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SEC24 homolog B, COPII coat complex component (SEC24 related gene family, member B (S. cerevisiae) (Predicted))

 D3ZW15_RAT              Unreviewed;      1242 AA.
D3ZW15;
20-APR-2010, integrated into UniProtKB/TrEMBL.
20-APR-2010, sequence version 1.
13-FEB-2019, entry version 77.
SubName: Full=SEC24 homolog B, COPII coat complex component {ECO:0000313|Ensembl:ENSRNOP00000037163};
SubName: Full=SEC24 related gene family, member B (S. cerevisiae) (Predicted) {ECO:0000313|EMBL:EDL82195.1};
Name=Sec24b {ECO:0000313|Ensembl:ENSRNOP00000037163,
ECO:0000313|RGD:1309358};
Synonyms=Sec24b_predicted {ECO:0000313|EMBL:EDL82195.1};
ORFNames=rCG_28935 {ECO:0000313|EMBL:EDL82195.1};
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000037163, ECO:0000313|Proteomes:UP000002494};
[1] {ECO:0000313|Ensembl:ENSRNOP00000037163, ECO:0000313|Proteomes:UP000002494}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000037163,
ECO:0000313|Proteomes:UP000002494};
PubMed=15057822; DOI=10.1038/nature02426;
Rat Genome Sequencing Project Consortium;
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
Collins F.S.;
"Genome sequence of the Brown Norway rat yields insights into
mammalian evolution.";
Nature 428:493-521(2004).
[2] {ECO:0000313|EMBL:EDL82195.1}
NUCLEOTIDE SEQUENCE.
STRAIN=BN {ECO:0000313|EMBL:EDL82195.1};
PubMed=15632090; DOI=10.1101/gr.2889405;
Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M.,
Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z.,
Istrail S., Li P., Sutton G.;
"Gene and alternative splicing annotation with AIR.";
Genome Res. 15:54-66(2005).
[3] {ECO:0000313|EMBL:EDL82195.1}
NUCLEOTIDE SEQUENCE.
STRAIN=BN {ECO:0000313|EMBL:EDL82195.1};
Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H.,
Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M.,
Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L.,
Lu F., Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C.,
Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[4] {ECO:0000313|Ensembl:ENSRNOP00000037163}
IDENTIFICATION.
STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000037163};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
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EMBL; AABR07013248; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH473952; EDL82195.1; -; Genomic_DNA.
RefSeq; NP_001099944.1; NM_001106474.1.
UniGene; Rn.102003; -.
SMR; D3ZW15; -.
STRING; 10116.ENSRNOP00000037163; -.
jPOST; D3ZW15; -.
Ensembl; ENSRNOT00000038509; ENSRNOP00000037163; ENSRNOG00000023373.
GeneID; 295461; -.
KEGG; rno:295461; -.
CTD; 10427; -.
RGD; 1309358; Sec24b.
eggNOG; KOG1985; Eukaryota.
eggNOG; COG5028; LUCA.
GeneTree; ENSGT00940000153603; -.
KO; K14007; -.
OMA; PAMYSAN; -.
OrthoDB; 330236at2759; -.
TreeFam; TF354244; -.
Reactome; R-RNO-204005; COPII-mediated vesicle transport.
Reactome; R-RNO-2132295; MHC class II antigen presentation.
Reactome; R-RNO-5694530; Cargo concentration in the ER.
Reactome; R-RNO-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC.
Proteomes; UP000002494; Chromosome 2.
Bgee; ENSRNOG00000023373; Expressed in 10 organ(s), highest expression level in testis.
GO; GO:0030127; C:COPII vesicle coat; IEA:Ensembl.
GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IDA:MGI.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0000139; C:Golgi membrane; IEA:GOC.
GO; GO:0008270; F:zinc ion binding; IEA:Ensembl.
GO; GO:0035909; P:aorta morphogenesis; IEA:Ensembl.
GO; GO:0060088; P:auditory receptor cell stereocilium organization; IEA:Ensembl.
GO; GO:0021747; P:cochlear nucleus development; IEA:Ensembl.
GO; GO:0090110; P:COPII-coated vesicle cargo loading; IEA:Ensembl.
GO; GO:0060982; P:coronary artery morphogenesis; IEA:Ensembl.
GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
GO; GO:0060463; P:lung lobe morphogenesis; IEA:Ensembl.
GO; GO:0001843; P:neural tube closure; IEA:Ensembl.
GO; GO:0003151; P:outflow tract morphogenesis; IEA:Ensembl.
GO; GO:0061156; P:pulmonary artery morphogenesis; IEA:Ensembl.
GO; GO:1901301; P:regulation of cargo loading into COPII-coated vesicle; IEA:Ensembl.
GO; GO:0090178; P:regulation of establishment of planar polarity involved in neural tube closure; IEA:Ensembl.
Gene3D; 3.40.20.10; -; 1.
Gene3D; 3.40.50.410; -; 1.
InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
InterPro; IPR007123; Gelsolin-like_dom.
InterPro; IPR036180; Gelsolin-like_dom_sf.
InterPro; IPR006900; Sec23/24_helical_dom.
InterPro; IPR036175; Sec23/24_helical_dom_sf.
InterPro; IPR006896; Sec23/24_trunk_dom.
InterPro; IPR012990; Sec23_24_beta_S.
InterPro; IPR036465; vWFA_dom_sf.
InterPro; IPR006895; Znf_Sec23_Sec24.
InterPro; IPR036174; Znf_Sec23_Sec24_sf.
Pfam; PF00626; Gelsolin; 1.
Pfam; PF08033; Sec23_BS; 1.
Pfam; PF04815; Sec23_helical; 1.
Pfam; PF04811; Sec23_trunk; 1.
Pfam; PF04810; zf-Sec23_Sec24; 1.
SUPFAM; SSF53300; SSF53300; 1.
SUPFAM; SSF81811; SSF81811; 1.
SUPFAM; SSF82754; SSF82754; 1.
SUPFAM; SSF82919; SSF82919; 1.
1: Evidence at protein level;
Complete proteome {ECO:0000313|Proteomes:UP000002494};
Protein transport {ECO:0000256|SAAS:SAAS00454053};
Proteomics identification {ECO:0000213|PeptideAtlas:D3ZW15};
Reference proteome {ECO:0000313|Proteomes:UP000002494};
Transport {ECO:0000256|SAAS:SAAS00454053}.
DOMAIN 576 612 zf-Sec23_Sec24.
{ECO:0000259|Pfam:PF04810}.
DOMAIN 649 888 Sec23_trunk. {ECO:0000259|Pfam:PF04811}.
DOMAIN 893 977 Sec23_BS. {ECO:0000259|Pfam:PF08033}.
DOMAIN 988 1088 Sec23_helical.
{ECO:0000259|Pfam:PF04815}.
DOMAIN 1115 1180 Gelsolin-like.
{ECO:0000259|Pfam:PF00626}.
SEQUENCE 1242 AA; 134716 MW; 711261A2F3B51EC0 CRC64;
MSAPAGSPHP AAGARMPPKL GGAVSGLAPP QQNGPAQSQM QVPSGYGLPH QNYMAPSGHY
SQGPGKMTSL PLDNQCENYY SRPYTAPTQN VGTPSSANQP GAQLMYGRGP SAPHMGASMP
GPFQGAPASA SHSYPSASQP YSSLGNRYSS PATYSATASV ASQGYPSTCS HYPISTVSNV
VYPNVSYPSL PASEPYGQMF TSQSAPPPAR PLKESYSGPS TAVAYPSRPP PPPSQHQQQQ
QQQQQQQQQS HSGYSSLPWS GPGLPPAQDS LIRNQMGSLA IPNSHPAINE NVQPPKPSSV
VATVLPGPSS TRMPPAPSHP VGPVPSAPPP PEQMQTKGMQ YGDYVNNQAS STPTPLSSAS
DDEEEEDEDE EAGVDSSSTT SSASPLPNSY DALEGGSYPD MHSSSASSPV PDRAPEPNST
LVPTPTAAQP AKVAKPFGYG YPTLQPAYQN AAAPPTTAHP SGPAYSGYPQ QYPGVHQLSS
GLGGLSLQSS PQPESLRPVN LTQEKNILPA TPIWAPVPNL SAELSKLNCS PDSFRCTLTS
IPQTQALLNK AKLPLGLLLH PFRDLTQLPV ITSNTIVRCR SCRTYINPFV SFIDQRRWKC
NLCYRVNDVP EEFLYNPLTR SYGEPHKRPE VQNSTVEFIA SSDYMLRPPQ PAVYLFVLDV
SHNAVEAGYL TVLCQSLLEN LDKLPGDSRT RIGFMTFDST IHFYNLQEGL SQPQMLIVSD
IDDVFLPTPD SLLVNLYESK ELIKDLLNAL PNMFINTRET HSALGPALQA AFKLMSPTGG
RVSVFQTQLP SLGAGLLQSR EDPNQRSSTK VVHHLGPATD FYKKLALDCS GQQTAVDLFL
LSSQYSDLAS LACMSKYSAG CIFYYPSFHS THNPSQAEKL QKDLKRYLTR KIGFEAVMRI
RCTKGLSMHT FHGNFFVRST DLLSLANINP DAGFAVQLSI EESLADTSLV CFQTALLYTS
SKGERRIRVH TLCLPVVSSL ADVYAGVDVQ AAICLLANMA VDRSVSSSLS DARDALVNAV
VDPLSAYSSA VSSVPRSTLT APSSLKLLPL YVLALLKQKA FRTGTSTRLD DRVYAMCQMK
SQPLVHLMKM IHPNLYRIDR LTDEGAIHVN DRVVPQPPLQ KLSAEKLTRE GAFLMDCGSV
FYIWIGKGCD SNFIENVLGY PDFGSIPQKM THLPELDTLP SERTRSFVTW LRDSRPLSPV
LHVVKDESPA RTDFFQHLVE DRTEAALSYY EFLIHVQQQV CK


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NUFIP2 NUF2 Gene NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)

Kits Elisa; taq POLYMERASE

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Pathways :
WP1012: IL-7 Signaling Pathway
WP1025: B Cell Receptor Signaling Pathway
WP1031: IL-3 Signaling Pathway
WP1052: Id Signaling Pathway
WP1055: IL-4 signaling Pathway
WP1122: Blood Clotting Cascade
WP1131: IL-7 Signaling Pathway
WP1144: B Cell Receptor Signaling Pathway
WP1150: IL-3 Signaling Pathway
WP1168: Id Signaling Pathway
WP1171: IL-4 signaling Pathway
WP118: IL-7 Signaling Pathway
WP1224: EBV LMP1 signaling
WP1346: IL-7 Signaling Pathway
WP1359: IL-3 Signaling Pathway
WP1374: Id Signaling Pathway
WP1376: IL-4 signaling Pathway
WP1571: EBV LMP1 signaling
WP1624: Bacterial secretion system
WP1713: Two-component system
WP1770: One carbon metabolism and related pathways
WP182: IL-4 Signaling Pathway
WP1963: The effect of Glucocorticoids on target gene expression
WP2199: Seed Development
WP2272: Pathogenic Escherichia coli infection

Related Genes :
[SEC24 ANU1 YIL109C] Protein transport protein SEC24 (Abnormal nuclear morphology 1)
[SEC24B] Protein transport protein Sec24B (SEC24-related protein B)
[SEC24A] Protein transport protein Sec24A (SEC24-related protein A)
[Sec24a] Protein transport protein Sec24A (SEC24-related protein A)
[SEC24A] Protein transport protein Sec24A (SEC24-related protein A)
[SAR1 YPL218W] Small COPII coat GTPase SAR1 (EC 3.6.5.-) (GTP-binding protein SAR1) (Secretion-associated RAS-related protein 1)
[GRH1 YDR517W] GRASP65 homolog protein 1
[sec24 NCU02391] Protein transport protein sec24
[SEC23B] Protein transport protein Sec23B (hSec23B) (SEC23-related protein B)
[SEC22 SLY2 TSL26 YLR268W L8479.3] Protein transport protein SEC22 (Suppressor of loss of YPT1 protein 2)
[sec24 DDB_G0281255] Protein transport protein SEC24
[TMED10 TMP21] Transmembrane emp24 domain-containing protein 10 (21 kDa transmembrane-trafficking protein) (S31III125) (S31I125) (Tmp-21-I) (Transmembrane protein Tmp21) (p23) (p24 family protein delta-1) (p24delta1) (p24delta)
[BET1 SLY12 YIL004C YIA4C] Protein transport protein BET1 (Suppressor of loss of YPT1 protein 12) (Protein SLY12)
[TMED2 RNP24] Transmembrane emp24 domain-containing protein 2 (Membrane protein p24A) (p24) (p24 family protein beta-1) (p24beta1)
[SEC22B SEC22L1] Vesicle-trafficking protein SEC22b (ER-Golgi SNARE of 24 kDa) (ERS-24) (ERS24) (SEC22 vesicle-trafficking protein homolog B) (SEC22 vesicle-trafficking protein-like 1)
[YIPF5 FINGER5 YIP1A PP12723 SB140 UNQ3123/PRO10275] Protein YIPF5 (Five-pass transmembrane protein localizing in the Golgi apparatus and the endoplasmic reticulum 5) (Smooth muscle cell-associated protein 5) (SMAP-5) (YIP1 family member 5) (YPT-interacting protein 1 A)
[Tmed10 Tmp21] Transmembrane emp24 domain-containing protein 10 (21 kDa transmembrane-trafficking protein) (Transmembrane protein Tmp21) (p24 family protein delta-1) (p24delta1)
[Tmed2 Rnp24] Transmembrane emp24 domain-containing protein 2 (COPI-coated vesicle membrane protein p24) (Membrane protein p24A) (RNP21.4) (p24 family protein beta-1) (p24beta1)
[Tmed2 Rnp24 Sid394] Transmembrane emp24 domain-containing protein 2 (COPI-coated vesicle membrane protein p24) (Membrane protein p24A) (Sid 394) (p24 family protein beta-1) (p24beta1)
[SEC13 ANU3 YLR208W L8167.4] Protein transport protein SEC13
[Tmed10 Tmp21] Transmembrane emp24 domain-containing protein 10 (21 kDa transmembrane-trafficking protein) (Transmembrane protein Tmp21) (p24 family protein delta-1) (p24delta1)
[SCAP] Sterol regulatory element-binding protein cleavage-activating protein (SCAP) (SREBP cleavage-activating protein)
[MIA3 KIAA0268 TANGO UNQ6077/PRO20088] Transport and Golgi organization protein 1 homolog (TANGO1) (C219-reactive peptide) (D320) (Melanoma inhibitory activity protein 3)
[MIA2 CTAGE5 MEA11 MEA6 MGEA11 MGEA6] Melanoma inhibitory activity protein 2 (CTAGE family member 5 ER export factor) (Meningioma-expressed antigen 6/11)
[Scap Kiaa0199] Sterol regulatory element-binding protein cleavage-activating protein (SCAP) (SREBP cleavage-activating protein)
[SCAP KIAA0199 PSEC0227] Sterol regulatory element-binding protein cleavage-activating protein (SCAP) (SREBP cleavage-activating protein)
[RNF139 TRC8] E3 ubiquitin-protein ligase RNF139 (EC 2.3.2.27) (RING finger protein 139) (RING-type E3 ubiquitin transferase RNF139) (Translocation in renal carcinoma on chromosome 8 protein)
[TMED2 RNP24] Transmembrane emp24 domain-containing protein 2 (COPI-coated vesicle membrane protein p24) (p24 family protein beta-1) (p24beta1) (Fragment)
[Yipf5 Yip1a] Protein YIPF5 (YIP1 family member 5) (YPT-interacting protein 1 A)
[Scap] Sterol regulatory element-binding protein cleavage-activating protein (SCAP) (SREBP cleavage-activating protein)

Bibliography :