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Sensor histidine kinase (Two-component sensor histidine kinase)

 Q1M2T9_ECOLX            Unreviewed;       490 AA.
Q1M2T9;
30-MAY-2006, integrated into UniProtKB/TrEMBL.
30-MAY-2006, sequence version 1.
13-FEB-2019, entry version 90.
SubName: Full=Two-component sensor histidine kinase {ECO:0000313|EMBL:RAX58464.1};
ORFNames=CCZ14_24655 {ECO:0000313|EMBL:RAX58464.1},
CCZ17_23915 {ECO:0000313|EMBL:RAX77079.1};
Escherichia coli.
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
Enterobacteriaceae; Escherichia.
NCBI_TaxID=562 {ECO:0000313|EMBL:CAK02709.1};
[1] {ECO:0000313|EMBL:CAK02709.1}
NUCLEOTIDE SEQUENCE.
PubMed=17064280; DOI=10.1111/j.1574-695X.2006.00140.x;
Sheshko V., Hejnova J., Rehakova Z., Sinkora J., Faldyna M., Alexa P.,
Felsberg J., Nemcova R., Bomba A., Sebo P.;
"HlyA knock out yields a safer Escherichia coli A0 34/86 variant with
unaffected colonization capacity in piglets.";
FEMS Immunol. Med. Microbiol. 48:257-266(2006).
[2] {ECO:0000313|EMBL:RAX58464.1, ECO:0000313|Proteomes:UP000250807, ECO:0000313|Proteomes:UP000251114}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=1408220042 {ECO:0000313|EMBL:RAX77079.1,
ECO:0000313|Proteomes:UP000251114}, and
1608190062 {ECO:0000313|EMBL:RAX58464.1,
ECO:0000313|Proteomes:UP000250807};
PubMed=29225701; DOI=.1186/s13099-017-0220-y;
Feng Y., Mannion A., Madden C.M., Swennes A.G., Townes C., Byrd C.,
Marini R.P., Fox J.G.;
"Cytotoxic Escherichia coli strains encoding colibactin and cytotoxic
necrotizing factor (CNF) colonize laboratory macaques.";
Gut Pathog 9:71-71(2017).
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EMBL; AM261284; CAK02709.1; -; Genomic_DNA.
EMBL; NHYU01000053; RAX58464.1; -; Genomic_DNA.
EMBL; NHYY01000029; RAX77079.1; -; Genomic_DNA.
RefSeq; WP_000995841.1; NZ_UIMO01000032.1.
EnsemblBacteria; OAO68595; OAO68595; OK10_25375.
PATRIC; fig|562.10500.peg.710; -.
eggNOG; ENOG4105BZU; Bacteria.
eggNOG; ENOG410XNMH; LUCA.
BioCyc; GCF_000159295-HMP:HMPREF0358_RS16860-MONOMER; -.
BioCyc; GCF_000164295-HMP:HMPREF9531_RS12700-MONOMER; -.
BioCyc; GCF_000164435-HMP:HMPREF9544_RS03615-MONOMER; -.
BioCyc; GCF_000164575-HMP:HMPREF9549_RS03315-MONOMER; -.
BioCyc; GCF_000488475-HMP:HMPREF1603_RS22910-MONOMER; -.
BioCyc; GCF_001693315:G1F03-4814-MONOMER; -.
Proteomes; UP000250807; Unassembled WGS sequence.
Proteomes; UP000251114; Unassembled WGS sequence.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
CDD; cd00075; HATPase_c; 1.
CDD; cd00082; HisKA; 1.
Gene3D; 3.30.565.10; -; 1.
InterPro; IPR003594; HATPase_C.
InterPro; IPR036890; HATPase_C_sf.
InterPro; IPR005467; His_kinase_dom.
InterPro; IPR003661; HisK_dim/P.
InterPro; IPR036097; HisK_dim/P_sf.
InterPro; IPR004358; Sig_transdc_His_kin-like_C.
Pfam; PF02518; HATPase_c; 1.
Pfam; PF00512; HisKA; 1.
PRINTS; PR00344; BCTRLSENSOR.
SMART; SM00387; HATPase_c; 1.
SMART; SM00388; HisKA; 1.
SUPFAM; SSF47384; SSF47384; 1.
SUPFAM; SSF55874; SSF55874; 1.
PROSITE; PS50109; HIS_KIN; 1.
4: Predicted;
ATP-binding {ECO:0000256|SAAS:SAAS00925949};
Complete proteome {ECO:0000313|Proteomes:UP000250807,
ECO:0000313|Proteomes:UP000251114};
Kinase {ECO:0000256|SAAS:SAAS01003914, ECO:0000313|EMBL:RAX58464.1};
Membrane {ECO:0000256|SAM:Phobius};
Nucleotide-binding {ECO:0000256|SAAS:SAAS00925949};
Transferase {ECO:0000256|SAAS:SAAS01003914,
ECO:0000313|EMBL:RAX58464.1}; Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius}.
TRANSMEM 12 32 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 180 203 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 275 490 Histidine kinase.
{ECO:0000259|PROSITE:PS50109}.
SEQUENCE 490 AA; 55454 MW; 84B39B008D49DCFB CRC64;
MNCSLTLSQR LSLVFTVVLL FCAAVTCGVH IYSSNLYGNA MVQRLSAGLA QQIVITEPLL
DNRGQVNHRT LKSLFERLMT LNPSVELYIV SPEGRLLVEA APPGHIKRRY INIAPLKKFL
SGAVWPVYGD DPRSVNKKKV FSTAPLYLRD DLKGYLYIIL QGEELNALTD AAWTKALWNA
LYWSLFLVVI CGLLSGMLVW YWVTRPIQQL TENVSGIEQD SISAIKQLAI QRPATPPSNE
VEILHNAFIE LARKISCQWD QLSESDQQRR EFIANISHDL RTPLTSLLGY LETLSMKSDS
LSSEDCHKYL TTALRQGHKV RHLSCQLFEL ARLEHGAIKP QLEQFSVCEL IQDVAQKFEL
SIETRRLQLR IMMSHSLPLI RADISMIERV ITNLLDNAVR HTPPEGSIRL KVWQEDNRLH
VEVADSGPGL TEDMRTHLFR RASVLCHEPS EEPRGGLGLL IVRRMLVLHG GDIRLTDSTT
GACFRFFLPL


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30-953 PRKAA1 belongs to the ser_thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells 0.05 mg
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Pathways :
WP1493: Carbon assimilation C4 pathway
WP1567: Glycolysis and Gluconeogenesis
WP1581: Histidine metabolism
WP1619: Amino sugar and nucleotide sugar metabolism
WP1653: Galactose metabolism
WP1681: Pantothenate and CoA biosynthesis
WP1701: Starch and sucrose metabolism
WP1703: Streptomycin biosynthesis
WP1844: MAP kinase cascade
WP1946: Cori Cycle
WP2185: Purine metabolism
WP2340: Thiamine (vitamin B1) biosynthesis and salvage
WP2341: vitamin B1 (thiamin) biosynthesis and salvage pathway
WP253: Glycolysis
WP32: Translation Factors
WP416: Superpathway of Histidine, Purine, and Pyrimidine
WP514: Histidine Biosynthesis
WP1624: Bacterial secretion system
WP1692: Protein export
WP1713: Two-component system

Related Genes :
[phoQ phoZ STM1230] Virulence sensor histidine kinase PhoQ (EC 2.7.13.3) (EC 3.1.3.-) (Sensor histidine protein kinase/phosphatase PhoQ)
[phoQ STM14_1408] Virulence sensor histidine kinase PhoQ (EC 2.7.13.3) (EC 3.1.3.-) (Sensor histidine protein kinase/phosphatase PhoQ)
[gchK Anae109_2438] Globin-coupled histidine kinase (EC 2.7.13.3) (AfGcHK) (Heme-based oxygen-sensor histidine kinase)
[phoQ b1129 JW1115] Sensor protein PhoQ (EC 2.7.13.3) (EC 3.1.3.-) (Sensor histidine protein kinase/phosphatase PhoQ)
[devS dosS Rv3132c] Oxygen sensor histidine kinase response regulator DevS/DosS (EC 2.7.13.3)
[dosT Rv2027c] Oxygen sensor histidine kinase response regulator DosT (EC 2.7.13.3)
[AHK4 CRE1 RAW1 WOL At2g01830 T23K3.2] Histidine kinase 4 (EC 2.7.13.3) (Arabidopsis histidine kinase 4) (AtHK4) (Cytokinin receptor CYTOKININ RESPONSE 1) (AtCRE1) (Cytokinin receptor CRE1) (Phosphoprotein phosphatase AHK4) (EC 3.1.3.16) (Protein AUTHENTIC HIS-KINASE 4) (Protein ROOT AS IN WOL 1) (Protein WOODEN LEG)
[cpxA ecfB eup ssd b3911 JW3882] Sensor histidine kinase CpxA (EC 2.7.13.3)
[AHK2 At5g35750 MXH1.16] Histidine kinase 2 (EC 2.7.13.3) (Arabidopsis histidine kinase 2) (AtHK2) (Protein AUTHENTIC HIS-KINASE 2)
[todS dhkD T1E_4275/T1E_4276] Sensor histidine kinase TodS (EC 2.7.13.3)
[AHK3 ORE12 At1g27320 F17L21.11] Histidine kinase 3 (EC 2.7.13.3) (Arabidopsis histidine kinase 3) (AtHK3) (Protein AUTHENTIC HIS-KINASE 3) (Protein ORESARA 12)
[mtrB Rv3245c MTCY20B11.20c] Sensor histidine kinase MtrB (EC 2.7.13.3)
[CKI1 At2g47430 T30B22.27] Histidine kinase CKI1 (EC 2.7.13.3) (Protein CYTOKININ-INDEPENDENT 1)
[SLN1 YPD2 YIL147C] Osmosensing histidine protein kinase SLN1 (EC 2.7.13.3) (Osmolarity two-component system protein SLN1) (Tyrosine phosphatase-dependent protein 2)
[NME2 NM23B] Nucleoside diphosphate kinase B (NDK B) (NDP kinase B) (EC 2.7.4.6) (C-myc purine-binding transcription factor PUF) (Histidine protein kinase NDKB) (EC 2.7.13.3) (nm23-H2)
[Nme2] Nucleoside diphosphate kinase B (NDK B) (NDP kinase B) (EC 2.7.4.6) (Histidine protein kinase NDKB) (EC 2.7.13.3) (P18) (nm23-M2)
[NME2] Nucleoside diphosphate kinase B (NDK B) (NDP kinase B) (EC 2.7.4.6) (Histidine protein kinase NDKB) (EC 2.7.13.3)
[Nme2] Nucleoside diphosphate kinase B (NDK B) (NDP kinase B) (EC 2.7.4.6) (Histidine protein kinase NDKB) (EC 2.7.13.3) (P18)
[NIK1 COS1 HIK1 CAALFM_C702800WA CaO19.12648 CaO19.5181] Histidine protein kinase NIK1 (EC 2.7.13.3)
[glnL glnR ntrB b3869 JW3840] Sensory histidine kinase/phosphatase NtrB (EC 2.7.13.3) (EC 3.1.3.-) (Nitrogen regulation protein NR(II)) (Nitrogen regulator II) (NRII)
[atoS b2219 JW2213] Signal transduction histidine-protein kinase AtoS (EC 2.7.13.3)
[PPIP5K1 HISPPD2A IP6K IPS1 KIAA0377 VIP1] Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 (EC 2.7.4.21) (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 1) (Histidine acid phosphatase domain-containing protein 2A) (IP6 kinase) (Inositol pyrophosphate synthase 1) (InsP6 and PP-IP5 kinase 1) (VIP1 homolog) (hsVIP1)
[PPIP5K2 HISPPD1 KIAA0433 VIP2] Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (EC 2.7.4.21) (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 2) (Histidine acid phosphatase domain-containing protein 1) (InsP6 and PP-IP5 kinase 2) (VIP1 homolog 2) (hsVIP2)
[Ppip5k2 Hisppd1 Kiaa0433 Vip2] Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (EC 2.7.4.21) (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 2) (Histidine acid phosphatase domain-containing protein 1) (InsP6 and PP-IP5 kinase 2) (VIP1 homolog 2) (mmVIP2)
[cph1 slr0473] Phytochrome-like protein cph1 (EC 2.7.13.3) (Bacteriophytochrome cph1) (Light-regulated histidine kinase 1)
[Ppip5k1 Hisppd2a Kiaa0377 Vip1] Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 (EC 2.7.4.21) (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 1) (Histidine acid phosphatase domain-containing protein 2A) (InsP6 and PP-IP5 kinase 1) (VIP1 homolog)
[NME2 NM23B] Nucleoside diphosphate kinase B (NDK B) (NDP kinase B) (EC 2.7.4.6) (Histidine protein kinase NDKB) (EC 2.7.13.3) (nm23-C2)
[luxN VIBHAR_02766] Autoinducer 1 sensor kinase/phosphatase LuxN (EC 2.7.13.3) (EC 3.1.3.-)
[HK3 OHK2 Os01g0923700 LOC_Os01g69920 B1455F06.33 P0592G05.17] Probable histidine kinase 3 (OsHK3) (EC 2.7.13.3) (OsCRL2)
[egtD MSMEG_6247 MSMEI_6086] Histidine N-alpha-methyltransferase (EC 2.1.1.44) (Histidine trimethyltransferase)

Bibliography :
[30866470] Structural Basis for the Inhibition of the Autophosphorylation Activity of HK853 by Luteolin.
[30825339] A two-component regulatory system VfmIH modulates multiple virulence traits in Dickeya zeae.
[30808807] Insights into histidine kinase activation mechanisms from the monomeric blue light sensor EL346.
[30778824] Sequences, Domain Architectures, and Biological Functions of the Serine/Threonine and Histidine Kinases in Synechocystis sp. PCC 6803.
[30773482] Identification of a Molecular Latch that Regulates Staphylococcal Virulence.
[30680878] Thiol-based redox sensing in the methyltransferase associated sensor kinase RdmS in Methanosarcina acetivorans.
[30673936] Chemical shift assignments of the catalytic and ATP-binding domain of HK853 from Thermotoga maritime.
[30642461] The histidine kinase slnCl1 of Colletotrichum lindemuthianum as a pathogenicity factor against Phaseolus vulgaris L.
[30620265] Reciprocal control of motility and biofilm formation by the PdhS2 two-component sensor kinase of Agrobacterium tumefaciens.
[30617244] Orphan Hybrid Histidine Protein Kinase SinK Acts as a Signal Integrator To Fine-Tune Multicellular Behavior in .