GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

Serine hydroxymethyltransferase 2, mitochondrial (AtSHMT2) (EC 2.1.2.1) (Glycine hydroxymethyltransferase 2) (Serine methylase 2)

 GLYM2_ARATH             Reviewed;         517 AA.
Q94C74; C0Z258; Q8GRI1;
29-MAY-2013, integrated into UniProtKB/Swiss-Prot.
29-MAY-2013, sequence version 2.
02-JUN-2021, entry version 115.
RecName: Full=Serine hydroxymethyltransferase 2, mitochondrial {ECO:0000303|PubMed:10806255};
Short=AtSHMT2 {ECO:0000303|PubMed:31873125};
EC=2.1.2.1 {ECO:0000269|PubMed:31873125};
AltName: Full=Glycine hydroxymethyltransferase 2 {ECO:0000305};
AltName: Full=Serine methylase 2 {ECO:0000305};
Flags: Precursor;
Name=SHM2 {ECO:0000303|PubMed:10806255};
Synonyms=SHMT2 {ECO:0000303|PubMed:31873125};
OrderedLocusNames=At5g26780 {ECO:0000312|Araport:AT5G26780};
ORFNames=F2P16.40;
Arabidopsis thaliana (Mouse-ear cress).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
NCBI_TaxID=3702;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
PubMed=11130714; DOI=10.1038/35048507;
Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
Bevan M., Fransz P.F.;
"Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
Nature 408:823-826(2000).
[2]
GENOME REANNOTATION.
STRAIN=cv. Columbia;
PubMed=27862469; DOI=10.1111/tpj.13415;
Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
Town C.D.;
"Araport11: a complete reannotation of the Arabidopsis thaliana reference
genome.";
Plant J. 89:789-804(2017).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
STRAIN=cv. Columbia;
PubMed=14593172; DOI=10.1126/science.1088305;
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
Ecker J.R.;
"Empirical analysis of transcriptional activity in the Arabidopsis
genome.";
Science 302:842-846(2003).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
STRAIN=cv. Columbia;
PubMed=19423640; DOI=10.1093/dnares/dsp009;
Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M.,
Shinozaki K.;
"Analysis of multiple occurrences of alternative splicing events in
Arabidopsis thaliana using novel sequenced full-length cDNAs.";
DNA Res. 16:155-164(2009).
[5]
GENE FAMILY, AND NOMENCLATURE.
PubMed=10806255; DOI=10.1104/pp.123.1.381;
McClung C.R., Hsu M., Painter J.E., Gagne J.M., Karlsberg S.D.,
Salome P.A.;
"Integrated temporal regulation of the photorespiratory pathway. Circadian
regulation of two Arabidopsis genes encoding serine
hydroxymethyltransferase.";
Plant Physiol. 123:381-392(2000).
[6]
REVIEW.
PubMed=12730263; DOI=10.1093/jxb/erg171;
Bauwe H., Kolukisaoglu U.;
"Genetic manipulation of glycine decarboxylation.";
J. Exp. Bot. 54:1523-1535(2003).
[7]
IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION [LARGE SCALE
ANALYSIS].
STRAIN=cv. Landsberg erecta;
PubMed=14671022; DOI=10.1105/tpc.016055;
Heazlewood J.L., Tonti-Filippini J.S., Gout A.M., Day D.A., Whelan J.,
Millar A.H.;
"Experimental analysis of the Arabidopsis mitochondrial proteome highlights
signaling and regulatory components, provides assessment of targeting
prediction programs, and indicates plant-specific mitochondrial proteins.";
Plant Cell 16:241-256(2004).
[8]
TISSUE SPECIFICITY, FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=16339799; DOI=10.1104/pp.105.071399;
Voll L.M., Jamai A., Renne P., Voll H., McClung C.R., Weber A.P.;
"The photorespiratory Arabidopsis shm1 mutant is deficient in SHM1.";
Plant Physiol. 140:59-66(2006).
[9]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
STRAIN=cv. Landsberg erecta;
PubMed=17272265; DOI=10.1074/mcp.m600408-mcp200;
Maor R., Jones A., Nuehse T.S., Studholme D.J., Peck S.C., Shirasu K.;
"Multidimensional protein identification technology (MudPIT) analysis of
ubiquitinated proteins in plants.";
Mol. Cell. Proteomics 6:601-610(2007).
[10]
GENE FAMILY.
PubMed=20518745; DOI=10.1042/bj20100566;
Zhang Y., Sun K., Sandoval F.J., Santiago K., Roje S.;
"One-carbon metabolism in plants: characterization of a plastid serine
hydroxymethyltransferase.";
Biochem. J. 430:97-105(2010).
[11]
TISSUE SPECIFICITY, AND FUNCTION.
PubMed=21976482; DOI=10.1104/pp.111.184564;
Engel N., Ewald R., Gupta K.J., Zrenner R., Hagemann M., Bauwe H.;
"The presequence of Arabidopsis serine hydroxymethyltransferase SHM2
selectively prevents import into mesophyll mitochondria.";
Plant Physiol. 157:1711-1720(2011).
[12]
X-RAY CRYSTALLOGRAPHY (1.54 ANGSTROMS) OF 54-517 IN COMPLEX WITH SERINE AND
THE ANTIFOLATES METHOTREXATE AND PEMETREXED, FUNCTION, CATALYTIC ACTIVITY,
COFACTOR, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, AND SUBUNIT.
PubMed=31873125; DOI=10.1038/s41598-019-56043-4;
Ruszkowski M., Sekula B., Ruszkowska A., Contestabile R., Nogues I.,
Angelaccio S., Szczepaniak A., Dauter Z.;
"Structural basis of methotrexate and pemetrexed action on serine
hydroxymethyltransferases revealed using plant models.";
Sci. Rep. 9:19614-19614(2019).
-!- FUNCTION: Functions outside the photorespiratory pathway in catalyzing
the interconversion of serine and glycine with the conversion of
tetrahydrofolate (THF) into 5,10-methylene-THF.
{ECO:0000269|PubMed:16339799, ECO:0000269|PubMed:21976482,
ECO:0000269|PubMed:31873125}.
-!- CATALYTIC ACTIVITY:
Reaction=(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O =
(6S)-5,6,7,8-tetrahydrofolate + L-serine; Xref=Rhea:RHEA:15481,
ChEBI:CHEBI:15377, ChEBI:CHEBI:15636, ChEBI:CHEBI:33384,
ChEBI:CHEBI:57305, ChEBI:CHEBI:57453; EC=2.1.2.1;
Evidence={ECO:0000269|PubMed:31873125};
-!- COFACTOR:
Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
Evidence={ECO:0000269|PubMed:31873125};
-!- ACTIVITY REGULATION: Inhibited by the antifolate drugs methotrexate and
pemetrexed. {ECO:0000269|PubMed:31873125}.
-!- BIOPHYSICOCHEMICAL PROPERTIES:
Kinetic parameters:
KM=11.65 mM for L-serine (at pH 6.5 and 30 degrees Celsius)
{ECO:0000269|PubMed:31873125};
KM=8.05 mM for L-serine (at pH 7.0 and 30 degrees Celsius)
{ECO:0000269|PubMed:31873125};
KM=2.86 mM for L-serine (at pH 8.0 and 30 degrees Celsius)
{ECO:0000269|PubMed:31873125};
KM=1.78 mM for L-serine (at pH 8.5 and 30 degrees Celsius)
{ECO:0000269|PubMed:31873125};
KM=0.71 mM for L-serine (at pH 9.5 and 30 degrees Celsius)
{ECO:0000269|PubMed:31873125};
KM=83.6 uM for (6S)-5,6,7,8-tetrahydrofolate (at pH 6.5 and 30
degrees Celsius) {ECO:0000269|PubMed:31873125};
KM=153.6 uM for (6S)-5,6,7,8-tetrahydrofolate (at pH 7.0 and 30
degrees Celsius) {ECO:0000269|PubMed:31873125};
KM=143.9 uM for (6S)-5,6,7,8-tetrahydrofolate (at pH 8.0 and 30
degrees Celsius) {ECO:0000269|PubMed:31873125};
KM=196.1 uM for (6S)-5,6,7,8-tetrahydrofolate (at pH 8.5 and 30
degrees Celsius) {ECO:0000269|PubMed:31873125};
KM=192.4 uM for (6S)-5,6,7,8-tetrahydrofolate (at pH 9.5 and 30
degrees Celsius) {ECO:0000269|PubMed:31873125};
-!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
{ECO:0000305}.
-!- SUBUNIT: Homotetramer. {ECO:0000269|PubMed:31873125}.
-!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:14671022}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q94C74-1; Sequence=Displayed;
Name=2;
IsoId=Q94C74-2; Sequence=VSP_046514;
-!- TISSUE SPECIFICITY: Ubiquitous. Mainly expressed in the shoot apical
meristem and roots. Also detected in the leaf vasculature, especially
in the protoxylem and adjacent cell layers.
{ECO:0000269|PubMed:16339799, ECO:0000269|PubMed:21976482}.
-!- DISRUPTION PHENOTYPE: Does not display a lethal photorespiratory
phenotype when grown at ambient carbon dioxide.
{ECO:0000269|PubMed:16339799}.
-!- MISCELLANEOUS: [Isoform 2]: May be due to a competing acceptor splice
site. {ECO:0000305}.
-!- SIMILARITY: Belongs to the SHMT family. {ECO:0000305}.
---------------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
---------------------------------------------------------------------------
EMBL; AF007270; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CP002688; AED93602.1; -; Genomic_DNA.
EMBL; CP002688; AED93603.1; -; Genomic_DNA.
EMBL; CP002688; AED93604.1; -; Genomic_DNA.
EMBL; CP002688; ANM69726.1; -; Genomic_DNA.
EMBL; AY035117; AAK59622.1; -; mRNA.
EMBL; BT001097; AAN61005.1; -; mRNA.
EMBL; BT001113; AAN64177.1; -; mRNA.
EMBL; AK318672; BAH56787.1; -; mRNA.
RefSeq; NP_001331385.1; NM_001343982.1. [Q94C74-1]
RefSeq; NP_568488.2; NM_122560.2. [Q94C74-2]
RefSeq; NP_851080.1; NM_180749.4. [Q94C74-1]
RefSeq; NP_851081.1; NM_180750.2. [Q94C74-2]
PDB; 6SMN; X-ray; 1.63 A; A/B/C/D=41-517.
PDB; 6SMW; X-ray; 1.54 A; A/B/C/D=41-517.
PDBsum; 6SMN; -.
PDBsum; 6SMW; -.
SMR; Q94C74; -.
STRING; 3702.AT5G26780.3; -.
PaxDb; Q94C74; -.
PRIDE; Q94C74; -.
ProteomicsDB; 248433; -. [Q94C74-1]
EnsemblPlants; AT5G26780.1; AT5G26780.1; AT5G26780. [Q94C74-1]
EnsemblPlants; AT5G26780.2; AT5G26780.2; AT5G26780. [Q94C74-2]
EnsemblPlants; AT5G26780.3; AT5G26780.3; AT5G26780. [Q94C74-2]
EnsemblPlants; AT5G26780.4; AT5G26780.4; AT5G26780. [Q94C74-1]
GeneID; 832736; -.
Gramene; AT5G26780.1; AT5G26780.1; AT5G26780. [Q94C74-1]
Gramene; AT5G26780.2; AT5G26780.2; AT5G26780. [Q94C74-2]
Gramene; AT5G26780.3; AT5G26780.3; AT5G26780. [Q94C74-2]
Gramene; AT5G26780.4; AT5G26780.4; AT5G26780. [Q94C74-1]
KEGG; ath:AT5G26780; -.
Araport; AT5G26780; -.
TAIR; locus:2148463; AT5G26780.
eggNOG; KOG2467; Eukaryota.
HOGENOM; CLU_022477_0_1_1; -.
InParanoid; Q94C74; -.
OMA; FSGRWFD; -.
OrthoDB; 372408at2759; -.
PhylomeDB; Q94C74; -.
UniPathway; UPA00193; -.
PRO; PR:Q94C74; -.
Proteomes; UP000006548; Chromosome 5.
ExpressionAtlas; Q94C74; baseline and differential.
Genevisible; Q94C74; AT.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0005829; C:cytosol; IDA:TAIR.
GO; GO:0005747; C:mitochondrial respiratory chain complex I; IDA:TAIR.
GO; GO:0005739; C:mitochondrion; IDA:TAIR.
GO; GO:0009536; C:plastid; HDA:TAIR.
GO; GO:0050897; F:cobalt ion binding; IDA:TAIR.
GO; GO:0004372; F:glycine hydroxymethyltransferase activity; IDA:UniProtKB.
GO; GO:0030170; F:pyridoxal phosphate binding; IBA:GO_Central.
GO; GO:0070905; F:serine binding; IBA:GO_Central.
GO; GO:0008270; F:zinc ion binding; IDA:TAIR.
GO; GO:0046655; P:folic acid metabolic process; IBA:GO_Central.
GO; GO:0019264; P:glycine biosynthetic process from serine; IBA:GO_Central.
GO; GO:0006544; P:glycine metabolic process; IDA:UniProtKB.
GO; GO:0006565; P:L-serine catabolic process; IBA:GO_Central.
GO; GO:0006563; P:L-serine metabolic process; IDA:UniProtKB.
GO; GO:0006730; P:one-carbon metabolic process; IBA:GO_Central.
GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
GO; GO:0046653; P:tetrahydrofolate metabolic process; IBA:GO_Central.
CDD; cd00378; SHMT; 1.
Gene3D; 3.40.640.10; -; 1.
Gene3D; 3.90.1150.10; -; 1.
HAMAP; MF_00051; SHMT; 1.
InterPro; IPR015424; PyrdxlP-dep_Trfase.
InterPro; IPR015422; PyrdxlP-dep_Trfase_dom1.
InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
InterPro; IPR001085; Ser_HO-MeTrfase.
InterPro; IPR019798; Ser_HO-MeTrfase_PLP_BS.
InterPro; IPR039429; SHMT-like_dom.
PANTHER; PTHR11680; PTHR11680; 1.
Pfam; PF00464; SHMT; 1.
PIRSF; PIRSF000412; SHMT; 1.
SUPFAM; SSF53383; SSF53383; 1.
PROSITE; PS00096; SHMT; 1.
1: Evidence at protein level;
3D-structure; Alternative splicing; Mitochondrion; One-carbon metabolism;
Pyridoxal phosphate; Reference proteome; Transferase; Transit peptide.
TRANSIT 1..29
/note="Mitochondrion"
/evidence="ECO:0000255"
CHAIN 30..517
/note="Serine hydroxymethyltransferase 2, mitochondrial"
/id="PRO_0000422347"
REGION 148..150
/note="Pemetrexed binding"
/evidence="ECO:0000269|PubMed:31873125,
ECO:0007744|PDB:6SMN, ECO:0007744|PDB:6SMW"
REGION 184..186
/note="Methotrexate binding"
/evidence="ECO:0000269|PubMed:31873125,
ECO:0007744|PDB:6SMN"
BINDING 82
/note="L-serine"
/evidence="ECO:0000269|PubMed:31873125,
ECO:0007744|PDB:6SMN, ECO:0007744|PDB:6SMW"
BINDING 82
/note="Pemetrexed"
/evidence="ECO:0000269|PubMed:31873125,
ECO:0007744|PDB:6SMN, ECO:0007744|PDB:6SMW"
BINDING 102
/note="Pemetrexed"
/evidence="ECO:0000269|PubMed:31873125,
ECO:0007744|PDB:6SMN, ECO:0007744|PDB:6SMW"
BINDING 104
/note="L-serine"
/evidence="ECO:0000269|PubMed:31873125,
ECO:0007744|PDB:6SMN, ECO:0007744|PDB:6SMW"
BINDING 104
/note="Methotrexate"
/evidence="ECO:0000269|PubMed:31873125,
ECO:0007744|PDB:6SMN"
BINDING 104
/note="Pemetrexed"
/evidence="ECO:0000269|PubMed:31873125,
ECO:0007744|PDB:6SMN, ECO:0007744|PDB:6SMW"
BINDING 112
/note="L-serine"
/evidence="ECO:0000269|PubMed:31873125,
ECO:0007744|PDB:6SMN, ECO:0007744|PDB:6SMW"
BINDING 112
/note="Pemetrexed"
/evidence="ECO:0000269|PubMed:31873125,
ECO:0007744|PDB:6SMN, ECO:0007744|PDB:6SMW"
BINDING 177
/note="Pemetrexed"
/evidence="ECO:0000269|PubMed:31873125,
ECO:0007744|PDB:6SMN"
BINDING 232
/note="Pemetrexed"
/evidence="ECO:0000269|PubMed:31873125,
ECO:0007744|PDB:6SMN, ECO:0007744|PDB:6SMW"
BINDING 260
/note="L-serine"
/evidence="ECO:0000269|PubMed:31873125,
ECO:0007744|PDB:6SMN, ECO:0007744|PDB:6SMW"
BINDING 260
/note="Pemetrexed"
/evidence="ECO:0000269|PubMed:31873125,
ECO:0007744|PDB:6SMN, ECO:0007744|PDB:6SMW"
BINDING 286
/note="L-serine"
/evidence="ECO:0000269|PubMed:31873125,
ECO:0007744|PDB:6SMW"
BINDING 331
/note="Pemetrexed; via amide nitrogen"
/evidence="ECO:0000269|PubMed:31873125,
ECO:0007744|PDB:6SMN, ECO:0007744|PDB:6SMW"
BINDING 414
/note="Methotrexate"
/evidence="ECO:0000269|PubMed:31873125,
ECO:0007744|PDB:6SMN, ECO:0007744|PDB:6SMW"
BINDING 430
/note="L-serine"
/evidence="ECO:0000269|PubMed:31873125,
ECO:0007744|PDB:6SMN, ECO:0007744|PDB:6SMW"
BINDING 430
/note="Pemetrexed"
/evidence="ECO:0000269|PubMed:31873125,
ECO:0007744|PDB:6SMN, ECO:0007744|PDB:6SMW"
MOD_RES 286
/note="N6-(pyridoxal phosphate)lysine"
/evidence="ECO:0000250"
VAR_SEQ 368
/note="E -> ELDIRPTVIISYGLSMQ (in isoform 2)"
/evidence="ECO:0000303|PubMed:14593172"
/id="VSP_046514"
CONFLICT 430
/note="R -> H (in Ref. 3; AAK59622)"
/evidence="ECO:0000305"
HELIX 44..52
/evidence="ECO:0007829|PDB:6SMW"
HELIX 55..58
/evidence="ECO:0007829|PDB:6SMW"
HELIX 60..75
/evidence="ECO:0007829|PDB:6SMW"
STRAND 76..78
/evidence="ECO:0007829|PDB:6SMW"
HELIX 88..94
/evidence="ECO:0007829|PDB:6SMW"
HELIX 97..100
/evidence="ECO:0007829|PDB:6SMW"
STRAND 109..113
/evidence="ECO:0007829|PDB:6SMW"
HELIX 116..132
/evidence="ECO:0007829|PDB:6SMW"
TURN 137..139
/evidence="ECO:0007829|PDB:6SMW"
STRAND 140..143
/evidence="ECO:0007829|PDB:6SMW"
HELIX 149..160
/evidence="ECO:0007829|PDB:6SMW"
STRAND 166..170
/evidence="ECO:0007829|PDB:6SMW"
HELIX 172..174
/evidence="ECO:0007829|PDB:6SMW"
HELIX 178..180
/evidence="ECO:0007829|PDB:6SMW"
HELIX 192..195
/evidence="ECO:0007829|PDB:6SMW"
STRAND 196..201
/evidence="ECO:0007829|PDB:6SMW"
TURN 205..207
/evidence="ECO:0007829|PDB:6SMW"
STRAND 208..210
/evidence="ECO:0007829|PDB:6SMW"
HELIX 212..222
/evidence="ECO:0007829|PDB:6SMW"
STRAND 225..229
/evidence="ECO:0007829|PDB:6SMW"
HELIX 240..250
/evidence="ECO:0007829|PDB:6SMW"
STRAND 253..257
/evidence="ECO:0007829|PDB:6SMW"
HELIX 259..261
/evidence="ECO:0007829|PDB:6SMW"
HELIX 262..266
/evidence="ECO:0007829|PDB:6SMW"
HELIX 273..275
/evidence="ECO:0007829|PDB:6SMW"
STRAND 278..286
/evidence="ECO:0007829|PDB:6SMW"
STRAND 294..299
/evidence="ECO:0007829|PDB:6SMW"
STRAND 301..305
/evidence="ECO:0007829|PDB:6SMW"
STRAND 311..313
/evidence="ECO:0007829|PDB:6SMW"
HELIX 317..324
/evidence="ECO:0007829|PDB:6SMW"
TURN 325..328
/evidence="ECO:0007829|PDB:6SMW"
HELIX 334..346
/evidence="ECO:0007829|PDB:6SMW"
HELIX 350..372
/evidence="ECO:0007829|PDB:6SMW"
HELIX 378..380
/evidence="ECO:0007829|PDB:6SMW"
STRAND 383..390
/evidence="ECO:0007829|PDB:6SMW"
HELIX 391..394
/evidence="ECO:0007829|PDB:6SMW"
HELIX 398..407
/evidence="ECO:0007829|PDB:6SMW"
STRAND 413..415
/evidence="ECO:0007829|PDB:6SMW"
STRAND 428..433
/evidence="ECO:0007829|PDB:6SMW"
HELIX 434..438
/evidence="ECO:0007829|PDB:6SMW"
HELIX 443..466
/evidence="ECO:0007829|PDB:6SMW"
STRAND 468..471
/evidence="ECO:0007829|PDB:6SMW"
HELIX 472..481
/evidence="ECO:0007829|PDB:6SMW"
HELIX 483..501
/evidence="ECO:0007829|PDB:6SMW"
STRAND 506..508
/evidence="ECO:0007829|PDB:6SMW"
HELIX 510..512
/evidence="ECO:0007829|PDB:6SMW"
SEQUENCE 517 AA; 57342 MW; DB31BC2D18334E31 CRC64;
MALALRRLSS SVKKPISLLS SNGGSLRFMS SLSTAAMAES EKSRSSWIKQ LNASLDEIDP
EVADIIELEK ARQWKGFELI PSENFTSLSV MQAVGSVMTN KYSEGYPGAR YYGGNEYIDM
AETLCQKRAL EAFQLDPSKW GVNVQSLSGS PANFQVYTAL LKPHERIMAL DLPHGGHLSH
GYQTDTKKIS AVSIFFETMP YRLDENTGYI DYDQLEKSAV LFRPKLIVAG ASAYARLYDY
ARIRKVCNKQ KAVMLADMAH ISGLVAAGVI PSPFEYADVV TTTTHKSLRG PRGAMIFFRK
GLKEINKQGK EVMYDYEDRI NQAVFPGLQG GPHNHTITGL AVALKQARTP EYKAYQDQVL
RNCSKFAETL LAKGYDLVSG GTDNHLVLVN LKNKGIDGSR VEKVLELVHI AANKNTVPGD
VSAMVPGGIR MGTPALTSRG FIEEDFAKVA EYFDLAVKIA LKIKAESQGT KLKDFVATMQ
SNEKLQSEMS KLREMVEEYA KQFPTIGFEK ETMRYKE


Related products :

Catalog number Product name Quantity
GLYM_RABIT Rabbit ELISA Kit FOR Serine hydroxymethyltransferase, mitochondrial 96T
C94217Hu CLIA Kit for Serine Hydroxymethyltransferase 2, Mitochondrial (SHMT2) 96T/Kit
201-20-5303 SHMT2{serine hydroxymethyltransferase 2 (mitochondrial)}rabbit.pAb 0.2ml
CSB-EL021274BO Bovine Serine hydroxymethyltransferase, mitochondrial(SHMT2) ELISA kit 96T
CSB-EL021274HU Human Serine hydroxymethyltransferase, mitochondrial(SHMT2) ELISA kit 96T
GWB-B25DEC Anti- SHMT2 (serine hydroxymethyltransferase 2 (mitochondrial)) Antibody
G9674 Serine hydroxymethyltransferase, mitochondrial (SHMT2), Bovine, ELISA Kit 96T
G9675 Serine hydroxymethyltransferase, mitochondrial (SHMT2), Human, ELISA Kit 96T
G9676 Serine hydroxymethyltransferase, mitochondrial (SHMT2), Rabbit, ELISA Kit 96T
CSB-EL021274RB Rabbit Serine hydroxymethyltransferase, mitochondrial(SHMT2) ELISA kit SpeciesRabbit 96T
CSB-EL021274HU Human Serine hydroxymethyltransferase, mitochondrial(SHMT2) ELISA kit SpeciesHuman 96T
CSB-EL021274BO Bovine Serine hydroxymethyltransferase, mitochondrial(SHMT2) ELISA kit SpeciesBovine 96T
C94217Hu CLIA Kit for Serine Hydroxymethyltransferase 2, Mitochondrial (SHMT2) Organism: Homo sapiens (Human) 96T
CSB-EL021274RB Rabbit serine hydroxymethyltransferase 2 (mitochondrial) (SHMT2) ELISA kit, Species Rabbit, Sample Type serum, plasma 96T
CSB-EL021274BO Bovine serine hydroxymethyltransferase 2 (mitochondrial) (SHMT2) ELISA kit, Species Bovine, Sample Type serum, plasma 96T
CSB-EL021274HU Human serine hydroxymethyltransferase 2 (mitochondrial) (SHMT2) ELISA kit, Species Human, Sample Type serum, plasma 96T
SHMT2 SHMT2 Gene serine hydroxymethyltransferase 2 (mitochondrial)
20312174-1 SHMT | serine hydroxymethyltransferase ( 200 uL
AS05 075 SHMT | serine hydroxymethyltransferase 200 ul
AS05075 SHMT | serine hydroxymethyltransferase 200 ul
enz-199 Recombinant Human Serine Hydroxymethyltransferase 1 20
REN-199 Recombinant Human Serine Hydroxymethyltransferase 1 5
enz-199 Recombinant Human Serine Hydroxymethyltransferase 1 5
enz-199 Recombinant Human Serine Hydroxymethyltransferase 1 1mg
enz-199 Recombinant Human Serine Hydroxymethyltransferase 1 ENZYMES 1mg
Pathways :
WP2185: Purine metabolism
WP218: Serine and Glycine biosynthesis
WP1659: Glycine, serine and threonine metabolism
WP459: Serine Biosynthesis
WP2199: Seed Development
WP390: Serine-isocitrate lyase pathway
WP1348: Androgen Receptor Signaling Pathway
WP580: Dauer formation
WP1107: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP1373: GPCRs, Class C Metabotropic glutamate, pheromone
WP2085: miRNAs involved in DDR
WP525: Mitochondrial Unfolded-Protein Response
WP1379: Diurnally regulated genes with circadian orthologs
WP1321: Myometrial Relaxation and Contraction Pathways
WP537: Translation Factors
WP1301: Mitochondrial Gene Expression
WP1329: Alpha6-Beta4 Integrin Signaling Pathway
WP394: RNA interference and miRNA
WP1502: Mitochondrial biogenesis
WP79: Tryptophan metabolism
WP1380: Regulation of Actin Cytoskeleton
WP270: Tryptophan metabolism
WP1355: One Carbon Metabolism
WP368: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP426: Urea cycle and metabolism of amino groups

Related Genes :
[mel-32 gly-1 C05D11.11] Serine hydroxymethyltransferase (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Glycosylation-related protein 1) (Maternal effect lethal protein 32) (Serine methylase)
[SHMT2] Serine hydroxymethyltransferase, mitochondrial (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase)
[SHM1 SHMT1 STM At4g37930 F20D10.50] Serine hydroxymethyltransferase 1, mitochondrial (AtSHMT1) (EC 2.1.2.1) (Glycine hydroxymethyltransferase 1) (Serine Transhydroxymethyltransferase) (STM) (Serine methylase 1)
[SHMT1] Serine hydroxymethyltransferase, cytosolic (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase)
[cbs-2 NCU05805] Putative serine hydroxymethyltransferase, mitochondrial (SHMT) (EC 2.1.2.1) (Carnitine biosynthesis protein 2) (Glycine hydroxymethyltransferase) (Serine methylase)
[glyA MJ1597] Serine hydroxymethyltransferase (SHMT) (Serine methylase) (EC 2.1.2.-) (L-allo-threonine aldolase) (EC 4.1.2.49)
[glyA SSO0530 C22_021] Serine hydroxymethyltransferase (SHMT) (Serine methylase) (EC 2.1.2.-)
[for B13D24.080 NCU02274] Serine hydroxymethyltransferase, cytosolic (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase)
[mel-32 CBG19673] Serine hydroxymethyltransferase (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Maternal effect lethal protein 32) (Serine methylase)
[] Genome polyprotein [Cleaved into: Capsid protein C (Capsid protein) (Core protein); Protein prM (Precursor membrane protein); Peptide pr (Peptide precursor); Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core protein (p21); Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); Viroporin p7; Protease NS2 (p23) (EC 3.4.22.-) (Non-structural protein 2) (NS2); Serine protease/helicase NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3 helicase) (NS3 protease) (NS3P) (Viroporin p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56/58); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[] Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core protein (p21); Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); Viroporin p7; Protease NS2 (p23) (EC 3.4.22.-) (Non-structural protein 2) (NS2); Serine protease/helicase NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3 helicase) (NS3 protease) (NS3P) (Viroporin p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56/58); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core protein (p21); Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); Viroporin p7; Protease NS2 (p23) (EC 3.4.22.-) (Non-structural protein 2) (NS2); Serine protease/helicase NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3 helicase) (NS3 protease) (NS3P) (Viroporin p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56/58); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[panB b0134 JW0130] 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC 2.1.2.11) (Ketopantoate hydroxymethyltransferase) (KPHMT)
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Non-structural protein 2A-alpha (NS2A-alpha); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[glyA glyA_1 glyA_2 A6592_14990 A6V01_10205 A9819_14740 A9P13_06725 A9R57_17035 A9X72_06640 AC789_1c28870 ACN68_11065 ACN81_26330 ACU57_10365 ACU90_01480 AJ318_18670 AM270_07205 AM333_24105 AM340_13835 AM375_09895 AM446_08040 AM464_04555 AM465_11625 AMK83_11330 AML35_21420 APT94_12230 APU18_00220 AUQ13_13210 AUS26_21660 AW059_05835 AWB10_06915 AWE53_011135 AWF06_10785 AWF59_015515 AZZ83_002738 B6V57_13760 B7C53_13185 B9N33_21325 B9T59_21000 BANRA_01096 BANRA_03249 BANRA_04526 BB545_05765 BE930_26645 BEN53_15950 BFD68_15230 BHF03_05445 BHS81_15565 BHS87_14440 BIZ41_08400 BJJ90_06515 BK248_16595 BK292_20755 BK296_24735 BK334_05000 BK383_22950 BMA87_03665 BMT91_09735 BN17_18381 BOH76_09300 BON63_10745 BON65_16000 BON69_13980 BON72_11375 BON75_17550 BON76_02745 BON83_11490 BON86_12460 BON87_06630 BON91_13665 BON92_01435 BON94_05240 BON95_11620 BON96_15660 BON98_06450 BTQ06_16650 BUE81_08015 BvCms2454_04469 BvCms28BK_03571 BvCmsC61A_04045 BvCmsHHP001_04807 BvCmsHHP019_04807 BvCmsHHP056_01827 BvCmsKKP061_03866 BvCmsKSNP073_01448 BvCmsKSNP081_01882 BvCmsKSNP120_01524 BvCmsKSP011_00149 BvCmsKSP024_05132 BvCmsKSP026_04306 BvCmsKSP045_04937 BvCmsKSP067_00300 BvCmsKSP076_03105 BvCmsNSP006_04169 BvCmsNSP047_01388 BvCmsNSP072_00268 BvCmsOUP014_02947 BvCmsSINP011_00665 BvCmsSINP022_03373 BvCmsSIP019_03822 BvCmsSIP024_00172 BvCmsSIP044_05091 BVL39_14060 BW690_11160 BZL31_13560 C2M16_05810 C2U48_21330 C3F40_24180 C4K41_12485 C4M78_10995 C5F72_07325 C5F73_21145 C5N07_10120 C5P01_05565 C5P44_15270 C6669_15965 C6984_14790 C6B13_21295 C7235_06810 C7B02_18410 C7B06_11375 C7B07_12180 C7B18_15410 C9114_06115 C9160_04925 C9162_08630 C9162_10270 C9201_01345 C9306_06610 C9E25_16700 C9Z03_13460 C9Z28_02330 C9Z37_03160 C9Z70_02105 CA593_14065 CCZ17_22135 CDC27_13525 CDL37_24890 CG692_02590 CI641_005650 CJU64_15035 CO706_10645 COD30_01040 COD46_11495 CQB02_04280 CQP61_07880 CR538_06900 CR539_17760 CRD98_15105 CRM83_27500 CSB64_12605 CT144_14495 CT146_18460 CUB99_20320 CV83915_03566 CWS33_10015 CY655_16575 D0X26_11515 D2184_18720 D2185_06685 D3821_11450 D3822_04910 D3O91_03575 D3Y67_23910 D4023_19220 D4M76_06095 D4U49_06920 D4V08_04730 D5H35_00980 D6004_00975 D6C57_05365 D6T60_00210 D7Y10_10355 D7Z75_10255 D9610_05055 D9C99_14315 D9D20_07555 D9D31_00200 D9D43_10120 D9D44_02505 D9D94_08365 D9E34_00200 D9E35_16365 D9E49_14180 D9E73_02125 D9E88_12000 D9F87_12910 D9G11_06440 D9G42_20580 D9G69_17675 D9G95_02855 D9H36_02315 D9H53_16110 D9H70_10355 D9H94_08915 D9I18_09860 D9I20_05680 D9I87_02605 D9I88_00195 D9I97_07910 D9J11_04295 D9J44_00065 D9J61_05955 D9K48_25845 D9K54_09225 D9Z28_05545 DAH30_03300 DAH37_19280 DB359_21190 DD762_08650 DEN89_09995 DEO04_07790 DEO20_03140 DIV22_11305 DJ503_18895 DL473_00220 DL530_01205 DL545_07250 DL637_03235 DL705_14220 DL800_19190 DL979_10025 DLU82_05750 DLX40_16265 DM102_07515 DM129_09030 DM155_03215 DMZ30_07960 DMZ50_09430 DN627_11835 DN660_09565 DN808_02500 DNC98_15255 DND79_08125 DNI21_11195 DNQ45_17665 DNR41_15705 DNX30_07470 DOT59_09395 DOY61_05330 DOY67_03355 DP258_15495 DP277_03625 DQF57_10625 DQO13_10555 DQP61_06330 DRW19_07050 DS143_00505 DS732_18880 DS966_22280 DT034_06380 DTL90_08220 DTM25_14750 DTM45_08975 DU333_02675 DW236_17270 DWB25_06960 DXT69_13070 E0I42_02100 E0L04_08280 E2112_00875 E2115_11460 E2119_10045 E2123_03095 E2127_03895 E2128_10365 E2129_06195 E2134_09850 E2135_00925 E2148_02380 E2855_03302 E2863_03209 E4K51_06760 E4K53_07930 E4K55_07930 E4K60_01580 E4K61_07855 E5P24_04065 E5P28_04535 E5S34_19615 E5S43_07605 E5S44_13315 E5S56_14405 E5S58_10240 E5S62_23735 E8P32_09515 EA184_11720 EA191_06790 EA206_12455 EA211_05440 EA213_03870 EA214_08000 EA219_14665 EA239_20085 EA250_18765 EA433_04100 EA435_09915 EA834_17655 EAI42_06335 EAI52_19665 EAM59_02400 EAX79_07285 EB525_RS04225 EBM08_03545 EC3234A_44c01580 EC382_15885 EC95NR1_01776 ECONIH1_14870 ECTO124_01352 ECTO6_01280 ED600_07765 EEP23_02355 EG599_00980 EG808_01370 EGT48_08335 EH412_02345 EHD79_09830 EHH55_21865 EHJ36_02420 EI021_12085 EI041_00205 EIA08_10400 EIA21_07490 EIZ93_07135 EJC75_11775 EKI52_21985 EL75_1096 EL79_1107 EL80_1110 ELT23_19340 ELT31_20595 ELT33_03345 ELT48_12545 ELT49_01975 ELT58_05205 ELU82_10305 ELU96_08685 ELV00_06865 ELV08_03295 ELV13_09100 ELV15_02510 ELV22_09700 ELV24_05745 ELV28_12290 ELX56_04905 ELX68_07400 ELX70_20105 ELX76_10710 ELX79_06675 ELX83_16095 ELX96_00410 ELY05_02135 ELY23_05775 ELY24_12010 ELY32_00200 ELY41_08005 ELY48_14840 ELY50_14220 EO241_23265 EPS70_13640 EPS76_08265 EPS91_19980 EPS94_14085 EPT01_18840 EQ820_10275 EQ823_08585 EQ825_18935 EQO00_06860 ERS085362_00040 ERS085379_04333 ERS085386_03166 ERS150873_01393 EST51_07035 ETECE1373_01271 ETECE1441_01232 ETECE1649_01247 ETECE1779_01862 ETECE36_01998 ETECE925_01268 EWK56_23300 ExPECSC038_01065 ExPECSC065_04817 EXX06_10825 EXX13_08215 EXX23_06740 EXX24_12775 EXX53_08505 EXX55_09745 EXX71_04795 EXX87_17350 EYD11_06215 EYV18_00710 EYY27_06030 EYY34_01875 EYY78_04400 F0L67_03370 F1E19_02165 F6T45_05185 F6T51_12995 F6V70_03895 F7F23_03725 F7F26_02340 F7F56_23715 F7O57_19245 F9B07_15475 F9X20_023115 F9X20_23370 FAF34_016650 FKC84_09965 FKO60_11190 FNJ67_07365 FNJ69_11240 FORC82_1264 FPI65_15875 FQ915_02830 FQU83_08425 FRV13_24305 FV293_03860 FV295_11170 FV438_06615 FVA71_07455 FY127_12120 FZC17_18475 FZN26_05255 G3565_12530 G4276_06735 G4280_06840 G5603_17965 G5606_12485 G5608_06210 G5632_01555 G5668_02335 G5670_00205 G5680_13465 G5688_24595 G5697_04530 G5V60_06400 G6Z99_06510 G9448_21200 G9P50_05635 GE057_06230 GE087_22080 GE400_18550 GF199_04825 GFU47_11500 GFY48_07215 GHD50_04095 GIJ01_17000 GJ11_16620 GKF34_12575 GKF52_12220 GKF86_17780 GKF89_05430 GKG12_07765 GNZ05_14090 GP650_10840 GP662_02580 GP666_02545 GP698_19205 GP711_05685 GP720_22435 GP935_11620 GP945_11645 GP946_10000 GP979_10170 GQA06_16300 GQE22_07385 GQE33_09975 GQE34_03490 GQE36_02650 GQE42_05365 GQE64_06945 GQE67_19620 GQE87_13230 GQF59_04220 GQM04_00640 GQM09_02785 GQM10_02125 GQM17_07935 GQM18_19095 GQM28_13535 GQN24_02860 GQY14_14475 GRC73_00195 GRW02_20740 GRW05_03265 GRW30_19760 GRW57_19155 GRW80_05730 GRW81_03155 GUB91_01280 GUB95_04310 GUC01_12805 GUC12_04295 GUI33_10120 GXC14_11205 H4P50_05960 H4P51_06005 H5C68_05160 HAP53_20655 HCR07_24930 HF523_06100 HF527_06645 HFD31_002198 HFD39_000189 HFD59_000090 HFD69_002352 HFU80_000028 HGR17_08250 HGR36_02290 HGR87_13865 HGR88_00195 HGS12_16410 HGS82_11040 HGS97_10550 HGT58_15140 HH117_09295 HH456_001625 HH707_002617 HH814_002559 HH830_000040 HHA77_001253 HHG54_001845 HHH24_000382 HHH97_001823 HHJ41_15465 HHJ44_09100 HI083_000039 HIA56_001242 HIB31_003523 HIO03_000886 HIQ74_002391 HIQ82_000219 HIR91_002952 HIZ62_003212 HJ359_002781 HJ411_002453 HJI76_000359 HJL93_002153 HJM41_000042 HJO02_003184 HJO44_001103 HJO53_003972 HJP34_000872 HJQ03_000516 HJR60_003358 HJR92_001425 HJS12_001859 HJS53_003090 HJT66_002321 HK427_000985 HKA14_000384 HKA45_001854 HKA57_000983 HKC58_003405 HL152_19545 HL186_05450 HL465_14670 HL601_02375 HLI97_000690 HLQ75_09655 HLQ92_00950 HLU13_19690 HLZ85_08730 HmCms169_04039 HmCms184_00602 HmCmsJML074_00191 HmCmsJML079_04828 HmCmsJML146_04464 HMG20_09650 HMG24_01210 HMG27_02150 HMG35_00950 HMP86_13620 HMP86_24525 HMQ05_16520 HMT01_03945 HMT08_05325 HMT08_28380 HMW26_06805 HMW26_28165 HNC38_16630 HNC38_26370 HNC40_08530 HNC40_27385 HNC59_20705 HNC59_28930 HNC73_12500 HNC73_26670 HNC80_18735 HNC80_27070 HNC88_02060 HNC88_27355 HNC94_04915 HNC94_26920 HNC99_17785 HNC99_29050 HND23_06660 HND23_27540 HNN86_18885 HNO03_06685 HNO08_08705 HNO42_16020 HNV44_18575 HNV91_10460 HNV94_19600 HNX16_07685 HNX34_06135 HP431_20395 HPE52_04585 HPM96_16240 HR075_06590 HS093_20060 HV005_05690 HV021_05775 HV022_05775 HV055_06710 HV065_11870 HV068_06050 HV098_06520 HV108_06675 HV109_05985 HV146_17215 HV149_06375 HV152_06330 HV156_20395 HV159_22270 HV168_21965 HV188_17615 HV226_11950 HV244_05880 HV297_05800 HV303_07355 HV348_06480 HVV37_22565 HVV39_04750 HVV70_15920 HVV73_06155 HVV78_16615 HVW04_22285 HVW09_17305 HVW11_17560 HVW22_13955 HVW33_21775 HVW37_06365 HVW43_23585 HVW45_06400 HVW59_20365 HVW60_05855 HVW76_05965 HVW90_20260 HVW98_16645 HVX00_06430 HVX22_05995 HVX24_05750 HVX28_06285 HVX31_05585 HVX33_20210 HVX51_07080 HVX60_22545 HVX69_06700 HVX96_20765 HVY01_05855 HVY77_07055 HVY79_16750 HVY93_05970 HVZ20_17300 HVZ21_06625 HVZ24_05790 HVZ29_15375 HVZ30_05585 HVZ33_06220 HVZ44_05930 HVZ53_06605 HVZ62_20840 HVZ71_06400 HX136_06045 HZT35_24215 IB283_16160 IMQ59_06535 JE86ST02C_30360 JE86ST05C_30410 MS6198_28810 MS8345_02738 NCTC10089_01301 NCTC10090_04352 NCTC10764_00540 NCTC10767_02577 NCTC10865_01632 NCTC11181_03553 NCTC13216_00621 NCTC13846_01415 NCTC7928_01404 NCTC8009_03153 NCTC8179_04380 NCTC8179_06948 NCTC8450_04313 NCTC8621_01385 NCTC8959_02478 NCTC8960_04038 NCTC8985_06125 NCTC9001_01571 NCTC9007_03666 NCTC9036_01391 NCTC9045_01523 NCTC9050_04622 NCTC9055_03269 NCTC9062_01811 NCTC9073_04580 NCTC9075_01955 NCTC9081_05610 NCTC9111_01964 NCTC9117_01852 NCTC9119_01502 NCTC9434_01268 NCTC9703_01118 NCTC9706_04594 NCTC9962_00728 NCTC9969_01508 PGD_00685 PU06_05405 RG28_09115 RG36_16460 RK56_022040 RX35_01444 SAMEA3472043_01057 SAMEA3472044_03008 SAMEA3472047_01010 SAMEA3472055_00914 SAMEA3472056_00896 SAMEA3472070_00043 SAMEA3472114_03227 SAMEA3472147_00187 SAMEA3484427_00462 SAMEA3484429_00571 SAMEA3484434_00274 SAMEA3485101_04514 SAMEA3751407_01508 SAMEA3752553_02326 SAMEA3752557_00947 SAMEA3752559_00670 SAMEA3753064_03078 SAMEA3753097_02774 SAMEA3753290_03574 SAMEA3753300_01048 SK85_02807 SY51_14610 TUM18780_11460 UC41_13350 UN86_05050 WP2S18E08_12970 WP4S17E03_12190 WP4S17E08_12400 WP4S18E08_12050 WP5S18E08_12720 WP5S18E09_12280 WP7S17E04_11090 WP7S18E09_12590 WQ89_05835 WR15_01085 YDC107_1129] Serine hydroxymethyltransferase (SHMT) (Serine methylase) (EC 2.1.2.1)
[GP1 MZ11_60484gpGP1 MZ11_60553gpGP1] Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (NS5)]
[] Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core protein (p21); Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); Viroporin p7; Protease NS2 (p23) (EC 3.4.22.-) (Non-structural protein 2) (NS2); Serine protease/helicase NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3 helicase) (NS3 protease) (NS3P) (Viroporin p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56/58); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[] Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core protein (p21); Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); Viroporin p7; Protease NS2 (p23) (EC 3.4.22.-) (Non-structural protein 2) (NS2); Serine protease/helicase NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3 helicase) (NS3 protease) (NS3P) (Viroporin p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56/58); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[] Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core protein (p21); Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); Viroporin p7; Protease NS2 (p23) (EC 3.4.22.-) (Non-structural protein 2) (NS2); Serine protease/helicase NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3 helicase) (NS3 protease) (NS3P) (Viroporin p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56/58); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[] Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core protein (p21); Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); Viroporin p7; Protease NS2 (p23) (EC 3.4.22.-) (Non-structural protein 2) (NS2); Serine protease/helicase NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3 helicase) (NS3 protease) (NS3P) (Viroporin p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56/58); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[glyA Mbar_A2316] Serine hydroxymethyltransferase (SHMT) (Serine methylase) (EC 2.1.2.1)

Bibliography :
No related Items