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Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small subunit)

 Q99CY2_BHV4             Unreviewed;       305 AA.
Q99CY2;
01-JUN-2001, integrated into UniProtKB/TrEMBL.
01-JUN-2001, sequence version 1.
13-FEB-2019, entry version 81.
RecName: Full=Ribonucleoside-diphosphate reductase small subunit {ECO:0000256|HAMAP-Rule:MF_04028};
EC=1.17.4.1 {ECO:0000256|HAMAP-Rule:MF_04028};
AltName: Full=Ribonucleotide reductase small subunit {ECO:0000256|HAMAP-Rule:MF_04028};
Name=ORF 60 {ECO:0000313|EMBL:AEL29804.1};
Synonyms=RIR2 {ECO:0000256|HAMAP-Rule:MF_04028};
Bovine herpesvirus 4 (BoHV-4) (Movar virus).
Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae;
Gammaherpesvirinae; Rhadinovirus.
NCBI_TaxID=10385 {ECO:0000313|EMBL:AAK07979.1, ECO:0000313|Proteomes:UP000109731};
NCBI_TaxID=9913; Bos taurus (Bovine).
NCBI_TaxID=9685; Felis catus (Cat) (Felis silvestris catus).
NCBI_TaxID=9689; Panthera leo (Lion).
[1] {ECO:0000313|EMBL:AAK07979.1, ECO:0000313|Proteomes:UP000109731}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=11152491; DOI=10.1128/JVI.75.3.1186-1194.2001;
Zimmermann W., Broll H., Ehlers B., Buhk H.-J., Rosenthal A.,
Goltz M.;
"Genome sequence of bovine herpesvirus 4, a bovine Rhadinovirus, and
identification of an origin of DNA replication.";
J. Virol. 75:1186-1194(2001).
[2] {ECO:0000313|EMBL:AEL29804.1}
NUCLEOTIDE SEQUENCE.
STRAIN=V.test {ECO:0000313|EMBL:AEL29804.1};
PubMed=21846388;
Palmeira L., Machiels B., Lete C., Vanderplasschen A., Gillet L.;
"Sequencing of Bovine herpesvirus 4 V.test strain reveals important
genome features.";
Virol. J. 8:406-406(2011).
[3] {ECO:0000313|EMBL:AIA82805.1}
NUCLEOTIDE SEQUENCE.
STRAIN=FMV09-1180503 {ECO:0000313|EMBL:AIA82805.1};
Music N., Laroche J., Tremblay D., Mandeville I., Bellehumeur C.,
Charette S.J., Gagnon C.A.;
"Seroprevalence against a Canadian isolate of bovine herpesvirus 4
(BHV4) is higher in various diseases affected bovine dairy herds
compared to healthy herds.";
Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Ribonucleoside-diphosphate reductase holoenzyme provides
the precursors necessary for viral DNA synthesis. Allows virus
growth in non-dividing cells, as well as reactivation from latency
in infected hosts. Catalyzes the biosynthesis of
deoxyribonucleotides from the corresponding ribonucleotides.
{ECO:0000256|HAMAP-Rule:MF_04028}.
-!- CATALYTIC ACTIVITY:
Reaction=[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-
diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-
diphosphate; Xref=Rhea:RHEA:23252, Rhea:RHEA-COMP:10698,
Rhea:RHEA-COMP:10700, ChEBI:CHEBI:15377, ChEBI:CHEBI:29950,
ChEBI:CHEBI:50058, ChEBI:CHEBI:57930, ChEBI:CHEBI:73316;
EC=1.17.4.1; Evidence={ECO:0000256|HAMAP-Rule:MF_04028};
-!- COFACTOR:
Name=Fe cation; Xref=ChEBI:CHEBI:24875;
Evidence={ECO:0000256|HAMAP-Rule:MF_04028};
-!- PATHWAY: Genetic information processing; DNA replication.
{ECO:0000256|HAMAP-Rule:MF_04028}.
-!- SUBUNIT: Heterotetramer composed of a homodimer of the large
subunit (R1) and a homodimer of the small subunit (R2). Larger
multisubunit protein complex are also active, composed of
(R1)n(R2)n. {ECO:0000256|HAMAP-Rule:MF_04028}.
-!- SUBCELLULAR LOCATION: Host membrane {ECO:0000256|HAMAP-
Rule:MF_04028}; Single-pass membrane protein {ECO:0000256|HAMAP-
Rule:MF_04028}.
-!- SIMILARITY: Belongs to the ribonucleoside diphosphate reductase
small chain family. {ECO:0000256|HAMAP-Rule:MF_04028}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AF318573; AAK07979.1; -; Genomic_DNA.
EMBL; JN133502; AEL29804.1; -; Genomic_DNA.
EMBL; KC999113; AIA82805.1; -; Genomic_DNA.
RefSeq; NP_076552.1; NC_002665.1.
GeneID; 1684946; -.
KEGG; vg:1684946; -.
OrthoDB; 3710at10239; -.
UniPathway; UPA00326; -.
Proteomes; UP000109731; Genome.
GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
GO; GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IEA:UniProtKB-UniRule.
GO; GO:0009186; P:deoxyribonucleoside diphosphate metabolic process; IEA:UniProtKB-UniRule.
GO; GO:0009263; P:deoxyribonucleotide biosynthetic process; IEA:InterPro.
GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
CDD; cd01049; RNRR2; 1.
Gene3D; 1.10.620.20; -; 1.
HAMAP; MF_04028; HSV_RIR2; 1.
InterPro; IPR009078; Ferritin-like_SF.
InterPro; IPR034715; HSV_RIR2.
InterPro; IPR012348; RNR-like.
InterPro; IPR033909; RNR_small.
InterPro; IPR030475; RNR_small_AS.
InterPro; IPR000358; RNR_small_fam.
PANTHER; PTHR23409; PTHR23409; 1.
Pfam; PF00268; Ribonuc_red_sm; 1.
SUPFAM; SSF47240; SSF47240; 1.
PROSITE; PS00368; RIBORED_SMALL; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000109731};
DNA replication {ECO:0000256|HAMAP-Rule:MF_04028};
Host membrane {ECO:0000256|HAMAP-Rule:MF_04028};
Iron {ECO:0000256|HAMAP-Rule:MF_04028};
Membrane {ECO:0000256|HAMAP-Rule:MF_04028};
Metal-binding {ECO:0000256|HAMAP-Rule:MF_04028};
Oxidoreductase {ECO:0000256|HAMAP-Rule:MF_04028};
Reference proteome {ECO:0000313|Proteomes:UP000109731};
Transmembrane {ECO:0000256|HAMAP-Rule:MF_04028};
Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_04028}.
TRANSMEM 150 171 Helical. {ECO:0000256|HAMAP-
Rule:MF_04028}.
ACT_SITE 101 101 {ECO:0000256|HAMAP-Rule:MF_04028}.
METAL 64 64 Iron 1. {ECO:0000256|HAMAP-
Rule:MF_04028}.
METAL 94 94 Iron 1. {ECO:0000256|HAMAP-
Rule:MF_04028}.
METAL 94 94 Iron 2. {ECO:0000256|HAMAP-
Rule:MF_04028}.
METAL 97 97 Iron 1. {ECO:0000256|HAMAP-
Rule:MF_04028}.
METAL 157 157 Iron 2. {ECO:0000256|HAMAP-
Rule:MF_04028}.
METAL 191 191 Iron 2. {ECO:0000256|HAMAP-
Rule:MF_04028}.
METAL 194 194 Iron 2. {ECO:0000256|HAMAP-
Rule:MF_04028}.
SEQUENCE 305 AA; 35548 MW; 352EFE84B987EBDE CRC64;
MDNVKKFLYS CDHQGFLKLL HETWQNRWFP SQVSLHGDVN HLKSLNVQDR EFYKFLFTFL
GMAESLVNFN IEDIIKQFES HDMLHYYTEQ MAMENIHARM YENILNMFFN NDPAEMYRYT
QMIINDRALI RKLDWLHSRI KSVSNKAEKV LLFLLVEGIF FVSSFYSIGL LRVRGMFNGV
CLANDYISRD ELLHTRAAAL LYNTMVSGAD KPHMLWVHNL FKEAVEVEHE FILVKSSGVS
AVNVDDIRSF LEATADRILK SINLPPIYGT PPPPKCPLVY TGCVKNVNFF ERDNSDYTSS
IKDDL


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Pathways :
WP1566: Citrate cycle (TCA cycle)
WP1626: Benzoate degradation via CoA ligation
WP1634: Butanoate metabolism
WP1671: Methane metabolism
WP1680: Oxidative phosphorylation
WP1711: Trinitrotoluene degradation
WP1006: metapathway biotransformation
WP1089: Small Ligand GPCRs
WP1124: metapathway biotransformation
WP1212: metapathway biotransformation
WP1251: metapathway biotransformation
WP1286: metapathway biotransformation
WP1317: Small Ligand GPCRs
WP1403: AMPK signaling
WP1461: Photosynthetic Carbon Reduction
WP161: Small Ligand GPCRs
WP1614: 1- and 2-Methylnaphthalene degradation
WP1644: DNA replication
WP1655: Geraniol degradation
WP1663: Homologous recombination
WP1672: Mismatch repair
WP1681: Pantothenate and CoA biosynthesis
WP1693: Purine metabolism
WP1694: Pyrimidine metabolism
WP1718: Vitamin B6 metabolism

Related Genes :
[RNR4 CRT3 YGR180C] Ribonucleoside-diphosphate reductase small chain 2 (EC 1.17.4.1) (Ribonucleotide reductase R2 subunit 2) (Ribonucleotide reductase small subunit 2)
[RNR2 CRT6 YJL026W J1271] Ribonucleoside-diphosphate reductase small chain 1 (EC 1.17.4.1) (Ribonucleotide reductase R2 subunit 1) (Ribonucleotide reductase small subunit 1)
[TSO2 At3g27060 MOJ10.13] Ribonucleoside-diphosphate reductase small chain C (EC 1.17.4.1) (Ribonucleoside-diphosphate reductase TSO2 subunit) (Ribonucleotide reductase small subunit C)
[RRM2B P53R2] Ribonucleoside-diphosphate reductase subunit M2 B (EC 1.17.4.1) (TP53-inducible ribonucleotide reductase M2 B) (p53-inducible ribonucleotide reductase small subunit 2-like protein) (p53R2)
[RRM1 RR1] Ribonucleoside-diphosphate reductase large subunit (EC 1.17.4.1) (Ribonucleoside-diphosphate reductase subunit M1) (Ribonucleotide reductase large subunit)
[Rrm2b P53r2] Ribonucleoside-diphosphate reductase subunit M2 B (EC 1.17.4.1) (TP53-inducible ribonucleotide reductase M2 B) (p53-inducible ribonucleotide reductase small subunit 2-like protein) (p53R2)
[RNR1 CRT7 RIR1 SDS12 YER070W] Ribonucleoside-diphosphate reductase large chain 1 (EC 1.17.4.1) (Ribonucleotide reductase R1 subunit 1) (Ribonucleotide reductase large subunit 1)
[nrdA dnaF b2234 JW2228] Ribonucleoside-diphosphate reductase 1 subunit alpha (EC 1.17.4.1) (Protein B1) (Ribonucleoside-diphosphate reductase 1 R1 subunit) (Ribonucleotide reductase 1)
[RNR3 DIN1 YIL066C] Ribonucleoside-diphosphate reductase large chain 2 (EC 1.17.4.1) (Ribonucleotide reductase DNA damage-inducible regulatory subunit 2) (Ribonucleotide reductase R1 subunit 2) (Ribonucleotide reductase large subunit 2)
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Non-structural protein 2A-alpha (NS2A-alpha); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Capsid protein) (Core protein); Protein prM (Precursor membrane protein); Peptide pr (Peptide precursor); Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Non-structural protein 2A-alpha (NS2A-alpha); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[GP1 MZ11_60484gpGP1 MZ11_60553gpGP1] Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (NS5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (NS5)] (Fragment)
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Non-structural protein 2A-alpha (NS2A-alpha); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[nrdG yjgE b4237 JW4196] Anaerobic ribonucleoside-triphosphate reductase-activating protein (EC 1.97.1.-) (Class III anaerobic ribonucleotide reductase small component)
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Non-structural protein 2A-alpha (NS2A-alpha); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]

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