GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

Regulator of G-protein signaling 6 (RGS6) (S914)

 RGS6_HUMAN              Reviewed;         472 AA.
P49758; C9JE95; F8W7W5; O75576; O75577; Q7Z4K3; Q7Z4K4; Q7Z4K5; Q7Z4K6;
Q8TE13; Q8TE14; Q8TE15; Q8TE16; Q8TE17; Q8TE18; Q8TE19; Q8TE20; Q8TE21;
Q8TE22; Q9UDS8; Q9UDT0; Q9Y245; Q9Y647;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
25-NOV-2008, sequence version 5.
22-APR-2020, entry version 186.
RecName: Full=Regulator of G-protein signaling 6;
Short=RGS6;
AltName: Full=S914;
Name=RGS6;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2; 5; 6; 7; 8; 9; 10;
11; 12; 13; 14; 15 AND 16), INTERACTION WITH GNB5, AND SUBCELLULAR
LOCATION.
PubMed=12761221; DOI=10.1074/jbc.m212687200;
Chatterjee T.K., Liu Z., Fisher R.A.;
"Human RGS6 gene structure, complex alternative splicing, and role of N
terminus and G protein gamma-subunit-like (GGL) domain in subcellular
localization of RGS6 splice variants.";
J. Biol. Chem. 278:30261-30271(2003).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), INTERACTION WITH GNB5, AND
MUTAGENESIS OF ASP-297 AND TRP-309.
TISSUE=Brain;
PubMed=10339615; DOI=10.1073/pnas.96.11.6489;
Snow B.E., Betts L., Mangion J., Sondek J., Siderovski D.P.;
"Fidelity of G protein beta-subunit association by the G protein gamma-
subunit-like domains of RGS6, RGS7, and RGS11.";
Proc. Natl. Acad. Sci. U.S.A. 96:6489-6494(1999).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH GNB5,
AND SUBCELLULAR LOCATION.
PubMed=10521509; DOI=10.1074/jbc.274.43.31087;
Posner B.A., Gilman A.G., Harris B.A.;
"Regulators of G protein signaling 6 and 7. Purification of complexes with
gbeta5 and assessment of their effects on g protein-mediated signaling
pathways.";
J. Biol. Chem. 274:31087-31093(1999).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=12508121; DOI=10.1038/nature01348;
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
Waterston R., Hood L., Weissenbach J.;
"The DNA sequence and analysis of human chromosome 14.";
Nature 421:601-607(2003).
[5]
NUCLEOTIDE SEQUENCE [MRNA] OF 362-472 (ISOFORM 1).
TISSUE=Brain;
PubMed=7596406; DOI=10.1038/375754a0;
Sherrington R., Rogaev E.I., Liang Y., Rogaeva E.A., Levesque G., Ikeda M.,
Chi H., Lin C., Li G., Holman K., Tsuda T., Mar L., Foncin J.-F.,
Bruni A.C., Montesi M.P., Sorbi S., Rainero I., Pinessi L., Nee L.,
Chumakov I., Pollen D., Brookes A., Sanseau P., Polinsky R.J., Wasco W.,
da Silva H.A.R., Haines J.L., Pericak-Vance M.A., Tanzi R.E., Roses A.D.,
Fraser P.E., Rommens J.M., St George-Hyslop P.H.;
"Cloning of a gene bearing missense mutations in early-onset familial
Alzheimer's disease.";
Nature 375:754-760(1995).
[6]
X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 325-470, AND INTERACTION WITH
GNAI1.
PubMed=18434541; DOI=10.1073/pnas.0801508105;
Soundararajan M., Willard F.S., Kimple A.J., Turnbull A.P., Ball L.J.,
Schoch G.A., Gileadi C., Fedorov O.Y., Dowler E.F., Higman V.A.,
Hutsell S.Q., Sundstroem M., Doyle D.A., Siderovski D.P.;
"Structural diversity in the RGS domain and its interaction with
heterotrimeric G protein alpha-subunits.";
Proc. Natl. Acad. Sci. U.S.A. 105:6457-6462(2008).
-!- FUNCTION: Regulates G protein-coupled receptor signaling cascades.
Inhibits signal transduction by increasing the GTPase activity of G
protein alpha subunits, thereby driving them into their inactive GDP-
bound form. The RGS6/GNB5 dimer enhances GNAO1 GTPase activity
(PubMed:10521509). {ECO:0000269|PubMed:10521509}.
-!- SUBUNIT: Interacts with GNB5 (PubMed:12761221, PubMed:10339615,
PubMed:10521509). Interacts with RGS7BP, leading to regulate the
subcellular location of the heterodimer formed with GNB5 (By
similarity). Interacts with GNAI1 (PubMed:18434541).
{ECO:0000250|UniProtKB:Q9Z2H2, ECO:0000269|PubMed:10339615,
ECO:0000269|PubMed:10521509, ECO:0000269|PubMed:12761221,
ECO:0000269|PubMed:18434541}.
-!- INTERACTION:
P49758; P08238: HSP90AB1; NbExp=2; IntAct=EBI-6426927, EBI-352572;
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12761221}.
Cytoplasm, cytosol {ECO:0000269|PubMed:10521509}. Membrane
{ECO:0000269|PubMed:10521509}; Peripheral membrane protein
{ECO:0000269|PubMed:10521509}. Nucleus {ECO:0000269|PubMed:12761221}.
Cell membrane {ECO:0000250|UniProtKB:Q9Z2H2}. Note=Interaction with
GNB5 mediates translocation to the nucleus.
{ECO:0000269|PubMed:12761221}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=15;
Comment=Additional isoforms seem to exist.
{ECO:0000269|PubMed:12761221};
Name=1; Synonyms=RGS6Lalpha2;
IsoId=P49758-4; Sequence=Displayed;
Name=2; Synonyms=RGS6Lgamma1, RGS6Lbeta1 {ECO:0000303|PubMed:12761221};
IsoId=P49758-2; Sequence=VSP_035848;
Name=3; Synonyms=RGS6Lalpha1;
IsoId=P49758-3; Sequence=VSP_035847;
Name=5; Synonyms=RGS6Lbeta;
IsoId=P49758-5; Sequence=VSP_035849;
Name=6; Synonyms=RGS6Lbeta-GGL;
IsoId=P49758-6; Sequence=VSP_035846, VSP_035849;
Name=7; Synonyms=RGS6Lalpha2-GGL;
IsoId=P49758-7; Sequence=VSP_035846;
Name=8; Synonyms=RGS6Lgamma2, RGS6Lbeta2 {ECO:0000303|PubMed:12761221};
IsoId=P49758-8; Sequence=VSP_035850;
Name=9; Synonyms=RGS6Lalpha1-GGL;
IsoId=P49758-9; Sequence=VSP_035846, VSP_035847;
Name=10; Synonyms=RGS6Lgamma1-GGL;
IsoId=P49758-10; Sequence=VSP_035846, VSP_035848;
Name=11; Synonyms=RGS6Lgamma2-GGL;
IsoId=P49758-11; Sequence=VSP_035846, VSP_035850;
Name=12; Synonyms=RGS6Sbeta1 {ECO:0000303|PubMed:12761221};
IsoId=P49758-12; Sequence=VSP_035845, VSP_035848;
Name=13; Synonyms=RGS6Lepsilon;
IsoId=P49758-13; Sequence=VSP_047806;
Name=14; Synonyms=RGS6Ldelta;
IsoId=P49758-14; Sequence=VSP_047807;
Name=15; Synonyms=RGS6Lgamma;
IsoId=P49758-15; Sequence=VSP_047808;
Name=16; Synonyms=RGS6Leta;
IsoId=P49758-16; Sequence=VSP_047809;
-!- DOMAIN: The RGS domain interacts avidly with Galpha and mediates the
acceleration of Galpha-mediated GTP hydrolysis.
-!- SEQUENCE CAUTION:
Sequence=AAC42001.1; Type=Frameshift; Evidence={ECO:0000305};
---------------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
---------------------------------------------------------------------------
EMBL; AF073920; AAC26049.2; -; mRNA.
EMBL; AF073921; AAC26050.1; -; mRNA.
EMBL; AY309097; AAP74386.1; -; mRNA.
EMBL; AY309098; AAP74387.1; -; mRNA.
EMBL; AY309099; AAP74388.1; -; mRNA.
EMBL; AY309100; AAP74389.1; -; mRNA.
EMBL; AF465727; AAM03004.1; -; Genomic_DNA.
EMBL; AF465711; AAM03004.1; JOINED; Genomic_DNA.
EMBL; AF465712; AAM03004.1; JOINED; Genomic_DNA.
EMBL; AF465713; AAM03004.1; JOINED; Genomic_DNA.
EMBL; AF465714; AAM03004.1; JOINED; Genomic_DNA.
EMBL; AF465715; AAM03004.1; JOINED; Genomic_DNA.
EMBL; AF465716; AAM03004.1; JOINED; Genomic_DNA.
EMBL; AF465717; AAM03004.1; JOINED; Genomic_DNA.
EMBL; AF465718; AAM03004.1; JOINED; Genomic_DNA.
EMBL; AF465719; AAM03004.1; JOINED; Genomic_DNA.
EMBL; AF465720; AAM03004.1; JOINED; Genomic_DNA.
EMBL; AF465721; AAM03004.1; JOINED; Genomic_DNA.
EMBL; AF465722; AAM03004.1; JOINED; Genomic_DNA.
EMBL; AF465723; AAM03004.1; JOINED; Genomic_DNA.
EMBL; AF465724; AAM03004.1; JOINED; Genomic_DNA.
EMBL; AF465725; AAM03004.1; JOINED; Genomic_DNA.
EMBL; AF465726; AAM03004.1; JOINED; Genomic_DNA.
EMBL; AF465727; AAM03005.1; -; Genomic_DNA.
EMBL; AF465711; AAM03005.1; JOINED; Genomic_DNA.
EMBL; AF465712; AAM03005.1; JOINED; Genomic_DNA.
EMBL; AF465713; AAM03005.1; JOINED; Genomic_DNA.
EMBL; AF465714; AAM03005.1; JOINED; Genomic_DNA.
EMBL; AF465715; AAM03005.1; JOINED; Genomic_DNA.
EMBL; AF465716; AAM03005.1; JOINED; Genomic_DNA.
EMBL; AF465717; AAM03005.1; JOINED; Genomic_DNA.
EMBL; AF465718; AAM03005.1; JOINED; Genomic_DNA.
EMBL; AF465719; AAM03005.1; JOINED; Genomic_DNA.
EMBL; AF465720; AAM03005.1; JOINED; Genomic_DNA.
EMBL; AF465721; AAM03005.1; JOINED; Genomic_DNA.
EMBL; AF465722; AAM03005.1; JOINED; Genomic_DNA.
EMBL; AF465723; AAM03005.1; JOINED; Genomic_DNA.
EMBL; AF465724; AAM03005.1; JOINED; Genomic_DNA.
EMBL; AF465725; AAM03005.1; JOINED; Genomic_DNA.
EMBL; AF465726; AAM03005.1; JOINED; Genomic_DNA.
EMBL; AF465726; AAM03006.1; -; Genomic_DNA.
EMBL; AF465711; AAM03006.1; JOINED; Genomic_DNA.
EMBL; AF465712; AAM03006.1; JOINED; Genomic_DNA.
EMBL; AF465713; AAM03006.1; JOINED; Genomic_DNA.
EMBL; AF465714; AAM03006.1; JOINED; Genomic_DNA.
EMBL; AF465715; AAM03006.1; JOINED; Genomic_DNA.
EMBL; AF465716; AAM03006.1; JOINED; Genomic_DNA.
EMBL; AF465717; AAM03006.1; JOINED; Genomic_DNA.
EMBL; AF465718; AAM03006.1; JOINED; Genomic_DNA.
EMBL; AF465719; AAM03006.1; JOINED; Genomic_DNA.
EMBL; AF465720; AAM03006.1; JOINED; Genomic_DNA.
EMBL; AF465721; AAM03006.1; JOINED; Genomic_DNA.
EMBL; AF465722; AAM03006.1; JOINED; Genomic_DNA.
EMBL; AF465723; AAM03006.1; JOINED; Genomic_DNA.
EMBL; AF465724; AAM03006.1; JOINED; Genomic_DNA.
EMBL; AF465725; AAM03006.1; JOINED; Genomic_DNA.
EMBL; AF465727; AAM03007.1; -; Genomic_DNA.
EMBL; AF465711; AAM03007.1; JOINED; Genomic_DNA.
EMBL; AF465712; AAM03007.1; JOINED; Genomic_DNA.
EMBL; AF465713; AAM03007.1; JOINED; Genomic_DNA.
EMBL; AF465714; AAM03007.1; JOINED; Genomic_DNA.
EMBL; AF465715; AAM03007.1; JOINED; Genomic_DNA.
EMBL; AF465716; AAM03007.1; JOINED; Genomic_DNA.
EMBL; AF465717; AAM03007.1; JOINED; Genomic_DNA.
EMBL; AF465718; AAM03007.1; JOINED; Genomic_DNA.
EMBL; AF465719; AAM03007.1; JOINED; Genomic_DNA.
EMBL; AF465720; AAM03007.1; JOINED; Genomic_DNA.
EMBL; AF465721; AAM03007.1; JOINED; Genomic_DNA.
EMBL; AF465723; AAM03007.1; JOINED; Genomic_DNA.
EMBL; AF465724; AAM03007.1; JOINED; Genomic_DNA.
EMBL; AF465725; AAM03007.1; JOINED; Genomic_DNA.
EMBL; AF465726; AAM03007.1; JOINED; Genomic_DNA.
EMBL; AF465727; AAM03008.1; -; Genomic_DNA.
EMBL; AF465711; AAM03008.1; JOINED; Genomic_DNA.
EMBL; AF465712; AAM03008.1; JOINED; Genomic_DNA.
EMBL; AF465713; AAM03008.1; JOINED; Genomic_DNA.
EMBL; AF465714; AAM03008.1; JOINED; Genomic_DNA.
EMBL; AF465715; AAM03008.1; JOINED; Genomic_DNA.
EMBL; AF465716; AAM03008.1; JOINED; Genomic_DNA.
EMBL; AF465717; AAM03008.1; JOINED; Genomic_DNA.
EMBL; AF465718; AAM03008.1; JOINED; Genomic_DNA.
EMBL; AF465719; AAM03008.1; JOINED; Genomic_DNA.
EMBL; AF465720; AAM03008.1; JOINED; Genomic_DNA.
EMBL; AF465721; AAM03008.1; JOINED; Genomic_DNA.
EMBL; AF465723; AAM03008.1; JOINED; Genomic_DNA.
EMBL; AF465724; AAM03008.1; JOINED; Genomic_DNA.
EMBL; AF465725; AAM03008.1; JOINED; Genomic_DNA.
EMBL; AF465726; AAM03008.1; JOINED; Genomic_DNA.
EMBL; AF465727; AAM03009.1; -; Genomic_DNA.
EMBL; AF465711; AAM03009.1; JOINED; Genomic_DNA.
EMBL; AF465712; AAM03009.1; JOINED; Genomic_DNA.
EMBL; AF465713; AAM03009.1; JOINED; Genomic_DNA.
EMBL; AF465714; AAM03009.1; JOINED; Genomic_DNA.
EMBL; AF465715; AAM03009.1; JOINED; Genomic_DNA.
EMBL; AF465716; AAM03009.1; JOINED; Genomic_DNA.
EMBL; AF465717; AAM03009.1; JOINED; Genomic_DNA.
EMBL; AF465718; AAM03009.1; JOINED; Genomic_DNA.
EMBL; AF465719; AAM03009.1; JOINED; Genomic_DNA.
EMBL; AF465720; AAM03009.1; JOINED; Genomic_DNA.
EMBL; AF465721; AAM03009.1; JOINED; Genomic_DNA.
EMBL; AF465722; AAM03009.1; JOINED; Genomic_DNA.
EMBL; AF465723; AAM03009.1; JOINED; Genomic_DNA.
EMBL; AF465724; AAM03009.1; JOINED; Genomic_DNA.
EMBL; AF465725; AAM03009.1; JOINED; Genomic_DNA.
EMBL; AF465727; AAM03010.1; -; Genomic_DNA.
EMBL; AF465711; AAM03010.1; JOINED; Genomic_DNA.
EMBL; AF465712; AAM03010.1; JOINED; Genomic_DNA.
EMBL; AF465713; AAM03010.1; JOINED; Genomic_DNA.
EMBL; AF465714; AAM03010.1; JOINED; Genomic_DNA.
EMBL; AF465715; AAM03010.1; JOINED; Genomic_DNA.
EMBL; AF465716; AAM03010.1; JOINED; Genomic_DNA.
EMBL; AF465717; AAM03010.1; JOINED; Genomic_DNA.
EMBL; AF465718; AAM03010.1; JOINED; Genomic_DNA.
EMBL; AF465719; AAM03010.1; JOINED; Genomic_DNA.
EMBL; AF465720; AAM03010.1; JOINED; Genomic_DNA.
EMBL; AF465721; AAM03010.1; JOINED; Genomic_DNA.
EMBL; AF465722; AAM03010.1; JOINED; Genomic_DNA.
EMBL; AF465723; AAM03010.1; JOINED; Genomic_DNA.
EMBL; AF465724; AAM03010.1; JOINED; Genomic_DNA.
EMBL; AF465725; AAM03010.1; JOINED; Genomic_DNA.
EMBL; AF465727; AAM03011.1; -; Genomic_DNA.
EMBL; AF465711; AAM03011.1; JOINED; Genomic_DNA.
EMBL; AF465712; AAM03011.1; JOINED; Genomic_DNA.
EMBL; AF465713; AAM03011.1; JOINED; Genomic_DNA.
EMBL; AF465714; AAM03011.1; JOINED; Genomic_DNA.
EMBL; AF465715; AAM03011.1; JOINED; Genomic_DNA.
EMBL; AF465716; AAM03011.1; JOINED; Genomic_DNA.
EMBL; AF465717; AAM03011.1; JOINED; Genomic_DNA.
EMBL; AF465718; AAM03011.1; JOINED; Genomic_DNA.
EMBL; AF465719; AAM03011.1; JOINED; Genomic_DNA.
EMBL; AF465720; AAM03011.1; JOINED; Genomic_DNA.
EMBL; AF465721; AAM03011.1; JOINED; Genomic_DNA.
EMBL; AF465723; AAM03011.1; JOINED; Genomic_DNA.
EMBL; AF465724; AAM03011.1; JOINED; Genomic_DNA.
EMBL; AF465725; AAM03011.1; JOINED; Genomic_DNA.
EMBL; AF465727; AAM03012.1; -; Genomic_DNA.
EMBL; AF465711; AAM03012.1; JOINED; Genomic_DNA.
EMBL; AF465712; AAM03012.1; JOINED; Genomic_DNA.
EMBL; AF465713; AAM03012.1; JOINED; Genomic_DNA.
EMBL; AF465714; AAM03012.1; JOINED; Genomic_DNA.
EMBL; AF465715; AAM03012.1; JOINED; Genomic_DNA.
EMBL; AF465716; AAM03012.1; JOINED; Genomic_DNA.
EMBL; AF465717; AAM03012.1; JOINED; Genomic_DNA.
EMBL; AF465718; AAM03012.1; JOINED; Genomic_DNA.
EMBL; AF465719; AAM03012.1; JOINED; Genomic_DNA.
EMBL; AF465720; AAM03012.1; JOINED; Genomic_DNA.
EMBL; AF465721; AAM03012.1; JOINED; Genomic_DNA.
EMBL; AF465723; AAM03012.1; JOINED; Genomic_DNA.
EMBL; AF465724; AAM03012.1; JOINED; Genomic_DNA.
EMBL; AF465725; AAM03012.1; JOINED; Genomic_DNA.
EMBL; AF465726; AAM03013.1; -; Genomic_DNA.
EMBL; AF465711; AAM03013.1; JOINED; Genomic_DNA.
EMBL; AF465712; AAM03013.1; JOINED; Genomic_DNA.
EMBL; AF465713; AAM03013.1; JOINED; Genomic_DNA.
EMBL; AF465714; AAM03013.1; JOINED; Genomic_DNA.
EMBL; AF465715; AAM03013.1; JOINED; Genomic_DNA.
EMBL; AF465716; AAM03013.1; JOINED; Genomic_DNA.
EMBL; AF465717; AAM03013.1; JOINED; Genomic_DNA.
EMBL; AF465718; AAM03013.1; JOINED; Genomic_DNA.
EMBL; AF465719; AAM03013.1; JOINED; Genomic_DNA.
EMBL; AF465720; AAM03013.1; JOINED; Genomic_DNA.
EMBL; AF465721; AAM03013.1; JOINED; Genomic_DNA.
EMBL; AF465723; AAM03013.1; JOINED; Genomic_DNA.
EMBL; AF465724; AAM03013.1; JOINED; Genomic_DNA.
EMBL; AF465725; AAM03013.1; JOINED; Genomic_DNA.
EMBL; AF107619; AAD34717.1; -; mRNA.
EMBL; AF107620; AAD34718.1; -; mRNA.
EMBL; AF156932; AAD40183.1; -; mRNA.
EMBL; AC004828; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AC005157; AAC83180.1; -; Genomic_DNA.
EMBL; AC005226; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AC005227; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AC005477; AAD05031.1; -; Genomic_DNA.
EMBL; AC005533; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AC005857; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AC005993; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; L40394; AAC42001.1; ALT_FRAME; mRNA.
CCDS; CCDS55924.1; -. [P49758-3]
CCDS; CCDS9808.1; -. [P49758-4]
RefSeq; NP_001191345.1; NM_001204416.2. [P49758-3]
RefSeq; NP_001191346.1; NM_001204417.2. [P49758-2]
RefSeq; NP_001191347.1; NM_001204418.2. [P49758-8]
RefSeq; NP_001191348.1; NM_001204419.2. [P49758-9]
RefSeq; NP_001191349.1; NM_001204420.2. [P49758-7]
RefSeq; NP_001191350.1; NM_001204421.2. [P49758-10]
RefSeq; NP_001191351.1; NM_001204422.2. [P49758-11]
RefSeq; NP_001191352.1; NM_001204423.1.
RefSeq; NP_001191353.1; NM_001204424.1. [P49758-3]
RefSeq; NP_004287.3; NM_004296.6. [P49758-4]
RefSeq; XP_016877315.1; XM_017021826.1. [P49758-13]
RefSeq; XP_016877318.1; XM_017021829.1.
RefSeq; XP_016877319.1; XM_017021830.1. [P49758-5]
RefSeq; XP_016877321.1; XM_017021832.1. [P49758-16]
RefSeq; XP_016877323.1; XM_017021834.1. [P49758-12]
PDB; 2ES0; X-ray; 2.10 A; A=325-470.
PDBsum; 2ES0; -.
SMR; P49758; -.
BioGrid; 114987; 10.
CORUM; P49758; -.
IntAct; P49758; 9.
STRING; 9606.ENSP00000451030; -.
iPTMnet; P49758; -.
PhosphoSitePlus; P49758; -.
BioMuta; RGS6; -.
DMDM; 215274268; -.
MassIVE; P49758; -.
PaxDb; P49758; -.
PeptideAtlas; P49758; -.
PRIDE; P49758; -.
ProteomicsDB; 56079; -. [P49758-4]
ProteomicsDB; 56080; -. [P49758-10]
ProteomicsDB; 56081; -. [P49758-11]
ProteomicsDB; 56082; -. [P49758-12]
ProteomicsDB; 56083; -. [P49758-2]
ProteomicsDB; 56084; -. [P49758-3]
ProteomicsDB; 56085; -. [P49758-5]
ProteomicsDB; 56086; -. [P49758-6]
ProteomicsDB; 56087; -. [P49758-7]
ProteomicsDB; 56088; -. [P49758-8]
ProteomicsDB; 56089; -. [P49758-9]
ProteomicsDB; 69197; -.
ProteomicsDB; 69198; -.
ProteomicsDB; 69199; -.
ProteomicsDB; 69200; -.
Antibodypedia; 145; 125 antibodies.
DNASU; 9628; -.
Ensembl; ENST00000355512; ENSP00000347699; ENSG00000182732. [P49758-16]
Ensembl; ENST00000404301; ENSP00000385243; ENSG00000182732. [P49758-15]
Ensembl; ENST00000406236; ENSP00000384218; ENSG00000182732. [P49758-13]
Ensembl; ENST00000407322; ENSP00000384612; ENSG00000182732. [P49758-14]
Ensembl; ENST00000553525; ENSP00000451030; ENSG00000182732. [P49758-3]
Ensembl; ENST00000553530; ENSP00000452331; ENSG00000182732. [P49758-4]
Ensembl; ENST00000554474; ENSP00000450858; ENSG00000182732. [P49758-5]
Ensembl; ENST00000554782; ENSP00000451912; ENSG00000182732. [P49758-12]
Ensembl; ENST00000555571; ENSP00000450936; ENSG00000182732. [P49758-4]
Ensembl; ENST00000556437; ENSP00000451855; ENSG00000182732. [P49758-3]
GeneID; 9628; -.
KEGG; hsa:9628; -.
UCSC; uc001xmy.5; human. [P49758-4]
CTD; 9628; -.
DisGeNET; 9628; -.
GeneCards; RGS6; -.
HGNC; HGNC:10002; RGS6.
HPA; ENSG00000182732; Tissue enhanced (brain).
MIM; 603894; gene.
neXtProt; NX_P49758; -.
OpenTargets; ENSG00000182732; -.
PharmGKB; PA34377; -.
eggNOG; KOG3589; Eukaryota.
eggNOG; ENOG410YMJD; LUCA.
GeneTree; ENSGT00940000157159; -.
InParanoid; P49758; -.
KO; K16449; -.
OMA; CRRERNP; -.
OrthoDB; 415625at2759; -.
PhylomeDB; P49758; -.
TreeFam; TF351956; -.
Reactome; R-HSA-418594; G alpha (i) signalling events.
Reactome; R-HSA-6814122; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
SIGNOR; P49758; -.
ChiTaRS; RGS6; human.
EvolutionaryTrace; P49758; -.
GeneWiki; RGS6; -.
GenomeRNAi; 9628; -.
Pharos; P49758; Tbio.
PRO; PR:P49758; -.
Proteomes; UP000005640; Chromosome 14.
RNAct; P49758; protein.
Bgee; ENSG00000182732; Expressed in frontal cortex and 126 other tissues.
ExpressionAtlas; P49758; baseline and differential.
Genevisible; P49758; HS.
GO; GO:0005829; C:cytosol; IDA:UniProtKB.
GO; GO:0019898; C:extrinsic component of membrane; IDA:UniProtKB.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0005096; F:GTPase activator activity; IDA:UniProtKB.
GO; GO:0003924; F:GTPase activity; TAS:Reactome.
GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:Reactome.
GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
GO; GO:0043547; P:positive regulation of GTPase activity; IDA:UniProtKB.
GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; TAS:ProtInc.
CDD; cd00068; GGL; 1.
CDD; cd08737; RGS_RGS6; 1.
Gene3D; 1.10.10.10; -; 1.
Gene3D; 1.10.196.10; -; 2.
Gene3D; 4.10.260.10; -; 1.
InterPro; IPR000591; DEP_dom.
InterPro; IPR015898; G-protein_gamma-like_dom.
InterPro; IPR036284; GGL_sf.
InterPro; IPR016137; RGS.
InterPro; IPR037956; RGS6_RGS.
InterPro; IPR040759; RGS_DHEX.
InterPro; IPR036305; RGS_sf.
InterPro; IPR024066; RGS_subdom1/3.
InterPro; IPR036388; WH-like_DNA-bd_sf.
InterPro; IPR036390; WH_DNA-bd_sf.
Pfam; PF00610; DEP; 1.
Pfam; PF00631; G-gamma; 1.
Pfam; PF00615; RGS; 1.
Pfam; PF18148; RGS_DHEX; 1.
PRINTS; PR01301; RGSPROTEIN.
SMART; SM00049; DEP; 1.
SMART; SM00224; GGL; 1.
SMART; SM00315; RGS; 1.
SUPFAM; SSF46785; SSF46785; 1.
SUPFAM; SSF48097; SSF48097; 1.
SUPFAM; SSF48670; SSF48670; 1.
PROSITE; PS50186; DEP; 1.
PROSITE; PS50132; RGS; 1.
1: Evidence at protein level;
3D-structure; Alternative splicing; Cell membrane; Cytoplasm;
GTPase activation; Membrane; Nucleus; Reference proteome;
Signal transduction inhibitor.
CHAIN 1..472
/note="Regulator of G-protein signaling 6"
/id="PRO_0000204192"
DOMAIN 40..115
/note="DEP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00066"
DOMAIN 261..330
/note="G protein gamma"
DOMAIN 336..441
/note="RGS"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00171"
VAR_SEQ 1..139
/note="Missing (in isoform 12)"
/evidence="ECO:0000303|PubMed:12761221"
/id="VSP_035845"
VAR_SEQ 285..321
/note="Missing (in isoform 6, isoform 7, isoform 9, isoform
10 and isoform 11)"
/evidence="ECO:0000303|PubMed:12761221"
/id="VSP_035846"
VAR_SEQ 456
/note="K -> KPESEQGRRTSLEKFTRSV (in isoform 3 and isoform
9)"
/evidence="ECO:0000303|PubMed:10339615,
ECO:0000303|PubMed:12761221"
/id="VSP_035847"
VAR_SEQ 457..472
/note="GKSLAGKRLTGLMQSS -> PESEQGRRTSLEKFTRSVG (in isoform
13)"
/evidence="ECO:0000303|PubMed:12761221"
/id="VSP_047806"
VAR_SEQ 457..472
/note="GKSLAGKRLTGLMQSS -> PESEQGRRTSLEKFTRSVLLF (in
isoform 14)"
/evidence="ECO:0000303|PubMed:12761221"
/id="VSP_047807"
VAR_SEQ 457..472
/note="GKSLAGKRLTGLMQSS -> PESEQGRRTSLEKFTRSVCLQLLF (in
isoform 15)"
/evidence="ECO:0000303|PubMed:12761221"
/id="VSP_047808"
VAR_SEQ 457..472
/note="GKSLAGKRLTGLMQSS -> VWLL (in isoform 16)"
/evidence="ECO:0000303|PubMed:12761221"
/id="VSP_047809"
VAR_SEQ 457..472
/note="GKSLAGKRLTGLMQSS -> PESEQGRRTSLEKFTRSVLYSNTPLAKRP
(in isoform 2, isoform 10 and isoform 12)"
/evidence="ECO:0000303|PubMed:12761221"
/id="VSP_035848"
VAR_SEQ 457..472
/note="GKSLAGKRLTGLMQSS -> KVSKVVELP (in isoform 5 and
isoform 6)"
/evidence="ECO:0000303|PubMed:12761221"
/id="VSP_035849"
VAR_SEQ 457..472
/note="GKSLAGKRLTGLMQSS -> LYSNTPLAKRP (in isoform 8 and
isoform 11)"
/evidence="ECO:0000303|PubMed:12761221"
/id="VSP_035850"
MUTAGEN 297
/note="D->A: Loss of interaction with GNB5."
/evidence="ECO:0000269|PubMed:10339615"
MUTAGEN 309
/note="W->F: Diminishes interaction with GNB5."
/evidence="ECO:0000269|PubMed:10339615"
CONFLICT 165
/note="R -> K (in Ref. 1; AAC26049/AAM03004/AAM03005/
AAM03006/AAM03007/AAM03008/AAM03009/AAM03010/AAM03011/
AAM03012/AAM03013)"
/evidence="ECO:0000305"
CONFLICT 210
/note="V -> L (in Ref. 1; AAC26049/AAM03004/AAM03005/
AAM03006/AAM03007/AAM03008/AAM03009/AAM03010/AAM03011/
AAM03012/AAM03013)"
/evidence="ECO:0000305"
CONFLICT 312..313
/note="DD -> EE (in Ref. 1; AAC26049/AAM03004/AAM03005/
AAM03006/AAM03009/AAM03010)"
/evidence="ECO:0000305"
CONFLICT 324
/note="E -> D (in Ref. 1; AAC26049/AAM03004/AAM03005/
AAM03006/AAM03007/AAM03008/AAM03009/AAM03010/AAM03011/
AAM03012/AAM03013)"
/evidence="ECO:0000305"
CONFLICT 465
/note="L -> C (in Ref. 5; AAC42001)"
/evidence="ECO:0000305"
HELIX 327..333
/evidence="ECO:0000244|PDB:2ES0"
HELIX 337..342
/evidence="ECO:0000244|PDB:2ES0"
HELIX 344..356
/evidence="ECO:0000244|PDB:2ES0"
HELIX 360..373
/evidence="ECO:0000244|PDB:2ES0"
HELIX 377..379
/evidence="ECO:0000244|PDB:2ES0"
HELIX 380..391
/evidence="ECO:0000244|PDB:2ES0"
HELIX 404..416
/evidence="ECO:0000244|PDB:2ES0"
TURN 417..422
/evidence="ECO:0000244|PDB:2ES0"
HELIX 423..436
/evidence="ECO:0000244|PDB:2ES0"
HELIX 438..443
/evidence="ECO:0000244|PDB:2ES0"
HELIX 445..448
/evidence="ECO:0000244|PDB:2ES0"
TURN 449..451
/evidence="ECO:0000244|PDB:2ES0"
SEQUENCE 472 AA; 54423 MW; 1424518EA697CD76 CRC64;
MAQGSGDQRA VGVADPEESS PNMIVYCKIE DIITKMQDDK TGGVPIRTVK SFLSKIPSVV
TGTDIVQWLM KNLSIEDPVE AIHLGSLIAA QGYIFPISDH VLTMKDDGTF YRFQAPYFWP
SNCWEPENTD YAIYLCKRTM QNKARLELAD YEAENLARLQ RAFARKWEFI FMQAEAQVKI
DRKKDKTERK ILDSQERAFW DVHRPVPGCV NTTEMDIRKC RRLKNPQKVK KSVYGVTEES
QAQSPVHVLS QPIRKTTKED IRKQITFLNA QIDRHCLKMS KVAESLIAYT EQYVEYDPLI
TPAEPSNPWI SDDVALWDIE MSKEPSQQRV KRWGFSFDEI LKDQVGRDQF LRFLESEFSS
ENLRFWLAVQ DLKKQPLQDV AKRVEEIWQE FLAPGAPSAI NLDSHSYEIT SQNVKDGGRY
TFEDAQEHIY KLMKSDSYAR FLRSNAYQDL LLAKKKGKSL AGKRLTGLMQ SS


Related products :

Catalog number Product name Quantity
EIAAB34583 Homo sapiens,Human,Regulator of G-protein signaling 6,RGS6,RGS6,S914
15-288-21306 Regulator of G-protein signaling 6 - RGS6; S914 Polyclonal 0.05 mg
18-003-42465 Regulator of G-protein signaling 6 - RGS6; S914 Polyclonal 0.05 mg Aff Pur
15-288-21306 Regulator of G-protein signaling 6 - RGS6; S914 Polyclonal 0.1 mg
EIAAB34584 Rat,Rattus norvegicus,Regulator of G-protein signaling 6,RGS6,Rgs6
EIAAB34582 Mouse,Mus musculus,Regulator of G-protein signaling 6,RGS6,Rgs6
DL-RGS6-Ra Rat Regulator Of G Protein Signaling 6 (RGS6) ELISA Kit 96T
RGS6 RGS6 Gene regulator of G-protein signaling 6
G7109 Regulator of G-protein signaling 6 (RGS6), Rat, ELISA Kit 96T
CSB-EL019658RA Rat Regulator of G-protein signaling 6(RGS6) ELISA kit 96T
G7049 Regulator Of G Protein Signaling 6 (RGS6), Rat, ELISA Kit 96T
201-11-1487 Rat Regulator Of G Protein Signaling 6 (RGS6)ELISA Kit 96T
201-11-1487 Rat Regulator Of G Protein Signaling 6(RGS6)ELISA Kit 96T
QY-E10158 Rat Regulator Of G Protein Signaling 6(RGS6)ELISA Kit 96T
UB-E10158 Rat Regulator Of G Protein Signaling 6(RGS6)ELISA Kit 96T
G7107 Regulator of G-protein signaling 6 (RGS6), Human, ELISA Kit 96T
G7108 Regulator of G-protein signaling 6 (RGS6), Mouse, ELISA Kit 96T
CSB-EL019658MO Mouse Regulator of G-protein signaling 6(RGS6) ELISA kit 96T
QY-E21314 Mouse Regulator Of G Protein Signaling 6(RGS6)ELISA Kit 96T
CSB-EL019658RA Rat Regulator of G-protein signaling 6(RGS6) ELISA kit SpeciesRat 96T
CSB-EL019658HU Human Regulator of G-protein signaling 6(RGS6) ELISA kit 96T
UB-E21314 Mouse Regulator Of G Protein Signaling 6(RGS6)ELISA Kit 96T
SED706Ra ELISA Kit for Regulator Of G Protein Signaling 6 (RGS6) Rattus norvegicus (Rat) 96T
CSB-EL019658MO Mouse Regulator of G-protein signaling 6(RGS6) ELISA kit SpeciesMouse 96T
CSB-EL019658HU Human Regulator of G-protein signaling 6(RGS6) ELISA kit SpeciesHuman 96T
Pathways :
WP1049: G Protein Signaling Pathways
WP2272: Pathogenic Escherichia coli infection
WP73: G Protein Signaling Pathways
WP1165: G Protein Signaling Pathways
WP232: G Protein Signaling Pathways
WP2203: TSLP Signaling Pathway
WP211: BMP signaling pathway
WP1689: Porphyrin and chlorophyll metabolism
WP813: G Protein Signaling Pathways
WP1371: G Protein Signaling Pathways
WP931: G Protein Signaling Pathways
WP2292: Chemokine signaling pathway
WP2032: TSH signaling pathway
WP35: G Protein Signaling Pathways
WP818: IL-4 signaling Pathway
WP1098: Wnt Signaling Pathway
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP12: Osteoclast Signaling
WP2218: sGC
WP1344: Wnt Signaling Pathway and Pluripotency
WP294: p38 MAPK Signaling Pathway (BioCarta)
WP1489: TOR signaling
WP437: EGF/EGFR Signaling Pathway
WP17: daf-2 or insulin signaling pathway
WP946: Delta-Notch Signaling Pathway

Related Genes :
[Rgs7bp D13Bwg1146e R7bp] Regulator of G-protein signaling 7-binding protein (R7 family-binding protein)
[Rgs14] Regulator of G-protein signaling 14 (RGS14) (RAP1/RAP2-interacting protein) (RPIP1)
[Rgs7bp R7bp] Regulator of G-protein signaling 7-binding protein (R7 family-binding protein)
[Gnai1 Gnai-1] Guanine nucleotide-binding protein G(i) subunit alpha-1 (Adenylate cyclase-inhibiting G alpha protein)
[RGS16 RGSR] Regulator of G-protein signaling 16 (RGS16) (A28-RGS14P) (Retinal-specific RGS) (RGS-r) (hRGS-r) (Retinally abundant regulator of G-protein signaling)
[GPSM3 AGS4 C6orf9 G18] G-protein-signaling modulator 3 (Activator of G-protein signaling 4) (G18.1b) (Protein G18)
[RGS1 At3g26090 MPE11.27 MPE11.28] Regulator of G-protein signaling 1 (AtRGS1)
[Rgs14] Regulator of G-protein signaling 14 (RGS14)
[loco CG5248] Regulator of G-protein signaling loco (RGS) (Locomotion defects protein) (Loco)
[RGS9] Regulator of G-protein signaling 9 (RGS9)
[GNB5] Guanine nucleotide-binding protein subunit beta-5 (Gbeta5) (Transducin beta chain 5)
[GNAI1] Guanine nucleotide-binding protein G(i) subunit alpha-1 (Adenylate cyclase-inhibiting G alpha protein)
[Shh Hhg1] Sonic hedgehog protein (SHH) (HHG-1) (Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains) (ShhNC) [Cleaved into: Sonic hedgehog protein N-product (ShhN) (Shh N-terminal processed signaling domains) (ShhNp) (Sonic hedgehog protein 19 kDa product)]
[Sh2b1 Sh2bpsm1] SH2B adapter protein 1 (Pro-rich, PH and SH2 domain-containing signaling mediator) (PSM) (SH2 domain-containing protein 1B) (SH2-B PH domain-containing signaling mediator 1)
[RGS4] Regulator of G-protein signaling 4 (RGP4) (RGS4)
[HSP90AB1 HSP90B HSPC2 HSPCB] Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84)
[GNAI1] Guanine nucleotide-binding protein G(i) subunit alpha-1 (Adenylate cyclase-inhibiting G alpha protein)
[RGS14] Regulator of G-protein signaling 14 (RGS14)
[Gnai1 Gnai-1] Guanine nucleotide-binding protein G(i) subunit alpha-1 (Adenylate cyclase-inhibiting G alpha protein)
[Rgs16 Rgsr] Regulator of G-protein signaling 16 (RGS16) (A28-RGS14P) (Retinal-specific RGS) (RGS-r) (Retinally abundant regulator of G-protein signaling)
[Rgs4] Regulator of G-protein signaling 4 (RGP4) (RGS4)
[Socs3 Cis3 Cish3] Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (Protein EF-10)
[Dynlt1 Tctel1 Tctex-1 Tctex1] Dynein light chain Tctex-type 1 (Activator of G-protein signaling 2) (AGS2) (T-complex testis-specific protein 1) (TCTEX-1)
[Socs7 Cish7 Nap4] Suppressor of cytokine signaling 7 (SOCS-7)
[Gpsm2 Lgn Pins] G-protein-signaling modulator 2 (Pins homolog)
[GNAI1] Guanine nucleotide-binding protein G(i) subunit alpha-1 (Adenylate cyclase-inhibiting G alpha protein)
[HFR1 BHLH26 EN68 FBI1 REP1 RSF1 At1g02340 T6A9.4 T6A9_13] Transcription factor HFR1 (Basic helix-loop-helix protein 26) (AtbHLH26) (bHLH 26) (Protein LONG HYPOCOTYL IN FAR-RED 1) (Protein REDUCED PHYTOCHROME SIGNALING) (Reduced sensitivity to far-red light) (Transcription factor EN 68) (bHLH transcription factor bHLH026)
[GNAI1] Guanine nucleotide-binding protein G(i) subunit alpha-1 (Adenylate cyclase-inhibiting G alpha protein)
[BAG6 BAT3 G3] Large proline-rich protein BAG6 (BAG family molecular chaperone regulator 6) (BCL2-associated athanogene 6) (BAG-6) (HLA-B-associated transcript 3) (Protein G3) (Protein Scythe)
[Cdc42] Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)

Bibliography :