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Ras-related GTP-binding protein B (Rag B) (RagB)

 RRAGB_RAT               Reviewed;         374 AA.
Q63487; Q6AZ37;
13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
16-JAN-2019, entry version 117.
RecName: Full=Ras-related GTP-binding protein B;
Short=Rag B {ECO:0000250|UniProtKB:Q5VZM2};
Short=RagB {ECO:0000303|PubMed:7499430};
Name=RragB {ECO:0000312|RGD:619805};
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
[1] {ECO:0000305, ECO:0000312|EMBL:CAA59467.1}
STRAIN=Sprague-Dawley {ECO:0000312|EMBL:CAA59467.1};
TISSUE=Brain {ECO:0000312|EMBL:CAA59467.1};
PubMed=7499430; DOI=10.1074/jbc.270.48.28982;
Schuermann A., Brauers A., Massmann S., Becker W., Joost H.-G.;
"Cloning of a novel family of mammalian GTP-binding proteins (RagA,
RagBs, RagBl) with remote similarity to the Ras-related GTPases.";
J. Biol. Chem. 270:28982-28988(1995).
TISSUE=Brain, and Lung;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: Guanine nucleotide-binding protein that plays a crucial
role in the cellular response to amino acid availability through
regulation of the mTORC1 signaling cascade. Forms heterodimeric
Rag complexes with RRAGC or RRAGD and cycle between an inactive
GDP-bound and an active GTP-bound form. In its active form
participates in the relocalization of mTORC1 to the lysosomes and
its subsequent activation by the GTPase RHEB. Involved in the
RCC1/Ran-GTPase pathway. {ECO:0000250|UniProtKB:Q5VZM2,
-!- ACTIVITY REGULATION: The activation of GTP-binding proteins is
generally mediated by a guanine exchange factor (GEF), while
inactivation through hydrolysis of bound GTP is catalyzed by a
GTPase activating protein (GAP). The GATOR1 complex functions as a
GAP and stimulates RRAGB GTPase activity to turn it into its
inactive GDP-bound form. {ECO:0000250|UniProtKB:Q5VZM2}.
-!- SUBUNIT: Interacts with RRAGC and RRAGD; heterodimerization
stabilizes RRAG proteins. In complex with RRAGC, but not with
RRAGA, interacts with RPTOR; this interaction is particularly
efficient with GTP-loaded RRAGB and GDP-loaded RRAGC. Interacts
with SH3BP4; the interaction with this negative regulator is most
probably direct, preferentially occurs with the inactive GDP-bound
form of RRAGB, is negatively regulated by amino acids and prevents
interaction with RPTOR. Interacts with the GATOR1 complex;
inactivates RRAGB. The Rag heterodimer interacts with SLC38A9; the
probable amino acid sensor. Interacts with SESN1, SESN2 AND SESN3.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q5VZM2}.
Lysosome {ECO:0000250|UniProtKB:Q5VZM2}.
Event=Alternative splicing; Named isoforms=2;
Name=1 {ECO:0000269|PubMed:7499430}; Synonyms=Long
IsoId=Q63487-1; Sequence=Displayed;
Note=According to PubMed:7499430 may not bind GTP.;
Name=2 {ECO:0000269|PubMed:7499430}; Synonyms=Short
IsoId=Q63487-2; Sequence=VSP_052074;
-!- TISSUE SPECIFICITY: 2 transcripts of 2.5 kb and 3.8 kb are
expressed at low levels in brain, testis, adrenal gland and
thymus. {ECO:0000269|PubMed:7499430}.
-!- SIMILARITY: Belongs to the GTR/RAG GTP-binding protein family.
-!- CAUTION: Has no detectable intrinsic GTPase activity according to
PubMed:7499430. {ECO:0000305}.
Copyrighted by the UniProt Consortium, see
Distributed under the Creative Commons Attribution (CC BY 4.0) License
EMBL; X85184; CAA59467.1; -; mRNA.
EMBL; BC078760; AAH78760.1; -; mRNA.
EMBL; BC087698; AAH87698.1; -; mRNA.
RefSeq; NP_446424.1; NM_053972.2. [Q63487-1]
RefSeq; XP_006256837.1; XM_006256775.3. [Q63487-2]
RefSeq; XP_006256841.1; XM_006256779.3. [Q63487-2]
RefSeq; XP_017457764.1; XM_017602275.1. [Q63487-1]
UniGene; Rn.203382; -.
UniGene; Rn.209947; -.
ProteinModelPortal; Q63487; -.
SMR; Q63487; -.
STRING; 10116.ENSRNOP00000066990; -.
jPOST; Q63487; -.
PaxDb; Q63487; -.
PRIDE; Q63487; -.
Ensembl; ENSRNOT00000004235; ENSRNOP00000004235; ENSRNOG00000003160. [Q63487-1]
Ensembl; ENSRNOT00000075249; ENSRNOP00000066990; ENSRNOG00000050535. [Q63487-1]
GeneID; 108348096; -.
GeneID; 117043; -.
KEGG; rno:108348096; -.
KEGG; rno:117043; -.
UCSC; RGD:619805; rat. [Q63487-1]
CTD; 10325; -.
RGD; 619805; RragB.
eggNOG; KOG3886; Eukaryota.
GeneTree; ENSGT00550000074769; -.
HOGENOM; HOG000173258; -.
HOVERGEN; HBG052715; -.
InParanoid; Q63487; -.
KO; K16185; -.
OrthoDB; 951213at2759; -.
PhylomeDB; Q63487; -.
TreeFam; TF300616; -.
Reactome; R-RNO-1632852; Macroautophagy.
Reactome; R-RNO-165159; mTOR signalling.
Reactome; R-RNO-166208; mTORC1-mediated signalling.
Reactome; R-RNO-380972; Energy dependent regulation of mTOR by LKB1-AMPK.
Reactome; R-RNO-5628897; TP53 Regulates Metabolic Genes.
Reactome; R-RNO-8943724; Regulation of PTEN gene transcription.
PRO; PR:Q63487; -.
Proteomes; UP000002494; Chromosome X.
Bgee; ENSRNOG00000003160; Expressed in 9 organ(s), highest expression level in brain.
Genevisible; Q63487; RN.
GO; GO:0005737; C:cytoplasm; ISS:HGNC.
GO; GO:0034448; C:EGO complex; IBA:GO_Central.
GO; GO:1990131; C:Gtr1-Gtr2 GTPase complex; IBA:GO_Central.
GO; GO:0005764; C:lysosome; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; IBA:GO_Central.
GO; GO:0005525; F:GTP binding; IDA:RGD.
GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
GO; GO:0032561; F:guanyl ribonucleotide binding; ISS:UniProtKB.
GO; GO:0034613; P:cellular protein localization; ISS:UniProtKB.
GO; GO:0071230; P:cellular response to amino acid stimulus; ISS:UniProtKB.
GO; GO:0009267; P:cellular response to starvation; IBA:GO_Central.
GO; GO:0032008; P:positive regulation of TOR signaling; ISS:UniProtKB.
GO; GO:0010506; P:regulation of autophagy; IBA:GO_Central.
CDD; cd11384; RagA_like; 1.
InterPro; IPR006762; Gtr1_RagA.
InterPro; IPR027417; P-loop_NTPase.
InterPro; IPR039397; RagA/B.
PANTHER; PTHR11259; PTHR11259; 1.
Pfam; PF04670; Gtr1_RagA; 1.
SUPFAM; SSF52540; SSF52540; 1.
1: Evidence at protein level;
Acetylation; Alternative splicing; Complete proteome; Cytoplasm;
GTP-binding; Isopeptide bond; Lysosome; Nucleotide-binding;
Reference proteome; Ubl conjugation.
CHAIN 1 374 Ras-related GTP-binding protein B.
NP_BIND 47 54 GTP. {ECO:0000250|UniProtKB:Q00582}.
NP_BIND 123 127 GTP. {ECO:0000250|UniProtKB:Q00582}.
NP_BIND 188 191 GTP. {ECO:0000250|UniProtKB:Q00582}.
MOD_RES 1 1 N-acetylmethionine.
CROSSLNK 203 203 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in ubiquitin).
CROSSLNK 281 281 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in ubiquitin).
CROSSLNK 291 291 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in ubiquitin).
CROSSLNK 305 305 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in ubiquitin).
VAR_SEQ 77 104 Missing (in isoform 2).
CONFLICT 262 262 D -> V (in Ref. 2; AAH78760).
SEQUENCE 374 AA; 43191 MW; 4F1F13AF06DDA16B CRC64;

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[RHOJ ARHJ RASL7B RHOI TCL] Rho-related GTP-binding protein RhoJ (Ras-like protein family member 7B) (Tc10-like GTP-binding protein)
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[RAB31 RAB22B] Ras-related protein Rab-31 (Ras-related protein Rab-22B)
[RHOQ ARHQ RASL7A TC10] Rho-related GTP-binding protein RhoQ (Ras-like protein TC10) (Ras-like protein family member 7A)
[Ran Rasl2-8] GTP-binding nuclear protein Ran (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein)
[RAB1B] Ras-related protein Rab-1B
[RAB9B RAB9L] Ras-related protein Rab-9B (Rab-9-like protein) (Rab-9L)
[RUNX1 AML1 CBFA2] Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit)
[Rab7a Rab7] Ras-related protein Rab-7a (Ras-related protein BRL-RAS) (Ras-related protein p23)
[RAN] GTP-binding nuclear protein Ran (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein)
[RAB39B] Ras-related protein Rab-39B
[Rab34 Rab39 Rah Rah1] Ras-related protein Rab-34 (Ras-related homolog) (Ras-related protein Rab-39) (Ras-related protein Rah)
[MRAS RRAS3] Ras-related protein M-Ras (Ras-related protein R-Ras3)
[ran] GTP-binding nuclear protein Ran (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein)
[Rhoq Arhq Tc10] Rho-related GTP-binding protein RhoQ (Ras-like protein TC10)
[Rhoq Tc10] Rho-related GTP-binding protein RhoQ (Ras-like protein TC10)
[Rab27a Rab27] Ras-related protein Rab-27A (Rab-27) (GTP-binding protein Ram) (Ram p25)
[RALB] Ras-related protein Ral-B
[RIT1 RIBB RIT ROC1] GTP-binding protein Rit1 (Ras-like protein expressed in many tissues) (Ras-like without CAAX protein 1)
[RAB8B] Ras-related protein Rab-8B
[Rab8b] Ras-related protein Rab-8B
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