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Receptor of activated protein C kinase 1 (Guanine nucleotide-binding protein subunit beta-2-like 1) (Receptor for activated C kinase) (Receptor of activated protein kinase C 1) [Cleaved into: Receptor of activated protein C kinase 1, N-terminally processed]

 RACK1_RAT               Reviewed;         317 AA.
P63245; P25388; P99049;
11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 3.
23-FEB-2022, entry version 143.
RecName: Full=Receptor of activated protein C kinase 1;
AltName: Full=Guanine nucleotide-binding protein subunit beta-2-like 1;
AltName: Full=Receptor for activated C kinase;
AltName: Full=Receptor of activated protein kinase C 1;
Contains:
RecName: Full=Receptor of activated protein C kinase 1, N-terminally processed;
Name=Rack1 {ECO:0000312|RGD:69229}; Synonyms=Gnb2l1;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
STRAIN=Sprague-Dawley; TISSUE=Brain;
PubMed=8302854; DOI=10.1073/pnas.91.3.839;
Ron D., Chen C.-H., Caldwell J., Jamieson L., Orr E., Mochly-Rosen D.;
"Cloning of an intracellular receptor for protein kinase C: a homolog of
the beta subunit of G proteins.";
Proc. Natl. Acad. Sci. U.S.A. 91:839-843(1994).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Pituitary;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
PROTEIN SEQUENCE OF 45-57; 89-100; 107-118; 258-280 AND 309-317, AND
IDENTIFICATION BY MASS SPECTROMETRY.
STRAIN=Sprague-Dawley; TISSUE=Hippocampus;
PubMed=17569602; DOI=10.1016/j.bbapap.2007.05.002;
Diao W.F., Hoger H., Chen W.Q., Pollak A., Lubec G.;
"Hippocampal signaling protein levels are different in early and late
metestrus in the rat.";
Biochim. Biophys. Acta 1774:1044-1051(2007).
[4]
FUNCTION, AND SUBUNIT.
PubMed=15340087; DOI=10.1128/mcb.24.18.8276-8287.2004;
Gerbasi V.R., Weaver C.M., Hill S., Friedman D.B., Link A.J.;
"Yeast Asc1p and mammalian RACK1 are functionally orthologous core 40S
ribosomal proteins that repress gene expression.";
Mol. Cell. Biol. 24:8276-8287(2004).
-!- FUNCTION: Scaffolding protein involved in the recruitment, assembly
and/or regulation of a variety of signaling molecules. Interacts with a
wide variety of proteins and plays a role in many cellular processes.
Component of the 40S ribosomal subunit involved in translational
repression (PubMed:15340087). Involved in the initiation of the
ribosome quality control (RQC), a pathway that takes place when a
ribosome has stalled during translation, by promoting ubiquitination of
a subset of 40S ribosomal subunits (By similarity). Binds to and
stabilizes activated protein kinase C (PKC), increasing PKC-mediated
phosphorylation. May recruit activated PKC to the ribosome, leading to
phosphorylation of EIF6. Inhibits the activity of SRC kinases including
SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase
of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and
inhibits transcriptional activity of the BMAL1-CLOCK heterodimer.
Facilitates ligand-independent nuclear translocation of AR following
PKC activation, represses AR transactivation activity and is required
for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin
signaling and promotes cell spreading and contact with the
extracellular matrix. Involved in PKC-dependent translocation of ADAM12
to the cell membrane. Promotes the ubiquitination and proteasome-
mediated degradation of proteins such as CLEC1B and HIF1A. Required for
VANGL2 membrane localization, inhibits Wnt signaling, and regulates
cellular polarization and oriented cell division during gastrulation.
Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates
internalization of the muscarinic receptor CHRM2. Promotes apoptosis by
increasing oligomerization of BAX and disrupting the interaction of BAX
with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity.
Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a
role in regulation of FLT1-mediated cell migration. Involved in the
transport of ABCB4 from the Golgi to the apical bile canalicular
membrane. {ECO:0000250|UniProtKB:P63244, ECO:0000269|PubMed:15340087,
ECO:0000269|PubMed:8302854}.
-!- SUBUNIT: Monomer; also forms homodimers and homooligomers (By
similarity). Interacts with CPNE3 (By similarity). May interact with
ABCB4 (By similarity) Component of the small (40S) ribosomal subunit
(PubMed:15340087). Interacts with LARP4. Interacts with LARP4B.
Interacts with PKD2L1 (By similarity). Binds SLC9A3R1. Forms a ternary
complex with TRIM63 and PRKCE. Interacts with HABP4, KRT1 and OTUB1.
Interacts with SRC (via SH2 domain); the interaction is enhanced by
tyrosine phosphorylation of RACK1. Recruited in a circadian manner into
a nuclear complex which also includes BMAL1 and PRKCA. Interacts with
AR. Interacts with IGF1R but not with INSR. Interacts with ADAM12.
Interacts with CLEC1B (via N-terminal region) and with HIF1A; the
interaction promotes their degradation. Interacts with RHOA; this
enhances RHOA activation and promotes cell migration. Interacts with
CHRM2; the interaction regulates CHRM2 internalization. Interacts with
TRPM6 (via kinase domain). Interacts with PTK2/FAK1; required for
PTK2/FAK1 phosphorylation and dephosphorylation. Interacts with FLT1.
Interacts with HRAS. {ECO:0000250|UniProtKB:P63244,
ECO:0000269|PubMed:15340087}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P63244};
Peripheral membrane protein {ECO:0000250|UniProtKB:P63244}. Cytoplasm
{ECO:0000250|UniProtKB:P63244}. Cytoplasm, perinuclear region
{ECO:0000250|UniProtKB:P63244}. Nucleus {ECO:0000250|UniProtKB:P63244}.
Perikaryon {ECO:0000250|UniProtKB:P68040}. Cell projection, dendrite
{ECO:0000250|UniProtKB:P68040}. Note=Recruited to the plasma membrane
through interaction with KRT1 which binds to membrane-bound ITGB1. Also
associated with the membrane in oncogene-transformed cells. PKC
activation induces translocation from the perinuclear region to the
cell periphery (By similarity). In the brain, detected mainly in cell
bodies and dendrites with little expression in axonal fibers or nuclei
(By similarity). {ECO:0000250|UniProtKB:P63244,
ECO:0000250|UniProtKB:P68040}.
-!- DOMAIN: The 7 WD repeats mediate protein-protein interactions with
binding partners. {ECO:0000250|UniProtKB:P63244}.
-!- PTM: Phosphorylated on Tyr-228 and/or Tyr-246 by SRC. This is required
for binding to SRC (By similarity). {ECO:0000250}.
-!- SIMILARITY: Belongs to the WD repeat G protein beta family. Ribosomal
protein RACK1 subfamily. {ECO:0000305}.
---------------------------------------------------------------------------
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---------------------------------------------------------------------------
EMBL; U03390; AAA18951.1; -; mRNA.
EMBL; BC063809; AAH63809.1; -; mRNA.
PIR; A36986; A36986.
RefSeq; NP_570090.2; NM_130734.2.
SMR; P63245; -.
BioGRID; 249704; 6.
CORUM; P63245; -.
IntAct; P63245; 4.
MINT; P63245; -.
STRING; 10116.ENSRNOP00000003334; -.
iPTMnet; P63245; -.
PhosphoSitePlus; P63245; -.
jPOST; P63245; -.
PaxDb; P63245; -.
PRIDE; P63245; -.
Ensembl; ENSRNOT00000072179; ENSRNOP00000068758; ENSRNOG00000049070.
Ensembl; ENSRNOT00000084232; ENSRNOP00000074147; ENSRNOG00000052620.
GeneID; 83427; -.
KEGG; rno:83427; -.
UCSC; RGD:69229; rat.
CTD; 10399; -.
RGD; 69229; Rack1.
eggNOG; KOG0279; Eukaryota.
GeneTree; ENSGT00940000154461; -.
HOGENOM; CLU_000288_57_7_1; -.
InParanoid; P63245; -.
OMA; CKAMLWD; -.
OrthoDB; 805365at2759; -.
PhylomeDB; P63245; -.
TreeFam; TF300600; -.
Reactome; R-RNO-5357905; Regulation of TNFR1 signaling.
Reactome; R-RNO-5357956; TNFR1-induced NFkappaB signaling pathway.
Reactome; R-RNO-5626978; TNFR1-mediated ceramide production.
PRO; PR:P63245; -.
Proteomes; UP000002494; Chromosome 10.
Proteomes; UP000002494; Chromosome 12.
Bgee; ENSRNOG00000049070; Expressed in pancreas and 17 other tissues.
ExpressionAtlas; P63245; baseline and differential.
Genevisible; P63245; RN.
GO; GO:0044297; C:cell body; ISO:RGD.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005829; C:cytosol; IBA:GO_Central.
GO; GO:0030425; C:dendrite; ISO:RGD.
GO; GO:1990630; C:IRE1-RACK1-PP2A complex; ISO:RGD.
GO; GO:0016020; C:membrane; HDA:UniProtKB.
GO; GO:0030496; C:midbody; ISS:UniProtKB.
GO; GO:0005739; C:mitochondrion; ISO:RGD.
GO; GO:0043005; C:neuron projection; ISO:RGD.
GO; GO:0043025; C:neuronal cell body; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
GO; GO:0001891; C:phagocytic cup; ISS:UniProtKB.
GO; GO:0015935; C:small ribosomal subunit; IDA:UniProtKB.
GO; GO:0051434; F:BH3 domain binding; ISO:RGD.
GO; GO:0030332; F:cyclin binding; ISO:RGD.
GO; GO:0008656; F:cysteine-type endopeptidase activator activity involved in apoptotic process; ISO:RGD.
GO; GO:0019899; F:enzyme binding; ISO:RGD.
GO; GO:0008200; F:ion channel inhibitor activity; ISO:RGD.
GO; GO:0042803; F:protein homodimerization activity; ISO:RGD.
GO; GO:0005080; F:protein kinase C binding; IDA:UniProtKB.
GO; GO:0019903; F:protein phosphatase binding; ISO:RGD.
GO; GO:0030292; F:protein tyrosine kinase inhibitor activity; ISS:UniProtKB.
GO; GO:0030971; F:receptor tyrosine kinase binding; ISS:UniProtKB.
GO; GO:0043022; F:ribosome binding; ISS:UniProtKB.
GO; GO:0042169; F:SH2 domain binding; ISS:UniProtKB.
GO; GO:0035591; F:signaling adaptor activity; ISO:RGD.
GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; ISO:RGD.
GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
GO; GO:0071333; P:cellular response to glucose stimulus; ISO:RGD.
GO; GO:0071363; P:cellular response to growth factor stimulus; ISS:UniProtKB.
GO; GO:0007369; P:gastrulation; IEA:UniProtKB-KW.
GO; GO:0030308; P:negative regulation of cell growth; ISS:UniProtKB.
GO; GO:0010629; P:negative regulation of gene expression; ISO:RGD.
GO; GO:1903208; P:negative regulation of hydrogen peroxide-induced neuron death; ISO:RGD.
GO; GO:0033137; P:negative regulation of peptidyl-serine phosphorylation; ISO:RGD.
GO; GO:0050765; P:negative regulation of phagocytosis; ISS:UniProtKB.
GO; GO:0032091; P:negative regulation of protein binding; ISO:RGD.
GO; GO:0051898; P:negative regulation of protein kinase B signaling; ISO:RGD.
GO; GO:0045879; P:negative regulation of smoothened signaling pathway; ISO:RGD.
GO; GO:0017148; P:negative regulation of translation; IMP:UniProtKB.
GO; GO:0030178; P:negative regulation of Wnt signaling pathway; ISS:UniProtKB.
GO; GO:0001649; P:osteoblast differentiation; HDA:UniProtKB.
GO; GO:0043473; P:pigmentation; ISO:RGD.
GO; GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.
GO; GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.
GO; GO:0051343; P:positive regulation of cyclic-nucleotide phosphodiesterase activity; ISO:RGD.
GO; GO:2000543; P:positive regulation of gastrulation; ISS:UniProtKB.
GO; GO:0042998; P:positive regulation of Golgi to plasma membrane protein transport; ISS:UniProtKB.
GO; GO:0043547; P:positive regulation of GTPase activity; ISS:UniProtKB.
GO; GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; ISO:RGD.
GO; GO:0051901; P:positive regulation of mitochondrial depolarization; ISO:RGD.
GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
GO; GO:0001934; P:positive regulation of protein phosphorylation; ISS:UniProtKB.
GO; GO:0031334; P:positive regulation of protein-containing complex assembly; ISS:UniProtKB.
GO; GO:0007205; P:protein kinase C-activating G protein-coupled receptor signaling pathway; TAS:UniProtKB.
GO; GO:0016567; P:protein ubiquitination; ISS:UniProtKB.
GO; GO:0051726; P:regulation of cell cycle; ISS:UniProtKB.
GO; GO:0051302; P:regulation of cell division; ISS:UniProtKB.
GO; GO:2000114; P:regulation of establishment of cell polarity; ISS:UniProtKB.
GO; GO:0032880; P:regulation of protein localization; ISS:UniProtKB.
GO; GO:1903076; P:regulation of protein localization to plasma membrane; IMP:RGD.
GO; GO:0072344; P:rescue of stalled ribosome; ISS:UniProtKB.
GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
GO; GO:0006412; P:translation; ISO:RGD.
Gene3D; 2.130.10.10; -; 1.
InterPro; IPR045223; Asc1/RACK1.
InterPro; IPR020472; G-protein_beta_WD-40_rep.
InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
InterPro; IPR001680; WD40_repeat.
InterPro; IPR019775; WD40_repeat_CS.
InterPro; IPR036322; WD40_repeat_dom_sf.
PANTHER; PTHR19868; PTHR19868; 1.
Pfam; PF00400; WD40; 7.
PRINTS; PR00320; GPROTEINBRPT.
SMART; SM00320; WD40; 7.
SUPFAM; SSF50978; SSF50978; 1.
PROSITE; PS00678; WD_REPEATS_1; 4.
PROSITE; PS50082; WD_REPEATS_2; 6.
PROSITE; PS50294; WD_REPEATS_REGION; 1.
1: Evidence at protein level;
Acetylation; Apoptosis; Biological rhythms; Cell cycle; Cell membrane;
Cell projection; Cytoplasm; Developmental protein;
Direct protein sequencing; Gastrulation; Growth regulation; Membrane;
Nucleus; Phosphoprotein; Reference proteome; Repeat; Ribonucleoprotein;
Ribosomal protein; Translation regulation; WD repeat.
CHAIN 1..317
/note="Receptor of activated protein C kinase 1"
/id="PRO_0000127734"
INIT_MET 1
/note="Removed; alternate"
/evidence="ECO:0000250|UniProtKB:P63244"
CHAIN 2..317
/note="Receptor of activated protein C kinase 1, N-
terminally processed"
/id="PRO_0000424484"
REPEAT 13..44
/note="WD 1"
REPEAT 61..91
/note="WD 2"
REPEAT 103..133
/note="WD 3"
REPEAT 146..178
/note="WD 4"
REPEAT 190..220
/note="WD 5"
REPEAT 231..260
/note="WD 6"
REPEAT 281..311
/note="WD 7"
MOD_RES 1
/note="N-acetylmethionine"
/evidence="ECO:0000250|UniProtKB:P63244"
MOD_RES 2
/note="N-acetylthreonine; in Guanine nucleotide-binding
protein subunit beta-2-like 1, N-terminally processed"
/evidence="ECO:0000250|UniProtKB:P63244"
MOD_RES 6
/note="Phosphothreonine"
/evidence="ECO:0000250|UniProtKB:P63244"
MOD_RES 10
/note="Phosphothreonine"
/evidence="ECO:0000250|UniProtKB:P63244"
MOD_RES 52
/note="Phosphotyrosine; by ABL1"
/evidence="ECO:0000250|UniProtKB:P63244"
MOD_RES 96
/note="Phosphothreonine"
/evidence="ECO:0000250|UniProtKB:P63244"
MOD_RES 130
/note="N6-acetyllysine"
/evidence="ECO:0000250|UniProtKB:P63244"
MOD_RES 183
/note="N6-acetyllysine"
/evidence="ECO:0000250|UniProtKB:P68040"
MOD_RES 228
/note="Phosphotyrosine"
/evidence="ECO:0000250|UniProtKB:P63244"
MOD_RES 276
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:P63244"
MOD_RES 277
/note="Phosphothreonine"
/evidence="ECO:0000250|UniProtKB:P63244"
MOD_RES 278
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:P63244"
MOD_RES 279
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:P63244"
MOD_RES 316
/note="Phosphothreonine"
/evidence="ECO:0000250|UniProtKB:P68040"
CONFLICT 266
/note="I -> M (in Ref. 1; AAA18951)"
/evidence="ECO:0000305"
SEQUENCE 317 AA; 35077 MW; 257F91E369ED2044 CRC64;
MTEQMTLRGT LKGHNGWVTQ IATTPQFPDM ILSASRDKTI IMWKLTRDET NYGIPQRALR
GHSHFVSDVV ISSDGQFALS GSWDGTLRLW DLTTGTTTRR FVGHTKDVLS VAFSSDNRQI
VSGSRDKTIK LWNTLGVCKY TVQDESHSEW VSCVRFSPNS SNPIIVSCGW DKLVKVWNLA
NCKLKTNHIG HTGYLNTVTV SPDGSLCASG GKDGQAMLWD LNEGKHLYTL DGGDIINALC
FSPNRYWLCA ATGPSIKIWD LEGKIIVDEL KQEVISTSSK AEPPQCTSLA WSADGQTLFA
GYTDNLVRVW QVTIGTR


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Related Genes :
[Rack1 Gnb2-rs1 Gnb2l1] Receptor of activated protein C kinase 1 (12-3) (Guanine nucleotide-binding protein subunit beta-2-like 1) (Receptor for activated C kinase) (Receptor of activated protein kinase C 1) (p205) [Cleaved into: Receptor of activated protein C kinase 1, N-terminally processed (Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed)]
[RACK1 GNB2L1 HLC7 PIG21] Receptor of activated protein C kinase 1 (Cell proliferation-inducing gene 21 protein) (Guanine nucleotide-binding protein subunit beta-2-like 1) (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Human lung cancer oncogene 7 protein) (HLC-7) (Receptor for activated C kinase) (Small ribosomal subunit protein RACK1) [Cleaved into: Receptor of activated protein C kinase 1, N-terminally processed (Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed)]
[Rack1 Gnb2l1] Receptor of activated protein C kinase 1 (Guanine nucleotide-binding protein subunit beta-2-like 1) (Receptor for activated C kinase) (Receptor of activated protein kinase C 1) [Cleaved into: Receptor of activated protein C kinase 1, N-terminally processed]
[RACK1 GNB2L1] Receptor of activated protein C kinase 1 (Guanine nucleotide-binding protein subunit beta-2-like 1) (Receptor for activated C kinase) (Receptor of activated protein kinase C 1) [Cleaved into: Receptor of activated protein C kinase 1, N-terminally processed]
[RACK1 GNB2L1] Receptor of activated protein C kinase 1 (Guanine nucleotide-binding protein subunit beta-2-like 1) (Receptor for activated C kinase) (Receptor of activated protein kinase C 1) [Cleaved into: Receptor of activated protein C kinase 1, N-terminally processed]
[RACK1 GNB2L1] Receptor of activated protein C kinase 1 (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Receptor for activated C kinase) (Receptor of activated protein kinase C 1) (RACK1)
[RACK1B At1g48630 F11I4.18 F9P7.2] Receptor for activated C kinase 1B (Guanine nucleotide-binding protein subunit beta-like protein B)
[RACK1A ARCA At1g18080 T10F20.9 T10O22.6] Receptor for activated C kinase 1A (Guanine nucleotide-binding protein subunit beta-like protein A) (WD-40 repeat auxin-dependent protein ARCA)
[Tnk2 Ack1] Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2)
[RACK1C At3g18130 MRC8.11] Receptor for activated C kinase 1C (Guanine nucleotide-binding protein subunit beta-like protein C)
[F2RL1 GPR11 PAR2] Proteinase-activated receptor 2 (PAR-2) (Coagulation factor II receptor-like 1) (G-protein coupled receptor 11) (Thrombin receptor-like 1) [Cleaved into: Proteinase-activated receptor 2, alternate cleaved 1; Proteinase-activated receptor 2, alternate cleaved 2]
[Rps6ka2 Mapkapk1c Rsk3] Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Protein-tyrosine kinase Mpk-9) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3)
[Ywhab] 14-3-3 protein beta/alpha (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
[Mapk9 Jnk2 Prkm9] Mitogen-activated protein kinase 9 (MAP kinase 9) (MAPK 9) (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2)
[MPK4 At4g01370 F2N1.1 F2N1_2-t] Mitogen-activated protein kinase 4 (AtMPK4) (MAP kinase 4) (EC 2.7.11.24)
[Mapk1 Erk2 Mapk Prkm1] Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
[Erbb4 Mer4] Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)]
[Tab2 Kiaa0733 Map3k7ip2] TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TAK1-binding protein 2) (TAB-2) (TGF-beta-activated kinase 1-binding protein 2)
[Prkaa1] 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (EC 2.7.11.27) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26)
[Med1 Crsp210 Drip205 Pbp Pparbp Trap220 Trip2] Mediator of RNA polymerase II transcription subunit 1 (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2)
[Mapk8ip3 Jip3 Jsap1 Syd2] C-Jun-amino-terminal kinase-interacting protein 3 (JIP-3) (JNK-interacting protein 3) (JNK MAP kinase scaffold protein 3) (JNK/SAPK-associated protein 1) (JSAP1) (Mitogen-activated protein kinase 8-interacting protein 3) (Sunday driver 2)
[gnb2l1 rack1] Guanine nucleotide-binding protein subunit beta-2-like 1 (Receptor of activated protein kinase C) (RACK)
[AHK4 CRE1 RAW1 WOL At2g01830 T23K3.2] Histidine kinase 4 (EC 2.7.13.3) (Arabidopsis histidine kinase 4) (AtHK4) (Cytokinin receptor CYTOKININ RESPONSE 1) (AtCRE1) (Cytokinin receptor CRE1) (Phosphoprotein phosphatase AHK4) (EC 3.1.3.16) (Protein AUTHENTIC HIS-KINASE 4) (Protein ROOT AS IN WOL 1) (Protein WOODEN LEG)
[Mapk14 Crk1 Csbp1 Csbp2] Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (CRK1) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha)
[Eif2ak2 Pkr Prkr Tik] Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (P1/eIF-2A protein kinase) (Protein kinase RNA-activated) (PKR) (Protein kinase R) (Serine/threonine-protein kinase TIK) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2) (p68 kinase)
[TNK2 ACK1 ACK2] Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Activated CDC42 kinase 2) (Tyrosine kinase non-receptor protein 2)
[MAPK8 JNK1 PRKM8 SAPK1 SAPK1C] Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (JNK-46) (Stress-activated protein kinase 1c) (SAPK1c) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1)
[Rps6ka3 Mapkapk1b Rps6ka-rs1 Rsk2] Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2)
[Rack1 CG7111] Guanine nucleotide-binding protein subunit beta-like protein (Receptor of activated protein kinase C homolog)
[MAPK9 JNK2 PRKM9 SAPK1A] Mitogen-activated protein kinase 9 (MAP kinase 9) (MAPK 9) (EC 2.7.11.24) (JNK-55) (Stress-activated protein kinase 1a) (SAPK1a) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2)

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