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Retinal guanylyl cyclase 1 (RETGC-1) (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (Guanylate cyclase E) (GC-E) (Rod outer segment membrane guanylate cyclase) (ROS-GC)

 GUC2D_CANLF             Reviewed;        1109 AA.
O19179;
15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
01-JAN-1998, sequence version 1.
16-JAN-2019, entry version 123.
RecName: Full=Retinal guanylyl cyclase 1;
Short=RETGC-1;
EC=4.6.1.2;
AltName: Full=Guanylate cyclase 2D, retinal;
AltName: Full=Guanylate cyclase E;
Short=GC-E;
AltName: Full=Rod outer segment membrane guanylate cyclase;
Short=ROS-GC;
Flags: Precursor;
Name=GUCY2D; Synonyms=GUC2D;
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
Canis.
NCBI_TaxID=9615;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND TISSUE SPECIFICITY.
STRAIN=Beagle X Briard; TISSUE=Leukocyte, and Retina;
PubMed=9651484; DOI=10.1016/S0005-2736(98)00047-9;
Veske A., Nilsson S.E.G., Gal A.;
"Organization of the canine gene encoding the E isoform of retinal
guanylate cyclase (cGC-E) and exclusion of its involvement in the
inherited retinal dystrophy of the Swedish Briard and Briard-beagle
dogs.";
Biochim. Biophys. Acta 1372:69-77(1998).
-!- CATALYTIC ACTIVITY:
Reaction=GTP = 3',5'-cyclic GMP + diphosphate;
Xref=Rhea:RHEA:13665, ChEBI:CHEBI:33019, ChEBI:CHEBI:37565,
ChEBI:CHEBI:57746; EC=4.6.1.2;
-!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
protein.
-!- TISSUE SPECIFICITY: Expressed in retina. Low expression in
cerebrum (occipital lobe). {ECO:0000269|PubMed:9651484}.
-!- PTM: There are 9 conserved cysteine residues in sensory guanylate
cyclases, 6 in the extracellular domain, which may be involved in
intra- or interchain disulfide bonds.
-!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl
cyclase family. {ECO:0000255|PROSITE-ProRule:PRU00099}.
-----------------------------------------------------------------------
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EMBL; Y15484; CAA75656.1; -; Genomic_DNA.
EMBL; Y15483; CAA75655.1; -; mRNA.
RefSeq; NP_001003207.1; NM_001003207.1.
UniGene; Cfa.3724; -.
ProteinModelPortal; O19179; -.
STRING; 9615.ENSCAFP00000024862; -.
PaxDb; O19179; -.
PRIDE; O19179; -.
GeneID; 403863; -.
KEGG; cfa:403863; -.
CTD; 3000; -.
eggNOG; KOG1023; Eukaryota.
eggNOG; COG2114; LUCA.
HOGENOM; HOG000293307; -.
HOVERGEN; HBG098487; -.
InParanoid; O19179; -.
KO; K12321; -.
OrthoDB; 229634at2759; -.
Proteomes; UP000002254; Unplaced.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
GO; GO:0005524; F:ATP binding; IEA:InterPro.
GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO; GO:0004383; F:guanylate cyclase activity; IBA:GO_Central.
GO; GO:0001653; F:peptide receptor activity; IBA:GO_Central.
GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
GO; GO:0006182; P:cGMP biosynthetic process; IBA:GO_Central.
GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
GO; GO:0007168; P:receptor guanylyl cyclase signaling pathway; IBA:GO_Central.
GO; GO:0007165; P:signal transduction; IBA:GO_Central.
GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
Gene3D; 3.30.70.1230; -; 1.
InterPro; IPR001054; A/G_cyclase.
InterPro; IPR018297; A/G_cyclase_CS.
InterPro; IPR001828; ANF_lig-bd_rcpt.
InterPro; IPR011645; HNOB_dom_associated.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR029787; Nucleotide_cyclase.
InterPro; IPR028082; Peripla_BP_I.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
Pfam; PF01094; ANF_receptor; 1.
Pfam; PF00211; Guanylate_cyc; 1.
Pfam; PF07701; HNOBA; 1.
Pfam; PF07714; Pkinase_Tyr; 1.
SMART; SM00044; CYCc; 1.
SUPFAM; SSF53822; SSF53822; 1.
SUPFAM; SSF55073; SSF55073; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
2: Evidence at transcript level;
cGMP biosynthesis; Complete proteome; Disulfide bond; Glycoprotein;
GTP-binding; Lyase; Membrane; Nucleotide-binding; Reference proteome;
Sensory transduction; Signal; Transmembrane; Transmembrane helix;
Vision.
SIGNAL 1 55 {ECO:0000250}.
CHAIN 56 1109 Retinal guanylyl cyclase 1.
/FTId=PRO_0000012380.
TOPO_DOM 56 466 Extracellular. {ECO:0000255}.
TRANSMEM 467 491 Helical. {ECO:0000255}.
TOPO_DOM 492 1109 Cytoplasmic. {ECO:0000255}.
DOMAIN 492 810 Protein kinase. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
DOMAIN 884 1014 Guanylate cyclase. {ECO:0000255|PROSITE-
ProRule:PRU00099}.
CARBOHYD 301 301 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 453 453 Interchain. {ECO:0000305}.
DISULFID 461 461 Interchain. {ECO:0000305}.
SEQUENCE 1109 AA; 119899 MW; A8C641498DCC6E90 CRC64;
MSACALLAGG LPDPRLCAPA RWARSPPGVP GAPPWPQPRL RLLLLLLLLP PSALSAVFTV
GVLGPWACDP IFARARPDLA ARLAAARLNR DAALEDGPRF EVTLLPEPCR TPGSLGAVSS
ALGRVSGLVG PVNPAACRPA ELLAQEAGVA LVPWSCPGTR AGGTTAPAGT PAADALYALL
RAFRWARVAL ITAPQDLWVE AGRALSAALR ARGLPVALVT TMEPSDLSGA REALRRVQDG
PRVRAVIMVM HSVLLGGEEQ RCLLQAAEEL GLADGSLVFL PFDTLHYALS PGPEALAVLA
NSSQLRRAHD AVLILTRHCP PGGSVMDNLR RAQEHQELPS DLDLQQVSPF FGTIYDAVLL
LAGGVARARA AAGGGWVSGA TVAHHIPDAQ VPGFCGTLGG AQEPPFVLLD TDAAGDRLFA
TYMLDPTRGS LLSAGTPVHF PRGGGTPGSD PSCWFEPGVI CNGGVEPGLV FLGFLLVVGM
GLTGAFLAHY LRHRLLHIQM VSGPNKIILT LDDVTFLHPH GGSTRKVVQG SRSSLAARST
SDIRSVPSQP LDNSNIGLFE GDWVWLKKFP GDQHIAIRPA TKTAFSKLRE LRHENVVLYL
GLFLGSGGAG GSAAGEGVLA VVSEHCARGS LHDLLAQRDI KLDWMFKSSL LLDLIKGMRY
LHHRGVAHGR LKSRNCVVDG RFVLKVTDHG HARLMEAQRV LLEPPSAEDQ LWTAPELLRD
PALERRGTLP GDVFSLGIIM QEVVCRSAPY AMLELTPEEV VERVRSPPPL CRPSVSMDQA
PVECIQLMKQ CWAEHPDLRP SLGHIFDQFK SINKGRKTNI IDSMLRMLEQ YSSNLEDLIR
ERTEELELEK QKTDRLLTQM LPPSVAEALK MGTPVEPEYF EEVTLYFSDI VGFTTISAMS
EPIEVVDLLN DLYTLFDAII GSHDVYKVET IGDAYMVASG LPQRNGQRHA AEIANMALDI
LSAVGSFRMR HMPEVPVRIR IGLHSGPCVA GVVGLTMPRY CLFGDTVNTA SRMESTGLPY
RIHVNMSTVR ILHALDEGFQ TEVRGRTELK GKGAEDTYWL VGRRGFNKPI PKPPDLQPGA
SNHGISLQEI PLDRRWKLEK ARPGQFSGK


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Pathways :
WP1693: Purine metabolism
WP668: Octadecanoid Pathway
WP1502: Mitochondrial biogenesis
WP535: neural retinal development
WP1488: CFTR activity in the plasma membrane
WP1614: 1- and 2-Methylnaphthalene degradation
WP1624: Bacterial secretion system
WP1626: Benzoate degradation via CoA ligation
WP1646: Ethylbenzene degradation
WP1665: Limonene and pinene degradation
WP1680: Oxidative phosphorylation
WP1686: Phenylalanine metabolism
WP1689: Porphyrin and chlorophyll metabolism
WP1692: Protein export
WP1713: Two-component system
WP1714: Tyrosine metabolism
WP1846: Membrane Trafficking
WP1873: NGF signalling via TRKA from the plasma membrane
WP2199: Seed Development

Related Genes :
[GUCY2D CORD6 GUC1A4 GUC2D RETGC RETGC1] Retinal guanylyl cyclase 1 (RETGC-1) (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (Rod outer segment membrane guanylate cyclase) (ROS-GC)
[GUCY2D GUC2D] Retinal guanylyl cyclase 1 (RETGC-1) (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (Guanylate cyclase E) (GC-E) (Rod outer segment membrane guanylate cyclase) (ROS-GC)
[GUCY2F GUC2F RETGC2] Retinal guanylyl cyclase 2 (RETGC-2) (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (Guanylate cyclase F) (GC-F) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2)
[GUCY2D GUC2D] Retinal guanylyl cyclase 1 (RETGC-1) (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (Guanylate cyclase E) (GC-E) (Rod outer segment membrane guanylate cyclase) (ROS-GC)
[Gucy2f Guc2f] Retinal guanylyl cyclase 2 (RETGC-2) (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (Guanylate cyclase F) (GC-F) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2)
[GUCY2F GUC2F] Retinal guanylyl cyclase 2 (RETGC-2) (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (Guanylate cyclase F) (GC-F) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2)
[Gucy2e Guc2e] Guanylyl cyclase GC-E (EC 4.6.1.2) (Guanylate cyclase 2E)
[GUCY2C GUC2C STAR] Heat-stable enterotoxin receptor (STA receptor) (hSTAR) (EC 4.6.1.2) (Guanylyl cyclase C) (GC-C) (Intestinal guanylate cyclase)
[Gucy2c Guc2c] Heat-stable enterotoxin receptor (STA receptor) (EC 4.6.1.2) (Guanylyl cyclase C) (GC-C) (Intestinal guanylate cyclase)
[Gucy2d] Olfactory guanylyl cyclase GC-D (EC 4.6.1.2) (Guanylate cyclase, olfactory)
[Gucy2c Guc2c] Heat-stable enterotoxin receptor (STA receptor) (EC 4.6.1.2) (Guanylyl cyclase C) (GC-C) (Intestinal guanylate cyclase)
[Gucy2g Ksgc] Guanylate cyclase 2G (EC 4.6.1.2) (Guanylyl cyclase receptor G) (GC-G) (Kinase-like domain-containing soluble guanylyl cyclase) (ksGC)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[GUCY1A1 GUC1A3 GUCSA3 GUCY1A3] Guanylate cyclase soluble subunit alpha-1 (GCS-alpha-1) (EC 4.6.1.2) (Guanylate cyclase soluble subunit alpha-3) (GCS-alpha-3) (Soluble guanylate cyclase large subunit)
[Gucy1a1 Gucy1a3] Guanylate cyclase soluble subunit alpha-1 (GCS-alpha-1) (EC 4.6.1.2) (Guanylate cyclase soluble subunit alpha-3) (GCS-alpha-3) (Soluble guanylate cyclase large subunit)
[GUCY1B1 GUC1B3 GUCY1B3] Guanylate cyclase soluble subunit beta-1 (GCS-beta-1) (EC 4.6.1.2) (Guanylate cyclase soluble subunit beta-3) (GCS-beta-3) (Soluble guanylate cyclase small subunit)
[NPR2 ANPRB] Atrial natriuretic peptide receptor 2 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type B) (ANP-B) (ANPR-B) (NPR-B) (Guanylate cyclase B) (GC-B)
[GUCY1B1 GUC1B3 GUCSB3 GUCY1B3] Guanylate cyclase soluble subunit beta-1 (GCS-beta-1) (EC 4.6.1.2) (Guanylate cyclase soluble subunit beta-3) (GCS-beta-3) (Soluble guanylate cyclase small subunit)
[Gucy1b1 Guc1b3 Gucy1b3] Guanylate cyclase soluble subunit beta-1 (GCS-beta-1) (EC 4.6.1.2) (Guanylate cyclase soluble subunit beta-3) (GCS-beta-3) (Soluble guanylate cyclase small subunit)
[Gucy2e Guc2e] Guanylyl cyclase GC-E (EC 4.6.1.2) (Guanylate cyclase 2E)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[gcy-36 C46E1.2] Soluble guanylate cyclase gcy-36 (EC 4.6.1.2)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]

Bibliography :