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Putative 3-methyladenine DNA glycosylase (EC 3.2.2.-)

 3MGH_LACH4              Reviewed;         210 AA.
A8YWM6;
26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
15-JAN-2008, sequence version 1.
08-MAY-2019, entry version 60.
RecName: Full=Putative 3-methyladenine DNA glycosylase {ECO:0000255|HAMAP-Rule:MF_00527};
EC=3.2.2.- {ECO:0000255|HAMAP-Rule:MF_00527};
OrderedLocusNames=lhv_0124;
Lactobacillus helveticus (strain DPC 4571).
Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
Lactobacillus.
NCBI_TaxID=405566;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=DPC 4571;
PubMed=17993529; DOI=10.1128/JB.01295-07;
Callanan M., Kaleta P., O'Callaghan J., O'Sullivan O., Jordan K.,
McAuliffe O., Sangrador-Vegas A., Slattery L., Fitzgerald G.F.,
Beresford T., Ross R.P.;
"Genome sequence of Lactobacillus helveticus: an organism
distinguished by selective gene loss and IS element expansion.";
J. Bacteriol. 190:727-735(2008).
-!- SIMILARITY: Belongs to the DNA glycosylase MPG family.
{ECO:0000255|HAMAP-Rule:MF_00527}.
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EMBL; CP000517; ABX26388.1; -; Genomic_DNA.
RefSeq; WP_012211263.1; NC_010080.1.
SMR; A8YWM6; -.
STRING; 405566.lhv_0124; -.
EnsemblBacteria; ABX26388; ABX26388; lhv_0124.
KEGG; lhe:lhv_0124; -.
eggNOG; ENOG4108VX5; Bacteria.
eggNOG; COG2094; LUCA.
HOGENOM; HOG000224224; -.
KO; K03652; -.
OMA; VEAYHHT; -.
BioCyc; LHEL405566:G1G7V-126-MONOMER; -.
Proteomes; UP000000790; Chromosome.
GO; GO:0003905; F:alkylbase DNA N-glycosylase activity; IEA:InterPro.
GO; GO:0003677; F:DNA binding; IEA:InterPro.
GO; GO:0006284; P:base-excision repair; IEA:InterPro.
CDD; cd00540; AAG; 1.
Gene3D; 3.10.300.10; -; 1.
HAMAP; MF_00527; 3MGH; 1.
InterPro; IPR011034; Formyl_transferase-like_C_sf.
InterPro; IPR003180; MPG.
InterPro; IPR036995; MPG_sf.
PANTHER; PTHR10429; PTHR10429; 1.
Pfam; PF02245; Pur_DNA_glyco; 1.
SUPFAM; SSF50486; SSF50486; 1.
TIGRFAMs; TIGR00567; 3mg; 1.
3: Inferred from homology;
Complete proteome; DNA damage; DNA repair; Hydrolase.
CHAIN 1 210 Putative 3-methyladenine DNA glycosylase.
/FTId=PRO_1000072494.
SEQUENCE 210 AA; 24079 MW; 1142831CC501C077 CRC64;
MNYSDYFTNR PTDEITRDLV GRPLIYDNGK EKIGGYIVEA EAYMGKNDRT AHSYGGHRSP
ANEGLYRRGG TIYIYAQRQY FFFDVACQEE NEPQGVLIRA IEPIWGIDTM IKNRSGKSGV
LLTNGPAKMM QAFGIHDKNW NLHFLSDSPF KIDLEDDHRK PAQEIIADKR VGINQSDPVW
ANKKLRYYVA GNPYVSDMKK RNYAKNNGWA


Related products :

Catalog number Product name Quantity
CSB-EL014749RA Rat DNA-3-methyladenine glycosylase(MPG) ELISA kit 96T
CSB-EL014749RA Rat DNA-3-methyladenine glycosylase(MPG) ELISA kit SpeciesRat 96T
CSB-EL014749MO Mouse DNA-3-methyladenine glycosylase(MPG) ELISA kit 96T
CSB-YP014749HU Recombinant human DNA-3-methyladenine glycosylase 500ug
CSB-EL014749HU Human DNA-3-methyladenine glycosylase(MPG) ELISA kit 96T
CSB-EL014749MO Mouse DNA-3-methyladenine glycosylase(MPG) ELISA kit SpeciesMouse 96T
CSB-EL014749HU Human DNA-3-methyladenine glycosylase(MPG) ELISA kit SpeciesHuman 96T
CSB-YP014749HU Recombinant human DNA-3-methyladenine glycosylase Source: Yeast 1mg
3MG_MOUSE ELISA Kit FOR DNA-3-methyladenine glycosylase; organism: Mouse; gene name: Mpg 96T
18-783-75582 RABBIT ANTI URACIL-DNA GLYCOSYLASE 2 (N-TERMINAL) - UNG2; EC 3.2.2.-; Uracil-DNA glycosylase 2; UDG2; Cyclin-like uracil-DNA glycosylase Polyclonal 0.1 mg
18-783-75585 RABBIT ANTI URACIL-DNA GLYCOSYLASE 2 - UNG2; EC 3.2.2.-; Uracil-DNA glycosylase 2; UDG2; Cyclin-like uracil-DNA glycosylase Polyclonal 0.1 mg
KI3780 3-Methyladenine 500mg
KI3779 3-Methyladenine 50mg
2249-25 3-Methyladenine 25 mg
2249-100 3-Methyladenine 100 mg
EIAAB41797 C-JUN leucine zipper interactive protein JZA-3,G_T mismatch-specific thymine DNA glycosylase,Mouse,Mus musculus,Tdg,Thymine-DNA glycosylase
LF-PA41235 anti-Uracil-DNA Glycosylase (UNG) , Rabbit polyclonal to racil-DNA Glycosylase (UNG) , Isotype IgG, Host Rabbit 50 ug
LF-PA41236 anti-Uracil-DNA Glycosylase (UNG) , Rabbit polyclonal to racil-DNA Glycosylase (UNG) , Isotype IgG, Host Rabbit 50 ug
EIAAB41798 G_T mismatch-specific thymine DNA glycosylase,Homo sapiens,Human,TDG,Thymine-DNA glycosylase
SCH-AHP1200T RABBIT ANTI URACIL_DNA GLYCOSYLASE 2 (N_TERMINAL), Product Type Polyclonal Antibody, Specificity URACIL_DNA GLYCOSYLASE 2 , Target Species Human, Host Rabbit, Format Purified, Isotypes Polyclona 50 µg
AHP1200T RABBIT ANTI URACIL_DNA GLYCOSYLASE 2 (N_TERMINAL), Product Type Polyclonal Antibody, Specificity URACIL_DNA GLYCOSYLASE 2 , Target Species Human, Host Rabbit, Format Purified, Isotypes Polyclona 50 µg
SCH-AHP1201T RABBIT ANTI URACIL_DNA GLYCOSYLASE 1 (C_TERMINAL), Product Type Polyclonal Antibody, Specificity URACIL_DNA GLYCOSYLASE 1 , Target Species Human, Host Rabbit, Format Purified, Isotypes Polyclona 50 µg
AHP1201T RABBIT ANTI URACIL_DNA GLYCOSYLASE 1 (C_TERMINAL), Product Type Polyclonal Antibody, Specificity URACIL_DNA GLYCOSYLASE 1 , Target Species Human, Host Rabbit, Format Purified, Isotypes Polyclona 50 µg
AHP1200 RABBIT ANTI URACIL_DNA GLYCOSYLASE 2 (N_TERMINAL), Product Type Polyclonal Antibody, Specificity URACIL_DNA GLYCOSYLASE 2 , Target Species Human, Host Rabbit, Format Purified, Isotypes Polyclona 0.1 mg
AHP1201 RABBIT ANTI URACIL_DNA GLYCOSYLASE 1 (C_TERMINAL), Product Type Polyclonal Antibody, Specificity URACIL_DNA GLYCOSYLASE 1 , Target Species Human, Host Rabbit, Format Purified, Isotypes Polyclona 0.1 mg
Pathways :
WP1581: Histidine metabolism
WP1673: Naphthalene and anthracene degradation
WP1700: Selenoamino acid metabolism
WP1625: Base excision repair
WP1692: Protein export
WP1714: Tyrosine metabolism
WP1624: Bacterial secretion system
WP1689: Porphyrin and chlorophyll metabolism
WP1709: Thiamine metabolism

Related Genes :
[alkA aidA b2068 JW2053] DNA-3-methyladenine glycosylase 2 (EC 3.2.2.21) (3-methyladenine-DNA glycosylase II, inducible) (TAG II) (DNA-3-methyladenine glycosidase II) (DNA-3-methyladenine glycosylase II)
[alkA ada Rv1317c MTCY130.02c] Probable bifunctional transcriptional activator/DNA repair enzyme AlkA (Regulatory protein AlkA) [Includes: Methylphosphotriester-DNA--protein-cysteine S-methyltransferase (EC 2.1.1.n11) (Methylphosphotriester-DNA methyltransferase); DNA-3-methyladenine glycosylase (EC 3.2.2.21) (DNA-3-methyladenine glycosidase)]
[mag1 SPAPB24D3.04c] DNA-3-methyladenine glycosylase 1 (EC 3.2.2.21) (3-methyladenine DNA glycosidase 1) (3MEA DNA glycosylase 1)
[Ogg1] N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (AP lyase) (EC 4.2.99.18)]
[mutM fpg] Formamidopyrimidine-DNA glycosylase (Fapy-DNA glycosylase) (EC 3.2.2.23) (DNA-(apurinic or apyrimidinic site) lyase MutM) (AP lyase MutM) (EC 4.2.99.18)
[nth-1 R10E4.5] Endonuclease III homolog (CeNTH) (EC 3.2.2.-) (EC 4.2.99.18) (Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase) (DNA glycosylase/AP lyase)
[Ung Ung1] Uracil-DNA glycosylase (UDG) (EC 3.2.2.27)
[MAG1 MAG YER142C] DNA-3-methyladenine glycosylase (EC 3.2.2.21) (3-methyladenine DNA glycosidase) (3MEA DNA glycosylase)
[NTG2 SCR2 YOL043C] Endonuclease III homolog 2 (EC 3.2.2.-) (EC 4.2.99.18) (Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase 2) (DNA glycosylase/AP lyase 2) (Endonuclease III-like glycosylase 2) (Redoxyendonuclease 2)
[FPG1 FPG2 At1g52500 F6D8.28] Formamidopyrimidine-DNA glycosylase (Fapy-DNA glycosylase) (EC 3.2.2.23) (EC 4.2.99.18) (DNA-(apurinic or apyrimidinic site) lyase FPG1) (Formamidopyrimidine-DNA glycosylase 1) (AtFPG-1) (Formamidopyrimidine-DNA glycosylase 2) (AtFPG-2) (Protein MutM homolog 1) (AtMMH-1) (Protein MutM homolog 2) (AtMMH-2)
[NTH2 At1g05900 T20M3.18] Endonuclease III homolog 2, chloroplastic (AtNTH2) (EC 3.2.2.-) (EC 4.2.99.18) (Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase 2) (DNA glycosylase/AP lyase 2)
[NTG1 OGG2 SCR1 YAL015C FUN33] Endonuclease III homolog 1 (EC 3.2.2.-) (EC 4.2.99.18) (Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase 1) (DNA glycosylase/AP lyase 1) (Endonuclease III-like glycosylase 1) (Redoxyendonuclease 1)
[NTHL1 NTH1 OCTS3] Endonuclease III-like protein 1 (hNTH1) (EC 3.2.2.-) (EC 4.2.99.18) (Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase) (DNA glycosylase/AP lyase)
[NTH1 At2g31450 T28P16.6] Endonuclease III homolog 1, chloroplastic (AtNTH1) (EC 3.2.2.-) (EC 4.2.99.18) (Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase 1) (DNA glycosylase/AP lyase 1)
[nth1 SPAC30D11.07] Endonuclease III homolog (EC 3.2.2.-) (EC 4.2.99.18) (Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase) (DNA glycosylase/AP lyase)
[Neil3] Endonuclease 8-like 3 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase FPG2) (DNA glycosylase/AP lyase Neil3) (Endonuclease VIII-like 3) (Nei-like protein 3)
[OGG1 MMH MUTM OGH1] N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (AP lyase) (EC 4.2.99.18)]
[mutM fpg b3635 JW3610] Formamidopyrimidine-DNA glycosylase (Fapy-DNA glycosylase) (EC 3.2.2.23) (DNA-(apurinic or apyrimidinic site) lyase MutM) (AP lyase MutM) (EC 4.2.99.18)
[fpg1 mutM Rv2924c MTCY338.13c] Formamidopyrimidine-DNA glycosylase 1 (Fapy-DNA glycosylase 1) (EC 3.2.2.23) (DNA-(apurinic or apyrimidinic site) lyase MutM 1) (AP lyase MutM 1) (EC 4.2.99.18)
[OGG1 YML060W YM9958.02] N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (AP lyase) (EC 4.2.99.18)]
[Nthl1 Nth1] Endonuclease III-like protein 1 (EC 3.2.2.-) (EC 4.2.99.18) (Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase) (DNA glycosylase/AP lyase)
[Ogg1 Mmh Ogh1] N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (AP lyase) (EC 4.2.99.18)]
[hchA A8C65_13880 A9R57_25255 AKG99_20940 AMK83_16550 B7C53_22525 B9M99_11580 B9T59_01945 BJJ90_15205 BMT49_12710 BMT53_00170 BUE81_10670 BvCms12BK_01457 BvCms28BK_04168 BvCmsHHP001_02632 BvCmsKKP061_00566 BvCmsKSP008_02510 BvCmsKSP015_01352 BvCmsKSP036_04668 BvCmsKSP045_04450 BvCmsKSP058_03204 BvCmsKSP067_02879 BvCmsKSP083_03900 BvCmsNSNP027_04914 BvCmsNSP006_03750 BvCmsNSP007_03329 BvCmsNSP039_03266 BvCmsNSP047_03567 BvCmsNSP078_03451 BvCmsSINP011_04162 BvCmsSIP006_05510 BvCmsSIP082_02402 BW690_17225 BZL69_29425 C2U48_24800 C5715_19445 C5N07_21380 C6669_19295 C7B06_02290 C7B07_03930 CDL37_00765 CIJ94_05515 COD46_23180 CQP61_17160 CRD98_26150 CY655_12940 D5618_21870 D9D20_21030 D9D43_06110 D9H68_20750 D9H70_25730 D9I87_15275 DL800_09215 DNQ41_14245 DQE83_22775 DTL43_21780 DTM25_06080 DU321_04440 E2855_02503 E2863_02392 EC95NR1_00961 ED648_25045 EFB45_10990 EPS97_16570 EPT01_11070 EQ825_23250 ERS085379_01273 ERS085386_05041 EVY21_22520 ExPECSC038_01920 EXX32_14605 EXX71_02385 EXX78_21815 EYD11_09165 HmCmsJML079_02678 HMPREF3040_01583 HW43_13705 NCTC10082_04431 NCTC10418_03071 NCTC10767_03558 NCTC11022_01867 NCTC11126_04427 NCTC11181_05650 NCTC12950_02263 NCTC13462_05714 NCTC8985_00529 NCTC9111_05933 NCTC9703_00277 PU06_24500 SAMEA3472043_00447 SAMEA3472055_03589 SAMEA3472056_01268 SAMEA3472070_00654 SAMEA3472080_04213 SAMEA3472090_03376 SAMEA3472110_00060 SAMEA3472112_00448 SAMEA3752372_00752 UN91_23615 WQ89_10695] Protein/nucleic acid deglycase HchA (EC 3.1.2.-) (EC 3.5.1.-) (EC 3.5.1.124) (Maillard deglycase)
[PAE2237] N-glycosylase/DNA lyase (8-oxoguanine DNA glycosylase) (EC 3.2.2.-) (AGOG) (DNA-(apurinic or apyrimidinic site) lyase) (AP lyase) (EC 4.2.99.18) (Pa-AGOG)
[alkA ada MT1358] Probable bifunctional transcriptional activator/DNA repair enzyme AlkA (Regulatory protein AlkA) [Includes: Methylphosphotriester-DNA--protein-cysteine S-methyltransferase (EC 2.1.1.n11) (Methylphosphotriester-DNA methyltransferase); DNA-3-methyladenine glycosylase (EC 3.2.2.21) (DNA-3-methyladenine glycosidase)]
[NEIL2] Endonuclease 8-like 2 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase/AP lyase Neil2) (DNA-(apurinic or apyrimidinic site) lyase Neil2) (Endonuclease VIII-like 2) (Nei homolog 2) (NEH2) (Nei-like protein 2)
[hchA A9819_11910 ACN81_03425 AML35_08765 AW059_23935 BANRA_00208 BANRA_00433 BANRA_02614 BHF46_18455 BMT91_24760 BvCmsC61A_00149 BvCmsH15A_00510 BvCmsKSNP120_04693 BvCmsKSP026_03873 BvCmsKSP076_04891 C4J69_22715 C7B08_25495 CR538_10415 D2F89_25795 D3Y67_22910 D9G42_11130 D9I97_22010 D9J11_25195 DP258_02540 E5M00_18610 EC3234A_36c00010 EC382_21100 ECTO6_01955 EFV06_13085 EPS71_23885 FORC82_1921 NCTC8500_02249 NCTC9037_02122 NCTC9117_02637 NCTC9969_02156 SAMEA3472108_01151 SAMEA3484427_04795 SAMEA3484429_02051 SAMEA3752557_05476 SAMEA3752559_04333] Protein/nucleic acid deglycase HchA (EC 3.1.2.-) (EC 3.5.1.-) (EC 3.5.1.124) (Maillard deglycase)
[nei1 nei2 Rv2464c MTV008.20c] Endonuclease 8 1 (DNA glycosylase/AP lyase Nei 1) (EC 3.2.2.-) (DNA-(apurinic or apyrimidinic site) lyase Nei 1) (EC 4.2.99.18) (Endonuclease VIII 1)
[NEIL1] Endonuclease 8-like 1 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase/AP lyase Neil1) (DNA-(apurinic or apyrimidinic site) lyase Neil1) (Endonuclease VIII-like 1) (FPG1) (Nei homolog 1) (NEH1) (Nei-like protein 1)
[nei b0714 JW0704] Endonuclease 8 (DNA glycosylase/AP lyase Nei) (EC 3.2.2.-) (EC 4.2.99.18) (DNA-(apurinic or apyrimidinic site) lyase Nei) (Endonuclease VIII)

Bibliography :
[22683793] Structure-function studies of an unusual 3-methyladenine DNA glycosylase II (AlkA) from Deinococcus radiodurans.
[10777493] A novel 3-methyladenine DNA glycosylase from Helicobacter pylori defines a new class within the endonuclease III family of base excision repair glycosylases.
[10684927] Interactions of the human, rat, Saccharomyces cerevisiae and Escherichia coli 3-methyladenine-DNA glycosylases with DNA containing dIMP residues.
[10606815] Endonuclease V protects Escherichia coli against specific mutations caused by nitrous acid.
[8589517] Structure of the mouse 3-methyladenine DNA glycosylase gene and exact localization upstream of the alpha-globin gene cluster on chromosome 11.
[2005641] Increased DNA synthesis and repair-enzyme expression in lymphocytes from patients with chronic lymphocytic leukemia resistant to nitrogen mustards.
[2265619] Cloning and expression in Escherichia coli of a gene for an alkylbase DNA glycosylase from Saccharomyces cerevisiae; a homologue to the bacterial alkA gene.