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Secreted frizzled-related protein 1 (sFRP-1)

 SFRP1_MOUSE             Reviewed;         314 AA.
Q8C4U3; O08861; Q505A2; Q8R1J4;
15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
27-JUL-2011, sequence version 3.
13-FEB-2019, entry version 141.
RecName: Full=Secreted frizzled-related protein 1;
Short=sFRP-1;
Flags: Precursor;
Name=Sfrp1;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
STRAIN=C57BL/6J; TISSUE=Embryonic eye;
PubMed=9096311; DOI=10.1073/pnas.94.7.2859;
Rattner A., Hsieh J.-C., Smallwood P.M., Gilbert D.J., Copeland N.G.,
Jenkins N.A., Nathans J.;
"A family of secreted proteins contains homology to the cysteine-rich
ligand-binding domain of frizzled receptors.";
Proc. Natl. Acad. Sci. U.S.A. 94:2859-2863(1997).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J, and FVB/N; TISSUE=Brain, and Colon;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 43-314.
STRAIN=C57BL/6J; TISSUE=Cerebellum;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[4]
DEVELOPMENTAL STAGE.
PubMed=9739103; DOI=10.1016/S0925-4773(98)00072-0;
Leimeister C., Bach A., Gessler M.;
"Developmental expression patterns of mouse sFRP genes encoding
members of the secreted frizzled related protein family.";
Mech. Dev. 75:29-42(1998).
[5]
INTERACTION WITH WNT8, AND DEVELOPMENTAL STAGE.
PubMed=10640709; DOI=10.1016/S0925-4773(99)00236-1;
Jaspard B., Couffinhal T., Dufourcq P., Moreau C., Duplaa C.;
"Expression pattern of mouse sFRP-1 and mWnt-8 gene during heart
morphogenesis.";
Mech. Dev. 90:263-267(2000).
[6]
FUNCTION AS AN ANGIOGENIC FACTOR.
PubMed=15306229; DOI=10.1016/j.cardiores.2004.05.006;
Ezan J., Leroux L., Barandon L., Dufourcq P., Jaspard B., Moreau C.,
Allieres C., Daret D., Couffinhal T., Duplaa C.;
"FrzA/sFRP-1, a secreted antagonist of the Wnt-Frizzled pathway,
controls vascular cell proliferation in vitro and in vivo.";
Cardiovasc. Res. 63:731-738(2004).
[7]
INTERACTION WITH MYOC.
PubMed=19188438; DOI=10.1128/MCB.01274-08;
Kwon H.S., Lee H.S., Ji Y., Rubin J.S., Tomarev S.I.;
"Myocilin is a modulator of Wnt signaling.";
Mol. Cell. Biol. 29:2139-2154(2009).
-!- FUNCTION: Soluble frizzled-related proteins (sFRPS) function as
modulators of Wnt signaling through direct interaction with Wnts.
They have a role in regulating cell growth and differentiation in
specific cell types. SFRP1 decreases intracellular beta-catenin
levels (By similarity). Has antiproliferative effects on vascular
cells, in vitro and in vivo, and can induce, in vivo, an
angiogenic response. In vascular cell cycle, delays the G1 phase
and entry into the S phase. In kidney development, inhibits tubule
formation and bud growth in metanephroi (By similarity). Inhibits
WNT1/WNT4-mediated TCF-dependent transcription (By similarity).
{ECO:0000250, ECO:0000269|PubMed:15306229}.
-!- SUBUNIT: Interacts with WNT8, WNT1, WNT2, WNT4 and FRZD6 (By
similarity). Interacts with MYOC. {ECO:0000250,
ECO:0000269|PubMed:10640709, ECO:0000269|PubMed:19188438}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Note=Cell membrane
or extracellular matrix-associated. Released by heparin-binding
(By similarity). {ECO:0000250}.
-!- TISSUE SPECIFICITY: Highly expressed in kidney and embryonic
heart. Also highly expressed in the eye, where it is principally
localized to the ciliary body and the lens epithelium. Weaker
expression in heart, lung and brain. In the brain, is expressed
exclusively in the choroid plexus. {ECO:0000269|PubMed:9096311}.
-!- DEVELOPMENTAL STAGE: In the developing kidney expressed at 13.5
dpc in the periphery of the metanophros and surrounding the uretic
and nephrogenic tubules. At 14.5 dpc, expression decreases in the
outer cortical cells and becomes visible in the tubular parts of
the nephron. From 15.5 dpc, highly expressed in the future loops
of Henle. In the developing CNS, expression located to the
forebrain and hindbrain. At 8.0 dpc, expressed in the future
forebrain and in the ventral portion of the presumptive hindbrain.
At 8.5 dpc, expression is maintained in these tissues with a
strong signal in rhombomere 4. Until 11.5 dpc, expression
continues in the hindbrain with additional expression at 9.5 dpc
and 10.5 dpc, in the nasal and epibranchial placodes. In the
forbrain, initial expression is found in the proencephalon of the
forebrain, and then strong expression in the telencephalic vesicle
up to 15.5 dpc. Expression is then found in specific cell
populations throughout the brain. In the developing eye,
expression, by 10.5 dpc, is confined to ectodermal cells overlying
the dorsal part of the optic cup. In later stages, expression
limited to the lens fiber cells and the future pigmented retina.
By 15.5 dpc, expression is confined to the anterior part of the
lens. During limb development, barely expressed until later
stages, when it is found in the distal part of the separating
phalanges. In other developing structures, expressed in nasal
placodes at 9.5 dpc, in medial nasal processes at 10.5 dpc and
then in the anterior portion of the invaginating olfactory
epithelium. At 15.5 dpc, expressed on the basal side of the nasal
epithelium. Also expressed in developing teeth, with the highest
levels at 15.5 dpc and 16.5 dpc in the mesenchyme and the dental
epithelium of the developing molars. As well, expressed in the
ventral body wall, in the mesenchyme derived adrenal cortex, the
cochlear epithelium and the branching epithelium of the salivary
gland. In the developing heart, weakly expressed from 8.5 dpc in
the tubular heart endocardium and myocardium. From 8.5 dpc to 12.5
dpc expressed in cardiomyocytes. At 9.5 dpc, expression found in
the common ventricular and atrial chamber of the developing heart,
in the aortic sac and in the sinus venosus. High expression found
from 11.5 dpc-12.5 dpc, in the trabeculated wall of the
ventricular chamber together with the wall of the atrial chamber.
Expression also found in the muscular part of the interventricular
septum. From 9.5 dpc-11.5 dpc expression in the visceral yolk sac
confined to the inner lining endothelial cell layer. Expression in
the developing heart decreases after 14.5 dpc.
{ECO:0000269|PubMed:10640709, ECO:0000269|PubMed:9739103}.
-!- DOMAIN: The FZ domain is involved in binding with Wnt ligands.
{ECO:0000250}.
-!- SIMILARITY: Belongs to the secreted frizzled-related protein
(sFRP) family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; U88566; AAC53145.1; -; mRNA.
EMBL; BC024495; AAH24495.1; -; mRNA.
EMBL; BC094662; AAH94662.1; -; mRNA.
EMBL; AK081052; BAC38123.1; -; mRNA.
CCDS; CCDS22191.1; -.
RefSeq; NP_038862.2; NM_013834.3.
RefSeq; XP_011240430.1; XM_011242128.1.
UniGene; Mm.281691; -.
ProteinModelPortal; Q8C4U3; -.
SMR; Q8C4U3; -.
BioGrid; 203185; 7.
STRING; 10090.ENSMUSP00000033952; -.
ChEMBL; CHEMBL1075304; -.
MEROPS; I93.002; -.
iPTMnet; Q8C4U3; -.
PhosphoSitePlus; Q8C4U3; -.
MaxQB; Q8C4U3; -.
PaxDb; Q8C4U3; -.
PeptideAtlas; Q8C4U3; -.
PRIDE; Q8C4U3; -.
Ensembl; ENSMUST00000033952; ENSMUSP00000033952; ENSMUSG00000031548.
GeneID; 20377; -.
KEGG; mmu:20377; -.
UCSC; uc009lev.2; mouse.
CTD; 6422; -.
MGI; MGI:892014; Sfrp1.
eggNOG; KOG3577; Eukaryota.
eggNOG; ENOG410XRC8; LUCA.
GeneTree; ENSGT00940000159875; -.
HOGENOM; HOG000231058; -.
HOVERGEN; HBG052928; -.
InParanoid; Q8C4U3; -.
KO; K02166; -.
OMA; DDVCIAM; -.
OrthoDB; 1306779at2759; -.
TreeFam; TF350133; -.
ChiTaRS; Sfrp1; mouse.
PRO; PR:Q8C4U3; -.
Proteomes; UP000000589; Chromosome 8.
Bgee; ENSMUSG00000031548; Expressed in 325 organ(s), highest expression level in epithelium of lens.
Genevisible; Q8C4U3; MM.
GO; GO:0009986; C:cell surface; ISO:MGI.
GO; GO:0062023; C:collagen-containing extracellular matrix; ISO:MGI.
GO; GO:0005829; C:cytosol; ISO:MGI.
GO; GO:0005615; C:extracellular space; HDA:BHF-UCL.
GO; GO:0005886; C:plasma membrane; ISO:MGI.
GO; GO:0004197; F:cysteine-type endopeptidase activity; ISO:MGI.
GO; GO:0008144; F:drug binding; ISO:MGI.
GO; GO:0005109; F:frizzled binding; ISO:MGI.
GO; GO:0008201; F:heparin binding; ISO:MGI.
GO; GO:0042802; F:identical protein binding; ISO:MGI.
GO; GO:0017147; F:Wnt-protein binding; ISO:MGI.
GO; GO:0030036; P:actin cytoskeleton organization; ISO:MGI.
GO; GO:0009952; P:anterior/posterior pattern specification; IGI:MGI.
GO; GO:0060346; P:bone trabecula formation; IMP:MGI.
GO; GO:0060070; P:canonical Wnt signaling pathway; ISO:MGI.
GO; GO:0071773; P:cellular response to BMP stimulus; IEA:Ensembl.
GO; GO:0071392; P:cellular response to estradiol stimulus; IEA:Ensembl.
GO; GO:0071391; P:cellular response to estrogen stimulus; IDA:UniProtKB.
GO; GO:0044344; P:cellular response to fibroblast growth factor stimulus; ISO:MGI.
GO; GO:0071363; P:cellular response to growth factor stimulus; ISO:MGI.
GO; GO:0071504; P:cellular response to heparin; ISO:MGI.
GO; GO:0071456; P:cellular response to hypoxia; IEA:Ensembl.
GO; GO:0071347; P:cellular response to interleukin-1; IEA:Ensembl.
GO; GO:0071380; P:cellular response to prostaglandin E stimulus; IEA:Ensembl.
GO; GO:0009267; P:cellular response to starvation; IEA:Ensembl.
GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEA:Ensembl.
GO; GO:0071356; P:cellular response to tumor necrosis factor; ISO:MGI.
GO; GO:0071305; P:cellular response to vitamin D; IEA:Ensembl.
GO; GO:0071481; P:cellular response to X-ray; IDA:UniProtKB.
GO; GO:0090246; P:convergent extension involved in somitogenesis; IGI:MGI.
GO; GO:0046546; P:development of primary male sexual characteristics; IGI:MGI.
GO; GO:0048546; P:digestive tract morphogenesis; IGI:MGI.
GO; GO:0071542; P:dopaminergic neuron differentiation; IDA:ParkinsonsUK-UCL.
GO; GO:0009950; P:dorsal/ventral axis specification; ISO:MGI.
GO; GO:0008585; P:female gonad development; IGI:MGI.
GO; GO:0002244; P:hematopoietic progenitor cell differentiation; ISO:MGI.
GO; GO:0060218; P:hematopoietic stem cell differentiation; ISO:MGI.
GO; GO:0030097; P:hemopoiesis; IMP:MGI.
GO; GO:0008584; P:male gonad development; IGI:MGI.
GO; GO:0060766; P:negative regulation of androgen receptor signaling pathway; ISO:MGI.
GO; GO:0043066; P:negative regulation of apoptotic process; ISO:MGI.
GO; GO:0045578; P:negative regulation of B cell differentiation; IMP:UniProtKB.
GO; GO:0030514; P:negative regulation of BMP signaling pathway; IGI:MGI.
GO; GO:0046851; P:negative regulation of bone remodeling; ISO:MGI.
GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IDA:UniProtKB.
GO; GO:2000080; P:negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation; ISO:MGI.
GO; GO:0030308; P:negative regulation of cell growth; ISO:MGI.
GO; GO:0030336; P:negative regulation of cell migration; ISO:MGI.
GO; GO:0008285; P:negative regulation of cell population proliferation; ISO:MGI.
GO; GO:0050680; P:negative regulation of epithelial cell proliferation; ISO:MGI.
GO; GO:0010719; P:negative regulation of epithelial to mesenchymal transition; ISO:MGI.
GO; GO:2000270; P:negative regulation of fibroblast apoptotic process; ISO:MGI.
GO; GO:0048147; P:negative regulation of fibroblast proliferation; ISO:MGI.
GO; GO:0010629; P:negative regulation of gene expression; IMP:MGI.
GO; GO:0046676; P:negative regulation of insulin secretion; ISO:MGI.
GO; GO:0043508; P:negative regulation of JUN kinase activity; IGI:MGI.
GO; GO:0030279; P:negative regulation of ossification; IMP:MGI.
GO; GO:0045668; P:negative regulation of osteoblast differentiation; IMP:MGI.
GO; GO:0033689; P:negative regulation of osteoblast proliferation; IMP:MGI.
GO; GO:0045671; P:negative regulation of osteoclast differentiation; IMP:MGI.
GO; GO:0050732; P:negative regulation of peptidyl-tyrosine phosphorylation; ISO:MGI.
GO; GO:2000041; P:negative regulation of planar cell polarity pathway involved in axis elongation; IGI:MGI.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:MGI.
GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IGI:MGI.
GO; GO:2000054; P:negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification; ISO:MGI.
GO; GO:0014034; P:neural crest cell fate commitment; IMP:MGI.
GO; GO:0001843; P:neural tube closure; IGI:MGI.
GO; GO:0021915; P:neural tube development; IGI:MGI.
GO; GO:0035567; P:non-canonical Wnt signaling pathway; IBA:GO_Central.
GO; GO:0001649; P:osteoblast differentiation; IEA:Ensembl.
GO; GO:0090179; P:planar cell polarity pathway involved in neural tube closure; IGI:MGI.
GO; GO:0043065; P:positive regulation of apoptotic process; ISO:MGI.
GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; ISO:MGI.
GO; GO:0030307; P:positive regulation of cell growth; ISO:MGI.
GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:MGI.
GO; GO:0050679; P:positive regulation of epithelial cell proliferation; ISO:MGI.
GO; GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; IMP:MGI.
GO; GO:1902043; P:positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; ISO:MGI.
GO; GO:0045600; P:positive regulation of fat cell differentiation; ISO:MGI.
GO; GO:2000271; P:positive regulation of fibroblast apoptotic process; ISO:MGI.
GO; GO:2000052; P:positive regulation of non-canonical Wnt signaling pathway; ISO:MGI.
GO; GO:0045880; P:positive regulation of smoothened signaling pathway; ISO:MGI.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:MGI.
GO; GO:0030177; P:positive regulation of Wnt signaling pathway; ISO:MGI.
GO; GO:0060527; P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; IMP:MGI.
GO; GO:0060687; P:regulation of branching involved in prostate gland morphogenesis; IMP:MGI.
GO; GO:0010564; P:regulation of cell cycle process; ISO:MGI.
GO; GO:0090175; P:regulation of establishment of planar polarity; IGI:MGI.
GO; GO:1904956; P:regulation of midbrain dopaminergic neuron differentiation; IGI:ParkinsonsUK-UCL.
GO; GO:0010975; P:regulation of neuron projection development; IDA:ParkinsonsUK-UCL.
GO; GO:0030278; P:regulation of ossification; ISO:MGI.
GO; GO:0042493; P:response to drug; IDA:UniProtKB.
GO; GO:0014070; P:response to organic cyclic compound; ISO:MGI.
GO; GO:0035019; P:somatic stem cell population maintenance; IMP:MGI.
GO; GO:0001756; P:somitogenesis; IGI:MGI.
GO; GO:0044345; P:stromal-epithelial cell signaling involved in prostate gland development; IEP:UniProtKB.
GO; GO:0034446; P:substrate adhesion-dependent cell spreading; ISO:MGI.
GO; GO:0001657; P:ureteric bud development; IEP:UniProtKB.
GO; GO:0090244; P:Wnt signaling pathway involved in somitogenesis; IGI:MGI.
GO; GO:0060071; P:Wnt signaling pathway, planar cell polarity pathway; IDA:MGI.
Gene3D; 1.10.2000.10; -; 1.
InterPro; IPR015526; Frizzled/SFRP.
InterPro; IPR020067; Frizzled_dom.
InterPro; IPR036790; Frizzled_dom_sf.
InterPro; IPR001134; Netrin_domain.
InterPro; IPR018933; Netrin_module_non-TIMP.
InterPro; IPR026559; SFRP1.
InterPro; IPR008993; TIMP-like_OB-fold.
PANTHER; PTHR11309; PTHR11309; 1.
PANTHER; PTHR11309:SF87; PTHR11309:SF87; 1.
Pfam; PF01392; Fz; 1.
Pfam; PF01759; NTR; 1.
SMART; SM00643; C345C; 1.
SMART; SM00063; FRI; 1.
SUPFAM; SSF50242; SSF50242; 1.
SUPFAM; SSF63501; SSF63501; 1.
PROSITE; PS50038; FZ; 1.
PROSITE; PS50189; NTR; 1.
1: Evidence at protein level;
Complete proteome; Developmental protein; Differentiation;
Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal;
Wnt signaling pathway.
SIGNAL 1 31 {ECO:0000255}.
CHAIN 32 314 Secreted frizzled-related protein 1.
/FTId=PRO_0000032539.
DOMAIN 53 169 FZ. {ECO:0000255|PROSITE-
ProRule:PRU00090}.
DOMAIN 186 306 NTR. {ECO:0000255|PROSITE-
ProRule:PRU00295}.
CARBOHYD 173 173 N-linked (GlcNAc...) asparagine.
{ECO:0000250}.
DISULFID 58 121 {ECO:0000250}.
DISULFID 68 114 {ECO:0000250}.
DISULFID 105 140 {ECO:0000250}.
DISULFID 129 166 {ECO:0000250}.
DISULFID 133 157 {ECO:0000250}.
DISULFID 186 256 {ECO:0000250}.
DISULFID 189 258 {ECO:0000250}.
DISULFID 203 306 {ECO:0000250}.
CONFLICT 28 28 A -> S (in Ref. 2; AAH24495).
{ECO:0000305}.
CONFLICT 245 245 R -> A (in Ref. 1; AAC53145).
{ECO:0000305}.
SEQUENCE 314 AA; 35413 MW; 3D98A15127DFA421 CRC64;
MGVGRSARGR GGAASGVLLA LAAALLAAGS ASEYDYVSFQ SDIGSYQSGR FYTKPPQCVD
IPVDLRLCHN VGYKKMVLPN LLEHETMAEV KQQASSWVPL LNKNCHMGTQ VFLCSLFAPV
CLDRPIYPCR WLCEAVRDSC EPVMQFFGFY WPEMLKCDKF PEGDVCIAMT PPNTTEASKP
QGTTVCPPCD NELKSEAIIE HLCASEFALR MKIKEVKKEN GDKKIVPKKK KPLKLGPIKK
KELKRLVLFL KNGADCPCHQ LDNLSHNFLI MGRKVKSQYL LTAIHKWDKK NKEFKNFMKR
MKNHECPTFQ SVFK


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C640 Secreted Frizzled-Related Protein 2 sFRP-2 lmg
EIAAB38037 Bos taurus,Bovine,Frizzled-related protein 1,FRZB,FRZB1,FrzB-1,Secreted frizzled-related protein 3,SFRP3,sFRP-3
CC82 Human Secreted Frizzled-Related Protein 2 sFRP-2 50
C544 Human Secreted Frizzled-Related Protein 2 sFRP-2 l0
31-085 Secreted frizzled-related protein 1 (SFRP1) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble m 0.1 mg
EIAAB38028 Mouse,Mus musculus,Secreted frizzled-related protein 1,Sfrp1,sFRP-1
EIAAB38029 Rat,Rattus norvegicus,Secreted frizzled-related protein 1,Sfrp1,sFRP-1
EIAAB38044 Bos taurus,Bovine,Secreted frizzled-related protein 5,SFRP5,sFRP-5
EIAAB38043 Mouse,Mus musculus,Secreted frizzled-related protein 5,Sfrp5,sFRP-5
C640 Recombinant Human Secreted Frizzled-Related Protein 2 per sFRP-2 per SARP1 (C-6His) 10ug
EIAAB38039 FRP-4,Mouse,Mus musculus,Secreted frizzled-related sequence protein 4,Sfrp4,sFRP-4
EIAAB38027 Bos taurus,Bovine,Frizzled in aorta protein,FRZA,FrzA protein,Secreted frizzled-related protein 1,SFRP1,sFRP-1
EIAAB38040 Ddc4,DDC-4 protein,Frp,Rat,Rattus norvegicus,Secreted frizzled-related protein 4,Sfrp4,sFRP-4
EIAAB38035 Chicken,Frizzled-related protein 1,FRZB,FrzB-1,Gallus gallus,Secreted frizzled-related protein 3,SFRP3,sFRP-3
EIAAB38041 Frizzled protein, human endometrium,FrpHE,FRPHE,Homo sapiens,Human,Secreted frizzled-related protein 4,SFRP4,sFRP-4

Kits Elisa; taq POLYMERASE

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Gentaur; yes we can

Pathways :
WP2199: Seed Development
WP2272: Pathogenic Escherichia coli infection
WP731: Sterol regulatory element binding protein related
WP1049: G Protein Signaling Pathways
WP1165: G Protein Signaling Pathways
WP1371: G Protein Signaling Pathways
WP1438: Influenza A virus infection
WP1493: Carbon assimilation C4 pathway
WP1497: Hedgehog-related genes
WP1502: Mitochondrial biogenesis
WP1531: Vitamin D synthesis
WP1559: TFs Regulate miRNAs related to cardiac hypertrophy
WP1566: Citrate cycle (TCA cycle)
WP1613: 1,4-Dichlorobenzene degradation
WP1616: ABC transporters
WP1624: Bacterial secretion system
WP1625: Base excision repair
WP1644: DNA replication
WP1650: Fluorobenzoate degradation
WP1654: gamma-Hexachlorocyclohexane degradation
WP1657: Glycerolipid metabolism
WP1659: Glycine, serine and threonine metabolism
WP1661: Glyoxylate and dicarboxylate metabolism
WP1663: Homologous recombination
WP1665: Limonene and pinene degradation

Related Genes :
[SFRP5 FRP1B SARP3] Secreted frizzled-related protein 5 (sFRP-5) (Frizzled-related protein 1b) (FRP-1b) (Secreted apoptosis-related protein 3) (SARP-3)
[SFRP1 FRP FRP1 SARP2] Secreted frizzled-related protein 1 (FRP-1) (sFRP-1) (Secreted apoptosis-related protein 2) (SARP-2)
[SFRP2 FRP2 SARP1 FKSG12 UNQ361/PRO697] Secreted frizzled-related protein 2 (FRP-2) (sFRP-2) (Secreted apoptosis-related protein 1) (SARP-1)
[SFRP1 FRZA] Secreted frizzled-related protein 1 (sFRP-1) (Frizzled in aorta protein) (FrzA protein)
[Sfrp1] Secreted frizzled-related protein 1 (sFRP-1)
[Sfrp1] Secreted frizzled-related protein 1 (sFRP-1) (Fragment)
[SFRP1] Secreted frizzled-related protein 1 (CsFRP1) (sFRP-1)
[MFRP] Membrane frizzled-related protein (Membrane-type frizzled-related protein)
[fz CG17697] Frizzled (Frizzled-1) (dFz1)
[FZD1] Frizzled-1 (Fz-1) (hFz1) (FzE1)
[Fzd1] Frizzled-1 (Fz-1) (rFz1)
[Fzd1] Frizzled-1 (Fz-1) (mFz1)
[FZD6] Frizzled-6 (Fz-6) (hFz6)
[Fzd10 Fz10] Frizzled-10 (Fz-10) (CD antigen CD350)
[Fzd2 Fzd10] Frizzled-2 (Fz-2) (mFz2) (Frizzled-10) (Fz-10) (mFz10)
[Smoc1 Srg] SPARC-related modular calcium-binding protein 1 (SPARC-related gene protein) (Secreted modular calcium-binding protein 1) (SMOC-1)
[1a] Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) (Leader protein); Non-structural protein 2 (nsp2) (p65 homolog); Non-structural protein 3 (nsp3) (EC 3.4.19.12) (EC 3.4.22.69) (PL2-PRO) (Papain-like proteinase) (PL-PRO) (SARS coronavirus main proteinase); Non-structural protein 4 (nsp4); 3C-like proteinase (3CL-PRO) (3CLp) (EC 3.4.22.-) (nsp5); Non-structural protein 6 (nsp6); Non-structural protein 7 (nsp7); Non-structural protein 8 (nsp8); Non-structural protein 9 (nsp9); Non-structural protein 10 (nsp10) (Growth factor-like peptide) (GFL); Non-structural protein 11 (nsp11)]
[Fzd9] Frizzled-9 (Frizzled-like protein 9) (rFz9)
[cat-1 NCU08791] Catalase-1 (EC 1.11.1.6)
[FZD4] Frizzled-4 (Fz-4) (hFz4) (FzE4) (CD antigen CD344)
[DKK1 UNQ492/PRO1008] Dickkopf-related protein 1 (Dickkopf-1) (Dkk-1) (hDkk-1) (SK)
[al-3 B8P8.010 NCU01427] Geranylgeranyl pyrophosphate synthase (GGPP synthase) (GGPPSase) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase) (Albino-3 protein) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Farnesyltranstransferase) (EC 2.5.1.29) (Geranylgeranyl diphosphate synthase) (Geranyltranstransferase) (EC 2.5.1.10)
[SMOC1] SPARC-related modular calcium-binding protein 1 (Secreted modular calcium-binding protein 1) (SMOC-1)
[Ceacam1 Bgp Bgp1] Carcinoembryonic antigen-related cell adhesion molecule 1 (Biliary glycoprotein 1) (BGP-1) (Biliary glycoprotein D) (MHVR1) (Murine hepatitis virus receptor) (MHV-R) (CD antigen CD66a)
[3a] Protein 3a (Accessory protein 3a) (Protein U274) (Protein X1)
[dim-5 29E8.110 NCU04402] Histone-lysine N-methyltransferase, H3 lysine-9 specific dim-5 (EC 2.1.1.43) (Histone H3-K9 methyltransferase dim-5) (H3-K9-HMTase dim-5) (HKMT)
[Atk TK] Tachykinins (AmTRP) (Tachykinin-related peptide) [Cleaved into: APTGHQEMQ-amide (AmTRP1) (Tachykinin-related peptide 1) (TRP1); ALMGFQGVR-amide (AmTRP2) (Tachykinin-related peptide 2) (TRP2); Brain peptide NSIINDVKNELFPEDIN; APMGFQGMR-amide 1 (AmTRP3) (Tachykinin-related peptide 3-1) (TRP3-1); Brain peptide ASFDDEYY; APMGFQGMR-amide 2 (AmTRP3) (Tachykinin-related peptide 3-2) (TRP3-2); Brain peptide SLEEILDEIK; Brain peptide SLEEILDEI; Brain peptide EILDEI; TTRFQDSRSKDVYLIDYPEDY-amide (AmTAP1) (Tachykinin-associated peptide 1); Brain peptide VLSMDGYQNILDKKDELLGEWE; Brain peptide APMGFYGT; APMGFYGTR-amide (AmTRP4) (Tachykinin-related peptide 4) (TRP4); Brain peptide IILDALEELD; Brain peptide ILDALEELD; Brain peptide GVMDFQIGLQ; ARMGFHGMR-amide (AmTRP5) (Tachykinin-related peptide 5) (TRP5); SPFRYLGAR-amide (AmTRP6) (Tachykinin-related peptide 6) (TRP6); NPRWEFRGKFVGVR-amide (AmTRP7) (Tachykinin-related peptide 7) (TRP7)]
[gag-pol] Gag-Pol polyprotein (Pr180gag-pol) [Cleaved into: Matrix protein p15 (MA); RNA-binding phosphoprotein p12 (pp12); Capsid protein p30 (CA); Nucleocapsid protein p10 (NC-pol); Protease p14 (PR) (EC 3.4.23.-); Reverse transcriptase/ribonuclease H p80 (RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase p46 (IN) (EC 2.7.7.-) (EC 3.1.-.-)]
[gag-pol] Gag-Pol polyprotein (Pr180gag-pol) [Cleaved into: Matrix protein p15 (MA); RNA-binding phosphoprotein p12 (pp12); Capsid protein p30 (CA); Nucleocapsid protein p10 (NC-pol); Protease p14 (PR) (EC 3.4.23.-); Reverse transcriptase/ribonuclease H p80 (RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase p46 (IN) (EC 2.7.7.-) (EC 3.1.-.-)]
[gag-pol] Gag-Pol polyprotein (Pr180gag-pol) [Cleaved into: Matrix protein p15 (MA); RNA-binding phosphoprotein p12 (pp12); Capsid protein p30 (CA); Nucleocapsid protein p10 (NC-pol); Protease p14 (PR) (EC 3.4.23.-); Reverse transcriptase/ribonuclease H p80 (RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase p46 (IN) (EC 2.7.7.-) (EC 3.1.-.-)]

Bibliography :
[30001654] Osteoprotegrin interacts with biomarkers and cytokines that have roles in osteoporosis, skin fibrosis, and vasculopathy in systemic sclerosis: A potential multifaceted relationship between OPG/RANKL/TRAIL and Wnt inhibitors.
[29900911] Canonical Wnt pathway gene expression and their clinical correlation in oral squamous cell carcinoma.
[29387332] A novel gene's role in an ancient mechanism: secreted Frizzled-related protein 1 is a critical component in the anterior-posterior Wnt signaling network that governs the establishment of the anterior neuroectoderm in sea urchin embryos.
[28315733] WT1 ameliorates podocyte injury via repression of EZH2/β-catenin pathway in diabetic nephropathy.
[28209772] Maternal smoke exposure decreases mesenchymal proliferation and modulates Rho-GTPase-dependent actin cytoskeletal signaling in fetal lungs.
[28153008] Correlation of blood bone turnover biomarkers and Wnt signaling antagonists with AS, DISH, OPLL, and OYL.
[25669938] Loss of secreted frizzled-related protein-1 leads to deterioration of cardiac function in mice and plays a role in human cardiomyopathy.
[25070480] Effect of nitric oxide synthase on multiple drug resistance is related to Wnt signaling in non-small cell lung cancer.
[23449484] Increased expression of secreted frizzled-related protein-1 and microtubule-associated protein light chain 3 in keratoconus.
[23319891] Neurons refine the Caenorhabditis elegans body plan by directing axial patterning by Wnts.
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