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Septin-4 (Apoptosis-related protein in the TGF-beta signaling pathway) (ARTS) (Bradeion beta) (Brain protein H5) (CE5B3 beta) (Cell division control-related protein 2) (hCDCREL-2) (Cerebral protein 7) (Peanut-like protein 2)

 SEPT4_HUMAN             Reviewed;         478 AA.
O43236; B2RD42; B3KSX9; B4DXC6; B4DXV5; Q6IAP3; Q9H315; Q9UM58;
15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
01-JUN-1998, sequence version 1.
17-JUN-2020, entry version 182.
RecName: Full=Septin-4;
AltName: Full=Apoptosis-related protein in the TGF-beta signaling pathway;
Short=ARTS;
AltName: Full=Bradeion beta;
AltName: Full=Brain protein H5;
AltName: Full=CE5B3 beta;
AltName: Full=Cell division control-related protein 2;
Short=hCDCREL-2;
AltName: Full=Cerebral protein 7;
AltName: Full=Peanut-like protein 2;
Name=SEPTIN4 {ECO:0000312|HGNC:HGNC:9165};
Synonyms=ARTS, PNUTL2, SEP4, SEPT4; ORFNames=hucep-7;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, AND TISSUE SPECIFICITY.
PubMed=9889007; DOI=10.1006/geno.1998.5612;
Paavola P., Horelli-Kuitunen N., Palotie A., Peltonen L.;
"Characterization of a novel gene, PNUTL2, on human chromosome 17q22-q23
and its exclusion as the Meckel syndrome gene.";
Genomics 55:122-125(1999).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND TISSUE SPECIFICITY.
TISSUE=Brain, and Fetal brain;
PubMed=11167005; DOI=10.1016/s0378-1119(00)00527-8;
Zieger B., Tran H., Hainmann I., Wunderle D., Zgaga-Griesz A., Blaeser S.,
Ware J.;
"Characterization and expression analysis of two human septin genes, PNUTL1
and PNUTL2.";
Gene 261:197-203(2000).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ARTS), FUNCTION, TISSUE SPECIFICITY,
SUBCELLULAR LOCATION, AND MUTAGENESIS OF 156-GLY--SER-158.
TISSUE=Fetal brain;
PubMed=11146656; DOI=10.1038/35046566;
Larisch S., Yi Y., Lotan R., Kerner H., Eimerl S., Parks W.T., Yossi G.,
Reffey S.B., de Caestecker M.P., Danielpour D., Book-Melamed N.,
Timberg R., Duckett C., Lechleider R.J., Steller H., Orly J., Kim S.-J.,
Roberts A.B.;
"A novel mitochondrial septin-like protein, ARTS, mediates apoptosis
dependent on its P-loop motif.";
Nat. Cell Biol. 2:915-921(2000).
[4]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
TISSUE=Brain;
PubMed=11511094; DOI=10.1006/bbrc.2001.5413;
Tanaka M., Tanaka T., Kijima H., Itoh J., Matsuda T., Hori S., Yamamoto M.;
"Characterization of tissue- and cell-type-specific expression of a novel
human septin family gene, Bradeion.";
Biochem. Biophys. Res. Commun. 286:547-553(2001).
[5]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Brain;
Yoshimoto M., Yazaki M., Matsumoto K., Takayama K.;
"Molecular cloning of a new GTP binding protein from human brain.";
Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Zha D., Hu G.;
Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
"Cloning of human full open reading frames in Gateway(TM) system entry
vector (pDONR201).";
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3; 4 AND 5).
TISSUE=Amygdala, Brain cortex, Subthalamic nucleus, and Testis;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[9]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
Hunkapiller M.W., Myers E.W., Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[10]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Hippocampus;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[11]
FUNCTION, INTERACTION WITH SEPTIN8, SUBCELLULAR LOCATION, AND TISSUE
SPECIFICITY.
PubMed=15116257; DOI=10.1160/th03-09-0578;
Blaeser S., Horn J., Wuermell P., Bauer H., Struempell S., Nurden P.,
Pagenstecher A., Busse A., Wunderle D., Hainmann I., Zieger B.;
"The novel human platelet septin SEPT8 is an interaction partner of
SEPT4.";
Thromb. Haemost. 91:959-966(2004).
[12]
PROTEIN SEQUENCE OF 141-157 AND 282-290, AND IDENTIFICATION BY MASS
SPECTROMETRY.
TISSUE=Fetal brain;
Lubec G., Chen W.-Q.;
Submitted (JAN-2009) to UniProtKB.
[13]
FUNCTION.
PubMed=15837787; DOI=10.1074/jbc.m501955200;
Lotan R., Rotem A., Gonen H., Finberg J.P.M., Kemeny S., Steller H.,
Ciechanover A., Larisch S.;
"Regulation of the proapoptotic ARTS protein by ubiquitin-mediated
degradation.";
J. Biol. Chem. 280:25802-25810(2005).
[14]
TISSUE SPECIFICITY.
PubMed=15915442; DOI=10.1002/path.1789;
Hall P.A., Jung K., Hillan K.J., Russell S.E.H.;
"Expression profiling the human septin gene family.";
J. Pathol. 206:269-278(2005).
[15]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-325, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Liver;
PubMed=18318008; DOI=10.1002/pmic.200700884;
Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D.,
Zou H., Gu J.;
"Large-scale phosphoproteome analysis of human liver tissue by enrichment
and fractionation of phosphopeptides with strong anion exchange
chromatography.";
Proteomics 8:1346-1361(2008).
[16]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-117; SER-118 AND SER-325, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Liver;
PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
Ye M., Zou H.;
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
phosphoproteome.";
J. Proteomics 96:253-262(2014).
[17]
INTERACTION WITH SEPTIN9 HNA VARIANTS.
PubMed=17546647; DOI=10.1002/humu.20554;
Sudo K., Ito H., Iwamoto I., Morishita R., Asano T., Nagata K.;
"SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are
associated with altered interactions with SEPT4/SEPT11 and resistance to
Rho/Rhotekin-signaling.";
Hum. Mutat. 28:1005-1013(2007).
[18]
FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH XIAP.
PubMed=15029247; DOI=10.1038/sj.emboj.7600155;
Gottfried Y., Rotem A., Lotan R., Steller H., Larisch S.;
"The mitochondrial ARTS protein promotes apoptosis through targeting
XIAP.";
EMBO J. 23:1627-1635(2004).
[19]
FUNCTION, SUBUNIT, AND SUBCELLULAR LOCATION.
PubMed=25588830; DOI=10.1242/jcs.158998;
Kuo Y.C., Shen Y.R., Chen H.I., Lin Y.H., Wang Y.Y., Chen Y.R., Wang C.Y.,
Kuo P.L.;
"SEPT12 orchestrates the formation of mammalian sperm annulus by organizing
core octomeric complexes with other SEPT proteins.";
J. Cell Sci. 128:923-934(2015).
-!- FUNCTION: Filament-forming cytoskeletal GTPase (By similarity). May
play a role in cytokinesis (Potential). Forms a filamentous structure
with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm
annulus which is required for the structural integrity and motility of
the sperm tail during postmeiotic differentiation (PubMed:25588830).
May play a role in platelet secretion. Isoform ARTS, but not the other
isoforms, is required for the induction of cell death mediated by TGF-
beta and by other apoptotic stimuli. {ECO:0000250,
ECO:0000269|PubMed:11146656, ECO:0000269|PubMed:15029247,
ECO:0000269|PubMed:15116257, ECO:0000269|PubMed:15837787,
ECO:0000269|PubMed:9889007, ECO:0000305, ECO:0000305|PubMed:25588830}.
-!- SUBUNIT: Septins polymerize into heterooligomeric protein complexes
that form filaments, and can associate with cellular membranes, actin
filaments and microtubules. GTPase activity is required for filament
formation (By similarity). Interacts with SEPTIN8. In a mesenchymal
cell line, interacts with SEPTIN9 isoform 2 variants HNA Trp-106 and
Phe-111, but not the wild type SEPTIN9. Component of a septin core
octomeric complex consisting of SEPTIN12, SEPTIN7, SEPTIN6 and SEPTIN2
or SEPTIN4 in the order 12-7-6-2-2-6-7-12 or 12-7-6-4-4-6-7-12 and
located in the sperm annulus. Isoform ARTS, but no other isoforms,
interacts with XIAP after the induction of apoptosis. {ECO:0000250,
ECO:0000269|PubMed:15029247, ECO:0000269|PubMed:15116257,
ECO:0000269|PubMed:17546647, ECO:0000269|PubMed:25588830}.
-!- INTERACTION:
O43236; Q8IYM1: SEPTIN12; NbExp=5; IntAct=EBI-1047513, EBI-2585067;
O43236-6; Q8IUQ4: SIAH1; NbExp=2; IntAct=EBI-4372019, EBI-747107;
O43236-6; P98170: XIAP; NbExp=4; IntAct=EBI-4372019, EBI-517127;
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton
{ECO:0000250}. Cell projection, cilium, flagellum
{ECO:0000269|PubMed:25588830}. Note=In platelets, found in areas
surrounding alpha-granules. Found in the sperm annulus
(PubMed:25588830). {ECO:0000269|PubMed:11146656,
ECO:0000269|PubMed:15029247, ECO:0000269|PubMed:15116257,
ECO:0000269|PubMed:25588830}.
-!- SUBCELLULAR LOCATION: [Isoform ARTS]: Mitochondrion. Nucleus.
Note=While predominantly localized in the mitochondria under resting
conditions, isoform ARTS translocates into the nucleus after TGF-beta
treatment and apoptosis induction.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=6;
Name=1; Synonyms=PNUTL2, PNUTL2a, H5/CDCrel2, SEPT4_i1;
IsoId=O43236-1; Sequence=Displayed;
Name=2; Synonyms=PNUTL2b;
IsoId=O43236-2; Sequence=VSP_006050;
Name=3;
IsoId=O43236-3; Sequence=VSP_038303;
Name=4;
IsoId=O43236-4; Sequence=VSP_038304;
Name=5;
IsoId=O43236-5; Sequence=VSP_038302;
Name=ARTS; Synonyms=SEPT4_i2;
IsoId=O43236-6; Sequence=VSP_006050, VSP_038305, VSP_038306;
-!- TISSUE SPECIFICITY: Widely expressed in adult and fetal tissues with
highest expression in adult brain (at protein level), heart, liver and
adrenal gland and fetal heart, kidney, liver and lung. Also expressed
in colorectal cancers and malignant melanomas. Expressed in platelets.
{ECO:0000269|PubMed:11146656, ECO:0000269|PubMed:11167005,
ECO:0000269|PubMed:11511094, ECO:0000269|PubMed:15116257,
ECO:0000269|PubMed:15915442, ECO:0000269|PubMed:9889007}.
-!- MISCELLANEOUS: [Isoform ARTS]: May be defective in GTP-binding.
{ECO:0000305}.
-!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
GTPase superfamily. Septin GTPase family. {ECO:0000255|PROSITE-
ProRule:PRU01056}.
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EMBL; AF073312; AAC25673.1; -; mRNA.
EMBL; U88829; AAD00653.1; -; mRNA.
EMBL; U88870; AAD00657.1; -; mRNA.
EMBL; AF176379; AAG45673.1; -; mRNA.
EMBL; AB008753; BAB70695.1; -; mRNA.
EMBL; D89278; BAB46922.1; -; mRNA.
EMBL; AF035811; AAB88512.1; -; mRNA.
EMBL; CR457111; CAG33392.1; -; mRNA.
EMBL; AK315396; BAG37789.1; -; mRNA.
EMBL; AK094579; BAG52891.1; -; mRNA.
EMBL; AK294094; BAG57432.1; -; mRNA.
EMBL; AK301914; BAG63338.1; -; mRNA.
EMBL; AK302146; BAG63517.1; -; mRNA.
EMBL; CH471109; EAW94440.1; -; Genomic_DNA.
EMBL; CH471109; EAW94442.1; -; Genomic_DNA.
EMBL; BC018056; AAH18056.3; -; mRNA.
CCDS; CCDS11609.1; -. [O43236-2]
CCDS; CCDS11610.1; -. [O43236-1]
CCDS; CCDS45743.1; -. [O43236-6]
CCDS; CCDS56041.1; -. [O43236-3]
CCDS; CCDS58581.1; -. [O43236-5]
CCDS; CCDS58582.1; -. [O43236-4]
RefSeq; NP_001185642.1; NM_001198713.1. [O43236-3]
RefSeq; NP_001243711.1; NM_001256782.1. [O43236-4]
RefSeq; NP_001243751.1; NM_001256822.1. [O43236-5]
RefSeq; NP_004565.1; NM_004574.4. [O43236-1]
RefSeq; NP_536340.1; NM_080415.3. [O43236-6]
RefSeq; NP_536341.1; NM_080416.3. [O43236-2]
RefSeq; XP_006722017.1; XM_006721954.2. [O43236-5]
RefSeq; XP_006722018.1; XM_006721955.2. [O43236-5]
RefSeq; XP_011523213.1; XM_011524911.1. [O43236-5]
RefSeq; XP_011523214.1; XM_011524912.1. [O43236-5]
SMR; O43236; -.
BioGRID; 111415; 20.
IntAct; O43236; 17.
MINT; O43236; -.
STRING; 9606.ENSP00000402000; -.
iPTMnet; O43236; -.
PhosphoSitePlus; O43236; -.
BioMuta; SEPT4; -.
jPOST; O43236; -.
MassIVE; O43236; -.
MaxQB; O43236; -.
PaxDb; O43236; -.
PeptideAtlas; O43236; -.
PRIDE; O43236; -.
ProteomicsDB; 48814; -. [O43236-1]
ProteomicsDB; 48815; -. [O43236-2]
ProteomicsDB; 48816; -. [O43236-3]
ProteomicsDB; 48817; -. [O43236-4]
ProteomicsDB; 48818; -. [O43236-5]
ProteomicsDB; 48819; -. [O43236-6]
Antibodypedia; 3484; 250 antibodies.
DNASU; 5414; -.
Ensembl; ENST00000317256; ENSP00000321071; ENSG00000108387. [O43236-2]
Ensembl; ENST00000317268; ENSP00000321674; ENSG00000108387. [O43236-1]
Ensembl; ENST00000393086; ENSP00000376801; ENSG00000108387. [O43236-2]
Ensembl; ENST00000412945; ENSP00000414779; ENSG00000108387. [O43236-3]
Ensembl; ENST00000426861; ENSP00000402348; ENSG00000108387. [O43236-6]
Ensembl; ENST00000457347; ENSP00000402000; ENSG00000108387. [O43236-4]
Ensembl; ENST00000583114; ENSP00000463768; ENSG00000108387. [O43236-5]
Ensembl; ENST00000672699; ENSP00000500355; ENSG00000108387. [O43236-4]
GeneID; 5414; -.
UCSC; uc002iwm.4; human. [O43236-1]
CTD; 5414; -.
DisGeNET; 5414; -.
EuPathDB; HostDB:ENSG00000108387.14; -.
GeneCards; SEPTIN4; -.
HGNC; HGNC:9165; SEPTIN4.
HPA; ENSG00000108387; Tissue enhanced (adrenal gland, brain).
MIM; 603696; gene.
neXtProt; NX_O43236; -.
OpenTargets; ENSG00000108387; -.
PharmGKB; PA33487; -.
eggNOG; KOG2655; Eukaryota.
eggNOG; COG5019; LUCA.
GeneTree; ENSGT00390000018146; -.
HOGENOM; CLU_017718_7_0_1; -.
InParanoid; O43236; -.
OMA; EVENIMQ; -.
OrthoDB; 845354at2759; -.
PhylomeDB; O43236; -.
TreeFam; TF101079; -.
Reactome; R-HSA-111457; Release of apoptotic factors from the mitochondria. [O43236-6]
Reactome; R-HSA-111469; SMAC, XIAP-regulated apoptotic response. [O43236-6]
BioGRID-ORCS; 5414; 1 hit in 767 CRISPR screens.
ChiTaRS; SEPT4; human.
GeneWiki; SEPT4; -.
GenomeRNAi; 5414; -.
Pharos; O43236; Tbio.
PRO; PR:O43236; -.
Proteomes; UP000005640; Chromosome 17.
RNAct; O43236; protein.
Bgee; ENSG00000108387; Expressed in corpus callosum and 179 other tissues.
ExpressionAtlas; O43236; baseline and differential.
Genevisible; O43236; HS.
GO; GO:0032153; C:cell division site; IBA:GO_Central.
GO; GO:0005829; C:cytosol; TAS:Reactome.
GO; GO:0015630; C:microtubule cytoskeleton; IBA:GO_Central.
GO; GO:0005741; C:mitochondrial outer membrane; TAS:Reactome.
GO; GO:0005739; C:mitochondrion; NAS:UniProtKB.
GO; GO:0005654; C:nucleoplasm; IDA:HPA.
GO; GO:0005634; C:nucleus; NAS:UniProtKB.
GO; GO:0031105; C:septin complex; IDA:UniProtKB.
GO; GO:0005940; C:septin ring; IBA:GO_Central.
GO; GO:0097227; C:sperm annulus; IDA:UniProtKB.
GO; GO:0008021; C:synaptic vesicle; IBA:GO_Central.
GO; GO:0005525; F:GTP binding; IMP:CAFA.
GO; GO:0003924; F:GTPase activity; IMP:CAFA.
GO; GO:0042802; F:identical protein binding; IPI:CAFA.
GO; GO:0000287; F:magnesium ion binding; IMP:CAFA.
GO; GO:0060090; F:molecular adaptor activity; IBA:GO_Central.
GO; GO:0005198; F:structural molecule activity; TAS:ProtInc.
GO; GO:0006915; P:apoptotic process; NAS:UniProtKB.
GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO; GO:0034613; P:cellular protein localization; IBA:GO_Central.
GO; GO:0061640; P:cytoskeleton-dependent cytokinesis; IBA:GO_Central.
GO; GO:0043065; P:positive regulation of apoptotic process; IDA:UniProtKB.
GO; GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; IMP:UniProtKB.
GO; GO:0031398; P:positive regulation of protein ubiquitination; IDA:UniProtKB.
GO; GO:0042981; P:regulation of apoptotic process; NAS:UniProtKB.
GO; GO:0017157; P:regulation of exocytosis; IBA:GO_Central.
GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
CDD; cd01850; CDC_Septin; 1.
DisProt; DP00537; -.
DisProt; DP01325; -. [O43236-6]
InterPro; IPR030379; G_SEPTIN_dom.
InterPro; IPR027417; P-loop_NTPase.
InterPro; IPR016491; Septin.
InterPro; IPR030643; Septin4.
PANTHER; PTHR18884:SF71; PTHR18884:SF71; 1.
Pfam; PF00735; Septin; 1.
PIRSF; PIRSF006698; Septin; 1.
SUPFAM; SSF52540; SSF52540; 1.
PROSITE; PS51719; G_SEPTIN; 1.
1: Evidence at protein level;
Alternative splicing; Cell cycle; Cell division; Cell projection; Cilium;
Coiled coil; Cytoplasm; Cytoskeleton; Differentiation;
Direct protein sequencing; Flagellum; GTP-binding; Mitochondrion;
Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism;
Reference proteome; Spermatogenesis.
CHAIN 1..478
/note="Septin-4"
/id="PRO_0000173519"
DOMAIN 141..414
/note="Septin-type G"
/evidence="ECO:0000255|PROSITE-ProRule:PRU01056"
NP_BIND 151..158
/note="GTP"
/evidence="ECO:0000250"
NP_BIND 290..298
/note="GTP"
/evidence="ECO:0000250"
REGION 151..158
/note="G1 motif"
/evidence="ECO:0000255|PROSITE-ProRule:PRU01056"
REGION 208..211
/note="G3 motif"
/evidence="ECO:0000255|PROSITE-ProRule:PRU01056"
REGION 289..292
/note="G4 motif"
/evidence="ECO:0000255|PROSITE-ProRule:PRU01056"
COILED 447..478
/evidence="ECO:0000255"
BINDING 185
/note="GTP"
/evidence="ECO:0000250"
BINDING 211
/note="GTP; via amide nitrogen"
/evidence="ECO:0000250"
BINDING 348
/note="GTP; via amide nitrogen and carbonyl oxygen"
/evidence="ECO:0000250"
BINDING 363
/note="GTP"
/evidence="ECO:0000250"
MOD_RES 117
/note="Phosphoserine"
/evidence="ECO:0000244|PubMed:24275569"
MOD_RES 118
/note="Phosphoserine"
/evidence="ECO:0000244|PubMed:24275569"
MOD_RES 325
/note="Phosphoserine"
/evidence="ECO:0000244|PubMed:18318008,
ECO:0000244|PubMed:24275569"
MOD_RES 432
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:P28661"
MOD_RES 434
/note="Phosphothreonine"
/evidence="ECO:0000250|UniProtKB:P28661"
VAR_SEQ 1..147
/note="Missing (in isoform 5)"
/evidence="ECO:0000303|PubMed:14702039"
/id="VSP_038302"
VAR_SEQ 1..20
/note="MDRSLGWQGNSVPEDRTEAG -> M (in isoform 2 and isoform
ARTS)"
/evidence="ECO:0000303|PubMed:11146656,
ECO:0000303|PubMed:11167005, ECO:0000303|PubMed:14702039,
ECO:0000303|PubMed:15489334"
/id="VSP_006050"
VAR_SEQ 1..20
/note="MDRSLGWQGNSVPEDRTEAG -> MPGFYSVMTDEE (in isoform 3)"
/evidence="ECO:0000303|PubMed:14702039"
/id="VSP_038303"
VAR_SEQ 1..20
/note="MDRSLGWQGNSVPEDRTEAG -> MRSSPALFSSRAAPQKPRKEGSQAAGLL
VFSDSLE (in isoform 4)"
/evidence="ECO:0000303|PubMed:14702039"
/id="VSP_038304"
VAR_SEQ 267..293
/note="LRPLDVEFMKALHQRVNIVPILAKADT -> YGPSLRLLAPPGAVKGTGQEH
QGQGCH (in isoform ARTS)"
/evidence="ECO:0000303|PubMed:11146656"
/id="VSP_038305"
VAR_SEQ 294..478
/note="Missing (in isoform ARTS)"
/evidence="ECO:0000303|PubMed:11146656"
/id="VSP_038306"
VARIANT 311
/note="E -> V (in dbSNP:rs17741424)"
/id="VAR_051935"
MUTAGEN 156..158
/note="GKS->ENP: Loss of TGF-beta-induced apoptosis. No
translocation to the nucleus following TGF-beta treatment.
Loss of XIAP-binding."
/evidence="ECO:0000269|PubMed:11146656"
CONFLICT 156
/note="G -> D (in Ref. 7; BAG37789)"
/evidence="ECO:0000305"
CONFLICT 382
/note="K -> E (in Ref. 7; BAG63517)"
/evidence="ECO:0000305"
SEQUENCE 478 AA; 55098 MW; 2F08D3611EF6523D CRC64;
MDRSLGWQGN SVPEDRTEAG IKRFLEDTTD DGELSKFVKD FSGNASCHPP EAKTWASRPQ
VPEPRPQAPD LYDDDLEFRP PSRPQSSDNQ QYFCAPAPLS PSARPRSPWG KLDPYDSSED
DKEYVGFATL PNQVHRKSVK KGFDFTLMVA GESGLGKSTL VNSLFLTDLY RDRKLLGAEE
RIMQTVEITK HAVDIEEKGV RLRLTIVDTP GFGDAVNNTE CWKPVAEYID QQFEQYFRDE
SGLNRKNIQD NRVHCCLYFI SPFGHGLRPL DVEFMKALHQ RVNIVPILAK ADTLTPPEVD
HKKRKIREEI EHFGIKIYQF PDCDSDEDED FKLQDQALKE SIPFAVIGSN TVVEARGRRV
RGRLYPWGIV EVENPGHCDF VKLRTMLVRT HMQDLKDVTR ETHYENYRAQ CIQSMTRLVV
KERNRNKLTR ESGTDFPIPA VPPGTDPETE KLIREKDEEL RRMQEMLHKI QKQMKENY


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WP2272: Pathogenic Escherichia coli infection
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WP211: BMP signaling pathway
WP2292: Chemokine signaling pathway
WP2032: TSH signaling pathway
WP2203: TSLP Signaling Pathway
WP232: G Protein Signaling Pathways
WP931: G Protein Signaling Pathways
WP73: G Protein Signaling Pathways
WP1493: Carbon assimilation C4 pathway
WP813: G Protein Signaling Pathways
WP1165: G Protein Signaling Pathways
WP1371: G Protein Signaling Pathways
WP2324: AGE/RAGE pathway
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WP35: G Protein Signaling Pathways
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Related Genes :
[SEPTIN4 ARTS PNUTL2 SEP4 SEPT4 hucep-7] Septin-4 (Apoptosis-related protein in the TGF-beta signaling pathway) (ARTS) (Bradeion beta) (Brain protein H5) (CE5B3 beta) (Cell division control-related protein 2) (hCDCREL-2) (Cerebral protein 7) (Peanut-like protein 2)
[Septin4 Pnutl2 Sept4] Septin-4 (Brain protein H5) (Peanut-like protein 2)
[TGFBR1 ALK5 SKR4] TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
[APP A4 AD1] Amyloid-beta precursor protein (APP) (ABPP) (APPI) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta A4 protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31]
[TSPYL2 CDA1 DENTT TSPX HRIHFB2216] Testis-specific Y-encoded-like protein 2 (TSPY-like protein 2) (Cell division autoantigen 1) (Cutaneous T-cell lymphoma-associated antigen se20-4) (CTCL-associated antigen se20-4) (Differentially-expressed nucleolar TGF-beta1 target protein) (Nuclear protein of 79 kDa) (NP79)
[CDK13 CDC2L CDC2L5 CHED KIAA1791] Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller)
[Tgfbr1] TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
[Map3k7 Tak1] Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
[PTK2B FAK2 PYK2 RAFTK] Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK)
[MAP3K7 TAK1] Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
[Tab2 Kiaa0733 Map3k7ip2] TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TAK1-binding protein 2) (TAB-2) (TGF-beta-activated kinase 1-binding protein 2)
[TGFBR2] TGF-beta receptor type-2 (TGFR-2) (EC 2.7.11.30) (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TGF-beta receptor type II) (TbetaR-II)
[RACK1 GNB2L1 HLC7 PIG21] Receptor of activated protein C kinase 1 (Cell proliferation-inducing gene 21 protein) (Guanine nucleotide-binding protein subunit beta-2-like 1) (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Human lung cancer oncogene 7 protein) (HLC-7) (Receptor for activated C kinase) (Small ribosomal subunit protein RACK1) [Cleaved into: Receptor of activated protein C kinase 1, N-terminally processed (Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed)]
[TGFB2] Transforming growth factor beta-2 proprotein (Cetermin) (Glioblastoma-derived T-cell suppressor factor) (G-TSF) [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-2 (TGF-beta-2)]
[Ptk2b Fak2 Pyk2 Raftk] Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK)
[TAB2 KIAA0733 MAP3K7IP2] TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TAK1-binding protein 2) (TAB-2) (TGF-beta-activated kinase 1-binding protein 2)
[Tgfbr1] TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (ESK2) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
[SMARCA4 BAF190A BRG1 SNF2B SNF2L4] Transcription activator BRG1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA4) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4)
[Rack1 Gnb2-rs1 Gnb2l1] Receptor of activated protein C kinase 1 (12-3) (Guanine nucleotide-binding protein subunit beta-2-like 1) (Receptor for activated C kinase) (Receptor of activated protein kinase C 1) (p205) [Cleaved into: Receptor of activated protein C kinase 1, N-terminally processed (Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed)]
[Cdc42] Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
[TGFBR1] TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
[TGFB1 TGFB] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFBR1] TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
[AP3B2] AP-3 complex subunit beta-2 (Adaptor protein complex AP-3 subunit beta-2) (Adaptor-related protein complex 3 subunit beta-2) (Beta-3B-adaptin) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP)
[CDK5 CDKN5] Cyclin-dependent-like kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)
[CLU APOJ CLI KUB1 AAG4] Clusterin (Aging-associated gene 4 protein) (Apolipoprotein J) (Apo-J) (Complement cytolysis inhibitor) (CLI) (Complement-associated protein SP-40,40) (Ku70-binding protein 1) (NA1/NA2) (Sulfated glycoprotein 2) (SGP-2) (Testosterone-repressed prostate message 2) (TRPM-2) [Cleaved into: Clusterin beta chain (ApoJalpha) (Complement cytolysis inhibitor a chain); Clusterin alpha chain (ApoJbeta) (Complement cytolysis inhibitor b chain)]
[MAPK11 PRKM11 SAPK2 SAPK2B] Mitogen-activated protein kinase 11 (MAP kinase 11) (MAPK 11) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (Stress-activated protein kinase 2b) (SAPK2b) (p38-2)
[XIAP API3 BIRC4 IAP3] E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP)
[CDC42BPB KIAA1124] Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta)
[Gsk3b] Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1)

Bibliography :
No related Items