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Serine/threonine-protein kinase TAO1 (EC 2 7 11 1) (Thousand and one amino acid protein 1)

 TAOK1_MOUSE             Reviewed;        1001 AA.
Q5F2E8; Q69ZL2; Q8JZX2; Q91VG7;
25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
15-MAR-2005, sequence version 1.
17-JUN-2020, entry version 146.
RecName: Full=Serine/threonine-protein kinase TAO1;
EC=2.7.11.1;
AltName: Full=Thousand and one amino acid protein 1;
Name=Taok1; Synonyms=Kiaa1361;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of the
mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 437-1001.
STRAIN=FVB/N; TISSUE=Mammary gland, and Thymus;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 657-1001.
TISSUE=Brain;
PubMed=15368895; DOI=10.1093/dnares/11.3.205;
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H.,
Nagase T., Ohara O., Koga H.;
"Prediction of the coding sequences of mouse homologues of KIAA gene: IV.
The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
identified by screening of terminal sequences of cDNA clones randomly
sampled from size-fractionated libraries.";
DNA Res. 11:205-218(2004).
[4]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain;
PubMed=16452087; DOI=10.1074/mcp.t500041-mcp200;
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.;
"Comprehensive identification of phosphorylation sites in postsynaptic
density preparations.";
Mol. Cell. Proteomics 5:914-922(2006).
[5]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain cortex;
PubMed=17114649; DOI=10.1074/mcp.m600046-mcp200;
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,
Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B.,
Panse C., Schlapbach R., Mansuy I.M.;
"Qualitative and quantitative analyses of protein phosphorylation in naive
and stimulated mouse synaptosomal preparations.";
Mol. Cell. Proteomics 6:283-293(2007).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-421, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
Thibault P.;
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Immunity 30:143-154(2009).
[7]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9 AND SER-421, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain, Heart, Kidney, Lung, and Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Serine/threonine-protein kinase involved in various processes
such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response
and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6
and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK
cascade by mediating phosphorylation and subsequent activation of the
upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled
receptor signaling to p38/MAPK14. In response to DNA damage, involved
in the G2/M transition DNA damage checkpoint by activating the
p38/MAPK14 stress-activated MAPK cascade, probably by mediating
phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of
cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading
to activate MARK2 kinase activity and subsequent phosphorylation and
detachment of MAPT/TAU from microtubules. Also acts as a regulator of
apoptosis: regulates apoptotic morphological changes, including cell
contraction, membrane blebbing and apoptotic bodies formation via
activation of the MAPK8/JNK cascade (By similarity). {ECO:0000250}.
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
EC=2.7.11.1;
-!- ACTIVITY REGULATION: Serine/threonine-protein kinase activity is
inhibited by SPRED1. {ECO:0000250}.
-!- SUBUNIT: Self-associates. Interacts with MAP2K3. Interacts with SPRED1
and TESK1. Interacts with MAP3K7 (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
-!- PTM: Proteolytically processed by caspase-3 (CASP3).
-!- PTM: Autophosphorylated (By similarity). Phosphorylated by ATM in
response to DNA damage. Phosphorylated by LRRK2. {ECO:0000250}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
protein kinase family. STE20 subfamily. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAH16522.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Sequence=BAD32434.1; Type=Erroneous initiation; Evidence={ECO:0000305};
---------------------------------------------------------------------------
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EMBL; AL591136; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC016522; AAH16522.1; ALT_INIT; mRNA.
EMBL; BC034906; AAH34906.1; -; mRNA.
EMBL; AK173156; BAD32434.1; ALT_INIT; mRNA.
CCDS; CCDS36235.1; -.
RefSeq; NP_659074.2; NM_144825.2.
RefSeq; XP_006533021.1; XM_006532958.3.
RefSeq; XP_006533022.1; XM_006532959.3.
RefSeq; XP_011247231.1; XM_011248929.2.
RefSeq; XP_011247232.1; XM_011248930.2.
RefSeq; XP_011247233.1; XM_011248931.2.
SMR; Q5F2E8; -.
BioGRID; 229824; 2.
IntAct; Q5F2E8; 1.
STRING; 10090.ENSMUSP00000055470; -.
iPTMnet; Q5F2E8; -.
PhosphoSitePlus; Q5F2E8; -.
EPD; Q5F2E8; -.
jPOST; Q5F2E8; -.
MaxQB; Q5F2E8; -.
PaxDb; Q5F2E8; -.
PRIDE; Q5F2E8; -.
Antibodypedia; 2089; 372 antibodies.
DNASU; 216965; -.
Ensembl; ENSMUST00000017435; ENSMUSP00000017435; ENSMUSG00000017291.
Ensembl; ENSMUST00000058496; ENSMUSP00000055470; ENSMUSG00000017291.
GeneID; 216965; -.
KEGG; mmu:216965; -.
UCSC; uc007khc.1; mouse.
CTD; 57551; -.
MGI; MGI:1914490; Taok1.
eggNOG; KOG0577; Eukaryota.
eggNOG; ENOG410Y259; LUCA.
GeneTree; ENSGT00940000155796; -.
HOGENOM; CLU_000288_2_2_1; -.
InParanoid; Q5F2E8; -.
KO; K04429; -.
OMA; XAKVMAN; -.
OrthoDB; 617606at2759; -.
PhylomeDB; Q5F2E8; -.
TreeFam; TF351444; -.
Reactome; R-MMU-141444; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
Reactome; R-MMU-2467813; Separation of Sister Chromatids.
Reactome; R-MMU-2500257; Resolution of Sister Chromatid Cohesion.
Reactome; R-MMU-5663220; RHO GTPases Activate Formins.
Reactome; R-MMU-68877; Mitotic Prometaphase.
Reactome; R-MMU-9648025; EML4 and NUDC in mitotic spindle formation.
BioGRID-ORCS; 216965; 2 hits in 14 CRISPR screens.
ChiTaRS; Taok1; mouse.
PRO; PR:Q5F2E8; -.
Proteomes; UP000000589; Chromosome 11.
RNAct; Q5F2E8; protein.
Bgee; ENSMUSG00000017291; Expressed in forebrain and 289 other tissues.
ExpressionAtlas; Q5F2E8; baseline and differential.
Genevisible; Q5F2E8; MM.
GO; GO:0005623; C:cell; IEA:GOC.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0015630; C:microtubule cytoskeleton; ISO:MGI.
GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:MGI.
GO; GO:0043014; F:alpha-tubulin binding; ISO:MGI.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0048487; F:beta-tubulin binding; ISO:MGI.
GO; GO:0016301; F:kinase activity; ISO:MGI.
GO; GO:0004709; F:MAP kinase kinase kinase activity; IBA:GO_Central.
GO; GO:0031489; F:myosin V binding; ISO:MGI.
GO; GO:0008022; F:protein C-terminus binding; ISO:MGI.
GO; GO:0030295; F:protein kinase activator activity; ISO:MGI.
GO; GO:0004672; F:protein kinase activity; ISO:MGI.
GO; GO:0019901; F:protein kinase binding; ISO:MGI.
GO; GO:0043539; F:protein serine/threonine kinase activator activity; ISO:MGI.
GO; GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
GO; GO:0000186; P:activation of MAPKK activity; IBA:GO_Central.
GO; GO:0032147; P:activation of protein kinase activity; IBA:GO_Central.
GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB.
GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
GO; GO:0097194; P:execution phase of apoptosis; ISS:UniProtKB.
GO; GO:0000226; P:microtubule cytoskeleton organization; ISO:MGI.
GO; GO:0007095; P:mitotic G2 DNA damage checkpoint; ISS:UniProtKB.
GO; GO:0007026; P:negative regulation of microtubule depolymerization; ISO:MGI.
GO; GO:0070050; P:neuron cellular homeostasis; ISO:MGI.
GO; GO:0016310; P:phosphorylation; ISO:MGI.
GO; GO:0046330; P:positive regulation of JNK cascade; ISS:UniProtKB.
GO; GO:1901985; P:positive regulation of protein acetylation; ISO:MGI.
GO; GO:0032874; P:positive regulation of stress-activated MAPK cascade; ISS:UniProtKB.
GO; GO:0046777; P:protein autophosphorylation; ISO:MGI.
GO; GO:0006468; P:protein phosphorylation; ISO:MGI.
GO; GO:0032956; P:regulation of actin cytoskeleton organization; ISO:MGI.
GO; GO:0051493; P:regulation of cytoskeleton organization; ISS:UniProtKB.
GO; GO:0070507; P:regulation of microtubule cytoskeleton organization; ISO:MGI.
GO; GO:0007346; P:regulation of mitotic cell cycle; IBA:GO_Central.
GO; GO:0023014; P:signal transduction by protein phosphorylation; IBA:GO_Central.
GO; GO:0031098; P:stress-activated protein kinase signaling cascade; IBA:GO_Central.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR008271; Ser/Thr_kinase_AS.
Pfam; PF00069; Pkinase; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
1: Evidence at protein level;
Apoptosis; ATP-binding; Coiled coil; Cytoplasm; DNA damage; DNA repair;
Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome;
Serine/threonine-protein kinase; Transferase.
CHAIN 1..1001
/note="Serine/threonine-protein kinase TAO1"
/id="PRO_0000086729"
DOMAIN 28..281
/note="Protein kinase"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
NP_BIND 34..42
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
COILED 458..651
/evidence="ECO:0000255"
COILED 754..877
/evidence="ECO:0000255"
COMPBIAS 330..334
/note="Poly-Glu"
ACT_SITE 151
/note="Proton acceptor"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
ECO:0000255|PROSITE-ProRule:PRU10027"
BINDING 57
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MOD_RES 9
/note="Phosphoserine"
/evidence="ECO:0000244|PubMed:21183079"
MOD_RES 421
/note="Phosphoserine"
/evidence="ECO:0000244|PubMed:19144319,
ECO:0000244|PubMed:21183079"
MOD_RES 445
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q7L7X3"
MOD_RES 669
/note="Phosphothreonine"
/evidence="ECO:0000250|UniProtKB:Q7L7X3"
MOD_RES 965
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q7L7X3"
SEQUENCE 1001 AA; 116050 MW; 59DF437EAB8127C2 CRC64;
MPSTNRAGSL KDPEIAELFF KEDPEKLFTD LREIGHGSFG AVYFARDVRT NEVVAIKKMS
YSGKQSTEKW QDIIKEVKFL QRIKHPNSIE YKGCYLREHT AWLVMEYCLG SASDLLEVHK
KPLQEVEIAA ITHGALQGLA YLHSHTMIHR DIKAGNILLT EPGQVKLADF GSASMASPAN
SFVGTPYWMA PEVILAMDEG QYDGKVDVWS LGITCIELAE RKPPLFNMNA MSALYHIAQN
ESPTLQSNEW SDYFRNFVDS CLQKIPQDRP TSEELLKHMF VLRERPETVL IDLIQRTKDA
VRELDNLQYR KMKKLLFQEA HNGPAVEAQE EEEEQDHGVG RTGTVNSVGS NQSIPSMSIS
ASSQSSSVNS LPDASDDKSE LDMMEGDHTV MSNSSVIHLK PEEENYQEEG DPRTRASDPQ
SPPQVSRHKS HYRNREHFAT IRTASLVTRQ MQEHEQDSEL REQMSGYKRM RRQHQKQLMT
LENKLKAEMD EHRLRLDKDL ETQRNNFAAE MEKLIKKHQA AMEKEAKVMA NEEKKFQQHI
QAQQKKELNS FLESQKREYK LRKEQLKEEL NENQSTPKKE KQEWLSKQKE NIQHFQAEEE
ANLLRRQRQY LELECRRFKR RMLLGRHNLE QDLVREELNK RQTQKDLEHA MLLRQHESMQ
ELEFRHLNTI QKMRCELIRL QHQTELTNQL EYNKRREREL RRKHVMEVRQ QPKSLKSKEL
QIKKQFQDTC KIQTRQYKAL RNHLLETTPK SEHKAVLKRL KEEQTRKLAI LAEQYDHSIN
EMLSTQALRL DEAQEAECQV LKMQLQQELE LLNAYQSKIK MQAEAQHDRE LRELEQRVSL
RRALLEQKIE EEMLALQNER TERIRSLLER QAREIEAFDS ESMRLGFSNM VLSNLSPEAF
SHSYPGASSW SHNPTGGPGP HWGHPMGGTP QAWGHPMQGG PQPWGHPSGP MQGVPRGSSM
GVRNSPQALR RTASGGRTEQ GMSRSTSVTS QISNGSHMSY T


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WP813: G Protein Signaling Pathways
WP1625: Base excision repair
WP232: G Protein Signaling Pathways
WP1644: DNA replication
WP1531: Vitamin D synthesis
WP1676: Non-homologous end-joining
WP210: Cytoplasmic Ribosomal Proteins
WP1577: amino acid conjugation of benzoic acid
WP1685: Peptidoglycan biosynthesis
WP1650: Fluorobenzoate degradation
WP1657: Glycerolipid metabolism
WP1892: Protein folding
WP1165: G Protein Signaling Pathways
WP1613: 1,4-Dichlorobenzene degradation
WP1690: Propanoate metabolism
WP2203: TSLP Signaling Pathway
WP1694: Pyrimidine metabolism

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[stk-1 bur1 B20D17.070 NCU01435] Serine/threonine-protein kinase bur1 (EC 2.7.11.22) (EC 2.7.11.23) (Serine-threonine kinase 1)
[UL97] Serine/threonine protein kinase UL97 (EC 2.7.1.-) (Ganciclovir kinase) (HSRF3 protein)
[hchA A8C65_13880 A9R57_25255 AMK83_16550 AWB10_10580 AWG90_013200 B7C53_22525 B9M99_11580 B9T59_01945 BJJ90_15205 BMT49_12710 BON65_01250 BON66_15955 BON86_06490 BON95_14610 BUE81_10670 BvCms12BK_01457 BvCms28BK_04168 BvCmsHHP001_02632 BvCmsKKP061_00566 BvCmsKSP045_04450 BvCmsKSP058_03204 BvCmsKSP067_02879 BvCmsNSP006_03750 BvCmsNSP007_03329 BvCmsNSP047_03567 BvCmsSINP011_04162 BW690_17225 BZL69_29425 C2U48_24800 C5715_19445 C5N07_21380 C6669_19295 C7B06_02290 C7B07_03930 C9Z23_21970 C9Z37_00915 C9Z43_06360 C9Z78_05610 CDC27_10055 CDL37_00765 CI693_17820 CI694_25210 CIG45_02340 COD46_23180 CQP61_17160 CRD98_26150 D2188_01360 D4628_09465 D6T98_10515 D6X36_17295 D9D20_21030 D9D43_06110 D9G29_20785 D9G69_01560 D9H68_20750 D9H70_25730 D9I87_15275 D9J58_04360 D9S45_22925 DEN89_24995 DEO04_05510 DL705_18425 DL800_09215 DLU50_17670 DLW88_16170 DLY44_04800 DND16_20085 DNR35_16895 DQE83_22775 DQP61_11280 DTL43_21780 DTZ20_09315 DU321_04440 DXT73_20690 E2134_24005 E2135_17195 E2855_02503 E2863_02392 E4K55_17625 E4K61_03800 E5P22_21380 E5S46_06650 EA213_19000 EA225_13320 EAX79_27320 EC95NR1_00961 ED648_25045 EG796_17135 EHD79_18540 EI028_00085 ELT20_21515 ELV08_24970 EPT01_11070 EQ825_23250 ERS085379_01273 ERS085386_05041 ExPECSC019_03873 ExPECSC038_01920 EXX71_02385 EXX78_21815 EYD11_09165 F7F11_20115 F7F18_11615 F7F29_22635 FNJ83_13175 FQ915_04255 FQR64_09390 FQZ46_21375 FWK02_18105 FZ043_14730 GIY13_02485 GNZ00_15670 GNZ02_11235 GNZ03_00440 GP712_09450 GQE64_12165 GQL64_10635 GQM17_02800 HmCmsJML079_02678 HMPREF3040_01583 HW43_13705 NCTC10082_04431 NCTC10418_03071 NCTC10767_03558 NCTC10974_02300 NCTC11022_01867 NCTC11126_04427 NCTC11181_05650 NCTC12950_02263 NCTC13216_04667 NCTC8985_00529 NCTC9111_05933 NCTC9703_00277 PGD_01271 PU06_24500 SAMEA3472043_00447 SAMEA3472055_03589 SAMEA3472056_01268 SAMEA3472070_00654 SAMEA3472080_04213 SAMEA3472090_03376 SAMEA3472110_00060 SAMEA3472112_00448 SAMEA3752372_00752 UN91_23615 WQ89_10695] Protein/nucleic acid deglycase HchA (EC 3.1.2.-) (EC 3.5.1.124) (Maillard deglycase)
[ERECTA ER QRP1 QRS1 TE1 At2g26330 T1D16.3] LRR receptor-like serine/threonine-protein kinase ERECTA (EC 2.7.11.1) (Protein QUANTITATIVE RESISTANCE TO PLECTOSPHAERELLA 1) (Protein QUANTITATIVE RESISTANCE TO RALSTONIA SOLANACEARUM 1) (Protein TRANSPIRATION EFFICIENCY 1)
[SRK2E OST1 SNRK2.6 At4g33950 F17I5.140] Serine/threonine-protein kinase SRK2E (EC 2.7.11.1) (Protein OPEN STOMATA 1) (SNF1-related kinase 2.6) (SnRK2.6) (Serine/threonine-protein kinase OST1)
[TOR1 DRR1 YJR066W J1803] Serine/threonine-protein kinase TOR1 (EC 2.7.11.1) (Dominant rapamycin resistance protein 1) (Phosphatidylinositol kinase homolog TOR1) (Target of rapamycin kinase 1)
[Pik3cg Pi3kg1] Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PI3-kinase subunit gamma) (PI3K-gamma) (PI3Kgamma) (PtdIns-3-kinase subunit gamma) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma) (PtdIns-3-kinase subunit p110-gamma) (p110gamma) (Phosphoinositide-3-kinase catalytic gamma polypeptide) (Serine/threonine protein kinase PIK3CG) (EC 2.7.11.1) (p120-PI3K)
[Eif2ak2 Pkr Prkr Tik] Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (P1/eIF-2A protein kinase) (Protein kinase RNA-activated) (PKR) (Protein kinase R) (Serine/threonine-protein kinase TIK) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2) (p68 kinase)
[BRSK1 KIAA1811 SAD1 SADB] Serine/threonine-protein kinase BRSK1 (EC 2.7.11.1) (Brain-selective kinase 1) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 1) (BR serine/threonine-protein kinase 1) (Serine/threonine-protein kinase SAD-B) (Synapses of Amphids Defective homolog 1) (SAD1 homolog) (hSAD1)
[Pak1 Paka] Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A) (p21-activated kinase 1) (PAK-1) (p65-PAK)
[GHR1 RCD7 At4g20940 T13K14.100] LRR receptor-like serine/threonine-protein kinase GHR1 (EC 2.7.11.1) (Protein GUARD CELL HYDROGEN PEROXIDE-RESISTANT 1) (AtGHR1) (Protein RADICAL-INDUCED CELL DEATH 7)
[STK4 KRS2 MST1] Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)]
[AURKA AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6] Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (hARK1) (Breast tumor-amplified kinase) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase aurora-A)
[hchA AM465_15370 AWF59_019055 AZZ83_004235 B9N33_26475 BFD68_20845 C7B02_06890 C9Z28_17130 CCZ14_26645 CCZ17_22700 CRJUMX01_1140054 CRT43_11430 CUB99_23505 D3C88_02905 D3P02_16265 D9D33_15385 D9D94_15735 D9E49_19020 D9I20_10460 D9J46_03345 DJ487_18960 DJ492_13470 DL251_00505 DL979_00380 DMC44_18755 DMZ50_24495 DNR41_00375 DS966_16070 DU333_03260 DW236_02290 E0L04_20335 EA159_21345 EA167_21075 EA189_00370 EA191_21560 EA198_02280 EA200_00370 EA203_21510 EA222_02305 EA232_20265 EA233_11705 EA242_17410 EA245_13290 EA429_05770 EA435_21775 EA834_21700 ECTO124_02024 EGT48_04930 ELT23_21030 ELT33_08025 ELT34_19745 ELU82_24705 ELU96_05025 ELV13_26065 ELX79_15035 ELX83_25640 ELY23_20490 ELY24_19085 ELY50_24510 EPS76_06485 EPS91_17475 EPS94_00505 ERS085406_02591 EWK56_00075 ExPECSC065_02714 EYX99_25670 FNJ67_10775 FV295_16190 GFU40_00360 GFU45_09680 GFU47_04835 GJ638_18410 GKE92_23545 GKF28_00040 GKF34_00055 GKF47_00040 GKG08_13460 GKG09_11990 GKG11_12245 GKG22_12830 GKG29_13740 GQE47_24120 GQN33_12435 GQS26_09145 NCTC10766_03778 NCTC7928_05955 NCTC8450_02317 NCTC9007_02951 NCTC9075_02834 SY51_11150 U12A_02105 U14A_02105] Protein/nucleic acid deglycase HchA (EC 3.1.2.-) (EC 3.5.1.124) (Maillard deglycase)
[Aurka Aik Airk Ark1 Aura Ayk1 Btak Iak1 Stk15 Stk6] Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora family kinase 1) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A)
[AURKB AIK2 AIM1 AIRK2 ARK2 STK1 STK12 STK5] Aurora kinase B (EC 2.7.11.1) (Aurora 1) (Aurora- and IPL1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (ARK-2) (Aurora-related kinase 2) (STK-1) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase 5) (Serine/threonine-protein kinase aurora-B)
[Mark1 Emk3 Kiaa1477] Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif serine/threonine-protein kinase 3) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (mPar-1c)
[Gsk3b] Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1)
[CIPK7 PKS7 SnRK3.10 SR2 SRPK1 At3g23000 MXC7.3] CBL-interacting serine/threonine-protein kinase 7 (EC 2.7.11.1) (SNF1-related kinase 3.10) (SOS2-like protein kinase PKS7) (Serine/threonine-protein kinase SR2) (AtSR2) (AtSRPK1)
[STK16 MPSK1 PKL12 TSF1] Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (Protein kinase PKL12) (TGF-beta-stimulated factor 1) (TSF-1) (Tyrosine-protein kinase STK16) (EC 2.7.10.2) (hPSK)
[Stk16 Edpk Krct Mpsk1 Pkl12 Tsf1] Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Embryo-derived protein kinase) (Edpk) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (Protein kinase Krct) (Protein kinase PKL12) (TGF-beta-stimulated factor 1) (TSF-1) (Tyrosine-protein kinase STK16) (EC 2.7.10.2)
[Brsk1 Gm1100 Sadb] Serine/threonine-protein kinase BRSK1 (EC 2.7.11.1) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 1) (BR serine/threonine-protein kinase 1) (Serine/threonine-protein kinase SAD-B)
[Brsk1 Sadb] Serine/threonine-protein kinase BRSK1 (EC 2.7.11.1) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 1) (BR serine/threonine-protein kinase 1) (Serine/threonine-protein kinase SAD-B)
[Aurkb Aik2 Aim1 Airk2 Ark2 Stk1 Stk12 Stk5] Aurora kinase B (EC 2.7.11.1) (Aurora 1) (Aurora- and IPL1-like midbody-associated protein 1) (Aurora/IPL1-related kinase 2) (ARK-2) (Aurora-related kinase 2) (STK-1) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase 5) (Serine/threonine-protein kinase aurora-B)
[HT1 SUU At1g62400 F24O1.13] Serine/threonine/tyrosine-protein kinase HT1 (EC 2.7.10.1) (EC 2.7.11.1) (High leaf temperature protein 1)
[CDK7 CAK CAK1 CDKN7 MO15 STK1] Cyclin-dependent kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (39 kDa protein kinase) (p39 Mo15) (CDK-activating kinase 1) (Cell division protein kinase 7) (Serine/threonine-protein kinase 1) (TFIIH basal transcription factor complex kinase subunit)
[Stk16 Mpsk1 Tsf1] Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (Protein kinase PKL12) (TGF-beta-stimulated factor 1) (TSF-1) (Tyrosine-protein kinase STK16) (EC 2.7.10.2)
[AURKA AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6] Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase aurora-A)
[AURKA AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6] Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase aurora-A)
[stk11 eek1] Serine/threonine-protein kinase stk11 (EC 2.7.11.1) (Liver kinase B1 homolog) (lkb1) (Serine/threonine-protein kinase XEEK1)

Bibliography :
[31230721] De Novo Variants in TAOK1 Cause Neurodevelopmental Disorders.
[28830982] Targeting TAO Kinases Using a New Inhibitor Compound Delays Mitosis and Induces Mitotic Cell Death in Centrosome Amplified Breast Cancer Cells.
[27108190] Mass spectrometric analysis of host cell proteins interacting with dengue virus nonstructural protein 1 in dengue virus-infected HepG2 cells.
[10497253] Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain.