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SH3 domain-binding protein 5 (SH3BP-5) (Vascular endothelial cell-specific protein 18)

 3BP5_RAT                Reviewed;         457 AA.
Q91Y80;
23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 2.
08-MAY-2019, entry version 115.
RecName: Full=SH3 domain-binding protein 5;
Short=SH3BP-5;
AltName: Full=Vascular endothelial cell-specific protein 18;
Name=Sh3bp5; Synonyms=Sab, Vesp18;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
Aoki T., Toyoda H., Nishimoto S., Tawara J., Komurasaki T.;
"Identification of VESP18, a vascular endothelial cell specific
protein.";
Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
[2]
INTERACTION WITH MAPK9 AND MAPK12, PHOSPHORYLATION AT SER-353 AND
SER-423, SUBCELLULAR LOCATION, AND MUTAGENESIS OF SER-353 AND SER-423.
PubMed=15158451; DOI=10.1016/j.bbrc.2004.04.148;
Court N.W., Kuo I., Quigley O., Bogoyevitch M.A.;
"Phosphorylation of the mitochondrial protein Sab by stress-activated
protein kinase 3.";
Biochem. Biophys. Res. Commun. 319:130-137(2004).
[3]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-420 AND SER-423, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22673903; DOI=10.1038/ncomms1871;
Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
Lundby C., Olsen J.V.;
"Quantitative maps of protein phosphorylation sites across 14
different rat organs and tissues.";
Nat. Commun. 3:876-876(2012).
-!- FUNCTION: Functions as guanine nucleotide exchange factor (GEF)
with specificity for RAB11A and RAB25. Inhibits the auto- and
transphosphorylation activity of BTK. Plays a negative regulatory
role in BTK-related cytoplasmic signaling in B-cells. May be
involved in BCR-induced apoptotic cell death.
{ECO:0000250|UniProtKB:O60239}.
-!- SUBUNIT: Interacts with BTK (PubMed:15158451). Interacts with all
isoforms of MAPK8, MAPK9, MAPK10 and MAPK12 (PubMed:15158451).
Interacts with GDP-bound and nucleotide-free forms of RAB11A (By
similarity). {ECO:0000250|UniProtKB:Q9Z131,
ECO:0000269|PubMed:15158451}.
-!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
{ECO:0000250|UniProtKB:O60239}; Peripheral membrane protein
{ECO:0000250|UniProtKB:O60239}. Mitochondrion
{ECO:0000269|PubMed:15158451}. Note=Colocalizes with RAB11A on
cytoplasmic vesicle membranes. {ECO:0000250|UniProtKB:O60239}.
-!- DOMAIN: The N-terminal half of the protein mediates interaction
with RAB11A and functions as guanine nucleotide exchange factor.
Four long alpha-helices (interrupted by a central kink) assemble
into coiled coils, giving rise to a 'V' shape.
{ECO:0000250|UniProtKB:O60239}.
-!- SIMILARITY: Belongs to the SH3BP5 family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=BAB47152.1; Type=Erroneous initiation; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; AB027562; BAB47152.1; ALT_INIT; mRNA.
RefSeq; NP_446463.2; NM_054011.1.
SMR; Q91Y80; -.
STRING; 10116.ENSRNOP00000026389; -.
iPTMnet; Q91Y80; -.
PhosphoSitePlus; Q91Y80; -.
PaxDb; Q91Y80; -.
PRIDE; Q91Y80; -.
Ensembl; ENSRNOT00000082172; ENSRNOP00000071111; ENSRNOG00000052391.
GeneID; 117186; -.
KEGG; rno:117186; -.
UCSC; RGD:620220; rat.
CTD; 9467; -.
RGD; 620220; Sh3bp5.
eggNOG; KOG2008; Eukaryota.
eggNOG; ENOG410ZK48; LUCA.
GeneTree; ENSGT00390000018500; -.
HOGENOM; HOG000212681; -.
InParanoid; Q91Y80; -.
OMA; PECDLER; -.
OrthoDB; 566222at2759; -.
PhylomeDB; Q91Y80; -.
TreeFam; TF105573; -.
PRO; PR:Q91Y80; -.
Proteomes; UP000002494; Chromosome 16.
Bgee; ENSRNOG00000052391; Expressed in 9 organ(s), highest expression level in heart.
Genevisible; Q91Y80; RN.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
GO; GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO; GO:0016604; C:nuclear body; IEA:Ensembl.
GO; GO:0004860; F:protein kinase inhibitor activity; IBA:GO_Central.
GO; GO:0017112; F:Rab guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
GO; GO:0017124; F:SH3 domain binding; TAS:RGD.
GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
GO; GO:0007254; P:JNK cascade; NAS:RGD.
GO; GO:0061099; P:negative regulation of protein tyrosine kinase activity; IBA:GO_Central.
InterPro; IPR007940; SH3BP5.
PANTHER; PTHR19423; PTHR19423; 1.
Pfam; PF05276; SH3BP5; 1.
1: Evidence at protein level;
Coiled coil; Complete proteome; Cytoplasmic vesicle;
Guanine-nucleotide releasing factor; Membrane; Mitochondrion;
Phosphoprotein; Reference proteome; SH3-binding.
CHAIN 1 457 SH3 domain-binding protein 5.
/FTId=PRO_0000064370.
REGION 33 267 Sufficient for interaction with RAB11A
and for guanine nucleotide exchange
activity. {ECO:0000250|UniProtKB:O60239}.
COILED 46 92 {ECO:0000250|UniProtKB:O60239}.
COILED 99 147 {ECO:0000250|UniProtKB:O60239}.
COILED 156 202 {ECO:0000250|UniProtKB:O60239}.
COILED 213 257 {ECO:0000250|UniProtKB:O60239}.
COMPBIAS 11 69 Glu-rich.
COMPBIAS 38 42 Poly-Glu.
MOD_RES 353 353 Phosphoserine; by MAPK12 and MAPK9.
{ECO:0000269|PubMed:15158451}.
MOD_RES 377 377 Phosphoserine.
{ECO:0000250|UniProtKB:Q9Z131}.
MOD_RES 378 378 Phosphoserine.
{ECO:0000250|UniProtKB:Q9Z131}.
MOD_RES 420 420 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 423 423 Phosphoserine; by MAPK12.
{ECO:0000244|PubMed:22673903,
ECO:0000269|PubMed:15158451}.
MUTAGEN 353 353 S->A: Large decrease in phosphorylation
by SAPK3. {ECO:0000269|PubMed:15158451}.
MUTAGEN 423 423 S->A: Slight decrease in phosphorylation
by SAPK3. {ECO:0000269|PubMed:15158451}.
SEQUENCE 457 AA; 50829 MW; 68339F6993950B7C CRC64;
MDTALKRSRS EEPVELPPPA REAEEKEEEE ERMEQGLEEE EEVDPRIQGE LEKLNQSTDD
INRRETELED ARQKFRSVLV EATVKLDELA KKIGKAVEDS KPYWEARRVA RQAQLEAQKA
TQDFQRATEV LRAAKETISL AEQRLLEDDK RQFDSAWQEM LNHATQRVME AEQTKTRSEL
VHKETAARYN AAMGRMRQLE KKLKRAINKS KPYFELKAKY YVQLEQLKKT VDDLQAKLAL
AKGEYKAALK SLERISDEIH ERRRSNAMGP RGCGVGAEGS ITSVENLPAS KPEPDAISVA
SEAFEDDNCG NLVSEDDSET QSVSSFSSGP TSPSEMPDQF PAVARPGSLD LPSPVSLSEF
GMMFPILGPR SECSGASSPE CEVERGDRAE GAENKMSDKA NNNRVLSSTS AGGGRSRSQS
STSLEGQALE TRMKQLSLQC SKGREGIIAD IKTVQIG


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[SH3BP1] SH3 domain-binding protein 1
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[ABI1 SSH3BP1] Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1)
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[Asap1 Ddef1 Kiaa1249 Shag1] Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP)
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Bibliography :