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Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha (TGF-alpha) (EGF-like TGF) (ETGF) (TGF type 1)]

 TGFA_RAT                Reviewed;         159 AA.
P01134; Q63749;
21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
15-JUL-1998, sequence version 2.
13-FEB-2019, entry version 150.
RecName: Full=Protransforming growth factor alpha;
Contains:
RecName: Full=Transforming growth factor alpha;
Short=TGF-alpha;
AltName: Full=EGF-like TGF;
Short=ETGF;
AltName: Full=TGF type 1;
Flags: Precursor;
Name=Tgfa;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3855503; DOI=10.1038/313489a0;
Lee D.C., Rose T.M., Webb N.R., Todaro G.J.;
"Cloning and sequence analysis of a cDNA for rat transforming growth
factor-alpha.";
Nature 313:489-491(1985).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
PubMed=2325647; DOI=10.1128/MCB.10.5.2111;
Blasband A.J., Rogers K.T., Chen X., Azizkhan J.C., Lee D.C.;
"Characterization of the rat transforming growth factor alpha gene and
identification of promoter sequences.";
Mol. Cell. Biol. 10:2111-2121(1990).
[3]
PROTEIN SEQUENCE OF 39-88.
PubMed=6320373; DOI=10.1126/science.6320373;
Marquardt H., Hunkapiller M.W., Hood L.E., Todaro G.J.;
"Rat transforming growth factor type 1: structure and relation to
epidermal growth factor.";
Science 223:1079-1082(1984).
[4]
PROTEIN SEQUENCE OF 39-67.
PubMed=6605968;
Massague J.;
"Epidermal growth factor-like transforming growth factor. I.
Isolation, chemical characterization, and potentiation by other
transforming factors from feline sarcoma virus-transformed rat
cells.";
J. Biol. Chem. 258:13606-13613(1983).
-!- FUNCTION: TGF alpha is a mitogenic polypeptide that is able to
bind to the EGF receptor/EGFR and to act synergistically with TGF
beta to promote anchorage-independent cell proliferation in soft
agar.
-!- SUBUNIT: Interacts with the PDZ domains of MAGI3, SDCBP and SNTA1.
The interaction with SDCBP, is required for the targeting to the
cell surface. In the endoplasmic reticulum, in its immature form
(i.e. with a prosegment and lacking full N-glycosylation),
interacts with CNIH. In the Golgi apparatus, may form a complex
with CNIH and GORASP2. Interacts (via cytoplasmic C-terminal
domain) with NKD2 (By similarity). {ECO:0000250}.
-!- INTERACTION:
Q9H190:SDCBP2 (xeno); NbExp=6; IntAct=EBI-16418721, EBI-742426;
-!- SUBCELLULAR LOCATION: Transforming growth factor alpha: Secreted,
extracellular space.
-!- SUBCELLULAR LOCATION: Protransforming growth factor alpha: Cell
membrane; Single-pass type I membrane protein.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; X02004; CAA26036.1; -; mRNA.
EMBL; M31075; AAA42234.1; -; Genomic_DNA.
EMBL; M31076; AAA42233.1; -; mRNA.
PIR; A93356; WFRT1.
PIR; I57497; I57497.
RefSeq; NP_036803.1; NM_012671.2.
UniGene; Rn.9952; -.
ProteinModelPortal; P01134; -.
SMR; P01134; -.
IntAct; P01134; 2.
STRING; 10116.ENSRNOP00000054248; -.
PaxDb; P01134; -.
PRIDE; P01134; -.
Ensembl; ENSRNOT00000057441; ENSRNOP00000054248; ENSRNOG00000016182.
GeneID; 24827; -.
KEGG; rno:24827; -.
UCSC; RGD:3849; rat.
CTD; 7039; -.
RGD; 3849; Tgfa.
eggNOG; ENOG410IVW5; Eukaryota.
eggNOG; ENOG4111Z4I; LUCA.
GeneTree; ENSGT00940000160058; -.
HOGENOM; HOG000013036; -.
HOVERGEN; HBG000330; -.
InParanoid; P01134; -.
KO; K08774; -.
OMA; CQALICR; -.
OrthoDB; 1401257at2759; -.
PhylomeDB; P01134; -.
TreeFam; TF332938; -.
Reactome; R-RNO-1257604; PIP3 activates AKT signaling.
Reactome; R-RNO-177929; Signaling by EGFR.
Reactome; R-RNO-179812; GRB2 events in EGFR signaling.
Reactome; R-RNO-180292; GAB1 signalosome.
Reactome; R-RNO-180336; SHC1 events in EGFR signaling.
Reactome; R-RNO-182971; EGFR downregulation.
Reactome; R-RNO-204005; COPII-mediated vesicle transport.
Reactome; R-RNO-212718; EGFR interacts with phospholipase C-gamma.
Reactome; R-RNO-5673001; RAF/MAP kinase cascade.
Reactome; R-RNO-5694530; Cargo concentration in the ER.
Reactome; R-RNO-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
Reactome; R-RNO-8856825; Cargo recognition for clathrin-mediated endocytosis.
Reactome; R-RNO-8856828; Clathrin-mediated endocytosis.
PRO; PR:P01134; -.
Proteomes; UP000002494; Chromosome 4.
Bgee; ENSRNOG00000016182; Expressed in 10 organ(s), highest expression level in brain.
Genevisible; P01134; RN.
GO; GO:0005615; C:extracellular space; IDA:RGD.
GO; GO:0005887; C:integral component of plasma membrane; TAS:RGD.
GO; GO:0005634; C:nucleus; IDA:RGD.
GO; GO:0005154; F:epidermal growth factor receptor binding; IDA:RGD.
GO; GO:0008083; F:growth factor activity; ISS:HGNC.
GO; GO:0000187; P:activation of MAPK activity; ISS:HGNC.
GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IBA:GO_Central.
GO; GO:0072574; P:hepatocyte proliferation; IDA:UniProtKB.
GO; GO:0060749; P:mammary gland alveolus development; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; IDA:RGD.
GO; GO:0048523; P:negative regulation of cellular process; IDA:RGD.
GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
GO; GO:0008284; P:positive regulation of cell population proliferation; IMP:RGD.
GO; GO:0045741; P:positive regulation of epidermal growth factor-activated receptor activity; ISS:HGNC.
GO; GO:0050679; P:positive regulation of epithelial cell proliferation; ISS:HGNC.
GO; GO:0045840; P:positive regulation of mitotic nuclear division; ISS:HGNC.
GO; GO:0042493; P:response to drug; IEP:RGD.
GO; GO:0042060; P:wound healing; IEP:RGD.
InterPro; IPR013032; EGF-like_CS.
InterPro; IPR000742; EGF-like_dom.
InterPro; IPR015497; EGF_rcpt_ligand.
PANTHER; PTHR10740; PTHR10740; 1.
PROSITE; PS00022; EGF_1; 1.
PROSITE; PS01186; EGF_2; 1.
PROSITE; PS50026; EGF_3; 1.
1: Evidence at protein level;
Cell membrane; Complete proteome; Direct protein sequencing;
Disulfide bond; EGF-like domain; Glycoprotein; Growth factor;
Lipoprotein; Membrane; Mitogen; Palmitate; Reference proteome;
Secreted; Signal; Transmembrane; Transmembrane helix.
SIGNAL 1 23 {ECO:0000255}.
CHAIN 24 159 Protransforming growth factor alpha.
/FTId=PRO_0000302748.
PROPEP 24 38 Removed in mature form.
/FTId=PRO_0000007764.
CHAIN 39 88 Transforming growth factor alpha.
/FTId=PRO_0000007765.
PROPEP 89 159 Removed in mature form.
/FTId=PRO_0000007766.
TOPO_DOM 24 97 Extracellular. {ECO:0000255}.
TRANSMEM 98 123 Helical. {ECO:0000255}.
TOPO_DOM 124 159 Cytoplasmic. {ECO:0000255}.
DOMAIN 42 82 EGF-like. {ECO:0000255|PROSITE-
ProRule:PRU00076}.
LIPID 152 152 S-palmitoyl cysteine. {ECO:0000250}.
LIPID 153 153 S-palmitoyl cysteine. {ECO:0000250}.
CARBOHYD 25 25 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 46 59 {ECO:0000255|PROSITE-ProRule:PRU00076}.
DISULFID 54 70 {ECO:0000255|PROSITE-ProRule:PRU00076}.
DISULFID 72 81 {ECO:0000255|PROSITE-ProRule:PRU00076}.
CONFLICT 28 28 S -> P (in Ref. 1; CAA26036).
{ECO:0000305}.
SEQUENCE 159 AA; 16960 MW; E9664EF04DFCF4D5 CRC64;
MVPAAGQLAL LALGILVAVC QALENSTSPL SDSPVAAAVV SHFNKCPDSH TQYCFHGTCR
FLVQEEKPAC VCHSGYVGVR CEHADLLAVV AASQKKQAIT ALVVVSIVAL AVLIITCVLI
HCCQVRKHCE WCRALVCRHE KPSALLKGRT ACCHSETVV


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Pathways :
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP1584: Type II diabetes mellitus
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP1899: Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP810: Signaling of Hepatocyte Growth Factor Receptor
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP94: Signaling of Hepatocyte Growth Factor Receptor
WP1003: Ovarian Infertility Genes
WP1047: TNF-alpha NF-kB Signaling Pathway
WP1120: Ovarian Infertility Genes
WP1163: TNF-alpha NF-kB Signaling Pathway
WP1209: EBV LMP1 signaling
WP1224: EBV LMP1 signaling
WP1225: estrogen signalling
WP1340: Ovarian Infertility Genes
WP1369: TNF-alpha NF-kB Signaling Pathway
WP1434: Osteopontin Signaling
WP1487: TNF-alpha and mucus production in lung epythelium
WP1531: Vitamin D synthesis

Related Genes :
[TGFBR1 ALK5 SKR4] TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
[TGFBR2] TGF-beta receptor type-2 (TGFR-2) (EC 2.7.11.30) (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TGF-beta receptor type II) (TbetaR-II)
[TGFBR1] TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
[Tgfbr3] Transforming growth factor beta receptor type 3 (TGF-beta receptor type 3) (TGFR-3) (Betaglycan) (Transforming growth factor beta receptor III) (TGF-beta receptor type III)
[Tgfbr1] TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
[TGFBR1] TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
[Tgfb1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1 TGFB] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[Tgfbr1] TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (ESK2) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
[Tgfb1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB2] Transforming growth factor beta-2 proprotein (Cetermin) (Glioblastoma-derived T-cell suppressor factor) (G-TSF) [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-2 (TGF-beta-2)]
[TGFB3] Transforming growth factor beta-3 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-3 (TGF-beta-3)]
[TGFB2] Transforming growth factor beta-2 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-2 (TGF-beta-2)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[LEFTY2 EBAF LEFTA LEFTYA TGFB4 PSEC0024] Left-right determination factor 2 (Endometrial bleeding-associated factor) (Left-right determination factor A) (Protein lefty-2) (Protein lefty-A) (Transforming growth factor beta-4) (TGF-beta-4)
[MAP3K7 TAK1] Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
[Lefty1 Ebaf Lefty Stra3 Tgfb4] Left-right determination factor 1 (Protein lefty-1) (Lefty protein) (Stimulated by retinoic acid gene 3 protein) (Transforming growth factor beta-4) (TGF-beta-4)
[Map3k7 Tak1] Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
[TGF-beta 1] Transforming growth factor beta
[TGF beta] Transforming growth factor beta
[PDGFRA PDGFR2 RHEPDGFRA] Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a)
[Pdgfra] Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (Platelet-derived growth factor alpha receptor) (CD antigen CD140a)

Bibliography :
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