GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Proto-oncogene c-ErbB-2) (p185erbB2) (CD antigen CD340)

 ERBB2_CANLF             Reviewed;        1259 AA.
O18735;
27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
01-JAN-1998, sequence version 1.
08-MAY-2019, entry version 150.
RecName: Full=Receptor tyrosine-protein kinase erbB-2;
EC=2.7.10.1;
AltName: Full=Proto-oncogene c-ErbB-2;
AltName: Full=p185erbB2;
AltName: CD_antigen=CD340;
Flags: Precursor;
Name=ERBB2;
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
Canis.
NCBI_TaxID=9615;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Mammary gland;
Yokota H.;
"cDNA cloning of erbB-2 from canine mammary gland.";
Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Protein tyrosine kinase that is part of several cell
surface receptor complexes, but that apparently needs a coreceptor
for ligand binding. Essential component of a neuregulin-receptor
complex, although neuregulins do not interact with it alone. GP30
is a potential ligand for this receptor. Regulates outgrowth and
stabilization of peripheral microtubules (MTs). Upon ERBB2
activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the
phosphorylation and thus the inhibition of GSK3B at cell membrane.
This prevents the phosphorylation of APC and CLASP2, allowing its
association with the cell membrane. In turn, membrane-bound APC
allows the localization of MACF1 to the cell membrane, which is
required for microtubule capture and stabilization (By
similarity). {ECO:0000250}.
-!- FUNCTION: In the nucleus is involved in transcriptional
regulation. Associates with the 5'-TCAAATTC-3' sequence in the
PTGS2/COX-2 promoter and activates its transcription. Implicated
in transcriptional activation of CDKN1A; the function involves
STAT3 and SRC. Involved in the transcription of rRNA genes by RNA
Pol I and enhances protein synthesis and cell growth (By
similarity). {ECO:0000250}.
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-
tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136,
Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
EC=2.7.10.1; Evidence={ECO:0000255|PROSITE-ProRule:PRU10028};
-!- SUBUNIT: Homodimer. Heterodimer with EGFR, ERBB3 and ERBB4. Part
of a complex with EGFR and either PIK3C2A or PIK3C2B. May interact
with PIK3C2B when phosphorylated on Tyr-1200. Interacts with
PRKCABP and PLXNB1. Interacts (when phosphorylated on Tyr-1252)
with MEMO1. Interacts with MUC1. Interacts (when phosphorylated on
Tyr-1138) with GRB7 (via SH2 domain). Interacts (when
phosphorylated on Tyr-1252) with ERBIN. Interacts with SRC, KPNB1,
PTK6, RANBP2, EEA1, CRM1, CLTC, RPA194, MYOC and ACTB. Interacts
(preferentially with the tyrosine phosphorylated form) with CPNE3;
this interaction occurs at the cell membrane and is increased in a
growth factor heregulin-dependent manner. Interacts with HSP90AA1
and HSP90AB1 in an ATP-dependent manner; the interaction
suppresses ERBB2 kinase activity (By similarity).
{ECO:0000250|UniProtKB:P04626, ECO:0000250|UniProtKB:P70424}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass
type I membrane protein {ECO:0000250}. Cytoplasm, perinuclear
region {ECO:0000250}. Nucleus {ECO:0000250}.
-!- PTM: Autophosphorylated. Autophosphorylation occurs in trans, i.e.
one subunit of the dimeric receptor phosphorylates tyrosine
residues on the other subunit. Ligand-binding increases
phosphorylation on tyrosine residues. Signaling via SEMA4C
promotes phosphorylation at Tyr-1252. Dephosphorylated by PTPN12.
{ECO:0000250|UniProtKB:P04626}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
kinase family. EGF receptor subfamily. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AB008451; BAA23127.1; -; mRNA.
SMR; O18735; -.
STRING; 9612.ENSCAFP00000024079; -.
PaxDb; O18735; -.
PRIDE; O18735; -.
eggNOG; KOG1025; Eukaryota.
eggNOG; ENOG410XNSR; LUCA.
HOGENOM; HOG000230982; -.
InParanoid; O18735; -.
Proteomes; UP000002254; Unplaced.
GO; GO:0009925; C:basal plasma membrane; IBA:GO_Central.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO; GO:0043235; C:receptor complex; IBA:GO_Central.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0001042; F:RNA polymerase I core binding; ISS:UniProtKB.
GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IBA:GO_Central.
GO; GO:0071364; P:cellular response to epidermal growth factor stimulus; ISS:UniProtKB.
GO; GO:0071363; P:cellular response to growth factor stimulus; ISS:UniProtKB.
GO; GO:0035556; P:intracellular signal transduction; ISS:UniProtKB.
GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
GO; GO:0030307; P:positive regulation of cell growth; ISS:UniProtKB.
GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
GO; GO:0043410; P:positive regulation of MAPK cascade; IBA:GO_Central.
GO; GO:0090314; P:positive regulation of protein targeting to membrane; ISS:UniProtKB.
GO; GO:0045943; P:positive regulation of transcription by RNA polymerase I; ISS:UniProtKB.
GO; GO:0045727; P:positive regulation of translation; ISS:UniProtKB.
GO; GO:0070372; P:regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.
GO; GO:0032886; P:regulation of microtubule-based process; ISS:UniProtKB.
GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
CDD; cd00064; FU; 3.
Gene3D; 3.80.20.20; -; 2.
InterPro; IPR006211; Furin-like_Cys-rich_dom.
InterPro; IPR006212; Furin_repeat.
InterPro; IPR032778; GF_recep_IV.
InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR000494; Rcpt_L-dom.
InterPro; IPR036941; Rcpt_L-dom_sf.
InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
InterPro; IPR008266; Tyr_kinase_AS.
InterPro; IPR020635; Tyr_kinase_cat_dom.
InterPro; IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
Pfam; PF00757; Furin-like; 1.
Pfam; PF14843; GF_recep_IV; 1.
Pfam; PF07714; Pkinase_Tyr; 1.
Pfam; PF01030; Recep_L_domain; 2.
PIRSF; PIRSF000619; TyrPK_EGF-R; 1.
PRINTS; PR00109; TYRKINASE.
SMART; SM00261; FU; 3.
SMART; SM00219; TyrKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
SUPFAM; SSF57184; SSF57184; 2.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
2: Evidence at transcript level;
Activator; ATP-binding; Cell membrane; Complete proteome; Cytoplasm;
Disulfide bond; Glycoprotein; Kinase; Membrane; Nucleotide-binding;
Nucleus; Phosphoprotein; Receptor; Reference proteome; Signal;
Transcription; Transcription regulation; Transferase; Transmembrane;
Transmembrane helix; Tyrosine-protein kinase.
SIGNAL 1 22 {ECO:0000255}.
CHAIN 23 1259 Receptor tyrosine-protein kinase erbB-2.
/FTId=PRO_0000016668.
TOPO_DOM 23 653 Extracellular. {ECO:0000255}.
TRANSMEM 654 674 Helical. {ECO:0000255}.
TOPO_DOM 675 1259 Cytoplasmic. {ECO:0000255}.
DOMAIN 719 986 Protein kinase. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
NP_BIND 725 733 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
REGION 675 688 Required for interaction with KPNB1 and
EEA1. {ECO:0000250}.
REGION 1199 1201 Interaction with PIK3C2B. {ECO:0000250}.
MOTIF 675 688 Nuclear localization signal.
{ECO:0000250}.
COMPBIAS 192 268 Cys-rich.
COMPBIAS 1101 1219 Pro-rich.
ACT_SITE 844 844 Proton acceptor. {ECO:0000255|PROSITE-
ProRule:PRU00159, ECO:0000255|PROSITE-
ProRule:PRU10028}.
BINDING 752 752 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
MOD_RES 182 182 Phosphothreonine.
{ECO:0000250|UniProtKB:P04626}.
MOD_RES 1077 1077 Phosphoserine.
{ECO:0000250|UniProtKB:P06494}.
MOD_RES 1082 1082 Phosphoserine.
{ECO:0000250|UniProtKB:P04626}.
MOD_RES 1106 1106 Phosphoserine.
{ECO:0000250|UniProtKB:P04626}.
MOD_RES 1111 1111 Phosphotyrosine.
{ECO:0000250|UniProtKB:P04626}.
MOD_RES 1138 1138 Phosphotyrosine; by autocatalysis.
{ECO:0000250|UniProtKB:P04626}.
MOD_RES 1165 1165 Phosphothreonine.
{ECO:0000250|UniProtKB:P04626}.
MOD_RES 1200 1200 Phosphotyrosine.
{ECO:0000250|UniProtKB:P04626}.
MOD_RES 1252 1252 Phosphotyrosine; by autocatalysis.
{ECO:0000250|UniProtKB:P04626}.
CARBOHYD 68 68 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 259 259 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 421 421 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 529 529 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 570 570 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 628 628 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 26 53 {ECO:0000250|UniProtKB:P04626}.
DISULFID 162 192 {ECO:0000250|UniProtKB:P04626}.
DISULFID 195 204 {ECO:0000250|UniProtKB:P04626}.
DISULFID 199 212 {ECO:0000250|UniProtKB:P04626}.
DISULFID 220 227 {ECO:0000250|UniProtKB:P04626}.
DISULFID 224 235 {ECO:0000250|UniProtKB:P04626}.
DISULFID 236 244 {ECO:0000250|UniProtKB:P04626}.
DISULFID 240 252 {ECO:0000250|UniProtKB:P04626}.
DISULFID 255 264 {ECO:0000250|UniProtKB:P04626}.
DISULFID 268 295 {ECO:0000250|UniProtKB:P04626}.
DISULFID 299 311 {ECO:0000250|UniProtKB:P04626}.
DISULFID 315 331 {ECO:0000250|UniProtKB:P04626}.
DISULFID 334 338 {ECO:0000250|UniProtKB:P04626}.
DISULFID 342 367 {ECO:0000250|UniProtKB:P04626}.
DISULFID 475 504 {ECO:0000250|UniProtKB:P04626}.
DISULFID 511 519 {ECO:0000250|UniProtKB:P04626}.
DISULFID 514 527 {ECO:0000250|UniProtKB:P04626}.
DISULFID 530 539 {ECO:0000250|UniProtKB:P04626}.
DISULFID 543 559 {ECO:0000250|UniProtKB:P04626}.
DISULFID 562 575 {ECO:0000250|UniProtKB:P04626}.
DISULFID 566 583 {ECO:0000250|UniProtKB:P04626}.
DISULFID 586 595 {ECO:0000250|UniProtKB:P04626}.
DISULFID 599 622 {ECO:0000250|UniProtKB:P04626}.
DISULFID 625 633 {ECO:0000250|UniProtKB:P04626}.
DISULFID 629 641 {ECO:0000250|UniProtKB:P04626}.
SEQUENCE 1259 AA; 137991 MW; E37364D49C4ACD46 CRC64;
MELAAWCRWG LLLALLPSGA AGTQVCTGTD MKLRLPASPE THLDMLRHLY QGCQVVQGNL
ELTYLPANAS LSFLQDIQEV QGYVLIAHSQ VRQIPLQRLR IVRGTQLFED NYALAVLDNG
DPLEGGIPAP GAAQGGLREL QLRSLTEILK GGVLIQRSPQ LCHQDTILWK DVFHKNNQLA
LTLIDTNRFS ACPPCSPACK DAHCWGASSG DCQSLTRTVC AGGCARCKGP QPTDCCHEQC
AAGCTGPKHS DCLACLHFNH SGICELHCPA LVTYNTDTFE SMPNPEGRYT FGASCVTSCP
YNYLSTDVGS CTLVCPLNNQ EVTAEDGTQR CEKCSKPCAR VCYGLGMEHL REVRAVTSAN
IQEFAGCKKI FGSLAFLPES FDGDPASNTA PLQPEQLRVF EALEEITGYL YISAWPDSLP
NLSVFQNLRV IRGRVLHDGA YSLTLQGLGI SWLGLRSLRE LGSGLALIHR NARLCFVHTV
PWDQLFRNPH QALLHSANRP EEECVGEGLA CYPCAHGHCW GPGPTQCVNC SQFLRGQECV
EECRVLQGLP REYVKDRYCL PCHSECQPQN GSVTCFGSEA DQCVACAHYK DPPFCVARCP
SGVKPDLSFM PIWKFADEEG TCQPCPINCT HSCADLDEKG CPAEQRASPV TSIIAAVVGI
LLAVVVGLVL GILIKRRRQK IRKYTMRRLL QETELVEPLT PSGAMPNQAQ MRILKETELR
KVKVLGSGAF GTVYKGIWIP DGENVKIPVA IKVLRENTSP KANKEILDEA YVMAGVGSPY
VSRLLGICLT STVQLVTQLM PYGCLLDHVR EHRGRLGSQD LLNWCVQIAK GMSYLEDVRL
VHRDLAARNV LVKSPNHVKI TDFGLARLLD IDETEYHADG GKVPIKWMAL ESIPPRRFTH
QSDVWSYGVT VWELMTFGAK PYDGIPAREI PDLLEKGERL PQPPICTIDV YMIMVKCWMI
DSECRPRFRE LVAEFSRMAR DPQRFVVIQN EDLGPASPLD STFYRSLLED DDMGDLVDAE
EYLVPQQGFF CPEPTPGAGG TAHRRHRSSS TRNGGGELTL GLEPSEEEPP KSPLAPSEGA
GSDVFDGDLG MGAAKGLQSL PSQDPSPLQR YSEDPTVPLP PETDGKVAPL TCSPQPEYVN
QPEVWPQPPL ALEGPLPPSR PAGATLERPK TLSPKTLSPG KNGVVKDVFA FGSAVENPEY
LAPRGRAAPQ PHPPPAFSPA FDNLYYWDQD PSERGSPPST FEGTPTAENP EYLGLDVPV


Related products :

Catalog number Product name Quantity
E0978m ELISA kit Erbb2,Kiaa3023,Mouse,Mus musculus,Neu,p185erbB2,Proto-oncogene c-ErbB-2,Proto-oncogene Neu,Receptor tyrosine-protein kinase erbB-2 96T
U0978m CLIA Erbb2,Kiaa3023,Mouse,Mus musculus,Neu,p185erbB2,Proto-oncogene c-ErbB-2,Proto-oncogene Neu,Receptor tyrosine-protein kinase erbB-2 96T
E0978m ELISA Erbb2,Kiaa3023,Mouse,Mus musculus,Neu,p185erbB2,Proto-oncogene c-ErbB-2,Proto-oncogene Neu,Receptor tyrosine-protein kinase erbB-2 96T
E0978h ELISA ERBB2,HER2,Homo sapiens,Human,Metastatic lymph node gene 19 protein,MLN 19,MLN19,NEU,NGL,p185erbB2,Proto-oncogene c-ErbB-2,Proto-oncogene Neu,Receptor tyrosine-protein kinase erbB-2,Tyrosine kin 96T
U0978h CLIA ERBB2,HER2,Homo sapiens,Human,Metastatic lymph node gene 19 protein,MLN 19,MLN19,NEU,NGL,p185erbB2,Proto-oncogene c-ErbB-2,Proto-oncogene Neu,Receptor tyrosine-protein kinase erbB-2,Tyrosine kina 96T
E0978r ELISA Epidermal growth factor receptor-related protein,Erbb2,Neu,p185erbB2,p185neu,Proto-oncogene c-ErbB-2,Proto-oncogene Neu,Rat,Rattus norvegicus,Receptor tyrosine-protein kinase erbB-2 96T
U0978r CLIA Epidermal growth factor receptor-related protein,Erbb2,Neu,p185erbB2,p185neu,Proto-oncogene c-ErbB-2,Proto-oncogene Neu,Rat,Rattus norvegicus,Receptor tyrosine-protein kinase erbB-2 96T
E0978r ELISA kit Epidermal growth factor receptor-related protein,Erbb2,Neu,p185erbB2,p185neu,Proto-oncogene c-ErbB-2,Proto-oncogene Neu,Rat,Rattus norvegicus,Receptor tyrosine-protein kinase erbB-2 96T
E0978h ELISA kit ERBB2,HER2,Homo sapiens,Human,Metastatic lymph node gene 19 protein,MLN 19,MLN19,NEU,NGL,p185erbB2,Proto-oncogene c-ErbB-2,Proto-oncogene Neu,Receptor tyrosine-protein kinase erbB-2,Tyrosin 96T
15-288-22631 Receptor tyrosine-protein kinase erbB-2 - EC 2.7.10.1; p185erbB2; C-erbB-2; NEU proto-oncogene; Tyrosine kinase-type cell surface receptor HER2; MLN 19 Polyclonal 0.1 mg
15-288-22631 Receptor tyrosine-protein kinase erbB-2 - EC 2.7.10.1; p185erbB2; C-erbB-2; NEU proto-oncogene; Tyrosine kinase-type cell surface receptor HER2; MLN 19 Polyclonal 0.05 mg
18-785-210195 HER2 (Ab-877) - EC 2.7.10.1; p185erbB2; C-erbB-2; NEU proto-oncogene; Tyrosine kinase-type cell surface receptor HER2; MLN 19; CD340 antigen Polyclonal 0.05 mg
18-785-210195 HER2 (Ab-877) - EC 2.7.10.1; p185erbB2; C-erbB-2; NEU proto-oncogene; Tyrosine kinase-type cell surface receptor HER2; MLN 19; CD340 antigen Polyclonal 0.1 mg
18-785-210196 HER2 (Ab-1221_1222) - EC 2.7.10.1; p185erbB2; C-erbB-2; NEU proto-oncogene; Tyrosine kinase-type cell surface receptor HER2; MLN 19; CD340 antigen Polyclonal 0.05 mg
18-785-210196 HER2 (Ab-1221_1222) - EC 2.7.10.1; p185erbB2; C-erbB-2; NEU proto-oncogene; Tyrosine kinase-type cell surface receptor HER2; MLN 19; CD340 antigen Polyclonal 0.1 mg
18-785-210197 HER2 (Ab-1248) - EC 2.7.10.1; p185erbB2; C-erbB-2; NEU proto-oncogene; Tyrosine kinase-type cell surface receptor HER2; MLN 19; CD340 antigen Polyclonal 0.1 mg
18-785-210197 HER2 (Ab-1248) - EC 2.7.10.1; p185erbB2; C-erbB-2; NEU proto-oncogene; Tyrosine kinase-type cell surface receptor HER2; MLN 19; CD340 antigen Polyclonal 0.05 mg
18-785-210193 HER2 (Phospho-Tyr1221_Tyr1222) - EC 2.7.10.1; p185erbB2; C-erbB-2; NEU proto-oncogene; Tyrosine kinase-type cell surface receptor HER2; MLN 19; CD340 antigen Polyclonal 0.05 mg
18-785-210192 HER2 (Phospho-Tyr877) - EC 2.7.10.1; p185erbB2; C-erbB-2; NEU proto-oncogene; Tyrosine kinase-type cell surface receptor HER2; MLN 19; CD340 antigen Polyclonal 0.05 mg
18-785-210192 HER2 (Phospho-Tyr877) - EC 2.7.10.1; p185erbB2; C-erbB-2; NEU proto-oncogene; Tyrosine kinase-type cell surface receptor HER2; MLN 19; CD340 antigen Polyclonal 0.1 mg
18-785-210194 HER2 (Phospho-Tyr1248) - EC 2.7.10.1; p185erbB2; C-erbB-2; NEU proto-oncogene; Tyrosine kinase-type cell surface receptor HER2; MLN 19; CD340 antigen Polyclonal 0.1 mg
18-785-210194 HER2 (Phospho-Tyr1248) - EC 2.7.10.1; p185erbB2; C-erbB-2; NEU proto-oncogene; Tyrosine kinase-type cell surface receptor HER2; MLN 19; CD340 antigen Polyclonal 0.05 mg
18-785-210193 HER2 (Phospho-Tyr1221_Tyr1222) - EC 2.7.10.1; p185erbB2; C-erbB-2; NEU proto-oncogene; Tyrosine kinase-type cell surface receptor HER2; MLN 19; CD340 antigen Polyclonal 0.1 mg
20-272-190599 ErbB2 - Rat monoclonal [ICR55] to ErbB2; EC 2.7.10.1; p185erbB2; C-erbB-2; NEU proto-oncogene; Tyrosine kinase-type cell surface receptor HER2; MLN 19; CD340 antigen Monoclonal 0.1 mg
20-272-191276 ErbB2 - Mouse monoclonal [N24] to ErbB2; EC 2.7.10.1; p185erbB2; C-erbB-2; NEU proto-oncogene; Tyrosine kinase-type cell surface receptor HER2; MLN 19; CD340 antigen Monoclonal 0.1 mg
Pathways :
WP807: ErbB signaling pathway
WP673: ErbB signaling pathway
WP2328: Allograft rejection
WP1160: ErbB signaling pathway
WP1714: Tyrosine metabolism
WP1366: ErbB signaling pathway
WP1044: ErbB signaling pathway
WP1261: ErbB signaling pathway
WP2292: Chemokine signaling pathway
WP1493: Carbon assimilation C4 pathway
WP1299: ErbB signaling pathway
WP924: ErbB signaling pathway
WP2272: Pathogenic Escherichia coli infection
WP1112: EPO Receptor Signaling
WP147: Kit Receptor Signaling Pathway
WP1694: Pyrimidine metabolism
WP232: G Protein Signaling Pathways
WP68: Androgen Receptor Signaling Pathway
WP1284: EPO Receptor Signaling
WP1659: Glycine, serine and threonine metabolism
WP1946: Cori Cycle
WP32: Translation Factors
WP829: Toll-like receptor signaling pathway
WP1336: EPO Receptor Signaling
WP1665: Limonene and pinene degradation

Related Genes :
[Erbb2 Kiaa3023 Neu] Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (p185erbB2) (CD antigen CD340)
[ERBB2 HER2 MLN19 NEU NGL] Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
[Erbb2 Neu] Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Epidermal growth factor receptor-related protein) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (p185erbB2) (p185neu) (CD antigen CD340)
[ERBB2 NEU] Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (p185erbB2) (CD antigen CD340)
[ERBB2] Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Proto-oncogene c-ErbB-2) (p185erbB2) (CD antigen CD340)
[EGFR ERBB ERBB1 HER1] Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
[Erbb4 Mer4] Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)]
[ERBB4 HER4] Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)]
[ERBB3 HER3] Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
[Erbb4 Tyro-2] Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)]
[Erbb3] Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Glial growth factor receptor) (Proto-oncogene-like protein c-ErbB-3)
[Erbb3] Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3)
[SRC SRC1] Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
[Ros1 Ros Ros-1] Proto-oncogene tyrosine-protein kinase ROS (EC 2.7.10.1) (Proto-oncogene c-Ros) (Proto-oncogene c-Ros-1) (Receptor tyrosine kinase c-ros oncogene 1) (c-Ros receptor tyrosine kinase)
[SRC] Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
[ABL1 ABL JTK7] Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
[KIT SCFR] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
[Src] Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
[Mertk Mer] Tyrosine-protein kinase Mer (EC 2.7.10.1) (Proto-oncogene c-Mer) (Receptor tyrosine kinase MerTK)
[Src] Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
[FGR SRC2] Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr)
[FGFR1 BFGFR CEK FGFBR FLG FLT2 HBGFR] Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
[Fyn] Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene c-Fyn) (p59-Fyn)
[ROS1 MCF3 ROS] Proto-oncogene tyrosine-protein kinase ROS (EC 2.7.10.1) (Proto-oncogene c-Ros) (Proto-oncogene c-Ros-1) (Receptor tyrosine kinase c-ros oncogene 1) (c-Ros receptor tyrosine kinase)
[Ros1] Proto-oncogene tyrosine-protein kinase ROS (EC 2.7.10.1) (Proto-oncogene c-Ros) (Proto-oncogene c-Ros-1) (Receptor tyrosine kinase c-ros oncogene 1) (c-Ros receptor tyrosine kinase)
[KIT] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
[src] Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
[Fgr] Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Proto-oncogene c-Fgr) (p55-Fgr)
[KIT] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
[RET CDHF12 CDHR16 PTC RET51] Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]

Bibliography :
No related Items