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Proteinase-activated receptor 2 (PAR-2) (Coagulation factor II receptor-like 1) (G-protein coupled receptor 11) (Thrombin receptor-like 1)

 PAR2_MOUSE              Reviewed;         399 AA.
P55086;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
01-OCT-1996, sequence version 1.
29-SEP-2021, entry version 168.
RecName: Full=Proteinase-activated receptor 2;
Short=PAR-2;
AltName: Full=Coagulation factor II receptor-like 1;
AltName: Full=G-protein coupled receptor 11;
AltName: Full=Thrombin receptor-like 1;
Flags: Precursor;
Name=F2rl1; Synonyms=Gpcr11, Gpr11, Par2;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=7890726; DOI=10.1074/jbc.270.11.5950;
Nystedt S., Larsson A.-K., Aaberg H., Sundelin J.;
"The mouse proteinase-activated receptor-2 cDNA and gene. Molecular cloning
and functional expression.";
J. Biol. Chem. 270:5950-5955(1995).
[2]
FUNCTION IN CARDIOVASCULAR RESPONSES.
PubMed=9918574;
Damiano B.P., Cheung W.M., Santulli R.J., Fung-Leung W.P., Ngo K., Ye R.D.,
Darrow A.L., Derian C.K., de Garavilla L., Andrade-Gordon P.;
"Cardiovascular responses mediated by protease-activated receptor-2 (PAR-2)
and thrombin receptor (PAR-1) are distinguished in mice deficient in PAR-2
or PAR-1.";
J. Pharmacol. Exp. Ther. 288:671-678(1999).
[3]
FUNCTION IN INFLAMMATORY RESPONSE, AND DISRUPTION PHENOTYPE.
PubMed=11086091; DOI=10.4049/jimmunol.165.11.6504;
Lindner J.R., Kahn M.L., Coughlin S.R., Sambrano G.R., Schauble E.,
Bernstein D., Foy D., Hafezi-Moghadam A., Ley K.;
"Delayed onset of inflammation in protease-activated receptor-2-deficient
mice.";
J. Immunol. 165:6504-6510(2000).
[4]
DISRUPTION PHENOTYPE.
PubMed=11859856; DOI=10.1254/jjp.88.77;
Kawagoe J., Takizawa T., Matsumoto J., Tamiya M., Meek S.E., Smith A.J.,
Hunter G.D., Plevin R., Saito N., Kanke T., Fujii M., Wada Y.;
"Effect of protease-activated receptor-2 deficiency on allergic dermatitis
in the mouse ear.";
Jpn. J. Pharmacol. 88:77-84(2002).
[5]
DISRUPTION PHENOTYPE.
PubMed=14519665; DOI=10.1096/fj.02-1112com;
Seeliger S., Derian C.K., Vergnolle N., Bunnett N.W., Nawroth R.,
Schmelz M., Von Der Weid P.Y., Buddenkotte J., Sunderkotter C., Metze D.,
Andrade-Gordon P., Harms E., Vestweber D., Luger T.A., Steinhoff M.;
"Proinflammatory role of proteinase-activated receptor-2 in humans and mice
during cutaneous inflammation in vivo.";
FASEB J. 17:1871-1885(2003).
[6]
FUNCTION IN CYTOSKELETAL REARRANGEMENT AND CHEMOTAXIS.
PubMed=12821670; DOI=10.1074/jbc.m300573200;
Ge L., Ly Y., Hollenberg M., DeFea K.;
"A beta-arrestin-dependent scaffold is associated with prolonged MAPK
activation in pseudopodia during protease-activated receptor-2-induced
chemotaxis.";
J. Biol. Chem. 278:34418-34426(2003).
[7]
POSSIBLE INVOLVEMENT IN LUNG INFLAMMATION.
PubMed=16081834; DOI=10.4049/jimmunol.175.4.2598;
Su X., Camerer E., Hamilton J.R., Coughlin S.R., Matthay M.A.;
"Protease-activated receptor-2 activation induces acute lung inflammation
by neuropeptide-dependent mechanisms.";
J. Immunol. 175:2598-2605(2005).
[8]
DISRUPTION PHENOTYPE.
PubMed=15879675; DOI=10.1254/jphs.scz050138;
Takizawa T., Tamiya M., Hara T., Matsumoto J., Saito N., Kanke T.,
Kawagoe J., Hattori Y.;
"Abrogation of bronchial eosinophilic inflammation and attenuated eotaxin
content in protease-activated receptor 2-deficient mice.";
J. Pharmacol. Sci. 98:99-102(2005).
[9]
INVOLVEMENT IN INFECTIOUS COLITIS, ACTIVATION BY GRANZYME A, AND DISRUPTION
PHENOTYPE.
PubMed=15919826; DOI=10.1073/pnas.0409535102;
Hansen K.K., Sherman P.M., Cellars L., Andrade-Gordon P., Pan Z.,
Baruch A., Wallace J.L., Hollenberg M.D., Vergnolle N.;
"A major role for proteolytic activity and proteinase-activated receptor-2
in the pathogenesis of infectious colitis.";
Proc. Natl. Acad. Sci. U.S.A. 102:8363-8368(2005).
[10]
DISRUPTION PHENOTYPE.
PubMed=16476770; DOI=10.1084/jem.20052148;
Noorbakhsh F., Tsutsui S., Vergnolle N., Boven L.A., Shariat N.,
Vodjgani M., Warren K.G., Andrade-Gordon P., Hollenberg M.D., Power C.;
"Proteinase-activated receptor 2 modulates neuroinflammation in
experimental autoimmune encephalomyelitis and multiple sclerosis.";
J. Exp. Med. 203:425-435(2006).
[11]
TRANSACTIVATION BY F2R.
PubMed=17965715; DOI=10.1038/ni1525;
Kaneider N.C., Leger A.J., Agarwal A., Nguyen N., Perides G., Derian C.,
Covic L., Kuliopulos A.;
"'Role reversal' for the receptor PAR1 in sepsis-induced vascular damage.";
Nat. Immunol. 8:1303-1312(2007).
[12]
DISRUPTION PHENOTYPE.
PubMed=20584806; DOI=10.1136/ard.2010.130336;
Ferrell W.R., Kelso E.B., Lockhart J.C., Plevin R., McInnes I.B.;
"Protease-activated receptor 2: a novel pathogenic pathway in a murine
model of osteoarthritis.";
Ann. Rheum. Dis. 69:2051-2054(2010).
[13]
FUNCTION.
PubMed=19845798; DOI=10.1111/j.1365-2567.2009.03144.x;
Ramelli G., Fuertes S., Narayan S., Busso N., Acha-Orbea H., So A.;
"Protease-activated receptor 2 signalling promotes dendritic cell antigen
transport and T-cell activation in vivo.";
Immunology 129:20-27(2010).
[14]
FUNCTION, AND INTERACTION WITH GNAQ; GNA11; GNA12; GNA13 AND GNA14.
PubMed=20215560; DOI=10.1124/mol.109.062018;
McCoy K.L., Traynelis S.F., Hepler J.R.;
"PAR1 and PAR2 couple to overlapping and distinct sets of G proteins and
linked signaling pathways to differentially regulate cell physiology.";
Mol. Pharmacol. 77:1005-1015(2010).
-!- FUNCTION: Receptor for trypsin and trypsin-like enzymes coupled to G
proteins. Its function is mediated through the activation of several
signaling pathways including phospholipase C (PLC), intracellular
calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-
kappaB and Rho. Can also be transactivated by cleaved F2r/Par1.
Involved in modulation of inflammatory responses and regulation of
innate and adaptive immunity, and acts as a sensor for proteolytic
enzymes generated during infection. Generally is promoting
inflammation. Can signal synergistically with Tlr4 and probably Tlr2 in
inflammatory responses and modulates Tlr3 signaling. Has a protective
role in establishing the endothelial barrier; the activity involves
coagulation factor X. Regulates endothelial cell barrier integrity
during neutrophil extravasation, probably following proteolytic
cleavage by PRTN3 (By similarity). Proposed to have a bronchoprotective
role in airway epithelium, but also shown to compromise the airway
epithelial barrier by interrupting E-cadherin adhesion. Involved in the
regulation of vascular tone; activation results in hypotension
presumably mediated by vasodilation. Associates with a subset of G
proteins alpha subunits such as GNAQ, GNA11, GNA14, GNA12 and GNA13,
but probably not with G(o) alpha, G(i) subunit alpha-1 and G(i) subunit
alpha-2. Believed to be a class B receptor which internalizes as a
complex with arrestin and traffic with it to endosomal vesicles,
presumably as desensitized receptor, for extended periods of time.
Mediates inhibition of TNF-alpha stimulated JNK phosphorylation via
coupling to GNAQ and GNA11; the function involves dissociation of Ripk1
and Tradd from Tnfr1. Mediates phosphorylation of nuclear factor NF-
kappa-B RELA subunit at 'Ser-536'; the function involves Ikbkb and is
predominantly independent of G proteins. Involved in cellular
migration. Involved in cytoskeletal rearrangement and chemotaxis
through beta-arrestin-promoted scaffolds; the function is independent
of GNAQ and GNA11 and involves promotion of cofilin dephosphorylation
and actin filament severing. Induces redistribution of Cops5 from the
plasma membrane to the cytosol and activation of the JNK cascade is
mediated by Cops5. Involved in the recruitment of leukocytes to the
sites of inflammation and is the major PAR receptor capable of
modulating eosinophil function such as proinflammatory cytokine
secretion, superoxide production and degranulation. During inflammation
promotes dendritic cell maturation, trafficking to the lymph nodes and
subsequent T-cell activation. Involved in antimicrobial response of
innate immune cells; activation enhances phagocytosis of Gram-positive
and killing of Gram-negative bacteria. Acts synergistically with
interferon-gamma in enhancing antiviral responses (By similarity).
{ECO:0000250|UniProtKB:P55085, ECO:0000269|PubMed:11086091,
ECO:0000269|PubMed:12821670, ECO:0000269|PubMed:19845798,
ECO:0000269|PubMed:20215560, ECO:0000269|PubMed:9918574}.
-!- SUBUNIT: Interacts with TLR4, COPS5 and TMED2 (By similarity).
Interacts with GNAQ, GNA11, GNA12, GNA13 and GNA14. {ECO:0000250,
ECO:0000269|PubMed:20215560}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
protein.
-!- PTM: A proteolytic cleavage generates a new N-terminus that functions
as a tethered ligand. Activating serine proteases include trypsin, mast
cell tryptase, coagulation factors VII and Xa, myeloblastin/PRTN3 and
membrane-type serine protease 1/ST14. Proposed subsequent cleavage by
serine proteases is leading to receptor deactivation and include
neutrophil elastase and cathepsin G. At least in part, implicated
proteases are also shown to activate the receptor; the glycosylation
status of the receptor is thought to contribute to the difference.
{ECO:0000250|UniProtKB:P55085}.
-!- PTM: N-glycosylated and sialylated. {ECO:0000250|UniProtKB:P55085}.
-!- PTM: Multiple phosphorylated on serine and threonine residues in the
cytoplasmic region upon receptor activation; required for receptor
desensitization and recruitment of beta-arrestin.
-!- PTM: Monoubiquitinated by Cbl at the plasma membrane and in early
endosomes; not required for receptor endocytosis but for translocation
to late endosomes or lysosomes. Deubiquitination involves Stambp and
Usp8; required for lysosomal trafficking and receptor degradation (By
similarity). {ECO:0000250}.
-!- DISRUPTION PHENOTYPE: Delayed onset of inflammation. Reduced
progression of osteoarthritis, infectious colitis, allergic dermatitis
and experimental autoimmune encephalomyelitis. Upon induced allergic
and toxic contact dermatitis ear swelling responses, plasma
extravasation and leuocyte adherence are significantly attenuated. Upon
ovalbumin (OA) sensitization and following challenge infiltration of
eosinophils and increase of eotaxin content in bronchoalveolar lavage
fluid are abrogated. {ECO:0000269|PubMed:11086091,
ECO:0000269|PubMed:11859856, ECO:0000269|PubMed:14519665,
ECO:0000269|PubMed:15879675, ECO:0000269|PubMed:15919826,
ECO:0000269|PubMed:16476770, ECO:0000269|PubMed:20584806}.
-!- MISCELLANEOUS: Synthetic PAR agonist peptides (APs) that mimic the
first six amino acids of the newly formed N-terminus activate the
native, uncleaved receptor nonenzymatically by binding directly to the
corresponding second extracellular loop to mediate signaling.
{ECO:0000250}.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
---------------------------------------------------------------------------
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EMBL; Z48043; CAA88097.1; -; mRNA.
CCDS; CCDS26700.1; -.
PIR; I48705; I48705.
RefSeq; NP_032000.3; NM_007974.4.
SMR; P55086; -.
STRING; 10090.ENSMUSP00000022185; -.
ChEMBL; CHEMBL3734647; -.
GlyGen; P55086; 2 sites.
iPTMnet; P55086; -.
PhosphoSitePlus; P55086; -.
PaxDb; P55086; -.
PeptideAtlas; P55086; -.
PRIDE; P55086; -.
ProteomicsDB; 294012; -.
Antibodypedia; 4569; 325 antibodies.
DNASU; 14063; -.
Ensembl; ENSMUST00000022185; ENSMUSP00000022185; ENSMUSG00000021678.
GeneID; 14063; -.
KEGG; mmu:14063; -.
UCSC; uc011zda.2; mouse.
CTD; 2150; -.
MGI; MGI:101910; F2rl1.
VEuPathDB; HostDB:ENSMUSG00000021678; -.
eggNOG; ENOG502QR8S; Eukaryota.
GeneTree; ENSGT00970000193405; -.
HOGENOM; CLU_009579_8_2_1; -.
InParanoid; P55086; -.
OMA; LAHDMFN; -.
OrthoDB; 892946at2759; -.
PhylomeDB; P55086; -.
TreeFam; TF330775; -.
Reactome; R-MMU-375276; Peptide ligand-binding receptors.
Reactome; R-MMU-416476; G alpha (q) signalling events.
BioGRID-ORCS; 14063; 1 hit in 61 CRISPR screens.
ChiTaRS; F2rl1; mouse.
PRO; PR:P55086; -.
Proteomes; UP000000589; Chromosome 13.
RNAct; P55086; protein.
Bgee; ENSMUSG00000021678; Expressed in skin of back and 166 other tissues.
Genevisible; P55086; MM.
GO; GO:0005769; C:early endosome; ISO:MGI.
GO; GO:0005887; C:integral component of plasma membrane; ISO:MGI.
GO; GO:0005886; C:plasma membrane; ISO:MGI.
GO; GO:0031143; C:pseudopodium; IDA:UniProtKB.
GO; GO:0004930; F:G protein-coupled receptor activity; IMP:UniProtKB.
GO; GO:0001965; F:G-protein alpha-subunit binding; IDA:UniProtKB.
GO; GO:0031681; F:G-protein beta-subunit binding; IDA:UniProtKB.
GO; GO:0032795; F:heterotrimeric G-protein binding; TAS:UniProtKB.
GO; GO:0015057; F:thrombin-activated receptor activity; IEA:InterPro.
GO; GO:0007596; P:blood coagulation; IEA:InterPro.
GO; GO:0045217; P:cell-cell junction maintenance; ISO:MGI.
GO; GO:0051607; P:defense response to virus; IDA:UniProtKB.
GO; GO:0061028; P:establishment of endothelial barrier; ISO:MGI.
GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISO:MGI.
GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
GO; GO:0050900; P:leukocyte migration; ISS:UniProtKB.
GO; GO:0070661; P:leukocyte proliferation; IDA:UniProtKB.
GO; GO:0097029; P:mature conventional dendritic cell differentiation; IDA:UniProtKB.
GO; GO:0032682; P:negative regulation of chemokine production; ISO:MGI.
GO; GO:0046329; P:negative regulation of JNK cascade; ISO:MGI.
GO; GO:0034140; P:negative regulation of toll-like receptor 3 signaling pathway; ISO:MGI.
GO; GO:0010804; P:negative regulation of tumor necrosis factor-mediated signaling pathway; ISO:MGI.
GO; GO:0042119; P:neutrophil activation; ISS:UniProtKB.
GO; GO:0030836; P:positive regulation of actin filament depolymerization; ISO:MGI.
GO; GO:0030335; P:positive regulation of cell migration; IDA:UniProtKB.
GO; GO:0032722; P:positive regulation of chemokine production; IDA:UniProtKB.
GO; GO:0050921; P:positive regulation of chemotaxis; IDA:UniProtKB.
GO; GO:0002720; P:positive regulation of cytokine production involved in immune response; ISS:UniProtKB.
GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IDA:UniProtKB.
GO; GO:0051482; P:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; IBA:GO_Central.
GO; GO:0043311; P:positive regulation of eosinophil degranulation; ISO:MGI.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:UniProtKB.
GO; GO:0003104; P:positive regulation of glomerular filtration; ISS:UniProtKB.
GO; GO:0043547; P:positive regulation of GTPase activity; ISO:MGI.
GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; ISS:UniProtKB.
GO; GO:0032729; P:positive regulation of interferon-gamma production; IDA:UniProtKB.
GO; GO:0032731; P:positive regulation of interleukin-1 beta production; ISS:UniProtKB.
GO; GO:0032733; P:positive regulation of interleukin-10 production; ISS:UniProtKB.
GO; GO:0032755; P:positive regulation of interleukin-6 production; ISS:UniProtKB.
GO; GO:0032757; P:positive regulation of interleukin-8 production; ISS:UniProtKB.
GO; GO:0046330; P:positive regulation of JNK cascade; ISO:MGI.
GO; GO:0002690; P:positive regulation of leukocyte chemotaxis; ISO:MGI.
GO; GO:0070963; P:positive regulation of neutrophil mediated killing of gram-negative bacterium; ISO:MGI.
GO; GO:0060100; P:positive regulation of phagocytosis, engulfment; ISO:MGI.
GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IDA:UniProtKB.
GO; GO:0050927; P:positive regulation of positive chemotaxis; ISO:MGI.
GO; GO:0031274; P:positive regulation of pseudopodium assembly; IDA:UniProtKB.
GO; GO:1900135; P:positive regulation of renin secretion into blood stream; IDA:UniProtKB.
GO; GO:0035025; P:positive regulation of Rho protein signal transduction; IDA:UniProtKB.
GO; GO:0032930; P:positive regulation of superoxide anion generation; ISS:UniProtKB.
GO; GO:0034137; P:positive regulation of toll-like receptor 2 signaling pathway; ISO:MGI.
GO; GO:0034141; P:positive regulation of toll-like receptor 3 signaling pathway; ISO:MGI.
GO; GO:0034145; P:positive regulation of toll-like receptor 4 signaling pathway; ISO:MGI.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
GO; GO:0030193; P:regulation of blood coagulation; ISO:MGI.
GO; GO:2000341; P:regulation of chemokine (C-X-C motif) ligand 2 production; ISS:UniProtKB.
GO; GO:0043122; P:regulation of I-kappaB kinase/NF-kappaB signaling; ISS:UniProtKB.
GO; GO:0046328; P:regulation of JNK cascade; ISS:UniProtKB.
GO; GO:0002286; P:T cell activation involved in immune response; IDA:UniProtKB.
GO; GO:0042311; P:vasodilation; IDA:GO_Central.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR002281; Pro_rcpt_2.
InterPro; IPR003912; Protea_act_rcpt.
Pfam; PF00001; 7tm_1; 1.
PRINTS; PR00237; GPCRRHODOPSN.
PRINTS; PR01428; PROTEASEAR.
PRINTS; PR01152; PROTEASEAR2.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
1: Evidence at protein level;
Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
Immunity; Inflammatory response; Innate immunity; Lipoprotein; Membrane;
Palmitate; Phosphoprotein; Receptor; Reference proteome; Signal;
Transducer; Transmembrane; Transmembrane helix; Ubl conjugation.
SIGNAL 1..25
/evidence="ECO:0000255"
PROPEP 26..38
/note="Removed for receptor activation"
/evidence="ECO:0000250"
/id="PRO_0000012752"
CHAIN 39..399
/note="Proteinase-activated receptor 2"
/id="PRO_0000012753"
TOPO_DOM 39..73
/note="Extracellular"
/evidence="ECO:0000250|UniProtKB:P55085"
TRANSMEM 74..103
/note="Helical; Name=1"
/evidence="ECO:0000250|UniProtKB:P55085"
TOPO_DOM 104..110
/note="Cytoplasmic"
/evidence="ECO:0000250|UniProtKB:P55085"
TRANSMEM 111..139
/note="Helical; Name=2"
/evidence="ECO:0000250|UniProtKB:P55085"
TOPO_DOM 140..151
/note="Extracellular"
/evidence="ECO:0000250|UniProtKB:P55085"
TRANSMEM 152..179
/note="Helical; Name=3"
/evidence="ECO:0000250|UniProtKB:P55085"
TOPO_DOM 180..185
/note="Cytoplasmic"
/evidence="ECO:0000250|UniProtKB:P55085"
TRANSMEM 186..213
/note="Helical; Name=4"
/evidence="ECO:0000250|UniProtKB:P55085"
TOPO_DOM 214..237
/note="Extracellular"
/evidence="ECO:0000250|UniProtKB:P55085"
TRANSMEM 238..271
/note="Helical; Name=5"
/evidence="ECO:0000250|UniProtKB:P55085"
TOPO_DOM 272..279
/note="Cytoplasmic"
/evidence="ECO:0000250|UniProtKB:P55085"
TRANSMEM 280..319
/note="Helical; Name=6"
/evidence="ECO:0000250|UniProtKB:P55085"
TOPO_DOM 320..325
/note="Extracellular"
/evidence="ECO:0000250|UniProtKB:P55085"
TRANSMEM 326..349
/note="Helical; Name=7"
/evidence="ECO:0000250|UniProtKB:P55085"
TOPO_DOM 350..399
/note="Cytoplasmic"
/evidence="ECO:0000250|UniProtKB:P55085"
SITE 38..39
/note="Cleavage; by trypsin"
/evidence="ECO:0000250"
LIPID 363
/note="S-palmitoyl cysteine"
/evidence="ECO:0000250"
CARBOHYD 33
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 224
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 150..228
/evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SEQUENCE 399 AA; 44752 MW; A93749425ED0B194 CRC64;
MRSLSLAWLL GGITLLAASV SCSRTENLAP GRNNSKGRSL IGRLETQPPI TGKGVPVEPG
FSIDEFSASI LTGKLTTVFL PVVYIIVFVI GLPSNGMALW IFLFRTKKKH PAVIYMANLA
LADLLSVIWF PLKISYHLHG NNWVYGEALC KVLIGFFYGN MYCSILFMTC LSVQRYWVIV
NPMGHPRKKA NIAVGVSLAI WLLIFLVTIP LYVMKQTIYI PALNITTCHD VLPEEVLVGD
MFNYFLSLAI GVFLFPALLT ASAYVLMIKT LRSSAMDEHS EKKRQRAIRL IITVLAMYFI
CFAPSNLLLV VHYFLIKTQR QSHVYALYLV ALCLSTLNSC IDPFVYYFVS KDFRDHARNA
LLCRSVRTVN RMQISLSSNK FSRKSGSYSS SSTSVKTSY


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18-461-10137 Proteinase-activated receptor 4 - PAR-4; Thrombin receptor-like 3; Coagulation factor II receptor-like 3 Polyclonal 0.05 ml
18-461-10291 Proteinase-activated receptor 3 - PAR-3; Thrombin receptor-like 2; Coagulation factor II receptor-like 2 Polyclonal 0.05 ml
18-461-10356 Proteinase-activated receptor 4 - PAR-4; Thrombin receptor-like 3; Coagulation factor II receptor-like 3 Polyclonal 0.05 ml
18-461-10355 Proteinase-activated receptor 4 - PAR-4; Thrombin receptor-like 3; Coagulation factor II receptor-like 3 Polyclonal 0.05 ml
EIAAB29884 Coagulation factor II receptor-like 2,F2RL2,Homo sapiens,Human,PAR3,PAR-3,Proteinase-activated receptor 3,Thrombin receptor-like 2
EIAAB29888 Coagulation factor II receptor-like 3,F2RL3,Homo sapiens,Human,PAR4,PAR-4,Proteinase-activated receptor 4,Thrombin receptor-like 3
U0826h CLIA CF2R,Coagulation factor II receptor,F2R,Homo sapiens,Human,PAR1,PAR-1,Proteinase-activated receptor 1,Thrombin receptor,TR 96T
E0826h ELISA kit CF2R,Coagulation factor II receptor,F2R,Homo sapiens,Human,PAR1,PAR-1,Proteinase-activated receptor 1,Thrombin receptor,TR 96T
E0826h ELISA CF2R,Coagulation factor II receptor,F2R,Homo sapiens,Human,PAR1,PAR-1,Proteinase-activated receptor 1,Thrombin receptor,TR 96T
H-8325.0025 TRAP_6 (2_6) Salt Trifluoroacetate Binding _ Synonym FLLRN, Coagulation Factor II Receptor (2_6) (human), PAR_1 (2_6) (human), Proteinase Activated Receptor 1 (2_6) (human), Thrombin Receptor (2_6) 25.0 mg
H-8325.0025 TRAP_6 (2_6) Salt Trifluoroacetate Binding _ Synonym FLLRN, Coagulation Factor II Receptor (2_6) (human), PAR_1 (2_6) (human), Proteinase Activated Receptor 1 (2_6) (human), Thrombin Receptor (2_6) 25.0 mg
H-8325.0005 TRAP_6 (2_6) Salt Trifluoroacetate Binding _ Synonym FLLRN, Coagulation Factor II Receptor (2_6) (human), PAR_1 (2_6) (human), Proteinase Activated Receptor 1 (2_6) (human), Thrombin Receptor (2_6) 5.0 mg
Pathways :
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP2328: Allograft rejection
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP94: Signaling of Hepatocyte Growth Factor Receptor
WP2292: Chemokine signaling pathway
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP810: Signaling of Hepatocyte Growth Factor Receptor
WP2272: Pathogenic Escherichia coli infection
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP1965: VEGF-receptor Signal Transduction
WP362: TGF-beta Receptor Signaling Pathway
WP886: Kit Receptor Signaling Pathway
WP1004: Kit Receptor Signaling Pathway
WP138: Androgen receptor signaling pathway
WP732: Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
WP1025: B Cell Receptor Signaling Pathway
WP1449: Regulation of toll-like receptor signaling pathway
WP1781: Advanced glycosylation endproduct receptor signaling
WP2355: Corticotropin-releasing hormone
WP75: Toll-like receptor signaling pathway
WP2079: Serotonin Receptor 2 and STAT3 Signaling

Related Genes :
[F2RL1 GPR11 PAR2] Proteinase-activated receptor 2 (PAR-2) (Coagulation factor II receptor-like 1) (G-protein coupled receptor 11) (Thrombin receptor-like 1) [Cleaved into: Proteinase-activated receptor 2, alternate cleaved 1; Proteinase-activated receptor 2, alternate cleaved 2]
[F2rl1 Gpcr11 Gpr11 Par2] Proteinase-activated receptor 2 (PAR-2) (Coagulation factor II receptor-like 1) (G-protein coupled receptor 11) (Thrombin receptor-like 1)
[F2rl1 Par2] Proteinase-activated receptor 2 (PAR-2) (Coagulation factor II receptor-like 1) (Thrombin receptor-like 1)
[F2RL1 PAR2] Proteinase-activated receptor 2 (PAR-2) (Coagulation factor II receptor-like 1) (Thrombin receptor-like 1)
[F2RL3 PAR4] Proteinase-activated receptor 4 (PAR-4) (Coagulation factor II receptor-like 3) (Thrombin receptor-like 3)
[F2rl3 Par4] Proteinase-activated receptor 4 (PAR-4) (Coagulation factor II receptor-like 3) (Thrombin receptor-like 3)
[F2rl3 Par4] Proteinase-activated receptor 4 (PAR-4) (Coagulation factor II receptor-like 3) (Thrombin receptor-like 3)
[F2] Prothrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain]
[Rack1 Gnb2-rs1 Gnb2l1] Receptor of activated protein C kinase 1 (12-3) (Guanine nucleotide-binding protein subunit beta-2-like 1) (Receptor for activated C kinase) (Receptor of activated protein kinase C 1) (p205) [Cleaved into: Receptor of activated protein C kinase 1, N-terminally processed (Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed)]
[OR51E2 PSGR] Olfactory receptor 51E2 (HPRAJ) (Olfactory receptor OR11-16) (Prostate-specific G-protein coupled receptor)
[GPER1 CEPR CMKRL2 DRY12 GPER GPR30] G-protein coupled estrogen receptor 1 (Chemoattractant receptor-like 2) (Flow-induced endothelial G-protein coupled receptor 1) (FEG-1) (G protein-coupled estrogen receptor 1) (G-protein coupled receptor 30) (GPCR-Br) (IL8-related receptor DRY12) (Lymphocyte-derived G-protein coupled receptor) (LYGPR) (Membrane estrogen receptor) (mER)
[Med1 Crsp210 Drip205 Pbp Pparbp Trap220 Trip2] Mediator of RNA polymerase II transcription subunit 1 (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2)
[AHK4 CRE1 RAW1 WOL At2g01830 T23K3.2] Histidine kinase 4 (EC 2.7.13.3) (Arabidopsis histidine kinase 4) (AtHK4) (Cytokinin receptor CYTOKININ RESPONSE 1) (AtCRE1) (Cytokinin receptor CRE1) (Phosphoprotein phosphatase AHK4) (EC 3.1.3.16) (Protein AUTHENTIC HIS-KINASE 4) (Protein ROOT AS IN WOL 1) (Protein WOODEN LEG)
[grk-2 W02B3.2] G protein-coupled receptor kinase 2 (EC 2.7.11.16)
[Gper1 Cmkrl2 Gper Gpr30 Gpr41] G-protein coupled estrogen receptor 1 (Chemoattractant receptor-like 2) (G protein-coupled estrogen receptor 1) (G-protein coupled receptor 30) (G-protein coupled receptor 41) (Membrane estrogen receptor) (mER)
[PROKR2 GPR73L1 PKR2] Prokineticin receptor 2 (PK-R2) (G-protein coupled receptor 73-like 1) (G-protein coupled receptor I5E) (GPR73b) (GPRg2)
[Met] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[TGFBR1 ALK5 SKR4] TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
[Gper1 Cmkrl2 Gper Gpr30] G-protein coupled estrogen receptor 1 (Chemoattractant receptor-like 2) (G protein-coupled estrogen receptor 1) (G-protein coupled receptor 30) (Membrane estrogen receptor) (mER)
[ADGRA2 GPR124 KIAA1531 TEM5] Adhesion G protein-coupled receptor A2 (G-protein coupled receptor 124) (Tumor endothelial marker 5)
[Adgra2 Gpr124 Tem5] Adhesion G protein-coupled receptor A2 (G-protein coupled receptor 124) (Tumor endothelial marker 5)
[NMUR2 NMU2R TGR1] Neuromedin-U receptor 2 (NMU-R2) (G-protein coupled receptor FM-4) (G-protein coupled receptor TGR-1)
[RACK1 GNB2L1 HLC7 PIG21] Receptor of activated protein C kinase 1 (Cell proliferation-inducing gene 21 protein) (Guanine nucleotide-binding protein subunit beta-2-like 1) (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Human lung cancer oncogene 7 protein) (HLC-7) (Receptor for activated C kinase) (Small ribosomal subunit protein RACK1) [Cleaved into: Receptor of activated protein C kinase 1, N-terminally processed (Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed)]
[Rack1 Gnb2l1] Receptor of activated protein C kinase 1 (Guanine nucleotide-binding protein subunit beta-2-like 1) (Receptor for activated C kinase) (Receptor of activated protein kinase C 1) [Cleaved into: Receptor of activated protein C kinase 1, N-terminally processed]
[GRK5 GPRK5] G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5)
[Grk5 Gprk5] G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5)
[PDGFRA PDGFR2 RHEPDGFRA] Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a)
[CCR7 CMKBR7 EBI1 EVI1] C-C chemokine receptor type 7 (C-C CKR-7) (CC-CKR-7) (CCR-7) (BLR2) (CDw197) (Epstein-Barr virus-induced G-protein coupled receptor 1) (EBI1) (EBV-induced G-protein coupled receptor 1) (MIP-3 beta receptor) (CD antigen CD197)
[ERECTA ER QRP1 QRS1 TE1 At2g26330 T1D16.3] LRR receptor-like serine/threonine-protein kinase ERECTA (EC 2.7.11.1) (Protein QUANTITATIVE RESISTANCE TO PLECTOSPHAERELLA 1) (Protein QUANTITATIVE RESISTANCE TO RALSTONIA SOLANACEARUM 1) (Protein TRANSPIRATION EFFICIENCY 1)
[GRK6 GPRK6] G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6)

Bibliography :