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Serine/threonine-protein kinase TAO1 (EC 2 7 11 1) (Thousand and one amino acid protein 1)

 TAOK1_RAT               Reviewed;        1001 AA.
O88664;
25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
01-NOV-1998, sequence version 1.
11-DEC-2019, entry version 137.
RecName: Full=Serine/threonine-protein kinase TAO1;
EC=2.7.11.1;
AltName: Full=Thousand and one amino acid protein 1;
Name=Taok1; Synonyms=Tao1;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH MKK3,
AUTOPHOSPHORYLATION, AND MUTAGENESIS OF ASP-169.
PubMed=9786855; DOI=10.1074/jbc.273.44.28625;
Hutchison M., Berman K.S., Cobb M.H.;
"Isolation of TAO1, a protein kinase that activates MEKs in stress-
activated protein kinase cascades.";
J. Biol. Chem. 273:28625-28632(1998).
[2]
FUNCTION, CATALYTIC ACTIVITY, AND INTERACTION WITH MARK2.
PubMed=14517247; DOI=10.1093/emboj/cdg447;
Timm T., Li X.Y., Biernat J., Jiao J., Mandelkow E., Vandekerckhove J.,
Mandelkow E.M.;
"MARKK, a Ste20-like kinase, activates the polarity-inducing kinase
MARK/PAR-1.";
EMBO J. 22:5090-5101(2003).
[3]
FUNCTION.
PubMed=17047359; DOI=10.1159/000095258;
Timm T., Matenia D., Li X.Y., Griesshaber B., Mandelkow E.M.;
"Signaling from MARK to tau: regulation, cytoskeletal crosstalk, and
pathological phosphorylation.";
Neurodegener. Dis. 3:207-217(2006).
[4]
INTERACTION WITH TESK1 AND SPRED1, ACTIVITY REGULATION, AND MUTAGENESIS OF
LYS-57.
PubMed=18216281; DOI=10.1091/mbc.e07-07-0730;
Johne C., Matenia D., Li X.Y., Timm T., Balusamy K., Mandelkow E.M.;
"Spred1 and TESK1--two new interaction partners of the kinase MARKK/TAO1
that link the microtubule and actin cytoskeleton.";
Mol. Biol. Cell 19:1391-1403(2008).
-!- FUNCTION: Serine/threonine-protein kinase involved in various processes
such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response
and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6
and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK
cascade by mediating phosphorylation and subsequent activation of the
upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled
receptor signaling to p38/MAPK14. In response to DNA damage, involved
in the G2/M transition DNA damage checkpoint by activating the
p38/MAPK14 stress-activated MAPK cascade, probably by mediating
phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of
cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading
to activate MARK2 kinase activity and subsequent phosphorylation and
detachment of MAPT/TAU from microtubules. Also acts as a regulator of
apoptosis: regulates apoptotic morphological changes, including cell
contraction, membrane blebbing and apoptotic bodies formation via
activation of the MAPK8/JNK cascade. {ECO:0000269|PubMed:14517247,
ECO:0000269|PubMed:17047359}.
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
Evidence={ECO:0000269|PubMed:14517247};
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
EC=2.7.11.1; Evidence={ECO:0000269|PubMed:14517247};
-!- ACTIVITY REGULATION: Serine/threonine-protein kinase activity is
inhibited by SPRED1. {ECO:0000269|PubMed:18216281}.
-!- SUBUNIT: Self-associates. Interacts with MAP2K3. Interacts with MAP3K7
(By similarity). Interacts with SPRED1 and TESK1. {ECO:0000250,
ECO:0000269|PubMed:14517247, ECO:0000269|PubMed:18216281,
ECO:0000269|PubMed:9786855}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
-!- PTM: Proteolytically processed by caspase-3 (CASP3). {ECO:0000250}.
-!- PTM: Autophosphorylated (By similarity). Phosphorylated by ATM in
response to DNA damage. Phosphorylated by LRRK2 (By similarity).
{ECO:0000250}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
protein kinase family. STE20 subfamily. {ECO:0000305}.
---------------------------------------------------------------------------
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EMBL; AF084205; AAC71014.1; -; mRNA.
PIR; T17365; T17365.
RefSeq; NP_775449.1; NM_173327.1.
SMR; O88664; -.
STRING; 10116.ENSRNOP00000021368; -.
iPTMnet; O88664; -.
PhosphoSitePlus; O88664; -.
jPOST; O88664; -.
PaxDb; O88664; -.
PRIDE; O88664; -.
GeneID; 286993; -.
KEGG; rno:286993; -.
CTD; 57551; -.
RGD; 708455; Taok1.
eggNOG; KOG0577; Eukaryota.
eggNOG; ENOG410Y259; LUCA.
HOGENOM; HOG000236358; -.
InParanoid; O88664; -.
KO; K04429; -.
OrthoDB; 617606at2759; -.
PhylomeDB; O88664; -.
Reactome; R-RNO-141444; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
Reactome; R-RNO-2467813; Separation of Sister Chromatids.
Reactome; R-RNO-2500257; Resolution of Sister Chromatid Cohesion.
Reactome; R-RNO-5663220; RHO GTPases Activate Formins.
Reactome; R-RNO-68877; Mitotic Prometaphase.
PRO; PR:O88664; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0005623; C:cell; IEA:GOC.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0015630; C:microtubule cytoskeleton; ISO:RGD.
GO; GO:0005634; C:nucleus; IBA:GO_Central.
GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:RGD.
GO; GO:0043014; F:alpha-tubulin binding; ISO:RGD.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0048487; F:beta-tubulin binding; ISO:RGD.
GO; GO:0016301; F:kinase activity; ISO:RGD.
GO; GO:0004709; F:MAP kinase kinase kinase activity; IBA:GO_Central.
GO; GO:0031489; F:myosin V binding; IPI:RGD.
GO; GO:0008022; F:protein C-terminus binding; IPI:ARUK-UCL.
GO; GO:0030295; F:protein kinase activator activity; IMP:RGD.
GO; GO:0004672; F:protein kinase activity; IDA:ARUK-UCL.
GO; GO:0019901; F:protein kinase binding; IDA:RGD.
GO; GO:0043539; F:protein serine/threonine kinase activator activity; IDA:ARUK-UCL.
GO; GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO; GO:0000186; P:activation of MAPKK activity; IBA:GO_Central.
GO; GO:0032147; P:activation of protein kinase activity; IBA:GO_Central.
GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB.
GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
GO; GO:0097194; P:execution phase of apoptosis; ISS:UniProtKB.
GO; GO:0000226; P:microtubule cytoskeleton organization; ISO:RGD.
GO; GO:0007095; P:mitotic G2 DNA damage checkpoint; ISS:UniProtKB.
GO; GO:0007026; P:negative regulation of microtubule depolymerization; ISO:RGD.
GO; GO:0070050; P:neuron cellular homeostasis; ISO:RGD.
GO; GO:0016310; P:phosphorylation; ISO:RGD.
GO; GO:0046330; P:positive regulation of JNK cascade; ISS:UniProtKB.
GO; GO:1901985; P:positive regulation of protein acetylation; ISO:RGD.
GO; GO:0032874; P:positive regulation of stress-activated MAPK cascade; ISS:UniProtKB.
GO; GO:0046777; P:protein autophosphorylation; IDA:ARUK-UCL.
GO; GO:0006468; P:protein phosphorylation; IMP:RGD.
GO; GO:0032956; P:regulation of actin cytoskeleton organization; IMP:ARUK-UCL.
GO; GO:0051493; P:regulation of cytoskeleton organization; IDA:UniProtKB.
GO; GO:0070507; P:regulation of microtubule cytoskeleton organization; IMP:ARUK-UCL.
GO; GO:0023014; P:signal transduction by protein phosphorylation; IBA:GO_Central.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR008271; Ser/Thr_kinase_AS.
Pfam; PF00069; Pkinase; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
1: Evidence at protein level;
Apoptosis; ATP-binding; Coiled coil; Cytoplasm; DNA damage; DNA repair;
Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome;
Serine/threonine-protein kinase; Transferase.
CHAIN 1..1001
/note="Serine/threonine-protein kinase TAO1"
/id="PRO_0000086730"
DOMAIN 28..281
/note="Protein kinase"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
NP_BIND 34..42
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
COILED 458..651
/evidence="ECO:0000255"
COILED 754..877
/evidence="ECO:0000255"
COMPBIAS 330..334
/note="Poly-Glu"
ACT_SITE 151
/note="Proton acceptor"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
ECO:0000255|PROSITE-ProRule:PRU10027"
BINDING 57
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MOD_RES 9
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q7L7X3"
MOD_RES 421
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q7L7X3"
MOD_RES 445
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q7L7X3"
MOD_RES 669
/note="Phosphothreonine"
/evidence="ECO:0000250|UniProtKB:Q7L7X3"
MOD_RES 965
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q7L7X3"
MUTAGEN 57
/note="K->A: Loss of serine/threonine-protein kinase
without affecting interaction with SPRED1."
/evidence="ECO:0000269|PubMed:18216281"
MUTAGEN 169
/note="D->A: No kinase activity."
/evidence="ECO:0000269|PubMed:9786855"
SEQUENCE 1001 AA; 115952 MW; 85511B62DBD62FCC CRC64;
MPSTNRAGSL KDPEIAELFF KEDPEKLFTD LREIGHGSFG AVYFARDVRT NEVVAIKKMS
YSGKQSTEKW QDIIKEVKFL QRIKHPNSIE YKGCYLREHT AWLVMEYCLG SASDLLEVHK
KPLQEVEIAA ITHGALQGLA YLHSHTMIHR DIKAGNILLT EPGQVKLADF GSASMASPAN
SFVGTPYWMA PEVILAMDEG QYDGKVDVWS LGITCIELAE RKPPLFNMNA MSALYHIAQN
ESPTLQSNEW SDYFRNFVDS CLQKIPQDRP TSEELLKHMF VLRERPETVL IDLIQRTKDA
VRELDNLQYR KMKKLLFQEA HNGPAVEAQE EEEEQDHGGG RTGTVNSVGS NQSIPSMSIS
ASSQSSSVNS LPDASDDKSE LDMMEGDHTV MSNSSVIHLK PEEENYQEEG DPRTRASAPQ
SPPQVSRHKS HYRNREHFAT IRTASLVTRQ MQEHEQDSEL REQMSGYKRM RRQHQKQLMT
LENKLKAEMD EHRLRLDKDL ETQRNNFAAE MEKLIKKHQA SMEKEAKVMA NEEKKFQQHI
QAQQKKELNS FLESQKREYK LRKEQLKEEL NENQSTPKKE KQEWLSKQKE NIQHFQAEEE
ANLLRRQRQY LELECRRFKR RMLLGRHNLE QDLVREELNK RQTQKDLEHA MLLRQHESMQ
ELEFRHLNTI QKMRCELIRL QHQTELTNQL EYNKRREREL RRKHVMEVRQ QPKSLKSKEL
QIKKQFQDTC KIQTRQYKAL RNHLLETTPK SEHKAVLKRL KEEQTRKLAI LAEQYDHSIN
EMLSTQALRL DEAQEAECQV LKMQLQQELE LLNAYQSKIK MQAEAQHDRE LRELEQRVSL
RRALLEQKIE EEMLALQNER TERIRSLLER QAREIEAFDS ESMRLGFSNM VLSNLSPEAF
SHSYPGASSW SHNPTGGSGP HWGHPMGGTP QAWGHPMQGG PQPWGHPSGP MQGVPRGSSI
GVRNSPQALR RTASGGRTEQ GMSRSTSVTS QISNGSHMSY T


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WP1659: Glycine, serine and threonine metabolism
WP1493: Carbon assimilation C4 pathway
WP2199: Seed Development
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WP1625: Base excision repair
WP232: G Protein Signaling Pathways
WP1008: amino acid conjugation of benzoic acid
WP1672: Mismatch repair
WP2032: TSH signaling pathway
WP813: G Protein Signaling Pathways
WP1531: Vitamin D synthesis
WP1676: Non-homologous end-joining
WP210: Cytoplasmic Ribosomal Proteins
WP1644: DNA replication
WP1650: Fluorobenzoate degradation
WP1577: amino acid conjugation of benzoic acid
WP1685: Peptidoglycan biosynthesis
WP1613: 1,4-Dichlorobenzene degradation
WP1690: Propanoate metabolism
WP2203: TSLP Signaling Pathway
WP1657: Glycerolipid metabolism
WP1892: Protein folding
WP1165: G Protein Signaling Pathways
WP1663: Homologous recombination

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[Aurka Aik Airk Ark1 Aura Ayk1 Btak Iak1 Stk15 Stk6] Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora family kinase 1) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A)
[Mark1 Emk3 Kiaa1477] Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif serine/threonine-protein kinase 3) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (mPar-1c)
[AURKB AIK2 AIM1 AIRK2 ARK2 STK1 STK12 STK5] Aurora kinase B (EC 2.7.11.1) (Aurora 1) (Aurora- and IPL1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (ARK-2) (Aurora-related kinase 2) (STK-1) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase 5) (Serine/threonine-protein kinase aurora-B)
[Gsk3b] Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1)
[BRSK1 KIAA1811 SAD1 SADB] Serine/threonine-protein kinase BRSK1 (EC 2.7.11.1) (Brain-selective kinase 1) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 1) (BR serine/threonine-protein kinase 1) (Serine/threonine-protein kinase SAD-B) (Synapses of Amphids Defective homolog 1) (SAD1 homolog) (hSAD1)
[CIPK7 PKS7 SnRK3.10 SR2 SRPK1 At3g23000 MXC7.3] CBL-interacting serine/threonine-protein kinase 7 (EC 2.7.11.1) (SNF1-related kinase 3.10) (SOS2-like protein kinase PKS7) (Serine/threonine-protein kinase SR2) (AtSR2) (AtSRPK1)
[STK16 MPSK1 PKL12 TSF1] Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (Protein kinase PKL12) (TGF-beta-stimulated factor 1) (TSF-1) (Tyrosine-protein kinase STK16) (EC 2.7.10.2) (hPSK)
[Aurkb Aik2 Aim1 Airk2 Ark2 Stk1 Stk12 Stk5] Aurora kinase B (EC 2.7.11.1) (Aurora 1) (Aurora- and IPL1-like midbody-associated protein 1) (Aurora/IPL1-related kinase 2) (ARK-2) (Aurora-related kinase 2) (STK-1) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase 5) (Serine/threonine-protein kinase aurora-B)
[Stk16 Edpk Krct Mpsk1 Pkl12 Tsf1] Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Embryo-derived protein kinase) (Edpk) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (Protein kinase Krct) (Protein kinase PKL12) (TGF-beta-stimulated factor 1) (TSF-1) (Tyrosine-protein kinase STK16) (EC 2.7.10.2)
[Brsk1 Gm1100 Sadb] Serine/threonine-protein kinase BRSK1 (EC 2.7.11.1) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 1) (BR serine/threonine-protein kinase 1) (Serine/threonine-protein kinase SAD-B)
[Brsk1 Sadb] Serine/threonine-protein kinase BRSK1 (EC 2.7.11.1) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 1) (BR serine/threonine-protein kinase 1) (Serine/threonine-protein kinase SAD-B)
[AURKA AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6] Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase aurora-A)
[AURKA AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6] Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase aurora-A)
[Stk16 Mpsk1 Tsf1] Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (Protein kinase PKL12) (TGF-beta-stimulated factor 1) (TSF-1) (Tyrosine-protein kinase STK16) (EC 2.7.10.2)
[CDK7 CAK CAK1 CDKN7 MO15 STK1] Cyclin-dependent kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (39 kDa protein kinase) (p39 Mo15) (CDK-activating kinase 1) (Cell division protein kinase 7) (Serine/threonine-protein kinase 1) (TFIIH basal transcription factor complex kinase subunit)
[stk11 eek1] Serine/threonine-protein kinase stk11 (EC 2.7.11.1) (Liver kinase B1 homolog) (lkb1) (Serine/threonine-protein kinase XEEK1)
[PLK1 PLK] Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13)
[SIK1 SIK SNF1LK] Serine/threonine-protein kinase SIK1 (EC 2.7.11.1) (Salt-inducible kinase 1) (SIK-1) (Serine/threonine-protein kinase SNF1-like kinase 1) (Serine/threonine-protein kinase SNF1LK)

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