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Retinoic acid hydroxylase

 Q8VIL0_RAT              Unreviewed;       497 AA.
Q8VIL0;
01-MAR-2002, integrated into UniProtKB/TrEMBL.
06-DEC-2005, sequence version 2.
16-JAN-2019, entry version 126.
SubName: Full=Retinoic acid hydroxylase {ECO:0000313|EMBL:AAL32056.2};
Name=Cyp26a1 {ECO:0000313|RGD:620161};
Synonyms=CYP26A1 {ECO:0000313|EMBL:AAL32056.2};
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116 {ECO:0000313|EMBL:AAL32056.2};
[1] {ECO:0000313|EMBL:AAL32056.2}
NUCLEOTIDE SEQUENCE.
TISSUE=Liver {ECO:0000313|EMBL:AAL32056.2};
PubMed=12054474; DOI=10.1016/S0003-9861(02)00043-7;
Wang Y., Zolfaghari R., Ross A.C.;
"Cloning of rat cytochrome P450RAI (CYP26) cDNA and regulation of its
gene expression by all-trans-retinoic acid in vivo.";
Arch. Biochem. Biophys. 401:235-243(2002).
[2] {ECO:0000313|EMBL:AAL32056.2}
NUCLEOTIDE SEQUENCE.
TISSUE=Liver {ECO:0000313|EMBL:AAL32056.2};
Zolfaghari R., Ross A.C.;
Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
-!- SIMILARITY: Belongs to the cytochrome P450 family.
{ECO:0000256|RuleBase:RU000461, ECO:0000256|SAAS:SAAS00578476}.
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EMBL; AF439720; AAL32056.2; -; mRNA.
RefSeq; NP_569092.2; NM_130408.2.
UniGene; Rn.81072; -.
ProteinModelPortal; Q8VIL0; -.
GeneID; 154985; -.
KEGG; rno:154985; -.
UCSC; RGD:620161; rat.
CTD; 1592; -.
RGD; 620161; Cyp26a1.
eggNOG; KOG0157; Eukaryota.
eggNOG; COG2124; LUCA.
HOVERGEN; HBG051099; -.
KO; K07437; -.
OrthoDB; 871849at2759; -.
PhylomeDB; Q8VIL0; -.
Genevisible; Q8VIL0; RN.
GO; GO:0020037; F:heme binding; IEA:InterPro.
GO; GO:0005506; F:iron ion binding; IEA:InterPro.
GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
GO; GO:0001822; P:kidney development; IEP:RGD.
GO; GO:0055114; P:oxidation-reduction process; IBA:GO_Central.
GO; GO:0032526; P:response to retinoic acid; IEP:RGD.
GO; GO:0033189; P:response to vitamin A; IEP:RGD.
GO; GO:0016125; P:sterol metabolic process; IBA:GO_Central.
Gene3D; 1.10.630.10; -; 1.
InterPro; IPR001128; Cyt_P450.
InterPro; IPR017972; Cyt_P450_CS.
InterPro; IPR002403; Cyt_P450_E_grp-IV.
InterPro; IPR036396; Cyt_P450_sf.
Pfam; PF00067; p450; 1.
PRINTS; PR00465; EP450IV.
PRINTS; PR00385; P450.
SUPFAM; SSF48264; SSF48264; 1.
PROSITE; PS00086; CYTOCHROME_P450; 1.
2: Evidence at transcript level;
Heme {ECO:0000256|RuleBase:RU000461, ECO:0000256|SAAS:SAAS01092997};
Iron {ECO:0000256|RuleBase:RU000461, ECO:0000256|SAAS:SAAS01092997};
Metal-binding {ECO:0000256|RuleBase:RU000461,
ECO:0000256|SAAS:SAAS01092997};
Monooxygenase {ECO:0000256|RuleBase:RU000461,
ECO:0000256|SAAS:SAAS00966021};
Oxidoreductase {ECO:0000256|RuleBase:RU000461,
ECO:0000256|SAAS:SAAS00966021}.
SEQUENCE 497 AA; 56174 MW; 242A6441F0E399EC CRC64;
MGLPALLASA LCTFVLPLLL FLAALKLWDL YCVSSRDRSC ALPLPPGTMG FPFFGETLQM
VLQRRKFLQM KRRKYGFIYK THLFGRPTVR VMGADNVRRI LLGEHRLVSV HWPASVRTIL
GAGCLSNLHD SSHKQRKKVI MQAFNREALQ CYVPVIAEEV SGCLEQWLSC GERGLLVYPE
VKRLMFRIAM RILLGCEPGP AGGGEDEQQL VEAFEEMTRN LFSLPIDVPF SGLYRGVKAR
NLIHARIEEN IRAKIRRLQA AEPDAGCKDA LQLLIEHSWE RGERLDMQAL KQSSTELLFG
GHETTASAAT SLITYLGLYP HVLQKVREEI KSKGLLCKSH HEDKLDMETL EQLKYIGCVI
KETLRLNPPV PGGFRVALKT FELNGYQIPK GWNVIYSICD THDVADSFTN KEEFNPDRFT
SLHPEDTSRF SFIPFGGGLR SCVGKEFAKI LLKIFTVELA RRCDWQLLNG PPTMKTSPPV
YPVDNLPARF THFQGDI


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Pathways :
WP1498: Dopminergic Neurogenesis
WP1008: amino acid conjugation of benzoic acid
WP1020: Fatty Acid Biosynthesis
WP1024: Steroid Biosynthesis
WP105: Fatty Acid Beta Oxidation 2
WP1061: Fatty Acid Beta Oxidation
WP1075: Folic Acid Network
WP1107: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP1127: amino acid conjugation of benzoic acid
WP1139: Fatty Acid Biosynthesis
WP1143: Steroid Biosynthesis
WP1177: Fatty Acid Beta Oxidation
WP1192: Folic Acid Network
WP1207: Fatty Acid Beta Oxidation
WP121: Colanic Acid Building Blocks Biosynthesis
WP1226: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP1228: Fatty Acid Biosynthesis
WP1237: Fatty Acid Beta Oxidation
WP1252: amino acid conjugation of benzoic acid
WP126: Fatty Acid Beta Oxidation 1
WP1269: Fatty Acid Beta Oxidation
WP1273: Folic Acid Network
WP1287: amino acid conjugation of benzoic acid
WP1307: Fatty Acid Beta Oxidation
WP1311: Folic Acid Network

Related Genes :
[CYP26A1 CYP26 P450RAI1] Cytochrome P450 26A1 (EC 1.14.13.-) (Cytochrome P450 retinoic acid-inactivating 1) (Cytochrome P450RAI) (hP450RAI) (Retinoic acid 4-hydroxylase) (Retinoic acid-metabolizing cytochrome)
[cyp26a1 cyp26] Cytochrome P450 26A1 (EC 1.14.13.-) (Cytochrome P450RAI) (Retinoic acid 4-hydroxylase) (Retinoic acid-metabolizing cytochrome)
[Cyp26a1 Cyp26 P450ra] Cytochrome P450 26A1 (EC 1.14.13.-) (Cytochrome P450RAI) (Retinoic acid 4-hydroxylase) (Retinoic acid-metabolizing cytochrome)
[CYP26B1 CYP26A2 P450RAI2] Cytochrome P450 26B1 (EC 1.14.13.-) (Cytochrome P450 26A2) (Cytochrome P450 retinoic acid-inactivating 2) (Cytochrome P450RAI-2) (Retinoic acid-metabolizing cytochrome)
[raraa nr1b1a rara2a zgc:109797] Retinoic acid receptor alpha-A (RAR-alpha-A) (Nuclear receptor subfamily 1 group B member 1-A) (Retinoic acid receptor alpha) (zRAR alpha) (Retinoic acid receptor alpha-2.A) (RAR-alpha-2.A)
[CRABP2] Cellular retinoic acid-binding protein 2 (Cellular retinoic acid-binding protein II) (CRABP-II)
[Crabp2] Cellular retinoic acid-binding protein 2 (Cellular retinoic acid-binding protein II) (CRABP-II)
[rarab nr1b1b rara2b] Retinoic acid receptor alpha-B (RAR-alpha-B) (Nuclear receptor subfamily 1 group B member 1-B) (Retinoic acid receptor alpha-2.B) (RAR-alpha-2.B)
[Stra6] Receptor for retinol uptake STRA6 (Retinoic acid-responsive protein) (Retinol-binding protein receptor STRA6) (Stimulated by retinoic acid gene 6 protein)
[DDX58] Probable ATP-dependent RNA helicase DDX58 (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I)
[rxrga nr2b1 nr2b3a rxr rxra rxrg] Retinoic acid receptor RXR-gamma-A (Nuclear receptor subfamily 2 group B member 3-A) (Retinoic acid receptor RXR-alpha) (Retinoid X receptor alpha) (Retinoid X receptor gamma-A)
[AOX1 AO] Aldehyde oxidase 1 (EC 1.2.3.1) (Azaheterocycle hydroxylase 1) (EC 1.17.3.-) (Retinal oxidase) (Retinoic acid synthase)
[GPRC5A GPCR5A RAI3 RAIG1] Retinoic acid-induced protein 3 (G-protein coupled receptor family C group 5 member A) (Phorbol ester induced gene 1) (PEIG-1) (Retinoic acid-induced gene 1 protein) (RAIG-1)
[CYP4F2] Phylloquinone omega-hydroxylase CYP4F2 (EC 1.14.14.78) (20-hydroxyeicosatetraenoic acid synthase) (20-HETE synthase) (EC 1.14.14.-) (Arachidonic acid omega-hydroxylase) (CYPIVF2) (Cytochrome P450 4F2) (Cytochrome P450-LTB-omega) (Leukotriene-B(4) 20-monooxygenase 1) (Leukotriene-B(4) omega-hydroxylase 1) (EC 1.14.14.94)
[Gprc5a Rai3 Raig1] Retinoic acid-induced protein 3 (G-protein coupled receptor family C group 5 member A) (Retinoic acid-induced gene 1 protein) (RAIG-1)
[Cyp26b1] Cytochrome P450 26B1 (EC 1.14.13.-) (Cytochrome P450 retinoic acid-inactivating 2) (Cytochrome P450RAI-2)
[RARA NR1B1 hCG_2007196] RARA protein (Retinoic acid nuclear receptor alpha variant 1) (Retinoic acid receptor, alpha, isoform CRA_c) (cDNA, FLJ92939, Homo sapiens retinoic acid receptor, alpha (RARA), mRNA)
[cyp26b1] Cytochrome P450 26B1 (Cyp26B1) (EC 1.14.13.-) (Retinoic acid-metabolizing cytochrome)
[NCOR2 CTG26] Nuclear receptor corepressor 2 (N-CoR2) (CTG repeat protein 26) (SMAP270) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (T3 receptor-associating factor) (TRAC) (Thyroid-, retinoic-acid-receptor-associated corepressor)
[Ddx58] Probable ATP-dependent RNA helicase DDX58 (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I)
[Rara rCG_33521] Retinoic acid receptor, alpha (Retinoic acid receptor, alpha, isoform CRA_a)
[Rara rCG_33521] Retinoic acid receptor, alpha (Retinoic acid receptor, alpha, isoform CRA_b)
[RARA NR1B1] Retinoic acid receptor alpha (RAR-alpha) (Nuclear receptor subfamily 1 group B member 1)
[Rara Nr1b1] Retinoic acid receptor alpha (RAR-alpha) (Nuclear receptor subfamily 1 group B member 1)
[RXRA NR2B1] Retinoic acid receptor RXR-alpha (Nuclear receptor subfamily 2 group B member 1) (Retinoid X receptor alpha)
[RARB HAP NR1B2] Retinoic acid receptor beta (RAR-beta) (HBV-activated protein) (Nuclear receptor subfamily 1 group B member 2) (RAR-epsilon)
[Rxra Nr2b1] Retinoic acid receptor RXR-alpha (Nuclear receptor subfamily 2 group B member 1) (Retinoid X receptor alpha)
[RARG NR1B3] Retinoic acid receptor gamma (RAR-gamma) (Nuclear receptor subfamily 1 group B member 3)
[rarga nr1b3a rarg rarg2 si:dkey-148f24.2] Retinoic acid receptor gamma-A (RAR-gamma-A) (zRAR gamma) (Nuclear receptor subfamily 1 group B member 3-A) (RAR-gamma-2)
[Rarb Nr1b2] Retinoic acid receptor beta (RAR-beta) (Nuclear receptor subfamily 1 group B member 2)

Bibliography :
[30935413] Silica nanoparticle-exposure during neuronal differentiation modulates dopaminergic and cholinergic phenotypes in SH-SY5Y cells.
[30373117] Altered Expression of Retinol Metabolism-Related Genes in an ANIT-Induced Cholestasis Rat Model.
[30366296] Long-term exposure of xenoestrogens with environmental relevant concentrations disrupted spermatogenesis of zebrafish through altering sex hormone balance, stimulating germ cell proliferation, meiosis and enhancing apoptosis.
[30296653] Testosterone-retinoic acid signaling directs spermatogonial differentiation and seasonal spermatogenesis in the Plateau pika (Ochotona curzoniae).
[30250298] Inhibition of 15-PGDH causes Kras-driven tumor expansion through prostaglandin E2-ALDH1 signaling in the pancreas.
[30203271] DT-Diaphorase Prevents Aminochrome-Induced Lysosome Dysfunction in SH-SY5Y Cells.
[30111657] RARγ is required for mesodermal gene expression prior to gastrulation in .
[30064139] Zedoarondiol Attenuates Endothelial Cells Injury Induced by Oxidized Low-Density Lipoprotein via Nrf2 Activation.
[30030988] Effects of trans-resveratrol on type 1 diabetes-induced inhibition of retinoic acid metabolism pathway in retinal pigment epithelium of Dark Agouti rats.
[29935399] Bardoxolone methyl induces neuritogenesis in Neuro2a cells.