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Receptor activity-modifying protein 2 (Calcitonin-receptor-like receptor activity-modifying protein 2) (CRLR activity-modifying protein 2)

 RAMP2_HUMAN             Reviewed;         175 AA.
O60895; A7L9S6; K7EMD3; Q8N1F2;
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
10-JAN-2003, sequence version 2.
13-FEB-2019, entry version 163.
RecName: Full=Receptor activity-modifying protein 2;
AltName: Full=Calcitonin-receptor-like receptor activity-modifying protein 2;
Short=CRLR activity-modifying protein 2;
Flags: Precursor;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
PubMed=9620797; DOI=10.1038/30666;
McLatchie L.M., Fraser N.J., Main M.J., Wise A., Brown J.,
Thompson N., Solari R., Lee M.G., Foord S.M.;
"RAMPs regulate the transport and ligand specificity of the
calcitonin-receptor-like receptor.";
Nature 393:333-339(1998).
Rorabaugh B.R., Witt K.M., Smith D.D., Abel P.W., Scofield M.A.;
"Characterization of adrenomedullin receptors and identification of a
receptor activity modifying protein 2 (RAMP2) variant in SV40LT-SMC
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
Kopatz S.A., Aronstam R.S., Sharma S.V.;
"cDNA clones of human proteins involved in signal transduction
sequenced by the Guthrie cDNA resource center (";
Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
PubMed=16625196; DOI=10.1038/nature04689;
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
"DNA sequence of human chromosome 17 and analysis of rearrangement in
the human lineage.";
Nature 440:1045-1049(2006).
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Structural genomics consortium (SGC);
"Structure of the extracellular domain of human RAMP2.";
Submitted (DEC-2010) to the PDB data bank.
PubMed=22102369; DOI=10.1002/pro.2003;
Kusano S., Kukimoto-Niino M., Hino N., Ohsawa N., Okuda K.,
Sakamoto K., Shirouzu M., Shindo T., Yokoyama S.;
"Structural basis for extracellular interactions between calcitonin
receptor-like receptor and receptor activity-modifying protein 2 for
adrenomedullin-specific binding.";
Protein Sci. 21:199-210(2012).
-!- FUNCTION: Transports the calcitonin gene-related peptide type 1
receptor (CALCRL) to the plasma membrane. Acts as a receptor for
adrenomedullin (AM) together with CALCRL.
{ECO:0000269|PubMed:22102369, ECO:0000269|PubMed:9620797}.
-!- SUBUNIT: Heterodimer of CALCRL and RAMP2. {ECO:0000250}.
Q16602:CALCRL; NbExp=6; IntAct=EBI-9009040, EBI-962878;
-!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
Event=Alternative splicing; Named isoforms=2;
IsoId=O60895-1; Sequence=Displayed;
IsoId=O60895-2; Sequence=VSP_055838;
-!- TISSUE SPECIFICITY: Strongly expressed in lung, breast, immune
system and fetal tissues. {ECO:0000269|PubMed:9620797}.
-!- SIMILARITY: Belongs to the RAMP family. {ECO:0000305}.
Copyrighted by the UniProt Consortium, see
Distributed under the Creative Commons Attribution (CC BY 4.0) License
EMBL; AJ001015; CAA04473.1; -; mRNA.
EMBL; EF687002; ABS28868.1; -; mRNA.
EMBL; AY265458; AAP23299.1; -; mRNA.
EMBL; AC100793; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC027975; AAH27975.1; -; mRNA.
CCDS; CCDS11437.1; -. [O60895-1]
RefSeq; NP_005845.2; NM_005854.2. [O60895-1]
UniGene; Hs.514193; -.
PDB; 2XVT; X-ray; 2.05 A; A/B/C/D/E/F=48-139.
PDB; 3AQE; X-ray; 2.00 A; A/B/C/D/E/F=56-139.
PDB; 3AQF; X-ray; 2.60 A; A=56-139.
PDB; 4RWF; X-ray; 1.76 A; A=55-138.
PDBsum; 2XVT; -.
PDBsum; 3AQE; -.
PDBsum; 3AQF; -.
PDBsum; 4RWF; -.
ProteinModelPortal; O60895; -.
SMR; O60895; -.
BioGrid; 115557; 1.
ComplexPortal; CPX-2191; Adrenomedullin receptor AM1 complex.
ComplexPortal; CPX-3186; Amylin receptor 2 complex.
CORUM; O60895; -.
IntAct; O60895; 3.
STRING; 9606.ENSP00000253796; -.
BindingDB; O60895; -.
ChEMBL; CHEMBL2364173; -.
DrugBank; DB01278; Pramlintide.
GuidetoPHARMACOLOGY; 52; -.
PhosphoSitePlus; O60895; -.
BioMuta; RAMP2; -.
EPD; O60895; -.
jPOST; O60895; -.
PaxDb; O60895; -.
PeptideAtlas; O60895; -.
PRIDE; O60895; -.
ProteomicsDB; 49658; -.
DNASU; 10266; -.
Ensembl; ENST00000253796; ENSP00000253796; ENSG00000131477. [O60895-1]
Ensembl; ENST00000587142; ENSP00000466455; ENSG00000131477. [O60895-2]
GeneID; 10266; -.
KEGG; hsa:10266; -.
UCSC; uc002ibg.5; human. [O60895-1]
CTD; 10266; -.
DisGeNET; 10266; -.
EuPathDB; HostDB:ENSG00000131477.10; -.
GeneCards; RAMP2; -.
HPA; HPA052020; -.
MIM; 605154; gene.
neXtProt; NX_O60895; -.
OpenTargets; ENSG00000131477; -.
PharmGKB; PA34203; -.
eggNOG; ENOG410IYPR; Eukaryota.
eggNOG; ENOG4112A9G; LUCA.
GeneTree; ENSGT00940000160264; -.
HOGENOM; HOG000230963; -.
HOVERGEN; HBG067366; -.
InParanoid; O60895; -.
KO; K08448; -.
OrthoDB; 1482534at2759; -.
PhylomeDB; O60895; -.
TreeFam; TF333286; -.
Reactome; R-HSA-418555; G alpha (s) signalling events.
Reactome; R-HSA-419812; Calcitonin-like ligand receptors.
ChiTaRS; RAMP2; human.
GeneWiki; RAMP2; -.
GenomeRNAi; 10266; -.
PRO; PR:O60895; -.
Proteomes; UP000005640; Chromosome 17.
Bgee; ENSG00000131477; Expressed in 167 organ(s), highest expression level in right lung.
ExpressionAtlas; O60895; baseline and differential.
Genevisible; O60895; HS.
GO; GO:1903143; C:adrenomedullin receptor complex; IDA:UniProtKB.
GO; GO:0150057; C:amylin receptor complex 2; IDA:ARUK-UCL.
GO; GO:0005623; C:cell; IDA:ARUK-UCL.
GO; GO:0009986; C:cell surface; IDA:UniProtKB.
GO; GO:0005905; C:clathrin-coated pit; TAS:ProtInc.
GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO; GO:0005764; C:lysosome; TAS:ProtInc.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0043235; C:receptor complex; IDA:UniProtKB.
GO; GO:1990409; F:adrenomedullin binding; IPI:UniProtKB.
GO; GO:0001605; F:adrenomedullin receptor activity; IPI:UniProtKB.
GO; GO:0015026; F:coreceptor activity; ISS:UniProtKB.
GO; GO:0008565; F:protein transporter activity; IDA:UniProtKB.
GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IGI:ARUK-UCL.
GO; GO:0034333; P:adherens junction assembly; IDA:UniProtKB.
GO; GO:1990410; P:adrenomedullin receptor signaling pathway; IPI:UniProtKB.
GO; GO:0097647; P:amylin receptor signaling pathway; IGI:ARUK-UCL.
GO; GO:0001525; P:angiogenesis; IDA:UniProtKB.
GO; GO:0070831; P:basement membrane assembly; ISS:UniProtKB.
GO; GO:0070830; P:bicellular tight junction assembly; IDA:UniProtKB.
GO; GO:0006816; P:calcium ion transport; IDA:UniProtKB.
GO; GO:0032870; P:cellular response to hormone stimulus; IBA:GO_Central.
GO; GO:0035924; P:cellular response to vascular endothelial growth factor stimulus; ISS:UniProtKB.
GO; GO:0007565; P:female pregnancy; IEA:Ensembl.
GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
GO; GO:0007507; P:heart development; ISS:UniProtKB.
GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
GO; GO:2000352; P:negative regulation of endothelial cell apoptotic process; IDA:UniProtKB.
GO; GO:0043116; P:negative regulation of vascular permeability; IDA:UniProtKB.
GO; GO:0045766; P:positive regulation of angiogenesis; ISS:UniProtKB.
GO; GO:0010628; P:positive regulation of gene expression; IDA:UniProtKB.
GO; GO:2001214; P:positive regulation of vasculogenesis; IEA:Ensembl.
GO; GO:0072659; P:protein localization to plasma membrane; IDA:UniProtKB.
GO; GO:0015031; P:protein transport; IDA:UniProtKB.
GO; GO:0031623; P:receptor internalization; IDA:UniProtKB.
GO; GO:0008217; P:regulation of blood pressure; ISS:UniProtKB.
GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:InterPro.
GO; GO:0032355; P:response to estradiol; IEA:Ensembl.
GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
GO; GO:0032570; P:response to progesterone; IEA:Ensembl.
GO; GO:0002040; P:sprouting angiogenesis; ISS:UniProtKB.
GO; GO:0097084; P:vascular smooth muscle cell development; ISS:UniProtKB.
GO; GO:0001570; P:vasculogenesis; IMP:UniProtKB.
Gene3D;; -; 1.
InterPro; IPR006985; RAMP.
InterPro; IPR038126; RAMP_sf.
PANTHER; PTHR14076; PTHR14076; 1.
Pfam; PF04901; RAMP; 1.
1: Evidence at protein level;
3D-structure; Alternative splicing; Complete proteome; Disulfide bond;
Glycoprotein; Membrane; Receptor; Reference proteome; Signal;
Transmembrane; Transmembrane helix; Transport.
SIGNAL 1 42 {ECO:0000255}.
CHAIN 43 175 Receptor activity-modifying protein 2.
TOPO_DOM 43 145 Extracellular. {ECO:0000255}.
TRANSMEM 146 166 Helical. {ECO:0000255}.
TOPO_DOM 167 175 Cytoplasmic. {ECO:0000255}.
CARBOHYD 130 130 N-linked (GlcNAc...) asparagine.
VAR_SEQ 54 54 E -> EASVPT (in isoform 2).
CONFLICT 13 13 R -> C (in Ref. 2; ABS28868).
CONFLICT 25 25 L -> V (in Ref. 1; CAA04473).
HELIX 49 54 {ECO:0000244|PDB:4RWF}.
HELIX 61 76 {ECO:0000244|PDB:4RWF}.
HELIX 77 82 {ECO:0000244|PDB:4RWF}.
HELIX 86 106 {ECO:0000244|PDB:4RWF}.
HELIX 114 126 {ECO:0000244|PDB:4RWF}.
TURN 127 130 {ECO:0000244|PDB:3AQE}.
SEQUENCE 175 AA; 19608 MW; AF69A9A461EFFCA3 CRC64;

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Pathways :
WP2272: Pathogenic Escherichia coli infection
WP2292: Chemokine signaling pathway
WP2197: Endothelin
WP1004: Kit Receptor Signaling Pathway
WP1011: T Cell Receptor Signaling Pathway
WP1014: Androgen receptor signaling pathway
WP1025: B Cell Receptor Signaling Pathway
WP1045: TGF-beta Receptor Signaling Pathway
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1049: G Protein Signaling Pathways
WP1067: Toll-like receptor signaling pathway
WP1112: EPO Receptor Signaling
WP1121: Kit Receptor Signaling Pathway
WP1130: T Cell Receptor Signaling Pathway
WP1133: Androgen receptor signaling pathway
WP1144: B Cell Receptor Signaling Pathway
WP1161: TGF-beta Receptor Signaling Pathway
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP1165: G Protein Signaling Pathways
WP1183: Toll-like receptor signaling pathway
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP1249: EPO Receptor Signaling
WP1271: Toll-like receptor signaling pathway
WP1284: EPO Receptor Signaling

Related Genes :
[Calcrl Crlr] Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor)
[CALCRL CGRPR] Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor)
[CALCRL CGRPR] Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor)
[GPER1 CEPR CMKRL2 DRY12 GPER GPR30] G-protein coupled estrogen receptor 1 (Chemoattractant receptor-like 2) (Flow-induced endothelial G-protein coupled receptor 1) (FEG-1) (G protein-coupled estrogen receptor 1) (G-protein coupled receptor 30) (GPCR-Br) (IL8-related receptor DRY12) (Lymphocyte-derived G-protein coupled receptor) (LYGPR) (Membrane estrogen receptor) (mER)
[Gper1 Cmkrl2 Gper Gpr30] G-protein coupled estrogen receptor 1 (Chemoattractant receptor-like 2) (G protein-coupled estrogen receptor 1) (G-protein coupled receptor 30) (Membrane estrogen receptor) (mER)
[Calcrl Cgrpr] Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor)
[daf-2 Y55D5A.5] Insulin-like receptor (IR) (EC (Abnormal dauer formation protein 2) [Cleaved into: Insulin-like receptor subunit alpha; Insulin-like receptor subunit beta]
[Rack1 Gnb2-rs1 Gnb2l1] Receptor of activated protein C kinase 1 (12-3) (Guanine nucleotide-binding protein subunit beta-2-like 1) (Receptor for activated C kinase) (Receptor of activated protein kinase C 1) (p205) [Cleaved into: Receptor of activated protein C kinase 1, N-terminally processed (Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed)]
[Med1 Crsp210 Drip205 Pbp Pparbp Trap220 Trip2] Mediator of RNA polymerase II transcription subunit 1 (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2)
[OR1D2 OLFR1] Olfactory receptor 1D2 (Olfactory receptor 17-4) (OR17-4) (Olfactory receptor OR17-6) (Olfactory receptor-like protein HGMP07E)
[Fcgr2 Fcgr2b Ly-17] Low affinity immunoglobulin gamma Fc region receptor II (Fc gamma receptor IIB) (Fc-gamma RII) (Fc-gamma-RIIB) (FcRII) (IgG Fc receptor II beta) (Lymphocyte antigen 17) (Ly-17) (CD antigen CD32)
[F2RL1 GPR11 PAR2] Proteinase-activated receptor 2 (PAR-2) (Coagulation factor II receptor-like 1) (G-protein coupled receptor 11) (Thrombin receptor-like 1) [Cleaved into: Proteinase-activated receptor 2, alternate cleaved 1; Proteinase-activated receptor 2, alternate cleaved 2]
[AHK4 CRE1 RAW1 WOL At2g01830 T23K3.2] Histidine kinase 4 (EC (Arabidopsis histidine kinase 4) (AtHK4) (Cytokinin receptor CYTOKININ RESPONSE 1) (AtCRE1) (Cytokinin receptor CRE1) (Phosphoprotein phosphatase AHK4) (EC (Protein AUTHENTIC HIS-KINASE 4) (Protein ROOT AS IN WOL 1) (Protein WOODEN LEG)
[PRNP PRN-P] Major prion protein homolog (65-21 protein) (Acetylcholine receptor-inducing activity) (ARIA) (PR-LP)
[vab-1 M03A1.1] Ephrin receptor 1 (EC (Tyrosine-protein kinase Eph receptor) (Variable abnormal protein 1)
[MED1 ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2] Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A)
[RARRES2 TIG2] Retinoic acid receptor responder protein 2 (Chemerin) (RAR-responsive protein TIG2) (Tazarotene-induced gene 2 protein)
[Epha2 Eck Myk2 Sek2] Ephrin type-A receptor 2 (EC (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK) (Tyrosine-protein kinase receptor MPK-5) (Tyrosine-protein kinase receptor SEK-2)
[NRG1 GGF HGL HRGA NDF SMDF] Pro-neuregulin-1, membrane-bound isoform (Pro-NRG1) [Cleaved into: Neuregulin-1 (Acetylcholine receptor-inducing activity) (ARIA) (Breast cancer cell differentiation factor p45) (Glial growth factor) (Heregulin) (HRG) (Neu differentiation factor) (Sensory and motor neuron-derived factor)]
[SUMF2 PSEC0171 UNQ1968/PRO4500] Inactive C-alpha-formylglycine-generating enzyme 2 (Paralog of formylglycine-generating enzyme) (pFGE) (Sulfatase-modifying factor 2)
[CRMB G2R G4R] Cytokine response-modifying protein B (CrmB) (Viral tumor necrosis factor receptor II) (vTNFR)
[ACVR1 ACVRLK2] Activin receptor type-1 (EC (Activin receptor type I) (ACTR-I) (Activin receptor-like kinase 2) (ALK-2) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I)
[PDGFRA PDGFR2 RHEPDGFRA] Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a)
[TRPV4 VRL2 VROAC] Transient receptor potential cation channel subfamily V member 4 (TrpV4) (Osm-9-like TRP channel 4) (OTRPC4) (Transient receptor potential protein 12) (TRP12) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC)
[BMPR2 PPH1] Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II)
[PELP1 HMX3 MNAR] Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of non-genomic activity of estrogen receptor) (Transcription factor HMX3)
[Ephb2 Epth3 Nuk Sek3] Ephrin type-B receptor 2 (EC (Neural kinase) (Nuk receptor tyrosine kinase) (Tyrosine-protein kinase receptor EPH-3) (Tyrosine-protein kinase receptor SEK-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2]
[TGFBR2] TGF-beta receptor type-2 (TGFR-2) (EC (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TGF-beta receptor type II) (TbetaR-II)
[Nr1h2 Lxrb] Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear receptor subfamily 1 group H member 2) (Orphan nuclear receptor OR-1) (Ubiquitously-expressed nuclear receptor) (UR)
[TGFBR1 ALK5 SKR4] TGF-beta receptor type-1 (TGFR-1) (EC (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)

Bibliography :
[27583470] Adrenomedullin2 (ADM2)/Intermedin (IMD): A Potential Role in the Pathophysiology of Preeclampsia.
[27108271] Effect of Valsartan on Cerebellar Adrenomedullin System Dysregulation During Hypertension.
[26927337] Hypercholesterolemia Up-Regulates the Expression of Intermedin and Its Receptor Components in the Aorta of Rats via Inducing the Oxidative Stress.
[26259851] Role of cerebellar adrenomedullin in blood pressure regulation.
[26014968] Intermedin is upregulated and attenuates renal fibrosis by inhibition of oxidative stress in rats with unilateral ureteral obstruction.
[25140812] Pharmacological characterization of the relaxant effect induced by adrenomedullin in rat cavernosal smooth muscle.
[24218431] Intermedin in paraventricular nucleus attenuates sympathetic activity and blood pressure via nitric oxide in hypertensive rats.
[24169318] Adrenomedullin expression in the developing human fetal lung.
[23849271] Temporo-spatial expression of adrenomedullin and its receptors in the bovine placenta.
[23585227] Regulation of myofibroblast differentiation and bleomycin-induced pulmonary fibrosis by adrenomedullin.