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Regulator of G-protein signaling 6 (RGS6) (S914)

 RGS6_HUMAN              Reviewed;         472 AA.
P49758; C9JE95; F8W7W5; O75576; O75577; Q7Z4K3; Q7Z4K4; Q7Z4K5;
Q7Z4K6; Q8TE13; Q8TE14; Q8TE15; Q8TE16; Q8TE17; Q8TE18; Q8TE19;
Q8TE20; Q8TE21; Q8TE22; Q9UDS8; Q9UDT0; Q9Y245; Q9Y647;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
25-NOV-2008, sequence version 5.
16-OCT-2019, entry version 183.
RecName: Full=Regulator of G-protein signaling 6;
Short=RGS6;
AltName: Full=S914;
Name=RGS6;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2; 5; 6; 7; 8;
9; 10; 11; 12; 13; 14; 15 AND 16), INTERACTION WITH GNB5, AND
SUBCELLULAR LOCATION.
PubMed=12761221; DOI=10.1074/jbc.m212687200;
Chatterjee T.K., Liu Z., Fisher R.A.;
"Human RGS6 gene structure, complex alternative splicing, and role of
N terminus and G protein gamma-subunit-like (GGL) domain in
subcellular localization of RGS6 splice variants.";
J. Biol. Chem. 278:30261-30271(2003).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), INTERACTION WITH GNB5,
AND MUTAGENESIS OF ASP-297 AND TRP-309.
TISSUE=Brain;
PubMed=10339615; DOI=10.1073/pnas.96.11.6489;
Snow B.E., Betts L., Mangion J., Sondek J., Siderovski D.P.;
"Fidelity of G protein beta-subunit association by the G protein
gamma-subunit-like domains of RGS6, RGS7, and RGS11.";
Proc. Natl. Acad. Sci. U.S.A. 96:6489-6494(1999).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH
GNB5, AND SUBCELLULAR LOCATION.
PubMed=10521509; DOI=10.1074/jbc.274.43.31087;
Posner B.A., Gilman A.G., Harris B.A.;
"Regulators of G protein signaling 6 and 7. Purification of complexes
with gbeta5 and assessment of their effects on g protein-mediated
signaling pathways.";
J. Biol. Chem. 274:31087-31093(1999).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=12508121; DOI=10.1038/nature01348;
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S.,
Sun H., Du H., Pepin K., Artiguenave F., Robert C., Cruaud C.,
Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P.,
Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N.,
Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C.,
Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S.,
Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B.,
Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M.,
Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S.,
Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D.,
Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A.,
Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L.,
Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J.,
Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W.,
Quetier F., Waterston R., Hood L., Weissenbach J.;
"The DNA sequence and analysis of human chromosome 14.";
Nature 421:601-607(2003).
[5]
NUCLEOTIDE SEQUENCE [MRNA] OF 362-472 (ISOFORM 1).
TISSUE=Brain;
PubMed=7596406; DOI=10.1038/375754a0;
Sherrington R., Rogaev E.I., Liang Y., Rogaeva E.A., Levesque G.,
Ikeda M., Chi H., Lin C., Li G., Holman K., Tsuda T., Mar L.,
Foncin J.-F., Bruni A.C., Montesi M.P., Sorbi S., Rainero I.,
Pinessi L., Nee L., Chumakov I., Pollen D., Brookes A., Sanseau P.,
Polinsky R.J., Wasco W., da Silva H.A.R., Haines J.L.,
Pericak-Vance M.A., Tanzi R.E., Roses A.D., Fraser P.E., Rommens J.M.,
St George-Hyslop P.H.;
"Cloning of a gene bearing missense mutations in early-onset familial
Alzheimer's disease.";
Nature 375:754-760(1995).
[6]
X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 325-470, AND INTERACTION WITH
GNAI1.
PubMed=18434541; DOI=10.1073/pnas.0801508105;
Soundararajan M., Willard F.S., Kimple A.J., Turnbull A.P., Ball L.J.,
Schoch G.A., Gileadi C., Fedorov O.Y., Dowler E.F., Higman V.A.,
Hutsell S.Q., Sundstroem M., Doyle D.A., Siderovski D.P.;
"Structural diversity in the RGS domain and its interaction with
heterotrimeric G protein alpha-subunits.";
Proc. Natl. Acad. Sci. U.S.A. 105:6457-6462(2008).
-!- FUNCTION: Regulates G protein-coupled receptor signaling cascades.
Inhibits signal transduction by increasing the GTPase activity of
G protein alpha subunits, thereby driving them into their inactive
GDP-bound form. The RGS6/GNB5 dimer enhances GNAO1 GTPase activity
(PubMed:10521509). {ECO:0000269|PubMed:10521509}.
-!- SUBUNIT: Interacts with GNB5 (PubMed:12761221, PubMed:10339615,
PubMed:10521509). Interacts with RGS7BP, leading to regulate the
subcellular location of the heterodimer formed with GNB5 (By
similarity). Interacts with GNAI1 (PubMed:18434541).
{ECO:0000250|UniProtKB:Q9Z2H2, ECO:0000269|PubMed:10339615,
ECO:0000269|PubMed:10521509, ECO:0000269|PubMed:12761221,
ECO:0000269|PubMed:18434541}.
-!- INTERACTION:
P08238:HSP90AB1; NbExp=2; IntAct=EBI-6426927, EBI-352572;
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12761221}.
Cytoplasm, cytosol {ECO:0000269|PubMed:10521509}. Membrane
{ECO:0000269|PubMed:10521509}; Peripheral membrane protein
{ECO:0000269|PubMed:10521509}. Nucleus
{ECO:0000269|PubMed:12761221}. Cell membrane
{ECO:0000250|UniProtKB:Q9Z2H2}. Note=Interaction with GNB5
mediates translocation to the nucleus.
{ECO:0000269|PubMed:12761221}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=15;
Comment=Additional isoforms seem to exist.
{ECO:0000269|PubMed:12761221};
Name=1; Synonyms=RGS6Lalpha2;
IsoId=P49758-4; Sequence=Displayed;
Name=2; Synonyms=RGS6Lgamma1, RGS6Lbeta1
{ECO:0000303|PubMed:12761221};
IsoId=P49758-2; Sequence=VSP_035848;
Name=3; Synonyms=RGS6Lalpha1;
IsoId=P49758-3; Sequence=VSP_035847;
Name=5; Synonyms=RGS6Lbeta;
IsoId=P49758-5; Sequence=VSP_035849;
Name=6; Synonyms=RGS6Lbeta-GGL;
IsoId=P49758-6; Sequence=VSP_035846, VSP_035849;
Name=7; Synonyms=RGS6Lalpha2-GGL;
IsoId=P49758-7; Sequence=VSP_035846;
Name=8; Synonyms=RGS6Lgamma2, RGS6Lbeta2
{ECO:0000303|PubMed:12761221};
IsoId=P49758-8; Sequence=VSP_035850;
Name=9; Synonyms=RGS6Lalpha1-GGL;
IsoId=P49758-9; Sequence=VSP_035846, VSP_035847;
Name=10; Synonyms=RGS6Lgamma1-GGL;
IsoId=P49758-10; Sequence=VSP_035846, VSP_035848;
Name=11; Synonyms=RGS6Lgamma2-GGL;
IsoId=P49758-11; Sequence=VSP_035846, VSP_035850;
Name=12; Synonyms=RGS6Sbeta1 {ECO:0000303|PubMed:12761221};
IsoId=P49758-12; Sequence=VSP_035845, VSP_035848;
Name=13; Synonyms=RGS6Lepsilon;
IsoId=P49758-13; Sequence=VSP_047806;
Name=14; Synonyms=RGS6Ldelta;
IsoId=P49758-14; Sequence=VSP_047807;
Name=15; Synonyms=RGS6Lgamma;
IsoId=P49758-15; Sequence=VSP_047808;
Name=16; Synonyms=RGS6Leta;
IsoId=P49758-16; Sequence=VSP_047809;
-!- DOMAIN: The RGS domain interacts avidly with Galpha and mediates
the acceleration of Galpha-mediated GTP hydrolysis.
-!- SEQUENCE CAUTION:
Sequence=AAC42001.1; Type=Frameshift; Evidence={ECO:0000305};
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EMBL; AF073920; AAC26049.2; -; mRNA.
EMBL; AF073921; AAC26050.1; -; mRNA.
EMBL; AY309097; AAP74386.1; -; mRNA.
EMBL; AY309098; AAP74387.1; -; mRNA.
EMBL; AY309099; AAP74388.1; -; mRNA.
EMBL; AY309100; AAP74389.1; -; mRNA.
EMBL; AF465727; AAM03004.1; -; Genomic_DNA.
EMBL; AF465711; AAM03004.1; JOINED; Genomic_DNA.
EMBL; AF465712; AAM03004.1; JOINED; Genomic_DNA.
EMBL; AF465713; AAM03004.1; JOINED; Genomic_DNA.
EMBL; AF465714; AAM03004.1; JOINED; Genomic_DNA.
EMBL; AF465715; AAM03004.1; JOINED; Genomic_DNA.
EMBL; AF465716; AAM03004.1; JOINED; Genomic_DNA.
EMBL; AF465717; AAM03004.1; JOINED; Genomic_DNA.
EMBL; AF465718; AAM03004.1; JOINED; Genomic_DNA.
EMBL; AF465719; AAM03004.1; JOINED; Genomic_DNA.
EMBL; AF465720; AAM03004.1; JOINED; Genomic_DNA.
EMBL; AF465721; AAM03004.1; JOINED; Genomic_DNA.
EMBL; AF465722; AAM03004.1; JOINED; Genomic_DNA.
EMBL; AF465723; AAM03004.1; JOINED; Genomic_DNA.
EMBL; AF465724; AAM03004.1; JOINED; Genomic_DNA.
EMBL; AF465725; AAM03004.1; JOINED; Genomic_DNA.
EMBL; AF465726; AAM03004.1; JOINED; Genomic_DNA.
EMBL; AF465727; AAM03005.1; -; Genomic_DNA.
EMBL; AF465711; AAM03005.1; JOINED; Genomic_DNA.
EMBL; AF465712; AAM03005.1; JOINED; Genomic_DNA.
EMBL; AF465713; AAM03005.1; JOINED; Genomic_DNA.
EMBL; AF465714; AAM03005.1; JOINED; Genomic_DNA.
EMBL; AF465715; AAM03005.1; JOINED; Genomic_DNA.
EMBL; AF465716; AAM03005.1; JOINED; Genomic_DNA.
EMBL; AF465717; AAM03005.1; JOINED; Genomic_DNA.
EMBL; AF465718; AAM03005.1; JOINED; Genomic_DNA.
EMBL; AF465719; AAM03005.1; JOINED; Genomic_DNA.
EMBL; AF465720; AAM03005.1; JOINED; Genomic_DNA.
EMBL; AF465721; AAM03005.1; JOINED; Genomic_DNA.
EMBL; AF465722; AAM03005.1; JOINED; Genomic_DNA.
EMBL; AF465723; AAM03005.1; JOINED; Genomic_DNA.
EMBL; AF465724; AAM03005.1; JOINED; Genomic_DNA.
EMBL; AF465725; AAM03005.1; JOINED; Genomic_DNA.
EMBL; AF465726; AAM03005.1; JOINED; Genomic_DNA.
EMBL; AF465726; AAM03006.1; -; Genomic_DNA.
EMBL; AF465711; AAM03006.1; JOINED; Genomic_DNA.
EMBL; AF465712; AAM03006.1; JOINED; Genomic_DNA.
EMBL; AF465713; AAM03006.1; JOINED; Genomic_DNA.
EMBL; AF465714; AAM03006.1; JOINED; Genomic_DNA.
EMBL; AF465715; AAM03006.1; JOINED; Genomic_DNA.
EMBL; AF465716; AAM03006.1; JOINED; Genomic_DNA.
EMBL; AF465717; AAM03006.1; JOINED; Genomic_DNA.
EMBL; AF465718; AAM03006.1; JOINED; Genomic_DNA.
EMBL; AF465719; AAM03006.1; JOINED; Genomic_DNA.
EMBL; AF465720; AAM03006.1; JOINED; Genomic_DNA.
EMBL; AF465721; AAM03006.1; JOINED; Genomic_DNA.
EMBL; AF465722; AAM03006.1; JOINED; Genomic_DNA.
EMBL; AF465723; AAM03006.1; JOINED; Genomic_DNA.
EMBL; AF465724; AAM03006.1; JOINED; Genomic_DNA.
EMBL; AF465725; AAM03006.1; JOINED; Genomic_DNA.
EMBL; AF465727; AAM03007.1; -; Genomic_DNA.
EMBL; AF465711; AAM03007.1; JOINED; Genomic_DNA.
EMBL; AF465712; AAM03007.1; JOINED; Genomic_DNA.
EMBL; AF465713; AAM03007.1; JOINED; Genomic_DNA.
EMBL; AF465714; AAM03007.1; JOINED; Genomic_DNA.
EMBL; AF465715; AAM03007.1; JOINED; Genomic_DNA.
EMBL; AF465716; AAM03007.1; JOINED; Genomic_DNA.
EMBL; AF465717; AAM03007.1; JOINED; Genomic_DNA.
EMBL; AF465718; AAM03007.1; JOINED; Genomic_DNA.
EMBL; AF465719; AAM03007.1; JOINED; Genomic_DNA.
EMBL; AF465720; AAM03007.1; JOINED; Genomic_DNA.
EMBL; AF465721; AAM03007.1; JOINED; Genomic_DNA.
EMBL; AF465723; AAM03007.1; JOINED; Genomic_DNA.
EMBL; AF465724; AAM03007.1; JOINED; Genomic_DNA.
EMBL; AF465725; AAM03007.1; JOINED; Genomic_DNA.
EMBL; AF465726; AAM03007.1; JOINED; Genomic_DNA.
EMBL; AF465727; AAM03008.1; -; Genomic_DNA.
EMBL; AF465711; AAM03008.1; JOINED; Genomic_DNA.
EMBL; AF465712; AAM03008.1; JOINED; Genomic_DNA.
EMBL; AF465713; AAM03008.1; JOINED; Genomic_DNA.
EMBL; AF465714; AAM03008.1; JOINED; Genomic_DNA.
EMBL; AF465715; AAM03008.1; JOINED; Genomic_DNA.
EMBL; AF465716; AAM03008.1; JOINED; Genomic_DNA.
EMBL; AF465717; AAM03008.1; JOINED; Genomic_DNA.
EMBL; AF465718; AAM03008.1; JOINED; Genomic_DNA.
EMBL; AF465719; AAM03008.1; JOINED; Genomic_DNA.
EMBL; AF465720; AAM03008.1; JOINED; Genomic_DNA.
EMBL; AF465721; AAM03008.1; JOINED; Genomic_DNA.
EMBL; AF465723; AAM03008.1; JOINED; Genomic_DNA.
EMBL; AF465724; AAM03008.1; JOINED; Genomic_DNA.
EMBL; AF465725; AAM03008.1; JOINED; Genomic_DNA.
EMBL; AF465726; AAM03008.1; JOINED; Genomic_DNA.
EMBL; AF465727; AAM03009.1; -; Genomic_DNA.
EMBL; AF465711; AAM03009.1; JOINED; Genomic_DNA.
EMBL; AF465712; AAM03009.1; JOINED; Genomic_DNA.
EMBL; AF465713; AAM03009.1; JOINED; Genomic_DNA.
EMBL; AF465714; AAM03009.1; JOINED; Genomic_DNA.
EMBL; AF465715; AAM03009.1; JOINED; Genomic_DNA.
EMBL; AF465716; AAM03009.1; JOINED; Genomic_DNA.
EMBL; AF465717; AAM03009.1; JOINED; Genomic_DNA.
EMBL; AF465718; AAM03009.1; JOINED; Genomic_DNA.
EMBL; AF465719; AAM03009.1; JOINED; Genomic_DNA.
EMBL; AF465720; AAM03009.1; JOINED; Genomic_DNA.
EMBL; AF465721; AAM03009.1; JOINED; Genomic_DNA.
EMBL; AF465722; AAM03009.1; JOINED; Genomic_DNA.
EMBL; AF465723; AAM03009.1; JOINED; Genomic_DNA.
EMBL; AF465724; AAM03009.1; JOINED; Genomic_DNA.
EMBL; AF465725; AAM03009.1; JOINED; Genomic_DNA.
EMBL; AF465727; AAM03010.1; -; Genomic_DNA.
EMBL; AF465711; AAM03010.1; JOINED; Genomic_DNA.
EMBL; AF465712; AAM03010.1; JOINED; Genomic_DNA.
EMBL; AF465713; AAM03010.1; JOINED; Genomic_DNA.
EMBL; AF465714; AAM03010.1; JOINED; Genomic_DNA.
EMBL; AF465715; AAM03010.1; JOINED; Genomic_DNA.
EMBL; AF465716; AAM03010.1; JOINED; Genomic_DNA.
EMBL; AF465717; AAM03010.1; JOINED; Genomic_DNA.
EMBL; AF465718; AAM03010.1; JOINED; Genomic_DNA.
EMBL; AF465719; AAM03010.1; JOINED; Genomic_DNA.
EMBL; AF465720; AAM03010.1; JOINED; Genomic_DNA.
EMBL; AF465721; AAM03010.1; JOINED; Genomic_DNA.
EMBL; AF465722; AAM03010.1; JOINED; Genomic_DNA.
EMBL; AF465723; AAM03010.1; JOINED; Genomic_DNA.
EMBL; AF465724; AAM03010.1; JOINED; Genomic_DNA.
EMBL; AF465725; AAM03010.1; JOINED; Genomic_DNA.
EMBL; AF465727; AAM03011.1; -; Genomic_DNA.
EMBL; AF465711; AAM03011.1; JOINED; Genomic_DNA.
EMBL; AF465712; AAM03011.1; JOINED; Genomic_DNA.
EMBL; AF465713; AAM03011.1; JOINED; Genomic_DNA.
EMBL; AF465714; AAM03011.1; JOINED; Genomic_DNA.
EMBL; AF465715; AAM03011.1; JOINED; Genomic_DNA.
EMBL; AF465716; AAM03011.1; JOINED; Genomic_DNA.
EMBL; AF465717; AAM03011.1; JOINED; Genomic_DNA.
EMBL; AF465718; AAM03011.1; JOINED; Genomic_DNA.
EMBL; AF465719; AAM03011.1; JOINED; Genomic_DNA.
EMBL; AF465720; AAM03011.1; JOINED; Genomic_DNA.
EMBL; AF465721; AAM03011.1; JOINED; Genomic_DNA.
EMBL; AF465723; AAM03011.1; JOINED; Genomic_DNA.
EMBL; AF465724; AAM03011.1; JOINED; Genomic_DNA.
EMBL; AF465725; AAM03011.1; JOINED; Genomic_DNA.
EMBL; AF465727; AAM03012.1; -; Genomic_DNA.
EMBL; AF465711; AAM03012.1; JOINED; Genomic_DNA.
EMBL; AF465712; AAM03012.1; JOINED; Genomic_DNA.
EMBL; AF465713; AAM03012.1; JOINED; Genomic_DNA.
EMBL; AF465714; AAM03012.1; JOINED; Genomic_DNA.
EMBL; AF465715; AAM03012.1; JOINED; Genomic_DNA.
EMBL; AF465716; AAM03012.1; JOINED; Genomic_DNA.
EMBL; AF465717; AAM03012.1; JOINED; Genomic_DNA.
EMBL; AF465718; AAM03012.1; JOINED; Genomic_DNA.
EMBL; AF465719; AAM03012.1; JOINED; Genomic_DNA.
EMBL; AF465720; AAM03012.1; JOINED; Genomic_DNA.
EMBL; AF465721; AAM03012.1; JOINED; Genomic_DNA.
EMBL; AF465723; AAM03012.1; JOINED; Genomic_DNA.
EMBL; AF465724; AAM03012.1; JOINED; Genomic_DNA.
EMBL; AF465725; AAM03012.1; JOINED; Genomic_DNA.
EMBL; AF465726; AAM03013.1; -; Genomic_DNA.
EMBL; AF465711; AAM03013.1; JOINED; Genomic_DNA.
EMBL; AF465712; AAM03013.1; JOINED; Genomic_DNA.
EMBL; AF465713; AAM03013.1; JOINED; Genomic_DNA.
EMBL; AF465714; AAM03013.1; JOINED; Genomic_DNA.
EMBL; AF465715; AAM03013.1; JOINED; Genomic_DNA.
EMBL; AF465716; AAM03013.1; JOINED; Genomic_DNA.
EMBL; AF465717; AAM03013.1; JOINED; Genomic_DNA.
EMBL; AF465718; AAM03013.1; JOINED; Genomic_DNA.
EMBL; AF465719; AAM03013.1; JOINED; Genomic_DNA.
EMBL; AF465720; AAM03013.1; JOINED; Genomic_DNA.
EMBL; AF465721; AAM03013.1; JOINED; Genomic_DNA.
EMBL; AF465723; AAM03013.1; JOINED; Genomic_DNA.
EMBL; AF465724; AAM03013.1; JOINED; Genomic_DNA.
EMBL; AF465725; AAM03013.1; JOINED; Genomic_DNA.
EMBL; AF107619; AAD34717.1; -; mRNA.
EMBL; AF107620; AAD34718.1; -; mRNA.
EMBL; AF156932; AAD40183.1; -; mRNA.
EMBL; AC004828; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AC005157; AAC83180.1; -; Genomic_DNA.
EMBL; AC005226; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AC005227; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AC005477; AAD05031.1; -; Genomic_DNA.
EMBL; AC005533; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AC005857; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AC005993; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; L40394; AAC42001.1; ALT_FRAME; mRNA.
CCDS; CCDS55924.1; -. [P49758-3]
CCDS; CCDS9808.1; -. [P49758-4]
RefSeq; NP_001191345.1; NM_001204416.2. [P49758-3]
RefSeq; NP_001191346.1; NM_001204417.2. [P49758-2]
RefSeq; NP_001191347.1; NM_001204418.2. [P49758-8]
RefSeq; NP_001191348.1; NM_001204419.2. [P49758-9]
RefSeq; NP_001191349.1; NM_001204420.2. [P49758-7]
RefSeq; NP_001191350.1; NM_001204421.2. [P49758-10]
RefSeq; NP_001191351.1; NM_001204422.2. [P49758-11]
RefSeq; NP_001191352.1; NM_001204423.1.
RefSeq; NP_001191353.1; NM_001204424.1. [P49758-3]
RefSeq; NP_004287.3; NM_004296.6. [P49758-4]
RefSeq; XP_016877315.1; XM_017021826.1. [P49758-13]
RefSeq; XP_016877318.1; XM_017021829.1.
RefSeq; XP_016877319.1; XM_017021830.1. [P49758-5]
RefSeq; XP_016877321.1; XM_017021832.1. [P49758-16]
RefSeq; XP_016877323.1; XM_017021834.1. [P49758-12]
PDB; 2ES0; X-ray; 2.10 A; A=325-470.
PDBsum; 2ES0; -.
SMR; P49758; -.
BioGrid; 114987; 10.
CORUM; P49758; -.
IntAct; P49758; 9.
STRING; 9606.ENSP00000451030; -.
iPTMnet; P49758; -.
PhosphoSitePlus; P49758; -.
BioMuta; RGS6; -.
DMDM; 215274268; -.
MassIVE; P49758; -.
PaxDb; P49758; -.
PeptideAtlas; P49758; -.
PRIDE; P49758; -.
ProteomicsDB; 56079; -. [P49758-4]
ProteomicsDB; 56080; -. [P49758-10]
ProteomicsDB; 56081; -. [P49758-11]
ProteomicsDB; 56082; -. [P49758-12]
ProteomicsDB; 56083; -. [P49758-2]
ProteomicsDB; 56084; -. [P49758-3]
ProteomicsDB; 56085; -. [P49758-5]
ProteomicsDB; 56086; -. [P49758-6]
ProteomicsDB; 56087; -. [P49758-7]
ProteomicsDB; 56088; -. [P49758-8]
ProteomicsDB; 56089; -. [P49758-9]
ProteomicsDB; 69197; -.
ProteomicsDB; 69198; -.
ProteomicsDB; 69199; -.
ProteomicsDB; 69200; -.
DNASU; 9628; -.
Ensembl; ENST00000355512; ENSP00000347699; ENSG00000182732. [P49758-16]
Ensembl; ENST00000404301; ENSP00000385243; ENSG00000182732. [P49758-15]
Ensembl; ENST00000406236; ENSP00000384218; ENSG00000182732. [P49758-13]
Ensembl; ENST00000407322; ENSP00000384612; ENSG00000182732. [P49758-14]
Ensembl; ENST00000553525; ENSP00000451030; ENSG00000182732. [P49758-3]
Ensembl; ENST00000553530; ENSP00000452331; ENSG00000182732. [P49758-4]
Ensembl; ENST00000554474; ENSP00000450858; ENSG00000182732. [P49758-5]
Ensembl; ENST00000554782; ENSP00000451912; ENSG00000182732. [P49758-12]
Ensembl; ENST00000555571; ENSP00000450936; ENSG00000182732. [P49758-4]
Ensembl; ENST00000556437; ENSP00000451855; ENSG00000182732. [P49758-3]
GeneID; 9628; -.
KEGG; hsa:9628; -.
UCSC; uc001xmy.5; human. [P49758-4]
CTD; 9628; -.
DisGeNET; 9628; -.
GeneCards; RGS6; -.
HGNC; HGNC:10002; RGS6.
HPA; HPA003067; -.
MIM; 603894; gene.
neXtProt; NX_P49758; -.
OpenTargets; ENSG00000182732; -.
PharmGKB; PA34377; -.
eggNOG; KOG3589; Eukaryota.
eggNOG; ENOG410YMJD; LUCA.
GeneTree; ENSGT00940000157159; -.
HOGENOM; HOG000220864; -.
InParanoid; P49758; -.
KO; K16449; -.
OMA; CRRERNP; -.
OrthoDB; 582058at2759; -.
PhylomeDB; P49758; -.
TreeFam; TF351956; -.
Reactome; R-HSA-418594; G alpha (i) signalling events.
Reactome; R-HSA-6814122; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
SIGNOR; P49758; -.
ChiTaRS; RGS6; human.
EvolutionaryTrace; P49758; -.
GeneWiki; RGS6; -.
GenomeRNAi; 9628; -.
Pharos; P49758; -.
PRO; PR:P49758; -.
Proteomes; UP000005640; Chromosome 14.
Bgee; ENSG00000182732; Expressed in 127 organ(s), highest expression level in frontal cortex.
ExpressionAtlas; P49758; baseline and differential.
Genevisible; P49758; HS.
GO; GO:0005829; C:cytosol; IDA:UniProtKB.
GO; GO:0019898; C:extrinsic component of membrane; IDA:UniProtKB.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0005096; F:GTPase activator activity; IDA:UniProtKB.
GO; GO:0003924; F:GTPase activity; TAS:Reactome.
GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:Reactome.
GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
GO; GO:0043547; P:positive regulation of GTPase activity; IDA:UniProtKB.
GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; TAS:ProtInc.
CDD; cd00068; GGL; 1.
CDD; cd08737; RGS_RGS6; 1.
Gene3D; 1.10.10.10; -; 1.
Gene3D; 1.10.196.10; -; 2.
Gene3D; 4.10.260.10; -; 1.
InterPro; IPR000591; DEP_dom.
InterPro; IPR015898; G-protein_gamma-like_dom.
InterPro; IPR036284; GGL_sf.
InterPro; IPR016137; RGS.
InterPro; IPR037956; RGS6_RGS.
InterPro; IPR040759; RGS_DHEX.
InterPro; IPR036305; RGS_sf.
InterPro; IPR024066; RGS_subdom1/3.
InterPro; IPR036388; WH-like_DNA-bd_sf.
InterPro; IPR036390; WH_DNA-bd_sf.
Pfam; PF00610; DEP; 1.
Pfam; PF00631; G-gamma; 1.
Pfam; PF00615; RGS; 1.
Pfam; PF18148; RGS_DHEX; 1.
PRINTS; PR01301; RGSPROTEIN.
SMART; SM00049; DEP; 1.
SMART; SM00224; GGL; 1.
SMART; SM00315; RGS; 1.
SUPFAM; SSF46785; SSF46785; 1.
SUPFAM; SSF48097; SSF48097; 1.
SUPFAM; SSF48670; SSF48670; 1.
PROSITE; PS50186; DEP; 1.
PROSITE; PS50132; RGS; 1.
1: Evidence at protein level;
3D-structure; Alternative splicing; Cell membrane; Complete proteome;
Cytoplasm; GTPase activation; Membrane; Nucleus; Reference proteome;
Signal transduction inhibitor.
CHAIN 1 472 Regulator of G-protein signaling 6.
/FTId=PRO_0000204192.
DOMAIN 40 115 DEP. {ECO:0000255|PROSITE-
ProRule:PRU00066}.
DOMAIN 261 330 G protein gamma.
DOMAIN 336 441 RGS. {ECO:0000255|PROSITE-
ProRule:PRU00171}.
VAR_SEQ 1 139 Missing (in isoform 12).
{ECO:0000303|PubMed:12761221}.
/FTId=VSP_035845.
VAR_SEQ 285 321 Missing (in isoform 6, isoform 7, isoform
9, isoform 10 and isoform 11).
{ECO:0000303|PubMed:12761221}.
/FTId=VSP_035846.
VAR_SEQ 456 456 K -> KPESEQGRRTSLEKFTRSV (in isoform 3
and isoform 9).
{ECO:0000303|PubMed:10339615,
ECO:0000303|PubMed:12761221}.
/FTId=VSP_035847.
VAR_SEQ 457 472 GKSLAGKRLTGLMQSS -> PESEQGRRTSLEKFTRSVG
(in isoform 13).
{ECO:0000303|PubMed:12761221}.
/FTId=VSP_047806.
VAR_SEQ 457 472 GKSLAGKRLTGLMQSS -> PESEQGRRTSLEKFTRSVLLF
(in isoform 14).
{ECO:0000303|PubMed:12761221}.
/FTId=VSP_047807.
VAR_SEQ 457 472 GKSLAGKRLTGLMQSS -> PESEQGRRTSLEKFTRSVCLQ
LLF (in isoform 15).
{ECO:0000303|PubMed:12761221}.
/FTId=VSP_047808.
VAR_SEQ 457 472 GKSLAGKRLTGLMQSS -> VWLL (in isoform 16).
{ECO:0000303|PubMed:12761221}.
/FTId=VSP_047809.
VAR_SEQ 457 472 GKSLAGKRLTGLMQSS -> PESEQGRRTSLEKFTRSVLYS
NTPLAKRP (in isoform 2, isoform 10 and
isoform 12).
{ECO:0000303|PubMed:12761221}.
/FTId=VSP_035848.
VAR_SEQ 457 472 GKSLAGKRLTGLMQSS -> KVSKVVELP (in isoform
5 and isoform 6).
{ECO:0000303|PubMed:12761221}.
/FTId=VSP_035849.
VAR_SEQ 457 472 GKSLAGKRLTGLMQSS -> LYSNTPLAKRP (in
isoform 8 and isoform 11).
{ECO:0000303|PubMed:12761221}.
/FTId=VSP_035850.
MUTAGEN 297 297 D->A: Loss of interaction with GNB5.
{ECO:0000269|PubMed:10339615}.
MUTAGEN 309 309 W->F: Diminishes interaction with GNB5.
{ECO:0000269|PubMed:10339615}.
CONFLICT 165 165 R -> K (in Ref. 1; AAC26049/AAM03004/
AAM03005/AAM03006/AAM03007/AAM03008/
AAM03009/AAM03010/AAM03011/AAM03012/
AAM03013). {ECO:0000305}.
CONFLICT 210 210 V -> L (in Ref. 1; AAC26049/AAM03004/
AAM03005/AAM03006/AAM03007/AAM03008/
AAM03009/AAM03010/AAM03011/AAM03012/
AAM03013). {ECO:0000305}.
CONFLICT 312 313 DD -> EE (in Ref. 1; AAC26049/AAM03004/
AAM03005/AAM03006/AAM03009/AAM03010).
{ECO:0000305}.
CONFLICT 324 324 E -> D (in Ref. 1; AAC26049/AAM03004/
AAM03005/AAM03006/AAM03007/AAM03008/
AAM03009/AAM03010/AAM03011/AAM03012/
AAM03013). {ECO:0000305}.
CONFLICT 465 465 L -> C (in Ref. 5; AAC42001).
{ECO:0000305}.
HELIX 327 333 {ECO:0000244|PDB:2ES0}.
HELIX 337 342 {ECO:0000244|PDB:2ES0}.
HELIX 344 356 {ECO:0000244|PDB:2ES0}.
HELIX 360 373 {ECO:0000244|PDB:2ES0}.
HELIX 377 379 {ECO:0000244|PDB:2ES0}.
HELIX 380 391 {ECO:0000244|PDB:2ES0}.
HELIX 404 416 {ECO:0000244|PDB:2ES0}.
TURN 417 422 {ECO:0000244|PDB:2ES0}.
HELIX 423 436 {ECO:0000244|PDB:2ES0}.
HELIX 438 443 {ECO:0000244|PDB:2ES0}.
HELIX 445 448 {ECO:0000244|PDB:2ES0}.
TURN 449 451 {ECO:0000244|PDB:2ES0}.
SEQUENCE 472 AA; 54423 MW; 1424518EA697CD76 CRC64;
MAQGSGDQRA VGVADPEESS PNMIVYCKIE DIITKMQDDK TGGVPIRTVK SFLSKIPSVV
TGTDIVQWLM KNLSIEDPVE AIHLGSLIAA QGYIFPISDH VLTMKDDGTF YRFQAPYFWP
SNCWEPENTD YAIYLCKRTM QNKARLELAD YEAENLARLQ RAFARKWEFI FMQAEAQVKI
DRKKDKTERK ILDSQERAFW DVHRPVPGCV NTTEMDIRKC RRLKNPQKVK KSVYGVTEES
QAQSPVHVLS QPIRKTTKED IRKQITFLNA QIDRHCLKMS KVAESLIAYT EQYVEYDPLI
TPAEPSNPWI SDDVALWDIE MSKEPSQQRV KRWGFSFDEI LKDQVGRDQF LRFLESEFSS
ENLRFWLAVQ DLKKQPLQDV AKRVEEIWQE FLAPGAPSAI NLDSHSYEIT SQNVKDGGRY
TFEDAQEHIY KLMKSDSYAR FLRSNAYQDL LLAKKKGKSL AGKRLTGLMQ SS


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