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Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B)

 RUNX1_RAT               Reviewed;         450 AA.
Q63046;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
16-JAN-2019, entry version 154.
RecName: Full=Runt-related transcription factor 1;
AltName: Full=Acute myeloid leukemia 1 protein;
AltName: Full=Core-binding factor subunit alpha-2;
Short=CBF-alpha-2;
AltName: Full=Oncogene AML-1;
AltName: Full=Polyomavirus enhancer-binding protein 2 alpha B subunit;
Short=PEA2-alpha B;
Short=PEBP2-alpha B;
Name=Runx1; Synonyms=Aml1, Cbfa2;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INDUCTION.
STRAIN=Sprague-Dawley; TISSUE=Skeletal muscle;
PubMed=7969143; DOI=10.1128/MCB.14.12.8051;
Zhu X., Yeadon J.E., Burden S.J.;
"AML1 is expressed in skeletal muscle and is regulated by
innervation.";
Mol. Cell. Biol. 14:8051-8057(1994).
[2]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-14 AND SER-21, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22673903; DOI=10.1038/ncomms1871;
Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
Lundby C., Olsen J.V.;
"Quantitative maps of protein phosphorylation sites across 14
different rat organs and tissues.";
Nat. Commun. 3:876-876(2012).
-!- FUNCTION: CBF binds to the core site, 5'-PYGPYGGT-3', of a number
of enhancers and promoters, including murine leukemia virus,
polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and
GM-CSF promoters. The alpha subunit binds DNA and appears to have
a role in the development of normal hematopoiesis. Isoform AML-1L
interferes with the transactivation activity of RUNX1. Acts
synergistically with ELF4 to transactivate the IL-3 promoter and
with ELF2 to transactivate the BLK promoter. Inhibits KAT6B-
dependent transcriptional activation. Controls the anergy and
suppressive function of regulatory T-cells (Treg) by associating
with FOXP3. Activates the expression of IL2 and IFNG and down-
regulates the expression of TNFRSF18, IL2RA and CTLA4, in
conventional T-cells (By similarity). Positively regulates the
expression of RORC in T-helper 17 cells (By similarity).
{ECO:0000250|UniProtKB:Q01196, ECO:0000250|UniProtKB:Q03347}.
-!- SUBUNIT: Heterodimer with CBFB. RUNX1 binds DNA as a monomer and
through the Runt domain. DNA-binding is increased by
heterodimerization. Interacts with TLE1 and ALYREF/THOC4.
Interacts with ELF1, ELF2 and SPI1. Interacts via its Runt domain
with the ELF4 N-terminal region. Interaction with ELF2 isoform 2
(NERF-1a) may act to repress RUNX1-mediated transactivation.
Interacts with KAT6A and KAT6B. Interacts with SUV39H1, leading to
abrogation of transactivating and DNA-binding properties of RUNX1.
Interacts with YAP1 and HIPK2. Interaction with CDK6 prevents
myeloid differentiation, reducing its transcription
transactivation activity. Found in a complex with PRMT5, RUNX1 and
CBFB. Interacts with FOXP3. Interacts with TBX21. Interacts with
DPF2 (By similarity). {ECO:0000250|UniProtKB:Q01196,
ECO:0000250|UniProtKB:Q03347}.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- TISSUE SPECIFICITY: Expressed in skeletal muscle.
{ECO:0000269|PubMed:7969143}.
-!- INDUCTION: Expression increases following denervation.
{ECO:0000269|PubMed:7969143}.
-!- DOMAIN: A proline/serine/threonine rich region at the C-terminus
is necessary for transcriptional activation of target genes.
-!- PTM: Phosphorylated in its C-terminus upon IL-6 treatment.
Phosphorylation enhances interaction with KAT6A (By similarity).
{ECO:0000250}.
-!- PTM: Methylated. {ECO:0000250}.
-!- PTM: Phosphorylated in Ser-249 Thr-272 and Ser-275 by HIPK2 when
associated with CBFB and DNA. This phosphorylation promotes
subsequent EP300 phosphorylation (By similarity). {ECO:0000250}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; L35271; AAA66191.1; -; mRNA.
RefSeq; NP_059021.1; NM_017325.2.
UniGene; Rn.11201; -.
ProteinModelPortal; Q63046; -.
SMR; Q63046; -.
BioGrid; 248410; 1.
ELM; Q63046; -.
STRING; 10116.ENSRNOP00000002313; -.
iPTMnet; Q63046; -.
PhosphoSitePlus; Q63046; -.
PaxDb; Q63046; -.
PRIDE; Q63046; -.
Ensembl; ENSRNOT00000002313; ENSRNOP00000002313; ENSRNOG00000001704.
GeneID; 50662; -.
KEGG; rno:50662; -.
UCSC; RGD:2283; rat.
CTD; 861; -.
RGD; 2283; Runx1.
eggNOG; KOG3982; Eukaryota.
eggNOG; ENOG4111J4Y; LUCA.
GeneTree; ENSGT00940000159255; -.
HOGENOM; HOG000045616; -.
HOVERGEN; HBG060268; -.
InParanoid; Q63046; -.
KO; K08367; -.
OrthoDB; 562214at2759; -.
PhylomeDB; Q63046; -.
Reactome; R-RNO-549127; Organic cation transport.
Reactome; R-RNO-8877330; RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs).
Reactome; R-RNO-8931987; RUNX1 regulates estrogen receptor mediated transcription.
Reactome; R-RNO-8934593; Regulation of RUNX1 Expression and Activity.
Reactome; R-RNO-8936459; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function.
Reactome; R-RNO-8939236; RUNX1 regulates transcription of genes involved in differentiation of HSCs.
Reactome; R-RNO-8939243; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known.
Reactome; R-RNO-8939245; RUNX1 regulates transcription of genes involved in BCR signaling.
Reactome; R-RNO-8939246; RUNX1 regulates transcription of genes involved in differentiation of myeloid cells.
Reactome; R-RNO-8939247; RUNX1 regulates transcription of genes involved in interleukin signaling.
Reactome; R-RNO-9018519; Estrogen-dependent gene expression.
PRO; PR:Q63046; -.
Proteomes; UP000002494; Chromosome 11.
Bgee; ENSRNOG00000001704; Expressed in 9 organ(s), highest expression level in spleen.
ExpressionAtlas; Q63046; baseline and differential.
Genevisible; Q63046; RN.
GO; GO:0016513; C:core-binding factor complex; TAS:UniProtKB.
GO; GO:0005634; C:nucleus; IDA:RGD.
GO; GO:0005524; F:ATP binding; IEA:InterPro.
GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
GO; GO:1990841; F:promoter-specific chromatin binding; IDA:RGD.
GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:RGD.
GO; GO:0030097; P:hemopoiesis; IBA:GO_Central.
GO; GO:0043371; P:negative regulation of CD4-positive, alpha-beta T cell differentiation; ISS:UniProtKB.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
GO; GO:0030728; P:ovulation; IEP:RGD.
GO; GO:0045766; P:positive regulation of angiogenesis; ISS:UniProtKB.
GO; GO:0043378; P:positive regulation of CD8-positive, alpha-beta T cell differentiation; ISS:UniProtKB.
GO; GO:0030854; P:positive regulation of granulocyte differentiation; ISS:UniProtKB.
GO; GO:2000872; P:positive regulation of progesterone secretion; IMP:RGD.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:RGD.
GO; GO:0014894; P:response to denervation involved in regulation of muscle adaptation; IEP:RGD.
Gene3D; 2.60.40.720; -; 1.
Gene3D; 4.10.770.10; -; 1.
InterPro; IPR000040; AML1_Runt.
InterPro; IPR008967; p53-like_TF_DNA-bd.
InterPro; IPR012346; p53/RUNT-type_TF_DNA-bd_sf.
InterPro; IPR013524; Runt_dom.
InterPro; IPR027384; Runx_central_dom_sf.
InterPro; IPR013711; RunxI_C_dom.
InterPro; IPR016554; TF_Runt-rel_RUNX.
PANTHER; PTHR11950; PTHR11950; 1.
Pfam; PF00853; Runt; 1.
Pfam; PF08504; RunxI; 1.
PIRSF; PIRSF009374; TF_Runt-rel_RUNX; 1.
PRINTS; PR00967; ONCOGENEAML1.
SUPFAM; SSF49417; SSF49417; 1.
PROSITE; PS51062; RUNT; 1.
1: Evidence at protein level;
Acetylation; Activator; Complete proteome; DNA-binding; Methylation;
Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription;
Transcription regulation.
CHAIN 1 450 Runt-related transcription factor 1.
/FTId=PRO_0000174657.
DOMAIN 50 178 Runt. {ECO:0000255|PROSITE-
ProRule:PRU00399}.
REGION 80 84 Interaction with DNA. {ECO:0000250}.
REGION 135 143 Interaction with DNA. {ECO:0000250}.
REGION 168 177 Interaction with DNA. {ECO:0000250}.
REGION 290 369 Interaction with KAT6A. {ECO:0000250}.
REGION 306 398 Interaction with KAT6B. {ECO:0000250}.
REGION 360 400 Interaction with FOXP3.
{ECO:0000250|UniProtKB:Q01196}.
COMPBIAS 187 450 Pro/Ser/Thr-rich.
BINDING 112 112 Chloride 1. {ECO:0000255|PROSITE-
ProRule:PRU00399}.
BINDING 116 116 Chloride 1; via amide nitrogen.
{ECO:0000255|PROSITE-ProRule:PRU00399}.
BINDING 139 139 Chloride 2. {ECO:0000255|PROSITE-
ProRule:PRU00399}.
BINDING 170 170 Chloride 2; via amide nitrogen.
{ECO:0000255|PROSITE-ProRule:PRU00399}.
MOD_RES 14 14 Phosphothreonine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 21 21 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 24 24 N6-acetyllysine.
{ECO:0000250|UniProtKB:Q01196}.
MOD_RES 43 43 N6-acetyllysine.
{ECO:0000250|UniProtKB:Q01196}.
MOD_RES 193 193 Phosphoserine.
{ECO:0000250|UniProtKB:Q01196}.
MOD_RES 212 212 Phosphoserine.
{ECO:0000250|UniProtKB:Q01196}.
MOD_RES 249 249 Phosphoserine; by HIPK2.
{ECO:0000250|UniProtKB:Q01196}.
MOD_RES 266 266 Phosphoserine.
{ECO:0000250|UniProtKB:Q01196}.
MOD_RES 267 267 Phosphoserine.
{ECO:0000250|UniProtKB:Q01196}.
MOD_RES 272 272 Phosphothreonine; by HIPK2.
{ECO:0000250|UniProtKB:Q01196}.
MOD_RES 275 275 Phosphoserine; by HIPK2.
{ECO:0000250|UniProtKB:Q01196}.
MOD_RES 295 295 Phosphothreonine.
{ECO:0000250|UniProtKB:Q01196}.
MOD_RES 433 433 Phosphoserine.
{ECO:0000250|UniProtKB:Q01196}.
SEQUENCE 450 AA; 48556 MW; 4B53AD706D487AC3 CRC64;
MRIPVDASTS RRFTPPSTAL SPGKMSEALP LGAPDGGAAL ASKLRSGDRS MVEVLADHPG
ELVRTDSPNF LCSVLPTHWR CNKTLPIAFK VVALGDVPDG TLVTVMAGND ENYSAELRNA
TAAMKNQVAR FNDLRFVGRS GRGKSFTLTI TVFTNPPQVA TYHRAIKITV DGPREPRRHR
QKLDDQTKPG SLSFSERLSE LEQLRRTAMR VSPHHPAPTP NPRASLNHST AFNPQPQSQM
QDARQIQPSP PWSYDQSYQY LGSITSSVHP ATPISPGRAS GMTSLSAELS SRLSTAPDLT
AFGDPRQFPT LPSISDPRMH YPGAFTYSPP VTSGIGIGMS AMSSTSRYHT YLPPPYPGSS
QAQAGPFQTG SPSYHLYYGT SAGSYQFSMV GGERSPPRIL PPCTNASTGA ALLNPSLPSQ
SDVVETEGSH SNSPTNMPPA RLEEAVWRPY


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Related Genes :
[Runx1 Aml1 Cbfa2 Pebp2ab] Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit)
[RUNX1 AML1 CBFA2] Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit)
[RUNX2 AML3 CBFA1 OSF2 PEBP2A] Runt-related transcription factor 2 (Acute myeloid leukemia 3 protein) (Core-binding factor subunit alpha-1) (CBF-alpha-1) (Oncogene AML-3) (Osteoblast-specific transcription factor 2) (OSF-2) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEA2-alpha A) (PEBP2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit)
[RUNX3 AML2 CBFA3 PEBP2A3] Runt-related transcription factor 3 (Acute myeloid leukemia 2 protein) (Core-binding factor subunit alpha-3) (CBF-alpha-3) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 alpha C subunit) (PEA2-alpha C) (PEBP2-alpha C) (SL3-3 enhancer factor 1 alpha C subunit) (SL3/AKV core-binding factor alpha C subunit)
[Runx3 Aml2 Cbfa3 Pebp2a3] Runt-related transcription factor 3 (Acute myeloid leukemia 2 protein) (Core-binding factor subunit alpha-3) (CBF-alpha-3) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 alpha C subunit) (PEA2-alpha C) (PEBP2-alpha C) (SL3-3 enhancer factor 1 alpha C subunit) (SL3/AKV core-binding factor alpha C subunit)
[Cbfb Pebp2b Pebpb2] Core-binding factor subunit beta (CBF-beta) (Polyomavirus enhancer-binding protein 2 beta subunit) (PEA2-beta) (PEBP2-beta) (SL3-3 enhancer factor 1 subunit beta) (SL3/AKV core-binding factor beta subunit)
[CBFB] Core-binding factor subunit beta (CBF-beta) (Polyomavirus enhancer-binding protein 2 beta subunit) (PEA2-beta) (PEBP2-beta) (SL3-3 enhancer factor 1 subunit beta) (SL3/AKV core-binding factor beta subunit)
[TCF3 BHLHB21 E2A ITF1] Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1)
[NFKB2 LYT10] Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit]
[] Genome polyprotein [Cleaved into: Protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Non-structural protein 2A-alpha (NS2A-alpha); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Non-structural protein 2A-alpha (NS2A-alpha); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[KMT2A ALL1 CXXC7 HRX HTRX MLL MLL1 TRX1] Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.43) (ALL-1) (CXXC-type zinc finger protein 7) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
[Akt1 Akt Rac] RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (AKT1 kinase) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha) (Thymoma viral proto-oncogene)
[PDGFRA PDGFR2 RHEPDGFRA] Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a)
[NR5A2 B1F CPF FTF] Nuclear receptor subfamily 5 group A member 2 (Alpha-1-fetoprotein transcription factor) (B1-binding factor) (hB1F) (CYP7A promoter-binding factor) (Hepatocytic transcription factor) (Liver receptor homolog 1) (LRH-1)
[CHUK IKKA TCF16] Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16)
[AKT1 PKB RAC] RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha)
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Non-structural protein 2A-alpha (NS2A-alpha); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Non-structural protein 2A-alpha (NS2A-alpha); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Non-structural protein 2A-alpha (NS2A-alpha); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Non-structural protein 2A-alpha (NS2A-alpha); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Non-structural protein 2A-alpha (NS2A-alpha); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Non-structural protein 2A-alpha (NS2A-alpha); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Non-structural protein 2A-alpha (NS2A-alpha); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Non-structural protein 2A-alpha (NS2A-alpha); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[TFAP2A AP2TF TFAP2] Transcription factor AP-2-alpha (AP2-alpha) (AP-2 transcription factor) (Activating enhancer-binding protein 2-alpha) (Activator protein 2) (AP-2)
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Non-structural protein 2A-alpha (NS2A-alpha); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Non-structural protein 2A-alpha (NS2A-alpha); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Non-structural protein 2A-alpha (NS2A-alpha); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[CEBPA CEBP] CCAAT/enhancer-binding protein alpha (C/EBP alpha)

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