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Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase)

 A0A1G4WCZ2_CORJE        Unreviewed;       323 AA.
A0A1G4WCZ2;
15-FEB-2017, integrated into UniProtKB/TrEMBL.
15-FEB-2017, sequence version 1.
16-JAN-2019, entry version 15.
RecName: Full=Ribose-phosphate pyrophosphokinase {ECO:0000256|HAMAP-Rule:MF_00583};
Short=RPPK {ECO:0000256|HAMAP-Rule:MF_00583};
EC=2.7.6.1 {ECO:0000256|HAMAP-Rule:MF_00583};
AltName: Full=5-phospho-D-ribosyl alpha-1-diphosphate {ECO:0000256|HAMAP-Rule:MF_00583};
AltName: Full=Phosphoribosyl diphosphate synthase {ECO:0000256|HAMAP-Rule:MF_00583};
AltName: Full=Phosphoribosyl pyrophosphate synthase {ECO:0000256|HAMAP-Rule:MF_00583};
Short=P-Rib-PP synthase {ECO:0000256|HAMAP-Rule:MF_00583};
Short=PRPP synthase {ECO:0000256|HAMAP-Rule:MF_00583};
Short=PRPPase {ECO:0000256|HAMAP-Rule:MF_00583};
Name=prs {ECO:0000256|HAMAP-Rule:MF_00583,
ECO:0000313|EMBL:SCX20561.1};
Synonyms=prsA {ECO:0000313|EMBL:SQI20337.1};
ORFNames=CJBVI_1496 {ECO:0000313|EMBL:SCX20561.1},
NCTC11913_00417 {ECO:0000313|EMBL:SUY80588.1},
NCTC11914_00835 {ECO:0000313|EMBL:SQI20337.1};
Corynebacterium jeikeium.
Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
Corynebacterium.
NCBI_TaxID=38289 {ECO:0000313|EMBL:SCX20561.1, ECO:0000313|Proteomes:UP000178164};
[1] {ECO:0000313|EMBL:SCX20561.1, ECO:0000313|Proteomes:UP000178164}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=BVI {ECO:0000313|EMBL:SCX20561.1};
de Groot N.N.;
Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|EMBL:SQI20337.1, ECO:0000313|Proteomes:UP000248732, ECO:0000313|Proteomes:UP000255294}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=NCTC11913 {ECO:0000313|EMBL:SUY80588.1,
ECO:0000313|Proteomes:UP000255294}, and
NCTC11914 {ECO:0000313|EMBL:SQI20337.1,
ECO:0000313|Proteomes:UP000248732};
Pathogen Informatics;
Doyle S.;
Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Involved in the biosynthesis of the central metabolite
phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of
pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate
(Rib-5-P). {ECO:0000256|HAMAP-Rule:MF_00583}.
-!- CATALYTIC ACTIVITY:
Reaction=ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-
diphosphate + AMP + H(+); Xref=Rhea:RHEA:15609,
ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:58017,
ChEBI:CHEBI:78346, ChEBI:CHEBI:456215; EC=2.7.6.1;
Evidence={ECO:0000256|HAMAP-Rule:MF_00583,
ECO:0000256|SAAS:SAAS01115190};
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Evidence={ECO:0000256|HAMAP-Rule:MF_00583};
Note=Binds 2 Mg(2+) ions per subunit. {ECO:0000256|HAMAP-
Rule:MF_00583};
-!- PATHWAY: Metabolic intermediate biosynthesis; 5-phospho-alpha-D-
ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-
diphosphate from D-ribose 5-phosphate (route I): step 1/1.
{ECO:0000256|HAMAP-Rule:MF_00583, ECO:0000256|SAAS:SAAS00956751}.
-!- SUBUNIT: Homohexamer. {ECO:0000256|HAMAP-Rule:MF_00583}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00583}.
-!- SIMILARITY: Belongs to the ribose-phosphate pyrophosphokinase
family. Class I subfamily. {ECO:0000256|HAMAP-Rule:MF_00583}.
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EMBL; FMTZ01000015; SCX20561.1; -; Genomic_DNA.
EMBL; LS483459; SQI20337.1; -; Genomic_DNA.
EMBL; UFXO01000002; SUY80588.1; -; Genomic_DNA.
RefSeq; WP_005293382.1; NZ_UIGW01000001.1.
GeneID; 3432987; -.
UniPathway; UPA00087; UER00172.
Proteomes; UP000178164; Unassembled WGS sequence.
Proteomes; UP000248732; Chromosome 1.
Proteomes; UP000255294; Unassembled WGS sequence.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
GO; GO:0004749; F:ribose phosphate diphosphokinase activity; IEA:UniProtKB-UniRule.
GO; GO:0006015; P:5-phosphoribose 1-diphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
GO; GO:0009116; P:nucleoside metabolic process; IEA:InterPro.
GO; GO:0009165; P:nucleotide biosynthetic process; IEA:UniProtKB-KW.
GO; GO:0009156; P:ribonucleoside monophosphate biosynthetic process; IEA:UniProtKB-UniRule.
CDD; cd06223; PRTases_typeI; 1.
HAMAP; MF_00583_B; RibP_PPkinase_B; 1.
InterPro; IPR000842; PRib_PP_synth_CS.
InterPro; IPR029099; Pribosyltran_N.
InterPro; IPR000836; PRibTrfase_dom.
InterPro; IPR029057; PRTase-like.
InterPro; IPR005946; Rib-P_diPkinase.
InterPro; IPR037515; Rib-P_diPkinase_bac.
PANTHER; PTHR10210; PTHR10210; 1.
Pfam; PF14572; Pribosyl_synth; 1.
Pfam; PF13793; Pribosyltran_N; 1.
SUPFAM; SSF53271; SSF53271; 1.
TIGRFAMs; TIGR01251; ribP_PPkin; 1.
PROSITE; PS00114; PRPP_SYNTHASE; 1.
3: Inferred from homology;
ATP-binding {ECO:0000256|HAMAP-Rule:MF_00583,
ECO:0000256|SAAS:SAAS00956731};
Complete proteome {ECO:0000313|Proteomes:UP000178164,
ECO:0000313|Proteomes:UP000248732, ECO:0000313|Proteomes:UP000255294};
Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00583};
Kinase {ECO:0000256|HAMAP-Rule:MF_00583,
ECO:0000256|SAAS:SAAS00956744, ECO:0000313|EMBL:SCX20561.1};
Magnesium {ECO:0000256|HAMAP-Rule:MF_00583,
ECO:0000256|SAAS:SAAS00956743};
Metal-binding {ECO:0000256|HAMAP-Rule:MF_00583,
ECO:0000256|SAAS:SAAS00956748};
Nucleotide biosynthesis {ECO:0000256|HAMAP-Rule:MF_00583,
ECO:0000256|SAAS:SAAS00956760};
Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00583,
ECO:0000256|SAAS:SAAS00956731};
Transferase {ECO:0000256|HAMAP-Rule:MF_00583,
ECO:0000256|SAAS:SAAS00956744, ECO:0000313|EMBL:SCX20561.1}.
DOMAIN 13 129 Pribosyltran_N.
{ECO:0000259|Pfam:PF13793}.
NP_BIND 46 48 ATP. {ECO:0000256|HAMAP-Rule:MF_00583}.
NP_BIND 105 106 ATP. {ECO:0000256|HAMAP-Rule:MF_00583}.
REGION 235 239 Ribose-5-phosphate binding.
{ECO:0000256|HAMAP-Rule:MF_00583}.
ACT_SITE 203 203 {ECO:0000256|HAMAP-Rule:MF_00583}.
METAL 139 139 Magnesium. {ECO:0000256|HAMAP-
Rule:MF_00583}.
METAL 179 179 Magnesium. {ECO:0000256|HAMAP-
Rule:MF_00583}.
BINDING 205 205 Ribose-5-phosphate. {ECO:0000256|HAMAP-
Rule:MF_00583}.
BINDING 231 231 Ribose-5-phosphate. {ECO:0000256|HAMAP-
Rule:MF_00583}.
SEQUENCE 323 AA; 35259 MW; F1DE006F5EC674CA CRC64;
MSTTHWIDNQ KNLMLFSGRA HPELGEAVAR ELGIEVTPTT ARDFANGEIF VRFEESVRGS
DAFVLQSHPQ PLNNWLMEQL IMIDALKRGS AKRITAILPF YPYARQDKKH RGREPISARL
VADLLKTAGA DRIVSVDLHT DQIQGFFDGP VDHMHAMPIL TDYVKANYNL DNICVVSPDA
GRVKVAEKWA NVLGDAPLAF IHKTRDVDVA NKVTANRVVG DVKGRTCVLL DDMIDTGGTI
AGAVGVLREA GAGDVIIATT HGVFSGPARE RLSSCGAREI ITTDTLPQST EGWDNLTVLP
IAPLVAKTIH EIFENGSVTT LFE


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WP677: Momilactone biosynthesis
WP2199: Seed Development
WP296: TCA Cycle - biocyc
WP1403: AMPK signaling
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WP626: Abscisic Acid Biosynthesis
WP668: Octadecanoid Pathway
WP1493: Carbon assimilation C4 pathway
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Related Genes :
[prs prsA b1207 JW1198] Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase)
[prs prsA STM1780] Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase)
[prs OR221_2795] Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase)
[prs OR1_02395] Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase)
[prs prpS C3733_19285 S101267_00063] Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase)
[prs OR214_03810] Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase)
[prs OR37_01923] Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase)
[prs OR16_19930] Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase)
[PRPS1] Ribose-phosphate pyrophosphokinase 1 (EC 2.7.6.1) (PPRibP) (Phosphoribosyl pyrophosphate synthase I) (PRS-I)
[prsA prs HPHPP62_0845] Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase)
[prs HPHPP1_0985] Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase)
[prs HPHPP2_0841] Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase)
[PRS5 PRPS5 YOL061W O1213] Ribose-phosphate pyrophosphokinase 5 (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthase 5)
[prs ATE51_01714 BOQ02_05145 CC14983A_0873] Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase)
[prs Loa_00548] Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase)
[prs MSMEI_5278] Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase)
[prs HPHPH6_0861] Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase)
[prs HPHPA6_0812] Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase)
[prs BJD20_09025 CW311_18640] Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase)
[prs GY22_09565] Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase)
[prsA prs HPCPY1124_0906] Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase)
[prsA prs HPHPH24_1049] Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase)
[prsA prs HPCPY1962_1150] Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase)
[prsA prs HPHPA4_0960] Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase)
[prsA prs HPCPY3281_0904] Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase)
[prsA prs HPCPY6311_0771] Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase)
[prsA prs HPHPH4_0736] Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase)
[prs HPHPP16_0900] Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase)
[prs HPHPP11_1085] Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase)
[prs HPHPP3_0938] Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase)

Bibliography :
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