 92..96
/evidence="ECO:0007829|PDB:3VW7"
HELIX 99..102
/evidence="ECO:0007829|PDB:3VW7"
HELIX 104..130
/evidence="ECO:0007829|PDB:3VW7"
HELIX 131..133
/evidence="ECO:0007829|PDB:3VW7"
HELIX 136..152
/evidence="ECO:0007829|PDB:3VW7"
HELIX 155..163
/evidence="ECO:0007829|PDB:3VW7"
HELIX 172..205
/evidence="ECO:0007829|PDB:3VW7"
HELIX 216..238
/evidence="ECO:0007829|PDB:3VW7"
STRAND 243..246
/evidence="ECO:0007829|PDB:3VW7"
TURN 247..250
/evidence="ECO:0007829|PDB:3VW7"
STRAND 251..257
/evidence="ECO:0007829|PDB:3VW7"
HELIX 265..296
/evidence="ECO:0007829|PDB:3VW7"
HELIX 305..324
/evidence="ECO:0007829|PDB:3VW7"
HELIX 327..338
/evidence="ECO:0007829|PDB:3VW7"
HELIX 347..360
/evidence="ECO:0007829|PDB:3VW7"
HELIX 363..373
/evidence="ECO:0007829|PDB:3VW7"
SEQUENCE 425 AA; 47441 MW; 41B742A99EEC96AB CRC64;
MGPRRLLLVA ACFSLCGPLL SARTRARRPE SKATNATLDP RSFLLRNPND KYEPFWEDEE
KNESGLTEYR LVSINKSSPL QKQLPAFISE DASGYLTSSW LTLFVPSVYT GVFVVSLPLN
IMAIVVFILK MKVKKPAVVY MLHLATADVL FVSVLPFKIS YYFSGSDWQF GSELCRFVTA
AFYCNMYASI LLMTVISIDR FLAVVYPMQS LSWRTLGRAS FTCLAIWALA IAGVVPLLLK
EQTIQVPGLN ITTCHDVLNE TLLEGYYAYY FSAFSAVFFF VPLIISTVCY VSIIRCLSSS
AVANRSKKSR ALFLSAAVFC IFIICFGPTN VLLIAHYSFL SHTSTTEAAY FAYLLCVCVS
SISCCIDPLI YYYASSECQR YVYSILCCKE SSDPSSYNSS GQLMASKMDT CSSNLNNSIY
KKLLT


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EIAAB29890 Coagulation factor II receptor-like 3,F2rl3,Par4,PAR-4,Proteinase-activated receptor 4,Rat,Rattus norvegicus,Thrombin receptor-like 3
EIAAB29882 Coagulation factor II receptor-like 2,F2rl2,Mouse,Mus musculus,Par3,PAR-3,Proteinase-activated receptor 3,Thrombin receptor-like 2
EIAAB29883 Coagulation factor II receptor-like 2,F2rl2,Par3,PAR-3,Proteinase-activated receptor 3,Rat,Rattus norvegicus,Thrombin receptor-like 2
18-461-10137 Proteinase-activated receptor 4 - PAR-4; Thrombin receptor-like 3; Coagulation factor II receptor-like 3 Polyclonal 0.05 ml
18-461-10170 Proteinase-activated receptor 1 - PAR-1; Thrombin receptor; Coagulation factor II receptor Polyclonal 0.05 ml
18-461-10291 Proteinase-activated receptor 3 - PAR-3; Thrombin receptor-like 2; Coagulation factor II receptor-like 2 Polyclonal 0.05 ml
18-461-10138 Proteinase-activated receptor 4 - PAR-4; Thrombin receptor-like 3; Coagulation factor II receptor-like 3 Polyclonal 0.05 ml
18-461-10356 Proteinase-activated receptor 4 - PAR-4; Thrombin receptor-like 3; Coagulation factor II receptor-like 3 Polyclonal 0.05 ml
18-461-10355 Proteinase-activated receptor 4 - PAR-4; Thrombin receptor-like 3; Coagulation factor II receptor-like 3 Polyclonal 0.05 ml
EIAAB29884 Coagulation factor II receptor-like 2,F2RL2,Homo sapiens,Human,PAR3,PAR-3,Proteinase-activated receptor 3,Thrombin receptor-like 2
EIAAB29888 Coagulation factor II receptor-like 3,F2RL3,Homo sapiens,Human,PAR4,PAR-4,Proteinase-activated receptor 4,Thrombin receptor-like 3
E0826h ELISA kit CF2R,Coagulation factor II receptor,F2R,Homo sapiens,Human,PAR1,PAR-1,Proteinase-activated receptor 1,Thrombin receptor,TR 96T
E0826h ELISA CF2R,Coagulation factor II receptor,F2R,Homo sapiens,Human,PAR1,PAR-1,Proteinase-activated receptor 1,Thrombin receptor,TR 96T
U0826h CLIA CF2R,Coagulation factor II receptor,F2R,Homo sapiens,Human,PAR1,PAR-1,Proteinase-activated receptor 1,Thrombin receptor,TR 96T
H-8325.0025 TRAP_6 (2_6) Salt Trifluoroacetate Binding _ Synonym FLLRN, Coagulation Factor II Receptor (2_6) (human), PAR_1 (2_6) (human), Proteinase Activated Receptor 1 (2_6) (human), Thrombin Receptor (2_6) 25.0 mg
H-8325.0025 TRAP_6 (2_6) Salt Trifluoroacetate Binding _ Synonym FLLRN, Coagulation Factor II Receptor (2_6) (human), PAR_1 (2_6) (human), Proteinase Activated Receptor 1 (2_6) (human), Thrombin Receptor (2_6) 25.0 mg
H-8325.0005 TRAP_6 (2_6) Salt Trifluoroacetate Binding _ Synonym FLLRN, Coagulation Factor II Receptor (2_6) (human), PAR_1 (2_6) (human), Proteinase Activated Receptor 1 (2_6) (human), Thrombin Receptor (2_6) 5.0 mg
Pathways :
WP94: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP2328: Allograft rejection
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP810: Signaling of Hepatocyte Growth Factor Receptor
WP1004: Kit Receptor Signaling Pathway
WP147: Kit Receptor Signaling Pathway
WP362: TGF-beta Receptor Signaling Pathway
WP926: TGF-beta Receptor Signaling Pathway
WP1183: Toll-like receptor signaling pathway
WP2197: Endothelin
WP75: Toll-like receptor signaling pathway
WP1249: EPO Receptor Signaling
WP2292: Chemokine signaling pathway
WP780: T Cell Receptor Signaling Pathway
WP1025: B Cell Receptor Signaling Pathway
WP1869: Neuroransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
WP1918: Signaling by Robo receptor
WP1309: Toll-like receptor signaling pathway

Related Genes :
[F2RL1 GPR11 PAR2] Proteinase-activated receptor 2 (PAR-2) (Coagulation factor II receptor-like 1) (G-protein coupled receptor 11) (Thrombin receptor-like 1) [Cleaved into: Proteinase-activated receptor 2, alternate cleaved 1; Proteinase-activated receptor 2, alternate cleaved 2]
[F2rl1 Gpcr11 Gpr11 Par2] Proteinase-activated receptor 2 (PAR-2) (Coagulation factor II receptor-like 1) (G-protein coupled receptor 11) (Thrombin receptor-like 1)
[F2rl1 Par2] Proteinase-activated receptor 2 (PAR-2) (Coagulation factor II receptor-like 1) (Thrombin receptor-like 1)
[F2RL1 PAR2] Proteinase-activated receptor 2 (PAR-2) (Coagulation factor II receptor-like 1) (Thrombin receptor-like 1)
[F2RL3 PAR4] Proteinase-activated receptor 4 (PAR-4) (Coagulation factor II receptor-like 3) (Thrombin receptor-like 3)
[F2rl3 Par4] Proteinase-activated receptor 4 (PAR-4) (Coagulation factor II receptor-like 3) (Thrombin receptor-like 3)
[F2rl3 Par4] Proteinase-activated receptor 4 (PAR-4) (Coagulation factor II receptor-like 3) (Thrombin receptor-like 3)
[F2] Prothrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain]
[Met] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[Rack1 Gnb2-rs1 Gnb2l1] Receptor of activated protein C kinase 1 (12-3) (Guanine nucleotide-binding protein subunit beta-2-like 1) (Receptor for activated C kinase) (Receptor of activated protein kinase C 1) (p205) [Cleaved into: Receptor of activated protein C kinase 1, N-terminally processed (Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed)]
[PDGFRA PDGFR2 RHEPDGFRA] Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a)
[F5] Coagulation factor V (Activated protein C cofactor) (Proaccelerin, labile factor) [Cleaved into: Coagulation factor V heavy chain; Coagulation factor V light chain]
[Med1 Crsp210 Drip205 Pbp Pparbp Trap220 Trip2] Mediator of RNA polymerase II transcription subunit 1 (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2)
[Igf1r] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[Pdgfra] Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (Platelet-derived growth factor alpha receptor) (CD antigen CD140a)
[Pdgfra] Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (Platelet-derived growth factor alpha receptor) (CD antigen CD140a)
[TGFBR1 ALK5 SKR4] TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
[Met] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[Rack1 Gnb2l1] Receptor of activated protein C kinase 1 (Guanine nucleotide-binding protein subunit beta-2-like 1) (Receptor for activated C kinase) (Receptor of activated protein kinase C 1) [Cleaved into: Receptor of activated protein C kinase 1, N-terminally processed]
[RACK1 GNB2L1] Receptor of activated protein C kinase 1 (Guanine nucleotide-binding protein subunit beta-2-like 1) (Receptor for activated C kinase) (Receptor of activated protein kinase C 1) [Cleaved into: Receptor of activated protein C kinase 1, N-terminally processed]
[RACK1 GNB2L1 HLC7 PIG21] Receptor of activated protein C kinase 1 (Cell proliferation-inducing gene 21 protein) (Guanine nucleotide-binding protein subunit beta-2-like 1) (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Human lung cancer oncogene 7 protein) (HLC-7) (Receptor for activated C kinase) (Small ribosomal subunit protein RACK1) [Cleaved into: Receptor of activated protein C kinase 1, N-terminally processed (Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed)]
[RACK1 GNB2L1] Receptor of activated protein C kinase 1 (Guanine nucleotide-binding protein subunit beta-2-like 1) (Receptor for activated C kinase) (Receptor of activated protein kinase C 1) [Cleaved into: Receptor of activated protein C kinase 1, N-terminally processed]
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[pdgfra] Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor)
[PDGFRA] Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor)
[MED1 ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2] Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A)
[AHK4 CRE1 RAW1 WOL At2g01830 T23K3.2] Histidine kinase 4 (EC 2.7.13.3) (Arabidopsis histidine kinase 4) (AtHK4) (Cytokinin receptor CYTOKININ RESPONSE 1) (AtCRE1) (Cytokinin receptor CRE1) (Phosphoprotein phosphatase AHK4) (EC 3.1.3.16) (Protein AUTHENTIC HIS-KINASE 4) (Protein ROOT AS IN WOL 1) (Protein WOODEN LEG)

Bibliography :
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