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Putative 3-methyladenine DNA glycosylase (EC 3.2.2.-)

 3MGH_ANADE              Reviewed;         207 AA.
Q2IHD7;
12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
07-MAR-2006, sequence version 1.
08-MAY-2019, entry version 69.
RecName: Full=Putative 3-methyladenine DNA glycosylase {ECO:0000255|HAMAP-Rule:MF_00527};
EC=3.2.2.- {ECO:0000255|HAMAP-Rule:MF_00527};
OrderedLocusNames=Adeh_4231;
Anaeromyxobacter dehalogenans (strain 2CP-C).
Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
Cystobacterineae; Anaeromyxobacteraceae; Anaeromyxobacter.
NCBI_TaxID=290397;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=2CP-C;
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C.,
Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M.,
Kyrpides N., Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S.,
Kirby J.R., Zhulin I.B., Loeffler F.E., Richardson P.;
"Complete sequence of Anaeromyxobacter dehalogenans 2CP-C.";
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
-!- SIMILARITY: Belongs to the DNA glycosylase MPG family.
{ECO:0000255|HAMAP-Rule:MF_00527}.
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EMBL; CP000251; ABC83995.1; -; Genomic_DNA.
RefSeq; WP_011423277.1; NC_007760.1.
SMR; Q2IHD7; -.
STRING; 290397.Adeh_4231; -.
EnsemblBacteria; ABC83995; ABC83995; Adeh_4231.
KEGG; ade:Adeh_4231; -.
eggNOG; ENOG4108VX5; Bacteria.
eggNOG; COG2094; LUCA.
HOGENOM; HOG000224224; -.
KO; K03652; -.
OMA; VEAYHHT; -.
BioCyc; ADEH290397:G1G5W-4389-MONOMER; -.
Proteomes; UP000001935; Chromosome.
GO; GO:0003905; F:alkylbase DNA N-glycosylase activity; IEA:InterPro.
GO; GO:0003677; F:DNA binding; IEA:InterPro.
GO; GO:0006284; P:base-excision repair; IEA:InterPro.
CDD; cd00540; AAG; 1.
Gene3D; 3.10.300.10; -; 1.
HAMAP; MF_00527; 3MGH; 1.
InterPro; IPR011034; Formyl_transferase-like_C_sf.
InterPro; IPR003180; MPG.
InterPro; IPR036995; MPG_sf.
PANTHER; PTHR10429; PTHR10429; 1.
Pfam; PF02245; Pur_DNA_glyco; 1.
SUPFAM; SSF50486; SSF50486; 1.
TIGRFAMs; TIGR00567; 3mg; 1.
3: Inferred from homology;
Complete proteome; DNA damage; DNA repair; Hydrolase;
Reference proteome.
CHAIN 1 207 Putative 3-methyladenine DNA glycosylase.
/FTId=PRO_0000264993.
SEQUENCE 207 AA; 22290 MW; 781C562EDA50157F CRC64;
MKLPQAFYAR DTRTVARALL GKVLVHLDGG VRRAARIVET EAYHGPDDRA SHARAGPTPR
AAIMFGPPGR AYVYLIYGTS HCMNVVTGPE GFPSAVLIRA AEPIEGCLHS TRGPGNLCRA
LAIRREHDNG RDLWGEELFI EDAPAPREAV VTGPRVNVGY AGPWAARPWR FALRGSAWVS
RPAPAGARAA RAPAPAPRPR RPRGSGP


Related products :

Catalog number Product name Quantity
CSB-EL014749RA Rat DNA-3-methyladenine glycosylase(MPG) ELISA kit 96T
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CSB-EL014749MO Mouse DNA-3-methyladenine glycosylase(MPG) ELISA kit 96T
CSB-YP014749HU Recombinant human DNA-3-methyladenine glycosylase 500ug
CSB-EL014749HU Human DNA-3-methyladenine glycosylase(MPG) ELISA kit 96T
CSB-EL014749MO Mouse DNA-3-methyladenine glycosylase(MPG) ELISA kit SpeciesMouse 96T
CSB-EL014749HU Human DNA-3-methyladenine glycosylase(MPG) ELISA kit SpeciesHuman 96T
CSB-YP014749HU Recombinant human DNA-3-methyladenine glycosylase Source: Yeast 1mg
3MG_MOUSE ELISA Kit FOR DNA-3-methyladenine glycosylase; organism: Mouse; gene name: Mpg 96T
18-783-75582 RABBIT ANTI URACIL-DNA GLYCOSYLASE 2 (N-TERMINAL) - UNG2; EC 3.2.2.-; Uracil-DNA glycosylase 2; UDG2; Cyclin-like uracil-DNA glycosylase Polyclonal 0.1 mg
18-783-75585 RABBIT ANTI URACIL-DNA GLYCOSYLASE 2 - UNG2; EC 3.2.2.-; Uracil-DNA glycosylase 2; UDG2; Cyclin-like uracil-DNA glycosylase Polyclonal 0.1 mg
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2249-25 3-Methyladenine 25 mg
2249-100 3-Methyladenine 100 mg
EIAAB41797 C-JUN leucine zipper interactive protein JZA-3,G_T mismatch-specific thymine DNA glycosylase,Mouse,Mus musculus,Tdg,Thymine-DNA glycosylase
LF-PA41235 anti-Uracil-DNA Glycosylase (UNG) , Rabbit polyclonal to racil-DNA Glycosylase (UNG) , Isotype IgG, Host Rabbit 50 ug
LF-PA41236 anti-Uracil-DNA Glycosylase (UNG) , Rabbit polyclonal to racil-DNA Glycosylase (UNG) , Isotype IgG, Host Rabbit 50 ug
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AHP1200T RABBIT ANTI URACIL_DNA GLYCOSYLASE 2 (N_TERMINAL), Product Type Polyclonal Antibody, Specificity URACIL_DNA GLYCOSYLASE 2 , Target Species Human, Host Rabbit, Format Purified, Isotypes Polyclona 50 µg
SCH-AHP1201T RABBIT ANTI URACIL_DNA GLYCOSYLASE 1 (C_TERMINAL), Product Type Polyclonal Antibody, Specificity URACIL_DNA GLYCOSYLASE 1 , Target Species Human, Host Rabbit, Format Purified, Isotypes Polyclona 50 µg
AHP1201T RABBIT ANTI URACIL_DNA GLYCOSYLASE 1 (C_TERMINAL), Product Type Polyclonal Antibody, Specificity URACIL_DNA GLYCOSYLASE 1 , Target Species Human, Host Rabbit, Format Purified, Isotypes Polyclona 50 µg
AHP1200 RABBIT ANTI URACIL_DNA GLYCOSYLASE 2 (N_TERMINAL), Product Type Polyclonal Antibody, Specificity URACIL_DNA GLYCOSYLASE 2 , Target Species Human, Host Rabbit, Format Purified, Isotypes Polyclona 0.1 mg
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Pathways :
WP1581: Histidine metabolism
WP1673: Naphthalene and anthracene degradation
WP1700: Selenoamino acid metabolism
WP1625: Base excision repair
WP1692: Protein export
WP1714: Tyrosine metabolism
WP1624: Bacterial secretion system
WP1689: Porphyrin and chlorophyll metabolism
WP1709: Thiamine metabolism

Related Genes :
[alkA aidA b2068 JW2053] DNA-3-methyladenine glycosylase 2 (EC 3.2.2.21) (3-methyladenine-DNA glycosylase II, inducible) (TAG II) (DNA-3-methyladenine glycosidase II) (DNA-3-methyladenine glycosylase II)
[alkA ada Rv1317c MTCY130.02c] Probable bifunctional transcriptional activator/DNA repair enzyme AlkA (Regulatory protein AlkA) [Includes: Methylphosphotriester-DNA--protein-cysteine S-methyltransferase (EC 2.1.1.n11) (Methylphosphotriester-DNA methyltransferase); DNA-3-methyladenine glycosylase (EC 3.2.2.21) (DNA-3-methyladenine glycosidase)]
[mag1 SPAPB24D3.04c] DNA-3-methyladenine glycosylase 1 (EC 3.2.2.21) (3-methyladenine DNA glycosidase 1) (3MEA DNA glycosylase 1)
[Ogg1] N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (AP lyase) (EC 4.2.99.18)]
[mutM fpg] Formamidopyrimidine-DNA glycosylase (Fapy-DNA glycosylase) (EC 3.2.2.23) (DNA-(apurinic or apyrimidinic site) lyase MutM) (AP lyase MutM) (EC 4.2.99.18)
[nth-1 R10E4.5] Endonuclease III homolog (CeNTH) (EC 3.2.2.-) (EC 4.2.99.18) (Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase) (DNA glycosylase/AP lyase)
[Ung Ung1] Uracil-DNA glycosylase (UDG) (EC 3.2.2.27)
[MAG1 MAG YER142C] DNA-3-methyladenine glycosylase (EC 3.2.2.21) (3-methyladenine DNA glycosidase) (3MEA DNA glycosylase)
[NTG2 SCR2 YOL043C] Endonuclease III homolog 2 (EC 3.2.2.-) (EC 4.2.99.18) (Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase 2) (DNA glycosylase/AP lyase 2) (Endonuclease III-like glycosylase 2) (Redoxyendonuclease 2)
[FPG1 FPG2 At1g52500 F6D8.28] Formamidopyrimidine-DNA glycosylase (Fapy-DNA glycosylase) (EC 3.2.2.23) (EC 4.2.99.18) (DNA-(apurinic or apyrimidinic site) lyase FPG1) (Formamidopyrimidine-DNA glycosylase 1) (AtFPG-1) (Formamidopyrimidine-DNA glycosylase 2) (AtFPG-2) (Protein MutM homolog 1) (AtMMH-1) (Protein MutM homolog 2) (AtMMH-2)
[NTH2 At1g05900 T20M3.18] Endonuclease III homolog 2, chloroplastic (AtNTH2) (EC 3.2.2.-) (EC 4.2.99.18) (Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase 2) (DNA glycosylase/AP lyase 2)
[NTG1 OGG2 SCR1 YAL015C FUN33] Endonuclease III homolog 1 (EC 3.2.2.-) (EC 4.2.99.18) (Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase 1) (DNA glycosylase/AP lyase 1) (Endonuclease III-like glycosylase 1) (Redoxyendonuclease 1)
[NTHL1 NTH1 OCTS3] Endonuclease III-like protein 1 (hNTH1) (EC 3.2.2.-) (EC 4.2.99.18) (Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase) (DNA glycosylase/AP lyase)
[NTH1 At2g31450 T28P16.6] Endonuclease III homolog 1, chloroplastic (AtNTH1) (EC 3.2.2.-) (EC 4.2.99.18) (Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase 1) (DNA glycosylase/AP lyase 1)
[nth1 SPAC30D11.07] Endonuclease III homolog (EC 3.2.2.-) (EC 4.2.99.18) (Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase) (DNA glycosylase/AP lyase)
[Neil3] Endonuclease 8-like 3 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase FPG2) (DNA glycosylase/AP lyase Neil3) (Endonuclease VIII-like 3) (Nei-like protein 3)
[OGG1 MMH MUTM OGH1] N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (AP lyase) (EC 4.2.99.18)]
[mutM fpg b3635 JW3610] Formamidopyrimidine-DNA glycosylase (Fapy-DNA glycosylase) (EC 3.2.2.23) (DNA-(apurinic or apyrimidinic site) lyase MutM) (AP lyase MutM) (EC 4.2.99.18)
[fpg1 mutM Rv2924c MTCY338.13c] Formamidopyrimidine-DNA glycosylase 1 (Fapy-DNA glycosylase 1) (EC 3.2.2.23) (DNA-(apurinic or apyrimidinic site) lyase MutM 1) (AP lyase MutM 1) (EC 4.2.99.18)
[OGG1 YML060W YM9958.02] N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (AP lyase) (EC 4.2.99.18)]
[Nthl1 Nth1] Endonuclease III-like protein 1 (EC 3.2.2.-) (EC 4.2.99.18) (Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase) (DNA glycosylase/AP lyase)
[Ogg1 Mmh Ogh1] N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (AP lyase) (EC 4.2.99.18)]
[hchA A8C65_13880 A9R57_25255 AKG99_20940 AMK83_16550 B7C53_22525 B9M99_11580 B9T59_01945 BJJ90_15205 BMT49_12710 BMT53_00170 BUE81_10670 BvCms12BK_01457 BvCms28BK_04168 BvCmsHHP001_02632 BvCmsKKP061_00566 BvCmsKSP008_02510 BvCmsKSP015_01352 BvCmsKSP036_04668 BvCmsKSP045_04450 BvCmsKSP058_03204 BvCmsKSP067_02879 BvCmsKSP083_03900 BvCmsNSNP027_04914 BvCmsNSP006_03750 BvCmsNSP007_03329 BvCmsNSP039_03266 BvCmsNSP047_03567 BvCmsNSP078_03451 BvCmsSINP011_04162 BvCmsSIP006_05510 BvCmsSIP082_02402 BW690_17225 BZL69_29425 C2U48_24800 C5715_19445 C5N07_21380 C6669_19295 C7B06_02290 C7B07_03930 CDL37_00765 CIJ94_05515 COD46_23180 CQP61_17160 CRD98_26150 CY655_12940 D5618_21870 D9D20_21030 D9D43_06110 D9H68_20750 D9H70_25730 D9I87_15275 DL800_09215 DNQ41_14245 DQE83_22775 DTL43_21780 DTM25_06080 DU321_04440 E2855_02503 E2863_02392 EC95NR1_00961 ED648_25045 EFB45_10990 EPS97_16570 EPT01_11070 EQ825_23250 ERS085379_01273 ERS085386_05041 EVY21_22520 ExPECSC038_01920 EXX32_14605 EXX71_02385 EXX78_21815 EYD11_09165 HmCmsJML079_02678 HMPREF3040_01583 HW43_13705 NCTC10082_04431 NCTC10418_03071 NCTC10767_03558 NCTC11022_01867 NCTC11126_04427 NCTC11181_05650 NCTC12950_02263 NCTC13462_05714 NCTC8985_00529 NCTC9111_05933 NCTC9703_00277 PU06_24500 SAMEA3472043_00447 SAMEA3472055_03589 SAMEA3472056_01268 SAMEA3472070_00654 SAMEA3472080_04213 SAMEA3472090_03376 SAMEA3472110_00060 SAMEA3472112_00448 SAMEA3752372_00752 UN91_23615 WQ89_10695] Protein/nucleic acid deglycase HchA (EC 3.1.2.-) (EC 3.5.1.-) (EC 3.5.1.124) (Maillard deglycase)
[PAE2237] N-glycosylase/DNA lyase (8-oxoguanine DNA glycosylase) (EC 3.2.2.-) (AGOG) (DNA-(apurinic or apyrimidinic site) lyase) (AP lyase) (EC 4.2.99.18) (Pa-AGOG)
[alkA ada MT1358] Probable bifunctional transcriptional activator/DNA repair enzyme AlkA (Regulatory protein AlkA) [Includes: Methylphosphotriester-DNA--protein-cysteine S-methyltransferase (EC 2.1.1.n11) (Methylphosphotriester-DNA methyltransferase); DNA-3-methyladenine glycosylase (EC 3.2.2.21) (DNA-3-methyladenine glycosidase)]
[NEIL2] Endonuclease 8-like 2 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase/AP lyase Neil2) (DNA-(apurinic or apyrimidinic site) lyase Neil2) (Endonuclease VIII-like 2) (Nei homolog 2) (NEH2) (Nei-like protein 2)
[hchA A9819_11910 ACN81_03425 AML35_08765 AW059_23935 BANRA_00208 BANRA_00433 BANRA_02614 BHF46_18455 BMT91_24760 BvCmsC61A_00149 BvCmsH15A_00510 BvCmsKSNP120_04693 BvCmsKSP026_03873 BvCmsKSP076_04891 C4J69_22715 C7B08_25495 CR538_10415 D2F89_25795 D3Y67_22910 D9G42_11130 D9I97_22010 D9J11_25195 DP258_02540 E5M00_18610 EC3234A_36c00010 EC382_21100 ECTO6_01955 EFV06_13085 EPS71_23885 FORC82_1921 NCTC8500_02249 NCTC9037_02122 NCTC9117_02637 NCTC9969_02156 SAMEA3472108_01151 SAMEA3484427_04795 SAMEA3484429_02051 SAMEA3752557_05476 SAMEA3752559_04333] Protein/nucleic acid deglycase HchA (EC 3.1.2.-) (EC 3.5.1.-) (EC 3.5.1.124) (Maillard deglycase)
[nei1 nei2 Rv2464c MTV008.20c] Endonuclease 8 1 (DNA glycosylase/AP lyase Nei 1) (EC 3.2.2.-) (DNA-(apurinic or apyrimidinic site) lyase Nei 1) (EC 4.2.99.18) (Endonuclease VIII 1)
[NEIL1] Endonuclease 8-like 1 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase/AP lyase Neil1) (DNA-(apurinic or apyrimidinic site) lyase Neil1) (Endonuclease VIII-like 1) (FPG1) (Nei homolog 1) (NEH1) (Nei-like protein 1)
[nei b0714 JW0704] Endonuclease 8 (DNA glycosylase/AP lyase Nei) (EC 3.2.2.-) (EC 4.2.99.18) (DNA-(apurinic or apyrimidinic site) lyase Nei) (Endonuclease VIII)

Bibliography :
[22683793] Structure-function studies of an unusual 3-methyladenine DNA glycosylase II (AlkA) from Deinococcus radiodurans.
[10777493] A novel 3-methyladenine DNA glycosylase from Helicobacter pylori defines a new class within the endonuclease III family of base excision repair glycosylases.
[10684927] Interactions of the human, rat, Saccharomyces cerevisiae and Escherichia coli 3-methyladenine-DNA glycosylases with DNA containing dIMP residues.
[10606815] Endonuclease V protects Escherichia coli against specific mutations caused by nitrous acid.
[8589517] Structure of the mouse 3-methyladenine DNA glycosylase gene and exact localization upstream of the alpha-globin gene cluster on chromosome 11.
[2005641] Increased DNA synthesis and repair-enzyme expression in lymphocytes from patients with chronic lymphocytic leukemia resistant to nitrogen mustards.
[2265619] Cloning and expression in Escherichia coli of a gene for an alkylbase DNA glycosylase from Saccharomyces cerevisiae; a homologue to the bacterial alkA gene.