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Riboflavin transporter rft-1 (Solute carrier family 52, riboflavin transporter rft-1)

 S52AA_CAEEL             Reviewed;         427 AA.
Q3LFN0;
20-DEC-2017, integrated into UniProtKB/Swiss-Prot.
21-MAR-2012, sequence version 2.
12-AUG-2020, entry version 96.
RecName: Full=Riboflavin transporter rft-1 {ECO:0000303|PubMed:23483992};
AltName: Full=Solute carrier family 52, riboflavin transporter rft-1 {ECO:0000305};
Name=rft-1 {ECO:0000303|PubMed:23483992, ECO:0000312|WormBase:Y47D7A.16a};
ORFNames=Y47D7A.16 {ECO:0000312|WormBase:Y47D7A.16a};
Caenorhabditis elegans.
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
Caenorhabditis.
NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
[1] {ECO:0000312|Proteomes:UP000001940}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
PubMed=9851916; DOI=10.1126/science.282.5396.2012;
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for investigating
biology.";
Science 282:2012-2018(1998).
[2] {ECO:0000305}
FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY, DEVELOPMENTAL
STAGE, INDUCTION, AND DISRUPTION PHENOTYPE.
PubMed=23483992; DOI=10.1371/journal.pone.0058190;
Biswas A., Elmatari D., Rothman J., LaMunyon C.W., Said H.M.;
"Identification and functional characterization of the Caenorhabditis
elegans riboflavin transporters rft-1 and rft-2.";
PLoS ONE 8:E58190-E58190(2013).
-!- FUNCTION: Riboflavin transporter. Riboflavin transport is Na(+)-
independent but pH-sensitive. {ECO:0000269|PubMed:23483992}.
-!- ACTIVITY REGULATION: Activity is strongly inhibited by riboflavin
analogs, such as lumiflavin and lumichrome.
{ECO:0000269|PubMed:23483992}.
-!- BIOPHYSICOCHEMICAL PROPERTIES:
pH dependence:
Optimum pH is 5. {ECO:0000269|PubMed:23483992};
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
protein {ECO:0000255}.
-!- TISSUE SPECIFICITY: Expressed in intestine.
{ECO:0000269|PubMed:23483992}.
-!- DEVELOPMENTAL STAGE: Highly expressed at L1 larval stage and to a
lesser extent in adults. {ECO:0000269|PubMed:23483992}.
-!- INDUCTION: Down-regulated by high levels of riboflavin.
{ECO:0000269|PubMed:23483992}.
-!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown causes a severe reduction
in the number of laid eggs; the few laid eggs fail to hatch.
{ECO:0000269|PubMed:23483992}.
-!- SIMILARITY: Belongs to the riboflavin transporter family.
{ECO:0000305}.
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EMBL; BX284605; CCD69385.2; -; Genomic_DNA.
RefSeq; NP_001033515.2; NM_001038426.2.
STRING; 6239.Y47D7A.16; -.
PaxDb; Q3LFN0; -.
EnsemblMetazoa; Y47D7A.16a.1; Y47D7A.16a.1; WBGene00044637.
GeneID; 3896860; -.
KEGG; cel:CELE_Y47D7A.16; -.
UCSC; Y47D7A.16; c. elegans.
CTD; 3896860; -.
WormBase; Y47D7A.16a; CE47043; WBGene00044637; rft-1.
eggNOG; KOG4255; Eukaryota.
GeneTree; ENSGT00390000003774; -.
HOGENOM; CLU_034789_1_0_1; -.
InParanoid; Q3LFN0; -.
KO; K14620; -.
OMA; TFLPFMF; -.
OrthoDB; 757564at2759; -.
Reactome; R-CEL-196843; Vitamin B2 (riboflavin) metabolism.
PRO; PR:Q3LFN0; -.
Proteomes; UP000001940; Chromosome V.
Bgee; WBGene00044637; Expressed in multi-cellular organism and 3 other tissues.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0032217; F:riboflavin transmembrane transporter activity; IDA:CACAO.
GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:CACAO.
GO; GO:0032218; P:riboflavin transport; IBA:GO_Central.
InterPro; IPR009357; Riboflavin_transptr.
PANTHER; PTHR12929; PTHR12929; 1.
Pfam; PF06237; DUF1011; 1.
1: Evidence at protein level;
Cell membrane; Membrane; Reference proteome; Transmembrane;
Transmembrane helix; Transport.
CHAIN 1..427
/note="Riboflavin transporter rft-1"
/id="PRO_0000442703"
TOPO_DOM 1..2
/note="Cytoplasmic"
/evidence="ECO:0000305"
TRANSMEM 3..23
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 24..42
/note="Extracellular"
/evidence="ECO:0000305"
TRANSMEM 43..63
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 64..73
/note="Cytoplasmic"
/evidence="ECO:0000305"
TRANSMEM 74..94
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 95..111
/note="Extracellular"
/evidence="ECO:0000305"
TRANSMEM 112..132
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 133..139
/note="Cytoplasmic"
/evidence="ECO:0000305"
TRANSMEM 140..160
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 161..184
/note="Extracellular"
/evidence="ECO:0000305"
TRANSMEM 185..205
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 206..261
/note="Cytoplasmic"
/evidence="ECO:0000305"
TRANSMEM 262..282
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 283..297
/note="Extracellular"
/evidence="ECO:0000305"
TRANSMEM 298..318
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 319..322
/note="Cytoplasmic"
/evidence="ECO:0000305"
TRANSMEM 323..343
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 344..353
/note="Extracellular"
/evidence="ECO:0000305"
TRANSMEM 354..374
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 375..391
/note="Cytoplasmic"
/evidence="ECO:0000305"
TRANSMEM 392..412
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 413..427
/note="Extracellular"
/evidence="ECO:0000305"
SEQUENCE 427 AA; 47067 MW; 86097E48B3D7AC14 CRC64;
MKTFLFTFCL VAIFGSSSWI GTNSVWMELS LLTAKLPEGW NLPSYLSAIV QIACLGPLIY
SIIHKGIKMT IPTVPLIFIF MVLACICQLG LCFFWDDTGY IFGAIRSWPL YLLLFGLAIV
DAISSVLFLP FMAQFHPSFL NAYFVGMGLS ALIPSLLSLI QGTSNYWCDD NKTPHYYPPR
FSVSMFFLIN FFFTCAAVAA FLVLYKIGAH KNSSQVEPEP KHSIQIIQGD STTDVNEVNT
ESSFQETSSI PDSSSATGAR LAFLLLTTAL VNAQMNGIVT SVQSYATLVY SQNTYHYAVT
LSNVISPLAS YLQFFVKIRS LPILAFLTLC SSLTTAVIIY LAALSPNWIF NSETAGTIIS
IASSLIAAGL HSYLRVMFAA LLREGNQKES RLFWCGAFIQ IGSFTGSAIM FPLVNVWKLF
HSAPSCR


Related products :

Catalog number Product name Quantity
E1198m Rat ELISA Kit FOR Solute carrier family 52, riboflavin transporter, member 3 96T
E1209b Pig ELISA Kit FOR Solute carrier family 52, riboflavin transporter, member 2 96T
E1253h Human ELISA Kit FOR Solute carrier family 52, riboflavin transporter, member 3 96T
EIAAB39156 Homo sapiens,Human,OATP2A1,PGT,Prostaglandin transporter,SLC21A2,SLCO2A1,Solute carrier family 21 member 2,Solute carrier organic anion transporter family member 2A1
EIAAB39157 Matr1,Matrin F_G 1,PGT,Prostaglandin transporter,Rat,Rattus norvegicus,Slc21a2,Slco2a1,Solute carrier family 21 member 2,Solute carrier organic anion transporter family member 2A1
EIAAB39155 Mouse,Mus musculus,Oatp2a1,PGT,Prostaglandin transporter,Slc21a2,Slco2a1,Solute carrier family 21 member 2,Solute carrier organic anion transporter family member 2A1
EIAAB36742 Carnitine transporter 2,CT2,Flipt 2,FLIPT2,Fly-like putative transporter 2,Homo sapiens,Human,OCT6,Organic cation transporter OKB1,Organic cation_carnitine transporter 6,SLC22A16,Solute carrier family
EIAAB36707 Ergothioneine transporter,ET transporter,ETT,Homo sapiens,Human,OCTN1,Organic cation_carnitine transporter 1,SLC22A4,Solute carrier family 22 member 4,UT2H
EIAAB36639 Homo sapiens,Human,OCTP,Osteoclast transporter,Peptide transporter 3,Peptide_histidine transporter 2,PHT2,PTR3,SLC15A3,Solute carrier family 15 member 3
EIAAB39171 Homo sapiens,Human,OATP5A1,OATPRP4,OATP-RP4,Organic anion transporter polypeptide-related protein 4,SLC21A15,SLCO5A1,Solute carrier family 21 member 15,Solute carrier organic anion transporter family
EIAAB39141 OAT-K1,OAT-K2,Oatp1a3,Rat,Rattus norvegicus,rOAT-K,Slc21a4,Slco1a3,Sodium-independent organic anion transporter K1,Solute carrier family 21 member 4,Solute carrier organic anion transporter family mem
EIAAB12295 Eaat1,Excitatory amino acid transporter 1,GLAST-1,Glial glutamate transporter,Rat,Rattus norvegicus,Slc1a3,Sodium-dependent glutamate_aspartate transporter 1,Solute carrier family 1 member 3
EIAAB12308 Eaat4,Excitatory amino acid transporter 4,High-affinity neuronal glutamate transporter,Rat,Rattus norvegicus,Slc1a6,Sodium-dependent glutamate_aspartate transporter,Solute carrier family 1 member 6
EIAAB36763 Homo sapiens,hSVCT2,Human,KIAA0238,Na(+)_L-ascorbic acid transporter 2,NBTL1,Nucleobase transporter-like 1 protein,SLC23A1,SLC23A2,Sodium-dependent vitamin C transporter 2,Solute carrier family 23 mem
EIAAB12307 Eaat4,Excitatory amino acid transporter 4,High-affinity neuronal glutamate transporter,Mouse,Mus musculus,Slc1a6,Sodium-dependent glutamate_aspartate transporter,Solute carrier family 1 member 6
EIAAB25211 Homo sapiens,Human,MCT 7,MCT 8,MCT8,Monocarboxylate transporter 7,Monocarboxylate transporter 8,SLC16A2,Solute carrier family 16 member 2,X-linked PEST-containing transporter,XPCT
EIAAB36913 3'-phosphoadenosine 5'-phosphosulfate transporter,Adenosine 3'-phospho 5'-phosphosulfate transporter 2,C6orf196,CGI-19,Homo sapiens,Human,PAPS transporter 2,PAPST2,SLC35B3,Solute carrier family 35 mem
EIAAB39150 Liver-specific organic anion transporter 1,LST-1,Mouse,Mus musculus,Oatp1b2,Slc21a10,SLC21A6,Slco1b2,Solute carrier family 21 member 10,Solute carrier organic anion transporter family member 1B2
EIAAB37153 Rat,Rattus norvegicus,Sit1,Slc6a20,Sodium- and chloride-dependent transporter XTRP3,Sodium_imino-acid transporter 1,Solute carrier family 6 member 20,Transporter rB21A,Xtrp3
EIAAB39153 BBB-specific anion transporter type 1,Blood-brain barrier-specific anion transporter 1,Bsat1,Oatp1c1,Oatpf,Rat,Rattus norvegicus,Slc21a14,Slco1c1,Solute carrier family 21 member 14,Solute carrier orga
EIAAB12297 EAAT2,Excitatory amino acid transporter 2,GLT1,Glutamate_aspartate transporter II,Homo sapiens,Human,SLC1A2,Sodium-dependent glutamate_aspartate transporter 2,Solute carrier family 1 member 2
EIAAB37152 Homo sapiens,Human,SIT1,SLC6A20,Sodium- and chloride-dependent transporter XTRP3,Sodium_imino-acid transporter 1,Solute carrier family 6 member 20,Transporter rB21A homolog,XT3,XTRP3
EIAAB39158 Oatp2b1,Organic anion transporter moatp1,Rat,Rattus norvegicus,Slc21a9,Slco2b1,Solute carrier family 21 member 9,Solute carrier organic anion transporter family member 2B1
EIAAB30131 Bos taurus,Bovine,HCP1,Heme carrier protein 1,PCFT,PCFT_HCP1,Proton-coupled folate transporter,Retinal pigment epithelium transporter,SLC46A1,Solute carrier family 46 member 1,TRPE
EIAAB45487 Oryctolagus cuniculus,Rabbit,SLC14A2,Solute carrier family 14 member 2,Urea transporter 2,Urea transporter, kidney,UT2,Vasopressin-regulated urea transporter
Pathways :
WP2347: vitamin B5 (pantothenate) and CoA biosynthesis Pathway
WP1455: Serotonin Transporter Activity
WP2345: vitamin B7 (biotin) biosynthesis pathway
WP381: Riboflavin, FMN, and FAD Biosynthesis
WP1689: Porphyrin and chlorophyll metabolism
WP2344: vitamin B6 (pyridoxine, pyridoxal, pyridoxamine) biosynthesis and salvage pathway
WP1493: Carbon assimilation C4 pathway
WP2349: vitamin B3 (niacin), NAD and NADP biosynthesis pathway
WP1680: Oxidative phosphorylation
WP1713: Two-component system
WP2339: vitamin B2 (riboflavin) biosynthesis and conversion to FMN and FAD pathway
WP1616: ABC transporters
WP1696: Riboflavin metabolism
WP1502: Mitochondrial biogenesis
WP1780: ABC-family proteins mediated transport
WP211: BMP signaling pathway
WP1909: Signal regulatory protein (SIRP) family interactions
WP1485: Interactions between CFTR and other ion channels
WP1799: Costimulation by the CD28 family
WP2199: Seed Development

Related Genes :
[SLC52A1 GPR172B PAR2 RFT1] Solute carrier family 52, riboflavin transporter, member 1 (Porcine endogenous retrovirus A receptor 2) (PERV-A receptor 2) (huPAR-2) (Protein GPR172B) (Riboflavin transporter 1) (hRFT1)
[SLC52A3 C20orf54 RFT2 RFVT3] Solute carrier family 52, riboflavin transporter, member 3 (Riboflavin transporter 2) (hRFT2)
[rft-1 Y47D7A.16] Riboflavin transporter rft-1 (Solute carrier family 52, riboflavin transporter rft-1)
[SLC19A1 FLOT1 RFC1] Reduced folate transporter (FOLT) (Intestinal folate carrier 1) (IFC-1) (Placental folate transporter) (Reduced folate carrier protein) (RFC) (hRFC) (Reduced folate transporter 1) (RFT-1) (Solute carrier family 19 member 1) (hSLC19A1)
[Slc2a1 Glut1] Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1) (GT1)
[SLC2A1 GLUT1] Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1) (HepG2 glucose transporter)
[SLC22A18 BWR1A BWSCR1A HET IMPT1 ITM ORCTL2 SLC22A1L TSSC5] Solute carrier family 22 member 18 (Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein) (Efflux transporter-like protein) (Imprinted multi-membrane-spanning polyspecific transporter-related protein 1) (Organic cation transporter-like protein 2) (ORCTL-2) (Solute carrier family 22 member 1-like) (Tumor-suppressing STF cDNA 5 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein) (p45-Beckwith-Wiedemann region 1 A) (p45-BWR1A)
[SLCO1B3 LST2 OATP1B3 OATP8 SLC21A8] Solute carrier organic anion transporter family member 1B3 (Liver-specific organic anion transporter 2) (LST-2) (Organic anion transporter 8) (Organic anion-transporting polypeptide 8) (OATP-8) (Solute carrier family 21 member 8)
[SLCO1B1 LST1 OATP1B1 OATP2 OATPC SLC21A6] Solute carrier organic anion transporter family member 1B1 (Liver-specific organic anion transporter 1) (LST-1) (OATP-C) (Sodium-independent organic anion-transporting polypeptide 2) (OATP-2) (Solute carrier family 21 member 6)
[Slco1b2 Oatp1b2 Slc21a10] Solute carrier organic anion transporter family member 1B2 (Liver-specific organic anion transporter 1) (rLST-1) (Sodium-independent organic anion-transporting polypeptide 4) (OATP-4) (Solute carrier family 21 member 10)
[Slco1a3 Oatp1a3 Slc21a4] Solute carrier organic anion transporter family member 1A3 (OAT-K2) (Sodium-independent organic anion transporter K1) (OAT-K1) (Solute carrier family 21 member 4) (rOAT-K)
[SLCO4C1 OATP4C1 OATPX SLC21A20] Solute carrier organic anion transporter family member 4C1 (OATP-H) (Organic anion transporter M1) (OATP-M1) (Solute carrier family 21 member 20)
[SLC40A1 FPN1 IREG1 SLC11A3 MSTP079] Solute carrier family 40 member 1 (Ferroportin-1) (Iron-regulated transporter 1)
[SLC46A1 HCP1 PCFT] Proton-coupled folate transporter (G21) (Heme carrier protein 1) (PCFT/HCP1) (Solute carrier family 46 member 1)
[Slco1c1 Bsat1 Oatp1c1 Oatpf Slc21a14] Solute carrier organic anion transporter family member 1C1 (BBB-specific anion transporter type 1) (Blood-brain barrier-specific anion transporter 1) (Solute carrier family 21 member 14) (Thyroxine transporter)
[SLC33A1 ACATN AT1] Acetyl-coenzyme A transporter 1 (AT-1) (Acetyl-CoA transporter 1) (Solute carrier family 33 member 1)
[Slc2a1 Glut1] Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1)
[SLC23A2 KIAA0238 NBTL1 SLC23A1 SVCT2 YSPL2] Solute carrier family 23 member 2 (Na(+)/L-ascorbic acid transporter 2) (Nucleobase transporter-like 1 protein) (Sodium-dependent vitamin C transporter 2) (hSVCT2) (Yolk sac permease-like molecule 2)
[SLC5A8 AIT SMCT SMCT1] Sodium-coupled monocarboxylate transporter 1 (Apical iodide transporter) (Electrogenic sodium monocarboxylate cotransporter) (Sodium iodide-related cotransporter) (Solute carrier family 5 member 8)
[SLC23A1 SVCT1 YSPL3] Solute carrier family 23 member 1 (Na(+)/L-ascorbic acid transporter 1) (Sodium-dependent vitamin C transporter 1) (hSVCT1) (Yolk sac permease-like molecule 3)
[SLC35B2 PAPST1 PSEC0149] Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (PAPS transporter 1) (Putative MAPK-activating protein PM15) (Putative NF-kappa-B-activating protein 48) (Solute carrier family 35 member B2)
[Slc23a1 Svct1] Solute carrier family 23 member 1 (Na(+)/L-ascorbic acid transporter 1) (Sodium-dependent vitamin C transporter 1)
[Slc40a1 Fpn1 Ireg1 Slc11a3 Slc39a1] Solute carrier family 40 member 1 (Ferroportin-1) (Iron-regulated transporter 1) (Metal transporter protein 1) (MTP1)
[SLC25A32 MFT MFTC] Mitochondrial folate transporter/carrier (Solute carrier family 25 member 32)
[SLC22A1 OCT1] Solute carrier family 22 member 1 (Organic cation transporter 1) (hOCT1)
[SLC16A12 MCT12] Monocarboxylate transporter 12 (MCT 12) (Creatine transporter 2) (CRT2) (Solute carrier family 16 member 12)
[SLC38A1 ATA1 NAT2 SAT1 SNAT1] Sodium-coupled neutral amino acid transporter 1 (Amino acid transporter A1) (N-system amino acid transporter 2) (Solute carrier family 38 member 1) (System A amino acid transporter 1) (System N amino acid transporter 1)
[Slc22a1 Lx1 Oct1] Solute carrier family 22 member 1 (Organic cation transporter 1) (mOCT1)
[Slc22a1 Oct1] Solute carrier family 22 member 1 (Organic cation transporter 1) (rOCT1)
[SLC2A1 GLUT1] Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1)

Bibliography :