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Serine hydroxymethyltransferase (SHMT) (Serine methylase) (EC 2.1.2.-)

 GLYA_SACS2              Reviewed;         433 AA.
Q9UWT5;
27-MAR-2002, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
29-SEP-2021, entry version 125.
RecName: Full=Serine hydroxymethyltransferase;
Short=SHMT;
Short=Serine methylase;
EC=2.1.2.-;
Name=glyA; OrderedLocusNames=SSO0530; ORFNames=C22_021;
Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
(Sulfolobus solfataricus).
Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
Saccharolobus.
NCBI_TaxID=273057;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 35092 / DSM 1617 / JCM 11322 / P2;
PubMed=10701121; DOI=10.1139/g99-108;
Charlebois R.L., Singh R.K., Chan-Weiher C.C.-Y., Allard G., Chow C.,
Confalonieri F., Curtis B., Duguet M., Erauso G., Faguy D., Gaasterland T.,
Garrett R.A., Gordon P., Jeffries A.C., Kozera C., Kushwaha N., Lafleur E.,
Medina N., Peng X., Penny S.L., She Q., St Jean A., van der Oost J.,
Young F., Zivanovic Y., Doolittle W.F., Ragan M.A., Sensen C.W.;
"Gene content and organization of a 281-kbp contig from the genome of the
extremely thermophilic archaeon, Sulfolobus solfataricus P2.";
Genome 43:116-136(2000).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 35092 / DSM 1617 / JCM 11322 / P2;
PubMed=11427726; DOI=10.1073/pnas.141222098;
She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J.,
Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G.,
Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J.,
Medina N., Peng X., Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C.,
Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T.,
Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J.;
"The complete genome of the crenarchaeon Sulfolobus solfataricus P2.";
Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001).
[3]
PARTIAL PROTEIN SEQUENCE, FUNCTION, MODIFIED FOLATE-DEPENDENT SERINE
HYDROXYMETHYLTRANSFERASE ACTIVITY, ALDOLASE ACTIVITY, COFACTOR, SUBSTRATE
SPECIFICITY, ACTIVITY REGULATION, AND SUBUNIT.
PubMed=9393711; DOI=10.1128/jb.179.23.7456-7461.1997;
Delle Fratte S., White R.H., Maras B., Bossa F., Schirch V.;
"Purification and properties of serine hydroxymethyltransferase from
Sulfolobus solfataricus.";
J. Bacteriol. 179:7456-7461(1997).
-!- FUNCTION: Catalyzes the reversible interconversion of serine and
glycine with the modified folate sulfopterin serving as the one-carbon
carrier. Cannot use tetrahydrofolate (THF or H4PteGlu) as the pteridine
substrate. Also exhibits a pteridine-independent aldolase activity
toward beta-hydroxyamino acids, producing glycine and aldehydes, via a
retro-aldol mechanism. Thus, is able to catalyze the cleavage of both
allo-threonine and beta-phenylserine. {ECO:0000269|PubMed:9393711}.
-!- CATALYTIC ACTIVITY:
Reaction=5,10-methylenetetrahydrosulfopterin + glycine + H2O = L-serine
+ tetrahydrosulfopterin; Xref=Rhea:RHEA:56608, ChEBI:CHEBI:15377,
ChEBI:CHEBI:33384, ChEBI:CHEBI:57305, ChEBI:CHEBI:140605,
ChEBI:CHEBI:140606;
-!- COFACTOR:
Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
Evidence={ECO:0000269|PubMed:9393711};
-!- ACTIVITY REGULATION: Is completely inhibited by addition of NaCNBH(3)
in vitro; this reagent is a known inhibitor of PLP enzymes, that
reduces the internal aldimine of PLP to the catalytically inactive and
stable secondary amine. Is also inhibited by L-cysteine, which forms a
thiazolidine complex with the active site PLP.
{ECO:0000269|PubMed:9393711}.
-!- PATHWAY: Amino-acid biosynthesis; glycine biosynthesis; glycine from L-
serine: step 1/1.
-!- SUBUNIT: Homodimer. {ECO:0000305|PubMed:9393711}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
-!- SIMILARITY: Belongs to the SHMT family. {ECO:0000305}.
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EMBL; Y18930; CAB57769.1; -; Genomic_DNA.
EMBL; AE006641; AAK40850.1; -; Genomic_DNA.
PIR; C90199; C90199.
RefSeq; WP_009991046.1; NC_002754.1.
SMR; Q9UWT5; -.
STRING; 273057.SSO0530; -.
EnsemblBacteria; AAK40850; AAK40850; SSO0530.
GeneID; 44129548; -.
KEGG; sso:SSO0530; -.
PATRIC; fig|273057.12.peg.529; -.
eggNOG; arCOG00070; Archaea.
HOGENOM; CLU_022477_2_1_2; -.
InParanoid; Q9UWT5; -.
OMA; SHPAGLI; -.
PhylomeDB; Q9UWT5; -.
BioCyc; SSOL273057:G1FZF-553-MONOMER; -.
BRENDA; 2.1.2.1; 6163.
UniPathway; UPA00288; UER01023.
Proteomes; UP000001974; Chromosome.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0050897; F:cobalt ion binding; IBA:GO_Central.
GO; GO:0004372; F:glycine hydroxymethyltransferase activity; IBA:GO_Central.
GO; GO:0030170; F:pyridoxal phosphate binding; IBA:GO_Central.
GO; GO:0070905; F:serine binding; IBA:GO_Central.
GO; GO:0008270; F:zinc ion binding; IBA:GO_Central.
GO; GO:0046655; P:folic acid metabolic process; IBA:GO_Central.
GO; GO:0019264; P:glycine biosynthetic process from serine; IBA:GO_Central.
GO; GO:0006565; P:L-serine catabolic process; IBA:GO_Central.
GO; GO:0006730; P:one-carbon metabolic process; IBA:GO_Central.
GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:InterPro.
GO; GO:0046653; P:tetrahydrofolate metabolic process; IBA:GO_Central.
CDD; cd00378; SHMT; 1.
Gene3D; 3.40.640.10; -; 1.
Gene3D; 3.90.1150.10; -; 1.
HAMAP; MF_00051; SHMT; 1.
InterPro; IPR015424; PyrdxlP-dep_Trfase.
InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
InterPro; IPR001085; Ser_HO-MeTrfase.
InterPro; IPR019798; Ser_HO-MeTrfase_PLP_BS.
InterPro; IPR039429; SHMT-like_dom.
PANTHER; PTHR11680; PTHR11680; 1.
Pfam; PF00464; SHMT; 1.
PIRSF; PIRSF000412; SHMT; 1.
SUPFAM; SSF53383; SSF53383; 1.
PROSITE; PS00096; SHMT; 1.
1: Evidence at protein level;
Amino-acid biosynthesis; Cytoplasm; Direct protein sequencing;
One-carbon metabolism; Pyridoxal phosphate; Reference proteome;
Transferase.
CHAIN 1..433
/note="Serine hydroxymethyltransferase"
/id="PRO_0000113725"
BINDING 31
/note="Pyridoxal phosphate"
/evidence="ECO:0000250"
BINDING 51
/note="Pyridoxal phosphate"
/evidence="ECO:0000250"
BINDING 53
/note="Substrate"
/evidence="ECO:0000250"
BINDING 60
/note="Substrate"
/evidence="ECO:0000250"
BINDING 61
/note="Pyridoxal phosphate"
/evidence="ECO:0000250"
BINDING 95
/note="Pyridoxal phosphate"
/evidence="ECO:0000250"
BINDING 172
/note="Pyridoxal phosphate"
/evidence="ECO:0000250"
BINDING 200
/note="Pyridoxal phosphate"
/evidence="ECO:0000250"
BINDING 226
/note="Pyridoxal phosphate"
/evidence="ECO:0000250"
BINDING 361
/note="Pyridoxal phosphate"
/evidence="ECO:0000250"
MOD_RES 227
/note="N6-(pyridoxal phosphate)lysine"
/evidence="ECO:0000250"
SEQUENCE 433 AA; 48509 MW; 8C239FA0FA3A285E CRC64;
MSLPKELEKV LEITKAQNVW RRTQTLNLIA SENVMSPLAE SVYMSDFMSR YAEGKPYKRY
YQGTKYTDEI ETLTMELMNE ITNSKDCDLR PTSGTIANAA VFRVLAEPGD KALIAPVQAG
AHVSHTKFGT LGALGIQHIE MPFDEENINV DVDKAIKMIE EVKPKFVVLG GSLYLFPHPT
KELAQHVHAV GAKLVYDAAH VYGLIEGKVW SNPLKDGADI MTVSTHKTFP GPQGGAIFSD
GSEVFKQVSK TIFPWFVSNH HLHRLPATAV TAIEMKYFGE SYANQILRNS KALAEALAER
GFKVIGENLG YTKSHQVAVD VRQFGGGNKI AKLLEDANII VNKNLLPYDK PEDVSDPSGL
RIGVQEMTRY GMKEGEMEEI AELFKKVIID KKDVNEVKKE VIEMRRNFLE VKYTFDDMKD
LEKYSSKSLK LII


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Pathways :
WP1659: Glycine, serine and threonine metabolism
WP2199: Seed Development
WP2185: Purine metabolism
WP459: Serine Biosynthesis
WP218: Serine and Glycine biosynthesis
WP390: Serine-isocitrate lyase pathway
WP1714: Tyrosine metabolism
WP1700: Selenoamino acid metabolism
WP1673: Naphthalene and anthracene degradation

Related Genes :
[mel-32 gly-1 C05D11.11] Serine hydroxymethyltransferase (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Glycosylation-related protein 1) (Maternal effect lethal protein 32) (Serine methylase)
[SHMT2] Serine hydroxymethyltransferase, mitochondrial (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase)
[SHMT1] Serine hydroxymethyltransferase, cytosolic (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase)
[SHM1 SHMT1 STM At4g37930 F20D10.50] Serine hydroxymethyltransferase 1, mitochondrial (AtSHMT1) (EC 2.1.2.1) (Glycine hydroxymethyltransferase 1) (Serine Transhydroxymethyltransferase) (STM) (Serine methylase 1)
[glyA MJ1597] Serine hydroxymethyltransferase (SHMT) (Serine methylase) (EC 2.1.2.-) (L-allo-threonine aldolase) (EC 4.1.2.49)
[cbs-2 NCU05805] Putative serine hydroxymethyltransferase, mitochondrial (SHMT) (EC 2.1.2.1) (Carnitine biosynthesis protein 2) (Glycine hydroxymethyltransferase) (Serine methylase)
[glyA SSO0530 C22_021] Serine hydroxymethyltransferase (SHMT) (Serine methylase) (EC 2.1.2.-)
[for B13D24.080 NCU02274] Serine hydroxymethyltransferase, cytosolic (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase)
[glyA glyA_1 glyA_2 A2F99_004035 A5U30_000702 A6519_003807 A6583_14965 A6592_14990 A8499_002706 A8W81_000919 A9819_14740 A9X72_06640 AAG43_000888 AAG80_002426 ABE90_018340 ACN68_11065 ACN81_26330 ACU57_10365 AM270_07205 AM340_13835 AM464_04555 AML23_07315 AT335_000336 AT845_003833 AUQ29_16240 AW059_05835 AZZ83_002738 B6R12_001697 B6R15_003263 B6R17_003161 B6R27_002434 B6R48_002696 B6R87_002477 B7C15_000754 B9T59_21000 BANRA_01096 BANRA_03637 BANRA_04526 BB545_05765 BE930_26645 BG821_001413 BG944_001682 BH692_13270 BHF52_10685 BHS81_15565 BHS87_14440 BIZ41_08400 BJI68_01910 BJJ90_06515 BK272_07090 BK292_20755 BMC34_000740 BMC79_001552 BMR21_20285 BMT50_17745 BMT91_09735 BN17_18381 BO068_003056 BOH76_09300 BON63_10745 BON65_16000 BON70_03210 BON72_11375 BON73_16440 BON76_02745 BON83_11490 BON86_12460 BON87_06630 BON91_13665 BON92_01435 BON93_12130 BON94_05240 BON95_11620 BON96_15660 BON98_06450 BR158_001213 BR331_10110 BRV34_002787 BRV41_000538 BTQ06_16650 BUE81_08015 BUE82_05775 BvCms2454_04469 BvCmsC61A_04045 BvCmsHHP019_04807 BvCmsHHP056_01827 BvCmsKKP057_02289 BvCmsKKP061_03866 BvCmsKSNP073_01448 BvCmsKSP011_00149 BvCmsKSP067_00300 BvCmsKSP076_03105 BvCmsNSNP036_03158 BvCmsSIP024_00172 BvCmsSIP082_04620 BVL39_14060 C2121_002622 C2M16_05810 C2U48_21330 C3F40_24180 C4M78_10995 C5542_000040 C5F72_07325 C5N07_10120 C5Y87_16910 C6B13_21295 C6B22_04970 C6N50_002361 C7B02_18410 C9114_06115 C9160_04925 C9Z62_03290 CA593_14065 CCS08_18520 CCV12_004265 CCV24_002515 CDC27_13525 CDL36_08290 CDL37_24890 CDL57_18775 CF32_000888 CG692_02590 CG831_000307 CIG67_15200 CN875_000561 CO706_10645 COD50_10050 CQB02_04280 CQP61_07880 CR539_17760 CT143_05895 CV83915_03566 CWS33_10015 CX692_004068 CX693_004074 CX694_000049 CX699_003925 CXJ73_001204 CY655_16575 D0X26_11515 D2183_14360 D3822_04910 D3G36_12950 D3O91_03575 D3Y67_23910 D4U49_06920 D4V09_10830 D5H22_07120 D6T60_00210 D9D31_00200 D9D43_10120 D9D77_19345 D9E34_00200 D9E49_14180 D9F92_05640 D9H13_02220 D9H94_08915 D9J11_04295 D9J61_05955 D9K17_07020 DAH37_19280 DAH50_15215 DB282_13200 DD762_08650 DEN89_09995 DEN95_00225 DEO15_02160 DIV22_11305 DLX40_16265 DM968_11320 DN627_11835 DNQ45_17665 DNX30_07470 DP258_15495 DRW19_07050 DS732_18880 DS966_22280 DTL90_08220 DTM45_08975 DXB10_16440 DXT69_13070 E0I42_02100 E0N24_05870 E0P28_20125 E2112_00875 E2119_10045 E2123_03095 E2127_03895 E2128_10365 E2129_06195 E2135_00925 E3N34_14205 E4K51_06760 E4K54_09005 E5P52_10190 E5S34_19615 E5S35_08625 E5S43_07605 E5S47_00205 E5S52_12900 E5S62_23735 EA239_20085 EA435_09915 EAX79_07285 EC3234A_44c01580 EC95NR1_01776 EGC08_02280 EH88_000039 EHD79_09830 EHH55_21865 EI021_12085 EI041_00205 EIA08_10400 EIA13_01830 EIZ93_07135 EKI52_21985 EL79_1107 EL80_1110 ELT21_03900 ELT31_20595 ELT33_03345 ELT48_12545 ELT49_01975 ELT58_05205 ELT72_07735 ELU95_20695 ELV08_03295 ELV10_01135 ELV13_09100 ELV15_02510 ELV22_09700 ELV24_05745 ELV28_12290 ELX56_04905 ELX68_07400 ELX70_20105 ELX76_10710 ELX79_06675 ELX83_16095 ELX96_00410 ELY05_02135 ELY23_05775 ELY24_12010 ELY32_00200 ELY41_08005 ELY48_14840 ELY50_14220 EO241_23265 EPS76_08265 EQO00_06860 ERS085358_02783 ERS085386_03166 ERS139208_00669 Esc0902E_27630 ETECE1373_01271 ETECE36_01998 ETECE925_01268 EWK56_23300 ExPECSC038_01065 EXX13_08215 EYX55_00965 EYY34_01875 F2N31_18805 F3N40_14380 F6U69_05510 F9400_03365 F9407_01615 F9571_20135 F9B07_15475 F9S76_20640 F9V07_06650 F9V22_04495 F9V24_05195 F9X20_023115 F9X20_23370 FA849_16675 FC554_02600 FDM60_16945 FE587_09870 FEJ01_07235 FEL34_05075 FGG80_19090 FJQ51_11510 FKO60_11190 FMP09_06555 FNJ67_07365 FOI11_000195 FOI11_19855 FPI65_15875 FPS82_21750 FQE77_01085 FQF29_20195 FV293_03860 FY127_12120 FZC17_18475 FZN26_05255 FZN31_07000 G3565_12530 G4A38_06695 G5603_17965 G5632_01555 G6P89_06550 G6Z99_06510 G7635_001523 G9448_21200 GAJ26_19585 GBE29_03815 GF147_23155 GF199_04825 GF646_18200 GF698_07250 GF699_06695 GFY34_09870 GFY48_07215 GFZ60_15130 GJ11_16620 GKF52_12220 GKF86_17780 GKF89_05430 GKG12_07765 GLW94_02240 GNO40_02270 GNZ05_14090 GOP20_13215 GP650_10840 GP662_02580 GP711_05685 GP946_10000 GP979_10170 GQA06_16300 GQE42_05365 GQE64_06945 GQE87_13230 GQF58_04245 GQF59_04220 GQM04_00640 GQM09_02785 GQM10_02125 GQR15_14015 GQW68_10520 GQW76_24840 GQW80_01335 GRC73_00195 GRQ19_07520 GRW05_03265 GRW57_19155 GRW80_05730 GRW81_03155 GTP88_04445 GUB92_10870 GUC01_12805 GUI33_10120 H0O72_14865 H4P47_06435 H4P50_05960 H4P51_06005 HCF72_002118 HH411_002591 HH795_000414 HHG09_000874 HHH44_003141 HIE29_003787 HIE44_000300 HIN64_001883 HIR12_000991 HJ940_002716 HJ942_002106 HJM92_002419 HJN04_001758 HJO75_001347 HJS37_000291 HJS41_003515 HKA49_001830 HL425_12460 HL601_02375 HLU10_13410 HLV18_13735 HLZ20_18775 HLZ50_15830 HmCms169_04039 HmCms184_00602 HmCmsJML074_00191 HMJ82_17400 HMJ82_28660 HMS79_02595 HMT08_05325 HMT08_28380 HMU06_20150 HMU06_28100 HMU48_06775 HMU48_30320 HMV41_00195 HMV95_11265 HMW38_06350 HMW38_26975 HNC36_04665 HNC38_16630 HNC38_26370 HNC52_02955 HNC52_27260 HNC59_20705 HNC59_28930 HNC99_17785 HNC99_29050 HND12_05600 HND12_30055 HND24_11790 HND24_27095 HNO08_08705 HNV65_05245 HNV94_19600 HNY50_10165 HNY54_11925 HV109_05985 HV146_17215 HVV39_04750 HVW04_22285 HVW11_17560 HVW22_13955 HVW43_23585 HVX31_05585 HVY77_07055 HVZ29_15375 HVZ30_05585 HVZ33_06220 HVZ71_06400 HX136_06045 HZ71_000688 HZ72_000211 I6H00_25235 I6H01_06745 I6H02_08060 JE86ST02C_30360 JE86ST05C_30410 MS7163_02680 NCTC10089_01301 NCTC10090_04352 NCTC10764_00540 NCTC10767_02577 NCTC10865_01632 NCTC11181_03553 NCTC13216_00621 NCTC4450_03256 NCTC7928_01404 NCTC8008_00717 NCTC8009_03153 NCTC8179_04380 NCTC8179_06948 NCTC8450_04313 NCTC8621_01385 NCTC8959_02478 NCTC8960_04038 NCTC8985_06125 NCTC9001_01571 NCTC9036_01391 NCTC9045_01523 NCTC9048_01374 NCTC9050_04622 NCTC9073_04580 NCTC9075_01955 NCTC9081_05610 NCTC9111_01964 NCTC9117_01852 NCTC9434_01268 NCTC9703_01118 NCTC9706_04594 NCTC9775_05117 NCTC9962_00728 NCTC9969_01508 ND22_000592 PGD_00685 PU06_05405 RG28_09115 SAMEA3472043_01057 SAMEA3472044_03008 SAMEA3472056_00896 SAMEA3472064_02137 SAMEA3472120_01063 SAMEA3472147_00187 SAMEA3484427_00462 SAMEA3484429_00571 SAMEA3485101_04514 SAMEA3485110_01302 SAMEA3751407_01508 SAMEA3752386_01589 SAMEA3752557_00947 SAMEA3753064_03078 SAMEA3753290_03574 SAMEA3753300_01048 SM09_02715 THOESC010_12030 TUM18780_11460 WP2S18E08_12970 WP4S18E08_12050 WQ89_05835 WR15_01085] Serine hydroxymethyltransferase (SHMT) (Serine methylase) (EC 2.1.2.1)
[mel-32 CBG19673] Serine hydroxymethyltransferase (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Maternal effect lethal protein 32) (Serine methylase)
[glyA Mbar_A2316] Serine hydroxymethyltransferase (SHMT) (Serine methylase) (EC 2.1.2.1)
[glyA ADS93_000467 APX88_06960 AW086_23235 BE963_28540 BF271_000534 BIQ87_14795 BK373_05810 BM922_000772 BMT49_16285 BON66_22645 BOY03_000809 BWI89_00470 BXT93_06535 BZL69_10180 C4952_000260 C5715_18420 C6L19_002959 C9Z43_04835 CD42_000695 D9J03_16095 DL654_17835 DLW88_09995 DTM10_01365 DU321_15995 E5S61_11485 ELT17_11325 ELU85_22250 ELX69_03020 ERS085366_02068 EVY14_08630 EXX79_12825 F2N27_06105 F2N28_04750 F7F11_13365 F9386_06435 F9S83_11330 FHR00_11495 FQ021_17175 FZN30_09840 G3813_001156 GKE84_10505 GKZ24_21975 GQM13_00200 GSY44_13780 GUB08_19520 GW978_10675 GXU05_001359 GXV26_004518 H5C78_16745 HI055_002154 HIT56_001020 HJQ60_000984 HJU54_004474 HLU56_22225 HNC30_03090 HNC30_26270 HNC66_24350 HNC66_27245 HNC75_00195 HNC75_28170 HVX16_06650 IA00_000588 MJ49_18170 NCTC10082_03735 NCTC12950_01513 NCTC7922_00863 NCTC7927_01477 NCTC9044_00307 NCTC9077_01684 NCTC9702_01552 NCTC9777_02594 SAMEA3472112_00758 SAMEA3472117_01110 SAMEA3752312_00040 WP4S18E07_12400] Serine hydroxymethyltransferase (SHMT) (Serine methylase) (EC 2.1.2.1)
[glyA MTH_1380] Serine hydroxymethyltransferase (SHMT) (Serine methylase) (EC 2.1.2.-)
[glyA MSMEG_5249 MSMEI_5111] Serine hydroxymethyltransferase (SHMT) (Serine methylase) (EC 2.1.2.1)
[cobA cysG cysG_1 A6519_000364 A8C65_03385 A8W81_000171 A9X72_01910 AAG43_001988 ACN002_3449 ACU57_16475 AM464_09505 AML23_10875 APX88_19990 AT335_001457 AT845_000838 AUQ29_05615 AW059_21670 B6R12_000433 B6R15_000438 B6R17_004119 B6R27_002236 B6R48_002892 B6R87_002674 B7C15_000091 B9T59_15360 BANRA_02000 BANRA_03616 BB545_11980 BFL24_22825 BG944_001170 BHF52_03295 BHS81_20170 BHS87_18900 BJI68_14980 BJJ90_01855 BK272_13250 BK292_07805 BMT50_12020 BMT91_03480 BN17_33031 BO068_001511 BON72_01440 BON73_10630 BON76_01755 BON86_09425 BON87_12715 BON92_08155 BON93_16715 BON94_27630 BON95_18940 BON96_09170 BON98_09595 BTQ06_10895 BUE81_05565 BUE82_00790 BvCmsHHP019_00453 BvCmsHHP056_00471 BvCmsKKP036_03618 BvCmsKKP057_01311 BvCmsKKP061_02746 BvCmsKSNP073_02778 BvCmsKSP011_02553 BvCmsKSP067_01776 BvCmsNSNP036_05030 BvCmsSIP082_00951 BVL39_09270 BXT93_04970 C2U48_16615 C3F40_19450 C5F72_02240 C5N07_12010 C5Y87_16100 C6B22_07295 C7B02_12700 C9160_13305 C9E67_02520 C9Z62_14100 CA593_09385 CCS08_20190 CD42_003636 CDL36_09890 CDL37_28050 CF32_001799 CG692_18475 CG831_001319 CN875_000031 CO706_15490 COD50_19655 CQP61_02825 CV83915_02742 D0X26_11130 D2183_13990 D3Y67_21055 D5H22_09295 D6T60_05985 D9D77_07850 D9F92_11480 D9H13_04530 D9J03_02940 D9K17_00290 DAH23_09650 DAH37_15045 DAH50_22180 DB282_10675 DLX40_09995 DM968_13795 DN627_01935 DP258_06300 DRW19_01875 DS732_24620 DTL43_13910 DXT71_09335 DXT73_15385 E0I42_11615 E0N24_03815 E2119_04420 E2123_13315 E2127_11625 E2128_02995 E2129_07715 E2135_05845 E4K51_10410 E4K54_10570 E5S34_10830 E5S38_11725 E5S61_12510 EAN77_07220 EAX79_11000 EC1094V2_285 EC3234A_57c00300 ECs4219 EGC08_07930 EH88_003902 EHD79_06180 EHH55_25160 EI041_10445 EIA13_10190 EIZ93_01520 EL79_0346 EL80_0339 ELT21_04095 ELT49_16745 ELT58_15470 ELV08_06310 ELX76_05275 ELY05_18405 ERS085366_00167 ERS139208_04133 ETECE925_00419 ExPECSC038_01180 EXX13_13990 EYX47_06865 EYX55_20730 F3N40_09040 F6U69_10365 F9400_11935 F9407_18885 F9S76_07985 F9V07_16735 F9V24_01660 F9X20_002305 F9X20_02300 FC554_09975 FDM60_01830 FGG80_13590 FKO60_13910 FMP09_05825 FOI11_018920 FOI11_04260 FQ021_15175 FQE77_01780 FQF29_05650 FV293_08795 FY127_06225 G4A38_16850 G5632_11415 G5696_11055 G7635_001600 G9448_16805 GAJ26_06530 GBE29_04490 GF646_05520 GF699_08140 GIB53_18980 GKF86_11410 GKF89_12400 GKG12_07200 GOP20_05305 GP650_08540 GP662_20205 GP946_11295 GQE42_03640 GQE87_04035 GQF58_07925 GQF59_06890 GQM09_05375 GQM10_10150 GQM13_20710 GQR15_07310 GQW76_01800 GQW80_09495 GRQ19_07870 GRW80_08835 GRW81_14155 GSY44_04895 GTP88_00155 GUC01_14450 H0O72_13320 H4P47_01965 H4P50_01695 H4P51_01685 HCF72_001194 HH795_001241 HHG09_001868 HHH44_000575 HIE44_001889 HJN04_002648 HJO75_000653 HJS37_002539 HJS41_003332 HLZ50_06645 HmCms184_03634 HMS79_01475 HMT08_09890 HMU48_07765 HMV95_07770 HNC38_10650 HNC52_07020 HNC59_07440 HNC99_05445 HND12_12975 HND24_08730 HNO08_01905 HNY50_07570 HNY54_08300 HPE39_23605 HV109_01850 HVV53_14305 HVW04_17265 HVW43_18400 HVY77_01835 HVZ33_01705 HVZ71_02090 HX136_01855 HZ71_001023 I6H00_19725 I6H01_10990 IA00_000722 NCTC10090_03474 NCTC10418_00625 NCTC10764_03803 NCTC10865_00602 NCTC13148_03528 NCTC13216_01418 NCTC4450_02421 NCTC8008_05413 NCTC8179_05884 NCTC8500_00246 NCTC9045_00486 NCTC9048_00450 NCTC9111_00814 NCTC9117_00666 NCTC9703_04912 PGD_00517 RG28_21890 SAMEA3472044_01095 SAMEA3472064_02718 SAMEA3472080_02892 SAMEA3472120_03946 SAMEA3484427_00030 SAMEA3484429_02801 SAMEA3485110_02595 SAMEA3751407_00091 SAMEA3752386_02356 SAMEA3753064_01813 SAMEA3753290_02445 SAMEA3753300_02295 SM09_03621 THOESC010_03830 TUM18780_03830 WP2S18E08_03400 WP4S18E08_03640 WQ89_11825 WR15_02785] Siroheme synthase [Includes: Uroporphyrinogen-III C-methyltransferase (Urogen III methylase) (EC 2.1.1.107) (SUMT) (Uroporphyrinogen III methylase) (UROM); Precorrin-2 dehydrogenase (EC 1.3.1.76); Sirohydrochlorin ferrochelatase (EC 4.99.1.4)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Capsid protein) (Core protein); Protein prM (Precursor membrane protein); Peptide pr (Peptide precursor); Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[glyA OR37_03805] Serine hydroxymethyltransferase (SHMT) (Serine methylase) (EC 2.1.2.1)
[glyA OR16_35110] Serine hydroxymethyltransferase (SHMT) (Serine methylase) (EC 2.1.2.1)
[glyA OR214_01806] Serine hydroxymethyltransferase (SHMT) (Serine methylase) (EC 2.1.2.1)
[glyA OR1_02280] Serine hydroxymethyltransferase (SHMT) (Serine methylase) (EC 2.1.2.1)
[glyA_1 glyA ACTI_12160] Serine hydroxymethyltransferase (SHMT) (Serine methylase) (EC 2.1.2.1)
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Non-structural protein 2A-alpha (NS2A-alpha); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[stk-1 bur1 B20D17.070 NCU01435] Serine/threonine-protein kinase bur1 (EC 2.7.11.22) (EC 2.7.11.23) (Serine-threonine kinase 1)
[glyA SAMN04487830_10882] Serine hydroxymethyltransferase (SHMT) (Serine methylase) (EC 2.1.2.1)
[GP1 MZ11_60484gpGP1 MZ11_60553gpGP1] Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease/Helicase NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (NS5)]
[glyA_2 glyA ACTI_25420] Serine hydroxymethyltransferase (SHMT) (Serine methylase) (EC 2.1.2.1)
[glyA GY22_01245] Serine hydroxymethyltransferase (SHMT) (Serine methylase) (EC 2.1.2.1)
[] Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core protein (p21); Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); Viroporin p7; Protease NS2 (p23) (EC 3.4.22.-) (Non-structural protein 2) (NS2); Serine protease/helicase NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3 helicase) (NS3 protease) (NS3P) (Viroporin p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56/58); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]

Bibliography :
[11469716] Update on antifolate drugs targets.