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SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein)

 SGIP1_PSAOB             Reviewed;         827 AA.
Q6IZA3;
05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
05-JUL-2004, sequence version 1.
08-MAY-2019, entry version 52.
RecName: Full=SH3-containing GRB2-like protein 3-interacting protein 1;
AltName: Full=Endophilin-3-interacting protein;
Name=SGIP1;
Psammomys obesus (Fat sand rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Gerbillinae; Psammomys.
NCBI_TaxID=48139;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND
INTERACTION WITH SH3GL3.
TISSUE=Hypothalamus;
PubMed=15919751; DOI=10.1210/en.2005-0282;
Trevaskis J., Walder K., Foletta V., Kerr-Bayles L., McMillan J.,
Cooper A., Lee S., Bolton K., Prior M., Fahey R., Whitecross K.,
Morton G.J., Schwartz M.W., Collier G.R.;
"Src homology 3-domain growth factor receptor-bound 2-like
(endophilin) interacting protein 1, a novel neuronal protein that
regulates energy balance.";
Endocrinology 146:3757-3764(2005).
-!- FUNCTION: May function in clathrin-mediated endocytosis. Has both
a membrane binding/tubulating activity and the ability to recruit
proteins essential to the formation of functional clathrin-coated
pits. Has a preference for membranes enriched in
phosphatidylserine and phosphoinositides and is required for the
endocytosis of the transferrin receptor. May also bind tubulin.
May play a role in the regulation of energy homeostasis.
{ECO:0000269|PubMed:15919751}.
-!- SUBUNIT: Interacts with proteins essential or regulating the
formation of functional clathrin-coated pits (Probable). Interacts
with CANX (By similarity). Interacts with AP2A1 (By similarity).
Interacts with EPS15 (By similarity). Interacts with SH3GL3
(PubMed:15919751). Interacts with AMPH (By similarity). Interacts
with ITSN1 (via SH3 domains) (By similarity). Interacts with and
REPS1 (By similarity). {ECO:0000250|UniProtKB:Q8VD37,
ECO:0000250|UniProtKB:Q9BQI5, ECO:0000269|PubMed:15919751,
ECO:0000305}.
-!- SUBCELLULAR LOCATION: Membrane, clathrin-coated pit
{ECO:0000250|UniProtKB:Q9BQI5}; Peripheral membrane protein
{ECO:0000250|UniProtKB:Q9BQI5}; Cytoplasmic side
{ECO:0000250|UniProtKB:Q9BQI5}.
-!- TISSUE SPECIFICITY: Specifically expressed in brain. Also detected
at lower levels in spleen and adipose tissue.
{ECO:0000269|PubMed:15919751}.
-!- MISCELLANEOUS: Brain-specific depletion by RNAi leads to body
weight reduction due to reduction of food intake without
concomitant reduction in metabolic rate.
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EMBL; AY611625; AAT37968.1; -; mRNA.
PRIDE; Q6IZA3; -.
GO; GO:0030122; C:AP-2 adaptor complex; ISS:UniProtKB.
GO; GO:0030136; C:clathrin-coated vesicle; ISS:UniProtKB.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO; GO:0008017; F:microtubule binding; ISS:UniProtKB.
GO; GO:0005543; F:phospholipid binding; ISS:UniProtKB.
GO; GO:0072583; P:clathrin-dependent endocytosis; IEA:InterPro.
GO; GO:0097009; P:energy homeostasis; IMP:UniProtKB.
GO; GO:2000253; P:positive regulation of feeding behavior; IMP:UniProtKB.
GO; GO:0048260; P:positive regulation of receptor-mediated endocytosis; ISS:UniProtKB.
GO; GO:0002021; P:response to dietary excess; IMP:UniProtKB.
GO; GO:0042594; P:response to starvation; IEP:UniProtKB.
CDD; cd09266; SGIP1_MHD; 1.
InterPro; IPR036168; AP2_Mu_C_sf.
InterPro; IPR028565; MHD.
InterPro; IPR018808; Muniscin_C.
InterPro; IPR037984; SGIP1_MHD.
Pfam; PF10291; muHD; 1.
SUPFAM; SSF49447; SSF49447; 1.
PROSITE; PS51072; MHD; 1.
1: Evidence at protein level;
Coated pit; Endocytosis; Membrane; Phosphoprotein.
CHAIN 1 827 SH3-containing GRB2-like protein 3-
interacting protein 1.
/FTId=PRO_0000248398.
DOMAIN 558 826 MHD. {ECO:0000255|PROSITE-
ProRule:PRU00404}.
REGION 560 566 Interaction with DPF motifs-containing
proteins. {ECO:0000250|UniProtKB:Q9BQI5}.
REGION 592 594 Interaction with DPF motifs-containing
proteins. {ECO:0000250|UniProtKB:Q9BQI5}.
REGION 648 827 Necessary and sufficient to mediate
interaction with CANX.
{ECO:0000250|UniProtKB:Q8VD37}.
REGION 666 669 Interaction with DPF motifs-containing
proteins. {ECO:0000250|UniProtKB:Q9BQI5}.
REGION 812 817 Interaction with DPF motifs-containing
proteins. {ECO:0000250|UniProtKB:Q9BQI5}.
COMPBIAS 106 112 Poly-Glu. {ECO:0000255}.
COMPBIAS 229 498 Pro-rich. {ECO:0000255|PROSITE-
ProRule:PRU00015}.
MOD_RES 78 78 Phosphoserine.
{ECO:0000250|UniProtKB:Q8VD37}.
MOD_RES 104 104 Phosphoserine.
{ECO:0000250|UniProtKB:P0DJJ3}.
MOD_RES 105 105 Phosphoserine.
{ECO:0000250|UniProtKB:P0DJJ3}.
MOD_RES 107 107 Phosphoserine.
{ECO:0000250|UniProtKB:P0DJJ3}.
MOD_RES 149 149 Phosphoserine.
{ECO:0000250|UniProtKB:Q8VD37}.
MOD_RES 151 151 Phosphoserine.
{ECO:0000250|UniProtKB:Q8VD37}.
MOD_RES 156 156 Phosphoserine.
{ECO:0000250|UniProtKB:Q8VD37}.
MOD_RES 169 169 Phosphoserine.
{ECO:0000250|UniProtKB:P0DJJ3}.
MOD_RES 180 180 Phosphothreonine.
{ECO:0000250|UniProtKB:Q8VD37}.
MOD_RES 182 182 Phosphothreonine.
{ECO:0000250|UniProtKB:Q8VD37}.
MOD_RES 236 236 Phosphoserine.
{ECO:0000250|UniProtKB:P0DJJ3}.
MOD_RES 247 247 Phosphothreonine.
{ECO:0000250|UniProtKB:Q8VD37}.
MOD_RES 259 259 Phosphothreonine.
{ECO:0000250|UniProtKB:Q8VD37}.
MOD_RES 265 265 Phosphoserine.
{ECO:0000250|UniProtKB:Q8VD37}.
MOD_RES 287 287 Phosphoserine.
{ECO:0000250|UniProtKB:Q8VD37}.
MOD_RES 289 289 Phosphoserine.
{ECO:0000250|UniProtKB:Q8VD37}.
MOD_RES 300 300 Phosphoserine.
{ECO:0000250|UniProtKB:Q8VD37}.
MOD_RES 316 316 Phosphoserine.
{ECO:0000250|UniProtKB:Q8VD37}.
MOD_RES 319 319 Phosphoserine.
{ECO:0000250|UniProtKB:Q8VD37}.
MOD_RES 324 324 Phosphothreonine.
{ECO:0000250|UniProtKB:Q8VD37}.
MOD_RES 328 328 Phosphothreonine.
{ECO:0000250|UniProtKB:Q8VD37}.
MOD_RES 335 335 Phosphothreonine.
{ECO:0000250|UniProtKB:P0DJJ3}.
MOD_RES 371 371 Phosphoserine.
{ECO:0000250|UniProtKB:Q8VD37}.
MOD_RES 398 398 Phosphoserine.
{ECO:0000250|UniProtKB:Q8VD37}.
MOD_RES 409 409 Phosphothreonine.
{ECO:0000250|UniProtKB:Q8VD37}.
MOD_RES 485 485 Phosphoserine.
{ECO:0000250|UniProtKB:Q8VD37}.
SEQUENCE 827 AA; 88451 MW; FDE1EFCB07339A60 CRC64;
MMEGLKKRTR KAFGIRKKEK DTDSTGSPDR DGMQPSPHEL PYHSKAECAR EGGNKASKKS
NGAPNGFYAE IDWERYNSPE LDEEGYSIRP EEPGSTKGKH FYSSSESEEE EESHKKFNIK
IKPLQSKDIL KNAATVDELK ASIGNIALSP SPVRKSPRRS PGAIKRNLSS EEVARPRRST
PTPELTSKKP LDDTLALAPL FGPPLESAFD GHKTEVLLDQ PEIWGSGQPV NPSMESPKLA
RPFPTGTPPP LPPKTVPATP PRTGSPLTVA TGNDQAATEA KIEKLPSISD LDSIFGPVLS
PKSVAVNTEE TWVHFSDASP EHVTPELTPR EKVVTPPAAS DIPADSPTPG PPGPPGSAGP
PGPPGPRNVP SPLNLEEVQK KVAEQTFIKD DYLETLSSPK ECGLGQRATP PPPPPPTYRT
VVSSPGPGSG SGTGTASGAS SPARPATPLV PCSCSTPPPP PPRPPSRPKL PPGKPGVGDV
SRPFSPPIHS SSPPPIAPLA RAESTSSISS TNSLSAATTP TVENEQXSLV WFDRGKFYLT
FEGSSRGPSP LTMGAQDTLP VAAAFTETVN AYFKGADPSK CIVKITGEMV LSFPAGITRH
FANNPSPAAL TFRVINSSRL EHVLPNPQLL CCDNTQNDAN TKEFWVNMPN LMTHLKKVSE
QKPQATYYNV DMLKYQVSAQ GIQSTPLNLA VNWRCEPSST DLRIDYKYNT DAMSTAVALN
NVQFLVPIDG GVTKLQAVLP PAVWNAEQQR ILWKIPDISQ KSENGGVGSL LARFQLAEGP
SKPSPLVVQF TSEGSTLSGC DIELVGAGYG FSLIKKRFAA GKYLADN


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[SGIP1] SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein)
[Sgip1] SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein)
[Sgip1] SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein)
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[GRB2 ASH] Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
[SGIP1] SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein)
[Grb2] Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)
[Grb2 Ash] Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
[SH3KBP1 CIN85] SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)
[NCKIPSD AF3P21 SPIN90] NCK-interacting protein with SH3 domain (54 kDa VacA-interacting protein) (54 kDa vimentin-interacting protein) (VIP54) (90 kDa SH3 protein interacting with Nck) (AF3p21) (Dia-interacting protein 1) (DIP-1) (Diaphanous protein-interacting protein) (SH3 adapter protein SPIN90) (WASP-interacting SH3-domain protein) (WISH) (Wiskott-Aldrich syndrome protein-interacting protein)
[EndoA endo CG14296] Endophilin-A (SH3 domain-containing GRB2-like protein)
[GRB2] Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)
[ABI1 SSH3BP1] Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1)
[Abi1 Ssh3bp1] Abl interactor 1 (Abelson interactor 1) (Abi-1) (Ablphilin-1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Spectrin SH3 domain-binding protein 1) (e3B1)
[Sh3kbp1 Ruk Seta] SH3 domain-containing kinase-binding protein 1 (Regulator of ubiquitous kinase) (Ruk) (SH3-containing, expressed in tumorigenic astrocytes)
[Sh3kbp1 Ruk Seta] SH3 domain-containing kinase-binding protein 1 (Regulator of ubiquitous kinase) (Ruk) (SH3-containing, expressed in tumorigenic astrocytes)
[UBASH3A STS2] Ubiquitin-associated and SH3 domain-containing protein A (Cbl-interacting protein 4) (CLIP4) (Suppressor of T-cell receptor signaling 2) (STS-2) (T-cell ubiquitin ligand 1) (TULA-1)
[Abi1] Abl interactor 1 (Abelson interactor 1) (Abi-1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1)
[MED28 EG1 FKSG20] Mediator of RNA polymerase II transcription subunit 28 (Endothelial-derived protein 1) (Mediator complex subunit 28) (Merlin and Grb2-interacting cytoskeletal protein) (Magicin) (Tumor angiogenesis marker EG-1)
[NCK1 NCK] Cytoplasmic protein NCK1 (NCK adaptor protein 1) (Nck-1) (SH2/SH3 adaptor protein NCK-alpha)
[GAB1] GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)
[GAREM1 C18orf11 FAM59A GAREM] GRB2-associated and regulator of MAPK protein 1 (GRB2-associated and regulator of MAPK1)
[UBASH3B KIAA1959 STS1] Ubiquitin-associated and SH3 domain-containing protein B (EC 3.1.3.48) (Cbl-interacting protein p70) (Suppressor of T-cell receptor signaling 1) (STS-1) (T-cell ubiquitin ligand 2) (TULA-2) (Tyrosine-protein phosphatase STS1/TULA2)
[Sh3bp1 3bp1] SH3 domain-binding protein 1 (3BP-1)
[tea4 wsh3 SPBC1706.01] Tip elongation aberrant protein Tea4 (Cell polarity protein tea4) (Win1-interacting SH3 domain protein)
[WIPF1 WASPIP WIP] WAS/WASL-interacting protein family member 1 (Protein PRPL-2) (Wiskott-Aldrich syndrome protein-interacting protein) (WASP-interacting protein)
[SH3BP1] SH3 domain-binding protein 1
[Sh3bp1] SH3 domain-binding protein 1

Bibliography :
[31053155] SGIP1α functions as a selective endocytic adaptor for the internalization of synaptotagmin 1 at synapses.