GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

Proteinase-activated receptor 3 (PAR-3) (Coagulation factor II receptor-like 2) (Thrombin receptor-like 2)

 PAR3_HUMAN              Reviewed;         374 AA.
O00254; B2R754; B4DQ13; Q52M68; Q7Z3W3;
15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
01-JUL-1997, sequence version 1.
29-SEP-2021, entry version 185.
RecName: Full=Proteinase-activated receptor 3;
Short=PAR-3;
AltName: Full=Coagulation factor II receptor-like 2;
AltName: Full=Thrombin receptor-like 2;
Flags: Precursor;
Name=F2RL2; Synonyms=PAR3;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND MUTAGENESIS OF THR-39 AND
PHE-40.
PubMed=9087410; DOI=10.1038/386502a0;
Ishihara H., Connolly A.J., Zeng D., Kahn M.L., Zheng Y.-W., Timmons C.,
Tram T., Coughlin S.R.;
"Protease-activated receptor 3 is a second thrombin receptor in humans.";
Nature 386:502-506(1997).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
TISSUE=Thymus;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Retina;
PubMed=17974005; DOI=10.1186/1471-2164-8-399;
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
Wiemann S., Schupp I.;
"The full-ORF clone resource of the German cDNA consortium.";
BMC Genomics 8:399-399(2007).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS SER-15; VAL-177 AND
ASP-250.
SeattleSNPs variation discovery resource;
Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15372022; DOI=10.1038/nature02919;
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
"The DNA sequence and comparative analysis of human chromosome 5.";
Nature 431:268-274(2004).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
Hunkapiller M.W., Myers E.W., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[8]
TISSUE SPECIFICITY.
PubMed=9614115; DOI=10.1074/jbc.273.24.15061;
Schmidt V.A., Nierman W.C., Maglott D.R., Cupit L.D., Moskowitz K.A.,
Wainer J.A., Bahou W.F.;
"The human proteinase-activated receptor-3 (PAR-3) gene. Identification
within a PAR gene cluster and characterization in vascular endothelial
cells and platelets.";
J. Biol. Chem. 273:15061-15068(1998).
[9]
FUNCTION.
PubMed=10079109; DOI=10.1172/jci6042;
Kahn M.L., Nakanishi-Matsui M., Shapiro M.J., Ishihara H., Coughlin S.R.;
"Protease-activated receptors 1 and 4 mediate activation of human platelets
by thrombin.";
J. Clin. Invest. 103:879-887(1999).
[10]
INTERACTION WITH INSC.
PubMed=16458856; DOI=10.1016/j.bbrc.2006.01.050;
Izaki T., Kamakura S., Kohjima M., Sumimoto H.;
"Two forms of human Inscuteable-related protein that links Par3 to the Pins
homologues LGN and AGS3.";
Biochem. Biophys. Res. Commun. 341:1001-1006(2006).
-!- FUNCTION: Receptor for activated thrombin coupled to G proteins that
stimulate phosphoinositide hydrolysis. {ECO:0000269|PubMed:10079109}.
-!- SUBUNIT: Interacts with INSC/inscuteable and probably GPSM2.
{ECO:0000269|PubMed:16458856}.
-!- INTERACTION:
O00254; P16333: NCK1; NbExp=2; IntAct=EBI-1751853, EBI-389883;
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=O00254-1; Sequence=Displayed;
Name=2;
IsoId=O00254-2; Sequence=VSP_045116;
-!- TISSUE SPECIFICITY: Highest expression in the megakaryocytes of the
bone marrow, lower in mature megakaryocytes, in platelets and in a
variety of other tissues such as heart and gut.
{ECO:0000269|PubMed:9614115}.
-!- PTM: A proteolytic cleavage generates a new N-terminus that functions
as a tethered ligand.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
-!- SEQUENCE CAUTION:
Sequence=CAD97628.1; Type=Frameshift; Evidence={ECO:0000305};
-!- WEB RESOURCE: Name=SeattleSNPs;
URL="http://pga.gs.washington.edu/data/f2rl2/";
---------------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
---------------------------------------------------------------------------
EMBL; U92971; AAC51218.1; -; mRNA.
EMBL; AK312848; BAG35701.1; -; mRNA.
EMBL; AK298585; BAG60775.1; -; mRNA.
EMBL; BX537386; CAD97628.1; ALT_FRAME; mRNA.
EMBL; AF374726; AAK51564.1; -; Genomic_DNA.
EMBL; AC026725; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH471084; EAW95778.1; -; Genomic_DNA.
EMBL; BC093648; AAH93648.1; -; mRNA.
EMBL; BC093650; AAH93650.1; -; mRNA.
CCDS; CCDS4031.1; -. [O00254-1]
CCDS; CCDS58959.1; -. [O00254-2]
RefSeq; NP_001243495.1; NM_001256566.1. [O00254-2]
RefSeq; NP_004092.1; NM_004101.3. [O00254-1]
SMR; O00254; -.
DIP; DIP-44337N; -.
IntAct; O00254; 10.
MINT; O00254; -.
STRING; 9606.ENSP00000296641; -.
ChEMBL; CHEMBL5477; -.
GlyGen; O00254; 3 sites.
iPTMnet; O00254; -.
PhosphoSitePlus; O00254; -.
BioMuta; F2RL2; -.
PaxDb; O00254; -.
PeptideAtlas; O00254; -.
PRIDE; O00254; -.
ProteomicsDB; 47807; -. [O00254-1]
ProteomicsDB; 4833; -.
Antibodypedia; 12465; 182 antibodies.
DNASU; 2151; -.
Ensembl; ENST00000296641; ENSP00000296641; ENSG00000164220. [O00254-1]
Ensembl; ENST00000504899; ENSP00000426703; ENSG00000164220. [O00254-2]
GeneID; 2151; -.
KEGG; hsa:2151; -.
UCSC; uc003kem.4; human. [O00254-1]
CTD; 2151; -.
DisGeNET; 2151; -.
GeneCards; F2RL2; -.
HGNC; HGNC:3539; F2RL2.
HPA; ENSG00000164220; Tissue enhanced (retina).
MIM; 601919; gene.
neXtProt; NX_O00254; -.
OpenTargets; ENSG00000164220; -.
PharmGKB; PA27948; -.
VEuPathDB; HostDB:ENSG00000164220; -.
eggNOG; ENOG502QWI1; Eukaryota.
GeneTree; ENSGT00970000193405; -.
HOGENOM; CLU_009579_8_2_1; -.
InParanoid; O00254; -.
OMA; MTIFYTN; -.
OrthoDB; 892946at2759; -.
PhylomeDB; O00254; -.
TreeFam; TF330775; -.
PathwayCommons; O00254; -.
Reactome; R-HSA-375276; Peptide ligand-binding receptors.
Reactome; R-HSA-416476; G alpha (q) signalling events.
Reactome; R-HSA-456926; Thrombin signalling through proteinase activated receptors (PARs).
SIGNOR; O00254; -.
BioGRID-ORCS; 2151; 5 hits in 1002 CRISPR screens.
GeneWiki; F2RL2; -.
GenomeRNAi; 2151; -.
Pharos; O00254; Tbio.
PRO; PR:O00254; -.
Proteomes; UP000005640; Chromosome 5.
RNAct; O00254; protein.
Bgee; ENSG00000164220; Expressed in pigmented layer of retina and 113 other tissues.
Genevisible; O00254; HS.
GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
GO; GO:0005576; C:extracellular region; TAS:Reactome.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0032991; C:protein-containing complex; IDA:UniProtKB.
GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
GO; GO:0004435; F:phosphatidylinositol phospholipase C activity; TAS:ProtInc.
GO; GO:0015057; F:thrombin-activated receptor activity; TAS:ProtInc.
GO; GO:0007596; P:blood coagulation; TAS:ProtInc.
GO; GO:0030168; P:platelet activation; TAS:Reactome.
GO; GO:0051482; P:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; IBA:GO_Central.
GO; GO:0035025; P:positive regulation of Rho protein signal transduction; IBA:GO_Central.
GO; GO:0009611; P:response to wounding; TAS:ProtInc.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR003943; Prot_act_rcpt_3.
InterPro; IPR003912; Protea_act_rcpt.
Pfam; PF00001; 7tm_1; 1.
PRINTS; PR00237; GPCRRHODOPSN.
PRINTS; PR01428; PROTEASEAR.
PRINTS; PR01429; PROTEASEAR3.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
1: Evidence at protein level;
Alternative splicing; Blood coagulation; Cell membrane; Disulfide bond;
G-protein coupled receptor; Glycoprotein; Hemostasis; Membrane; Receptor;
Reference proteome; Signal; Transducer; Transmembrane; Transmembrane helix.
SIGNAL 1..21
/evidence="ECO:0000255"
PROPEP 22..38
/note="Removed for receptor activation"
/evidence="ECO:0000250"
/id="PRO_0000012756"
CHAIN 39..374
/note="Proteinase-activated receptor 3"
/id="PRO_0000012757"
TOPO_DOM 39..94
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 95..120
/note="Helical; Name=1"
/evidence="ECO:0000255"
TOPO_DOM 121..128
/note="Cytoplasmic"
/evidence="ECO:0000255"
TRANSMEM 129..148
/note="Helical; Name=2"
/evidence="ECO:0000255"
TOPO_DOM 149..167
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 168..189
/note="Helical; Name=3"
/evidence="ECO:0000255"
TOPO_DOM 190..206
/note="Cytoplasmic"
/evidence="ECO:0000255"
TRANSMEM 207..230
/note="Helical; Name=4"
/evidence="ECO:0000255"
TOPO_DOM 231..260
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 261..280
/note="Helical; Name=5"
/evidence="ECO:0000255"
TOPO_DOM 281..297
/note="Cytoplasmic"
/evidence="ECO:0000255"
TRANSMEM 298..322
/note="Helical; Name=6"
/evidence="ECO:0000255"
TOPO_DOM 323..336
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 337..361
/note="Helical; Name=7"
/evidence="ECO:0000255"
TOPO_DOM 362..374
/note="Cytoplasmic"
/evidence="ECO:0000255"
SITE 38..39
/note="Cleavage; by thrombin"
/evidence="ECO:0000250"
CARBOHYD 25
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 82
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 331
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 166..245
/evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
VAR_SEQ 1..22
/note="Missing (in isoform 2)"
/evidence="ECO:0000303|PubMed:14702039"
/id="VSP_045116"
VARIANT 15
/note="L -> S (in dbSNP:rs2069649)"
/evidence="ECO:0000269|Ref.4"
/id="VAR_012849"
VARIANT 177
/note="M -> V (in dbSNP:rs2069700)"
/evidence="ECO:0000269|Ref.4"
/id="VAR_012850"
VARIANT 250
/note="N -> D (in dbSNP:rs2069683)"
/evidence="ECO:0000269|Ref.4"
/id="VAR_012851"
MUTAGEN 39
/note="T->P: No proteolytic cleavage by thrombin."
/evidence="ECO:0000269|PubMed:9087410"
MUTAGEN 40
/note="F->A: Altered signal upon thrombin cleavage."
/evidence="ECO:0000269|PubMed:9087410"
SEQUENCE 374 AA; 42508 MW; C45C15A695DD1ABB CRC64;
MKALIFAAAG LLLLLPTFCQ SGMENDTNNL AKPTLPIKTF RGAPPNSFEE FPFSALEGWT
GATITVKIKC PEESASHLHV KNATMGYLTS SLSTKLIPAI YLLVFVVGVP ANAVTLWMLF
FRTRSICTTV FYTNLAIADF LFCVTLPFKI AYHLNGNNWV FGEVLCRATT VIFYGNMYCS
ILLLACISIN RYLAIVHPFT YRGLPKHTYA LVTCGLVWAT VFLYMLPFFI LKQEYYLVQP
DITTCHDVHN TCESSSPFQL YYFISLAFFG FLIPFVLIIY CYAAIIRTLN AYDHRWLWYV
KASLLILVIF TICFAPSNII LIIHHANYYY NNTDGLYFIY LIALCLGSLN SCLDPFLYFL
MSKTRNHSTA YLTK


Related products :

Catalog number Product name Quantity
18-461-10067 Proteinase-activated receptor 2 - PAR-2; Thrombin receptor-like 1; Coagulation factor II receptor-like 1; G-protein coupled receptor 11 Polyclonal 0.05 ml
18-461-10068 Proteinase-activated receptor 2 - PAR-2; Thrombin receptor-like 1; Coagulation factor II receptor-like 1; G-protein coupled receptor 11 Polyclonal 0.05 ml
EIAAB29881 Coagulation factor II receptor-like 1,F2RL1,GPR11,G-protein coupled receptor 11,Homo sapiens,Human,PAR2,PAR-2,Proteinase-activated receptor 2,Thrombin receptor-like 1
EIAAB29879 Coagulation factor II receptor-like 1,F2rl1,Gpcr11,Gpr11,G-protein coupled receptor 11,Mouse,Mus musculus,Par2,PAR-2,Proteinase-activated receptor 2,Thrombin receptor-like 1
EIAAB29885 Bos taurus,Bovine,Coagulation factor II receptor-like 2,F2RL2,PAR3,PAR-3,Proteinase-activated receptor 3,Thrombin receptor-like 2
EIAAB29878 Coagulation factor II receptor-like 1,F2rl1,Par2,PAR-2,Proteinase-activated receptor 2,Rat,Rattus norvegicus,Thrombin receptor-like 1
EIAAB29889 Coagulation factor II receptor-like 3,F2rl3,Mouse,Mus musculus,Par4,PAR-4,Proteinase-activated receptor 4,Thrombin receptor-like 3
EIAAB29880 Bos taurus,Bovine,Coagulation factor II receptor-like 1,F2RL1,PAR2,PAR-2,Proteinase-activated receptor 2,Thrombin receptor-like 1
EIAAB29890 Coagulation factor II receptor-like 3,F2rl3,Par4,PAR-4,Proteinase-activated receptor 4,Rat,Rattus norvegicus,Thrombin receptor-like 3
EIAAB29882 Coagulation factor II receptor-like 2,F2rl2,Mouse,Mus musculus,Par3,PAR-3,Proteinase-activated receptor 3,Thrombin receptor-like 2
EIAAB29883 Coagulation factor II receptor-like 2,F2rl2,Par3,PAR-3,Proteinase-activated receptor 3,Rat,Rattus norvegicus,Thrombin receptor-like 2
18-461-10137 Proteinase-activated receptor 4 - PAR-4; Thrombin receptor-like 3; Coagulation factor II receptor-like 3 Polyclonal 0.05 ml
18-461-10170 Proteinase-activated receptor 1 - PAR-1; Thrombin receptor; Coagulation factor II receptor Polyclonal 0.05 ml
18-461-10291 Proteinase-activated receptor 3 - PAR-3; Thrombin receptor-like 2; Coagulation factor II receptor-like 2 Polyclonal 0.05 ml
18-461-10138 Proteinase-activated receptor 4 - PAR-4; Thrombin receptor-like 3; Coagulation factor II receptor-like 3 Polyclonal 0.05 ml
18-461-10356 Proteinase-activated receptor 4 - PAR-4; Thrombin receptor-like 3; Coagulation factor II receptor-like 3 Polyclonal 0.05 ml
18-461-10355 Proteinase-activated receptor 4 - PAR-4; Thrombin receptor-like 3; Coagulation factor II receptor-like 3 Polyclonal 0.05 ml
EIAAB29884 Coagulation factor II receptor-like 2,F2RL2,Homo sapiens,Human,PAR3,PAR-3,Proteinase-activated receptor 3,Thrombin receptor-like 2
EIAAB29888 Coagulation factor II receptor-like 3,F2RL3,Homo sapiens,Human,PAR4,PAR-4,Proteinase-activated receptor 4,Thrombin receptor-like 3
E0826h ELISA kit CF2R,Coagulation factor II receptor,F2R,Homo sapiens,Human,PAR1,PAR-1,Proteinase-activated receptor 1,Thrombin receptor,TR 96T
E0826h ELISA CF2R,Coagulation factor II receptor,F2R,Homo sapiens,Human,PAR1,PAR-1,Proteinase-activated receptor 1,Thrombin receptor,TR 96T
U0826h CLIA CF2R,Coagulation factor II receptor,F2R,Homo sapiens,Human,PAR1,PAR-1,Proteinase-activated receptor 1,Thrombin receptor,TR 96T
H-8325.0025 TRAP_6 (2_6) Salt Trifluoroacetate Binding _ Synonym FLLRN, Coagulation Factor II Receptor (2_6) (human), PAR_1 (2_6) (human), Proteinase Activated Receptor 1 (2_6) (human), Thrombin Receptor (2_6) 25.0 mg
H-8325.0025 TRAP_6 (2_6) Salt Trifluoroacetate Binding _ Synonym FLLRN, Coagulation Factor II Receptor (2_6) (human), PAR_1 (2_6) (human), Proteinase Activated Receptor 1 (2_6) (human), Thrombin Receptor (2_6) 25.0 mg
H-8325.0005 TRAP_6 (2_6) Salt Trifluoroacetate Binding _ Synonym FLLRN, Coagulation Factor II Receptor (2_6) (human), PAR_1 (2_6) (human), Proteinase Activated Receptor 1 (2_6) (human), Thrombin Receptor (2_6) 5.0 mg
Pathways :
WP94: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP2328: Allograft rejection
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP810: Signaling of Hepatocyte Growth Factor Receptor
WP2197: Endothelin
WP75: Toll-like receptor signaling pathway
WP1004: Kit Receptor Signaling Pathway
WP147: Kit Receptor Signaling Pathway
WP362: TGF-beta Receptor Signaling Pathway
WP926: TGF-beta Receptor Signaling Pathway
WP1183: Toll-like receptor signaling pathway
WP1249: EPO Receptor Signaling
WP2292: Chemokine signaling pathway
WP780: T Cell Receptor Signaling Pathway
WP1025: B Cell Receptor Signaling Pathway
WP1869: Neuroransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
WP809: TGF-beta Receptor Signaling Pathway
WP1918: Signaling by Robo receptor

Related Genes :
[F2RL1 GPR11 PAR2] Proteinase-activated receptor 2 (PAR-2) (Coagulation factor II receptor-like 1) (G-protein coupled receptor 11) (Thrombin receptor-like 1) [Cleaved into: Proteinase-activated receptor 2, alternate cleaved 1; Proteinase-activated receptor 2, alternate cleaved 2]
[F2RL3 PAR4] Proteinase-activated receptor 4 (PAR-4) (Coagulation factor II receptor-like 3) (Thrombin receptor-like 3)
[F2rl1 Gpcr11 Gpr11 Par2] Proteinase-activated receptor 2 (PAR-2) (Coagulation factor II receptor-like 1) (G-protein coupled receptor 11) (Thrombin receptor-like 1)
[F2rl1 Par2] Proteinase-activated receptor 2 (PAR-2) (Coagulation factor II receptor-like 1) (Thrombin receptor-like 1)
[F2RL1 PAR2] Proteinase-activated receptor 2 (PAR-2) (Coagulation factor II receptor-like 1) (Thrombin receptor-like 1)
[F2rl3 Par4] Proteinase-activated receptor 4 (PAR-4) (Coagulation factor II receptor-like 3) (Thrombin receptor-like 3)
[F2rl3 Par4] Proteinase-activated receptor 4 (PAR-4) (Coagulation factor II receptor-like 3) (Thrombin receptor-like 3)
[F2] Prothrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain]
[Rack1 Gnb2-rs1 Gnb2l1] Receptor of activated protein C kinase 1 (12-3) (Guanine nucleotide-binding protein subunit beta-2-like 1) (Receptor for activated C kinase) (Receptor of activated protein kinase C 1) (p205) [Cleaved into: Receptor of activated protein C kinase 1, N-terminally processed (Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed)]
[AHK4 CRE1 RAW1 WOL At2g01830 T23K3.2] Histidine kinase 4 (EC 2.7.13.3) (Arabidopsis histidine kinase 4) (AtHK4) (Cytokinin receptor CYTOKININ RESPONSE 1) (AtCRE1) (Cytokinin receptor CRE1) (Phosphoprotein phosphatase AHK4) (EC 3.1.3.16) (Protein AUTHENTIC HIS-KINASE 4) (Protein ROOT AS IN WOL 1) (Protein WOODEN LEG)
[Med1 Crsp210 Drip205 Pbp Pparbp Trap220 Trip2] Mediator of RNA polymerase II transcription subunit 1 (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2)
[Traf2] TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2)
[Met] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[egl-15 F58A3.2] Myoblast growth factor receptor egl-15 (EC 2.7.10.1) (Egg-laying defective protein 15)
[RACK1 GNB2L1 HLC7 PIG21] Receptor of activated protein C kinase 1 (Cell proliferation-inducing gene 21 protein) (Guanine nucleotide-binding protein subunit beta-2-like 1) (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Human lung cancer oncogene 7 protein) (HLC-7) (Receptor for activated C kinase) (Small ribosomal subunit protein RACK1) [Cleaved into: Receptor of activated protein C kinase 1, N-terminally processed (Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed)]
[PDGFRA PDGFR2 RHEPDGFRA] Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a)
[Havcr2 Tim3 Timd3] Hepatitis A virus cellular receptor 2 homolog (HAVcr-2) (T-cell immunoglobulin and mucin domain-containing protein 3) (TIMD-3) (T-cell immunoglobulin mucin receptor 3) (TIM-3) (T-cell membrane protein 3) (CD antigen CD366)
[ORF1ab orf1ab] 2'-O-methyltransferase (EC 2.7.7.48) (EC 3.4.19.12) (EC 3.4.22.69) (EC 3.6.4.12) (EC 3.6.4.13) (3C-like proteinase) (Growth factor-like peptide) (Guanine-N7 methyltransferase) (Helicase) (Host translation inhibitor nsp1) (Leader protein) (NendoU) (Non-structural protein 10) (Non-structural protein 2) (Non-structural protein 3) (Non-structural protein 4) (Non-structural protein 6) (Non-structural protein 7) (Non-structural protein 8) (Non-structural protein 9) (ORF1ab polyprotein) (Papain-like proteinase) (RNA-directed RNA polymerase) (Replicase polyprotein 1ab) (Uridylate-specific endoribonuclease) (p65 homolog)
[ORF1ab orf1ab] 2'-O-methyltransferase (EC 2.7.7.48) (EC 3.4.19.12) (EC 3.4.22.69) (EC 3.6.4.12) (EC 3.6.4.13) (3C-like proteinase) (Growth factor-like peptide) (Guanine-N7 methyltransferase) (Helicase) (Host translation inhibitor nsp1) (Leader protein) (NendoU) (Non-structural protein 10) (Non-structural protein 2) (Non-structural protein 3) (Non-structural protein 4) (Non-structural protein 6) (Non-structural protein 7) (Non-structural protein 8) (Non-structural protein 9) (ORF1ab polyprotein) (Papain-like proteinase) (RNA-directed RNA polymerase) (Replicase polyprotein 1ab) (Uridylate-specific endoribonuclease) (p65 homolog)
[odr-7 T18D3.2] Nuclear hormone receptor family member odr-7 (Odorant response abnormal protein 7)
[ORF1ab orf1ab] 2'-O-methyltransferase (EC 2.7.7.48) (EC 3.4.19.12) (EC 3.4.22.69) (EC 3.6.4.12) (EC 3.6.4.13) (3C-like proteinase) (Growth factor-like peptide) (Guanine-N7 methyltransferase) (Helicase) (Host translation inhibitor nsp1) (Leader protein) (NendoU) (Non-structural protein 10) (Non-structural protein 2) (Non-structural protein 3) (Non-structural protein 4) (Non-structural protein 6) (Non-structural protein 7) (Non-structural protein 8) (Non-structural protein 9) (ORF1ab polyprotein) (Papain-like proteinase) (RNA-directed RNA polymerase) (Replicase polyprotein 1ab) (Uridylate-specific endoribonuclease) (p65 homolog)
[Ripk3 Rip3] Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3)
[Tas1r3 Sac T1r3 Tr3] Taste receptor type 1 member 3 (Saccharin preference protein) (Sweet taste receptor T1R3)
[F5] Coagulation factor V (Activated protein C cofactor) (Proaccelerin, labile factor) [Cleaved into: Coagulation factor V heavy chain; Coagulation factor V light chain]
[PIAS2 PIASX] E3 SUMO-protein ligase PIAS2 (EC 2.3.2.-) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (E3 SUMO-protein transferase PIAS2) (Msx-interacting zinc finger protein) (Miz1) (PIAS-NY protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2)
[Ncoa6 Aib3 Rap250 Trbp] Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein) (Fragment)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[Pias2 Miz1 Piasx] E3 SUMO-protein ligase PIAS2 (EC 2.3.2.-) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (E3 SUMO-protein transferase PIAS2) (Msx-interacting-zinc finger protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2)
[Pdgfra] Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (Platelet-derived growth factor alpha receptor) (CD antigen CD140a)
[Ncoa6 Aib3 Prip Rap250 Trbp] Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Thyroid hormone receptor-binding protein)

Bibliography :