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SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein)

 SGIP1_PSAOB             Reviewed;         827 AA.
Q6IZA3;
05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
05-JUL-2004, sequence version 1.
11-DEC-2019, entry version 53.
RecName: Full=SH3-containing GRB2-like protein 3-interacting protein 1;
AltName: Full=Endophilin-3-interacting protein;
Name=SGIP1;
Psammomys obesus (Fat sand rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Gerbillinae; Psammomys.
NCBI_TaxID=48139;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND INTERACTION
WITH SH3GL3.
TISSUE=Hypothalamus;
PubMed=15919751; DOI=10.1210/en.2005-0282;
Trevaskis J., Walder K., Foletta V., Kerr-Bayles L., McMillan J.,
Cooper A., Lee S., Bolton K., Prior M., Fahey R., Whitecross K.,
Morton G.J., Schwartz M.W., Collier G.R.;
"Src homology 3-domain growth factor receptor-bound 2-like (endophilin)
interacting protein 1, a novel neuronal protein that regulates energy
balance.";
Endocrinology 146:3757-3764(2005).
-!- FUNCTION: May function in clathrin-mediated endocytosis. Has both a
membrane binding/tubulating activity and the ability to recruit
proteins essential to the formation of functional clathrin-coated pits.
Has a preference for membranes enriched in phosphatidylserine and
phosphoinositides and is required for the endocytosis of the
transferrin receptor. May also bind tubulin. May play a role in the
regulation of energy homeostasis. {ECO:0000269|PubMed:15919751}.
-!- SUBUNIT: Interacts with proteins essential or regulating the formation
of functional clathrin-coated pits (Probable). Interacts with CANX (By
similarity). Interacts with AP2A1 (By similarity). Interacts with EPS15
(By similarity). Interacts with SH3GL3 (PubMed:15919751). Interacts
with AMPH (By similarity). Interacts with ITSN1 (via SH3 domains) (By
similarity). Interacts with and REPS1 (By similarity).
{ECO:0000250|UniProtKB:Q8VD37, ECO:0000250|UniProtKB:Q9BQI5,
ECO:0000269|PubMed:15919751, ECO:0000305}.
-!- SUBCELLULAR LOCATION: Membrane, clathrin-coated pit
{ECO:0000250|UniProtKB:Q9BQI5}; Peripheral membrane protein
{ECO:0000250|UniProtKB:Q9BQI5}; Cytoplasmic side
{ECO:0000250|UniProtKB:Q9BQI5}.
-!- TISSUE SPECIFICITY: Specifically expressed in brain. Also detected at
lower levels in spleen and adipose tissue.
{ECO:0000269|PubMed:15919751}.
-!- MISCELLANEOUS: Brain-specific depletion by RNAi leads to body weight
reduction due to reduction of food intake without concomitant reduction
in metabolic rate.
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EMBL; AY611625; AAT37968.1; -; mRNA.
PRIDE; Q6IZA3; -.
GO; GO:0030122; C:AP-2 adaptor complex; ISS:UniProtKB.
GO; GO:0030136; C:clathrin-coated vesicle; ISS:UniProtKB.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO; GO:0008017; F:microtubule binding; ISS:UniProtKB.
GO; GO:0005543; F:phospholipid binding; ISS:UniProtKB.
GO; GO:0072583; P:clathrin-dependent endocytosis; IEA:InterPro.
GO; GO:0097009; P:energy homeostasis; IMP:UniProtKB.
GO; GO:2000253; P:positive regulation of feeding behavior; IMP:UniProtKB.
GO; GO:0048260; P:positive regulation of receptor-mediated endocytosis; ISS:UniProtKB.
GO; GO:0002021; P:response to dietary excess; IMP:UniProtKB.
GO; GO:0042594; P:response to starvation; IEP:UniProtKB.
CDD; cd09266; SGIP1_MHD; 1.
InterPro; IPR036168; AP2_Mu_C_sf.
InterPro; IPR028565; MHD.
InterPro; IPR018808; Muniscin_C.
InterPro; IPR037984; SGIP1_MHD.
Pfam; PF10291; muHD; 1.
SUPFAM; SSF49447; SSF49447; 1.
PROSITE; PS51072; MHD; 1.
1: Evidence at protein level;
Coated pit; Endocytosis; Membrane; Phosphoprotein.
CHAIN 1..827
/note="SH3-containing GRB2-like protein 3-interacting
protein 1"
/id="PRO_0000248398"
DOMAIN 558..826
/note="MHD"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00404"
REGION 560..566
/note="Interaction with DPF motifs-containing proteins"
/evidence="ECO:0000250|UniProtKB:Q9BQI5"
REGION 592..594
/note="Interaction with DPF motifs-containing proteins"
/evidence="ECO:0000250|UniProtKB:Q9BQI5"
REGION 648..827
/note="Necessary and sufficient to mediate interaction with
CANX"
/evidence="ECO:0000250|UniProtKB:Q8VD37"
REGION 666..669
/note="Interaction with DPF motifs-containing proteins"
/evidence="ECO:0000250|UniProtKB:Q9BQI5"
REGION 812..817
/note="Interaction with DPF motifs-containing proteins"
/evidence="ECO:0000250|UniProtKB:Q9BQI5"
COMPBIAS 106..112
/note="Poly-Glu"
/evidence="ECO:0000255"
COMPBIAS 229..498
/note="Pro-rich"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00015"
MOD_RES 78
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q8VD37"
MOD_RES 104
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:P0DJJ3"
MOD_RES 105
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:P0DJJ3"
MOD_RES 107
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:P0DJJ3"
MOD_RES 149
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q8VD37"
MOD_RES 151
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q8VD37"
MOD_RES 156
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q8VD37"
MOD_RES 169
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:P0DJJ3"
MOD_RES 180
/note="Phosphothreonine"
/evidence="ECO:0000250|UniProtKB:Q8VD37"
MOD_RES 182
/note="Phosphothreonine"
/evidence="ECO:0000250|UniProtKB:Q8VD37"
MOD_RES 236
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:P0DJJ3"
MOD_RES 247
/note="Phosphothreonine"
/evidence="ECO:0000250|UniProtKB:Q8VD37"
MOD_RES 259
/note="Phosphothreonine"
/evidence="ECO:0000250|UniProtKB:Q8VD37"
MOD_RES 265
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q8VD37"
MOD_RES 287
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q8VD37"
MOD_RES 289
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q8VD37"
MOD_RES 300
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q8VD37"
MOD_RES 316
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q8VD37"
MOD_RES 319
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q8VD37"
MOD_RES 324
/note="Phosphothreonine"
/evidence="ECO:0000250|UniProtKB:Q8VD37"
MOD_RES 328
/note="Phosphothreonine"
/evidence="ECO:0000250|UniProtKB:Q8VD37"
MOD_RES 335
/note="Phosphothreonine"
/evidence="ECO:0000250|UniProtKB:P0DJJ3"
MOD_RES 371
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q8VD37"
MOD_RES 398
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q8VD37"
MOD_RES 409
/note="Phosphothreonine"
/evidence="ECO:0000250|UniProtKB:Q8VD37"
MOD_RES 485
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q8VD37"
SEQUENCE 827 AA; 88451 MW; FDE1EFCB07339A60 CRC64;
MMEGLKKRTR KAFGIRKKEK DTDSTGSPDR DGMQPSPHEL PYHSKAECAR EGGNKASKKS
NGAPNGFYAE IDWERYNSPE LDEEGYSIRP EEPGSTKGKH FYSSSESEEE EESHKKFNIK
IKPLQSKDIL KNAATVDELK ASIGNIALSP SPVRKSPRRS PGAIKRNLSS EEVARPRRST
PTPELTSKKP LDDTLALAPL FGPPLESAFD GHKTEVLLDQ PEIWGSGQPV NPSMESPKLA
RPFPTGTPPP LPPKTVPATP PRTGSPLTVA TGNDQAATEA KIEKLPSISD LDSIFGPVLS
PKSVAVNTEE TWVHFSDASP EHVTPELTPR EKVVTPPAAS DIPADSPTPG PPGPPGSAGP
PGPPGPRNVP SPLNLEEVQK KVAEQTFIKD DYLETLSSPK ECGLGQRATP PPPPPPTYRT
VVSSPGPGSG SGTGTASGAS SPARPATPLV PCSCSTPPPP PPRPPSRPKL PPGKPGVGDV
SRPFSPPIHS SSPPPIAPLA RAESTSSISS TNSLSAATTP TVENEQXSLV WFDRGKFYLT
FEGSSRGPSP LTMGAQDTLP VAAAFTETVN AYFKGADPSK CIVKITGEMV LSFPAGITRH
FANNPSPAAL TFRVINSSRL EHVLPNPQLL CCDNTQNDAN TKEFWVNMPN LMTHLKKVSE
QKPQATYYNV DMLKYQVSAQ GIQSTPLNLA VNWRCEPSST DLRIDYKYNT DAMSTAVALN
NVQFLVPIDG GVTKLQAVLP PAVWNAEQQR ILWKIPDISQ KSENGGVGSL LARFQLAEGP
SKPSPLVVQF TSEGSTLSGC DIELVGAGYG FSLIKKRFAA GKYLADN


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WP2218: sGC
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WP1888: Post-translational protein modification
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WP1678: Nucleotide excision repair
WP1613: 1,4-Dichlorobenzene degradation
WP1690: Propanoate metabolism
WP525: Mitochondrial Unfolded-Protein Response
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WP1909: Signal regulatory protein (SIRP) family interactions
WP35: G Protein Signaling Pathways
WP931: G Protein Signaling Pathways
WP1676: Non-homologous end-joining

Related Genes :
[SGIP1] SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein)
[Sgip1] SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein)
[Sgip1] SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein)
[Sh3gl2 Sh3d2a Sh3p4] Endophilin-A1 (Endophilin-1) (SH3 domain protein 2A) (SH3 domain-containing GRB2-like protein 2) (SH3p4)
[SH3GL2 CNSA2 SH3D2A] Endophilin-A1 (EEN-B1) (Endophilin-1) (SH3 domain protein 2A) (SH3 domain-containing GRB2-like protein 2)
[SH3GLB1 KIAA0491 CGI-61] Endophilin-B1 (Bax-interacting factor 1) (Bif-1) (SH3 domain-containing GRB2-like protein B1)
[GRB2 ASH] Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
[SGIP1] SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein)
[SH3KBP1 CIN85] SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)
[Grb2] Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)
[Grb2 Ash] Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
[NCKIPSD AF3P21 SPIN90] NCK-interacting protein with SH3 domain (54 kDa VacA-interacting protein) (54 kDa vimentin-interacting protein) (VIP54) (90 kDa SH3 protein interacting with Nck) (AF3p21) (Dia-interacting protein 1) (DIP-1) (Diaphanous protein-interacting protein) (SH3 adapter protein SPIN90) (WASP-interacting SH3-domain protein) (WISH) (Wiskott-Aldrich syndrome protein-interacting protein)
[EndoA endo CG14296] Endophilin-A (SH3 domain-containing GRB2-like protein)
[GRB2] Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)
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[Sh3kbp1 Ruk Seta] SH3 domain-containing kinase-binding protein 1 (Regulator of ubiquitous kinase) (Ruk) (SH3-containing, expressed in tumorigenic astrocytes)
[Abi1] Abl interactor 1 (Abelson interactor 1) (Abi-1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1)
[UBASH3A STS2] Ubiquitin-associated and SH3 domain-containing protein A (Cbl-interacting protein 4) (CLIP4) (Suppressor of T-cell receptor signaling 2) (STS-2) (T-cell ubiquitin ligand 1) (TULA-1)
[MED28 EG1 FKSG20] Mediator of RNA polymerase II transcription subunit 28 (Endothelial-derived protein 1) (Mediator complex subunit 28) (Merlin and Grb2-interacting cytoskeletal protein) (Magicin) (Tumor angiogenesis marker EG-1)
[NCK1 NCK] Cytoplasmic protein NCK1 (NCK adaptor protein 1) (Nck-1) (SH2/SH3 adaptor protein NCK-alpha)
[GAB1] GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)
[GAREM1 C18orf11 FAM59A GAREM] GRB2-associated and regulator of MAPK protein 1 (GRB2-associated and regulator of MAPK1)
[UBASH3B KIAA1959 STS1] Ubiquitin-associated and SH3 domain-containing protein B (EC 3.1.3.48) (Cbl-interacting protein p70) (Suppressor of T-cell receptor signaling 1) (STS-1) (T-cell ubiquitin ligand 2) (TULA-2) (Tyrosine-protein phosphatase STS1/TULA2)
[Sh3bp1 3bp1] SH3 domain-binding protein 1 (3BP-1)
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[SH3BP1] SH3 domain-binding protein 1
[Sh3bp1] SH3 domain-binding protein 1
[WIPF1 WASPIP WIP] WAS/WASL-interacting protein family member 1 (Protein PRPL-2) (Wiskott-Aldrich syndrome protein-interacting protein) (WASP-interacting protein)

Bibliography :
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