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Set1 complex component spp1 (Set1C component spp1) (COMPASS component spp1) (Complex proteins associated with set1 protein spp1)

 SPP1_SCHPO              Reviewed;         424 AA.
O74508;
08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
01-NOV-1998, sequence version 1.
17-JUN-2020, entry version 116.
RecName: Full=Set1 complex component spp1;
Short=Set1C component spp1;
AltName: Full=COMPASS component spp1;
AltName: Full=Complex proteins associated with set1 protein spp1;
Name=spp1; ORFNames=SPCC594.05c;
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
Schizosaccharomyces.
NCBI_TaxID=284812;
[1] {ECO:0000312|EMBL:CAA20664.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=972 / ATCC 24843;
PubMed=11859360; DOI=10.1038/nature724;
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
Nurse P.;
"The genome sequence of Schizosaccharomyces pombe.";
Nature 415:871-880(2002).
[2] {ECO:0000305}
FUNCTION, AND COMPOSITION OF THE SET1 COMPLEX.
PubMed=12488447; DOI=10.1074/jbc.m209562200;
Roguev A., Schaft D., Shevchenko A., Aasland R., Shevchenko A.,
Stewart A.F.;
"High conservation of the Set1/Rad6 axis of histone 3 lysine 4 methylation
in budding and fission yeasts.";
J. Biol. Chem. 278:8487-8493(2003).
[3] {ECO:0000305}
COMPOSITION OF THE SET1 COMPLEX.
PubMed=14617822; DOI=10.1074/mcp.m300081-mcp200;
Roguev A., Shevchenko A., Schaft D., Thomas H., Stewart A.F.,
Shevchenko A.;
"A comparative analysis of an orthologous proteomic environment in the
yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe.";
Mol. Cell. Proteomics 3:125-132(2004).
-!- FUNCTION: The Set1 complex specifically methylates 'Lys-4' of histone
H3. {ECO:0000269|PubMed:12488447}.
-!- SUBUNIT: Component of the Set1 complex composed of ash2, sdc1, set1,
shg1, spp1, swd1, swd2 and swd3. {ECO:0000269|PubMed:12488447,
ECO:0000269|PubMed:14617822}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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EMBL; CU329672; CAA20664.1; -; Genomic_DNA.
PIR; T41449; T41449.
RefSeq; NP_587791.1; NM_001022784.2.
SMR; O74508; -.
BioGRID; 275596; 193.
STRING; 4896.SPCC594.05c.1; -.
iPTMnet; O74508; -.
MaxQB; O74508; -.
PaxDb; O74508; -.
PRIDE; O74508; -.
EnsemblFungi; SPCC594.05c.1; SPCC594.05c.1:pep; SPCC594.05c.
GeneID; 2539023; -.
KEGG; spo:SPCC594.05c; -.
EuPathDB; FungiDB:SPCC594.05c; -.
PomBase; SPCC594.05c; -.
HOGENOM; CLU_654092_0_0_1; -.
InParanoid; O74508; -.
KO; K14960; -.
OMA; MLGCDGC; -.
PhylomeDB; O74508; -.
PRO; PR:O74508; -.
Proteomes; UP000002485; Chromosome III.
GO; GO:0005829; C:cytosol; HDA:PomBase.
GO; GO:0000790; C:nuclear chromatin; IC:PomBase.
GO; GO:0005634; C:nucleus; HDA:PomBase.
GO; GO:0048188; C:Set1C/COMPASS complex; IDA:PomBase.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0070869; P:heterochromatin assembly involved in chromatin silencing; IC:PomBase.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
GO; GO:0051569; P:regulation of histone H3-K4 methylation; IMP:PomBase.
Gene3D; 3.30.40.10; -; 1.
InterPro; IPR037869; Spp1/CFP1.
InterPro; IPR019786; Zinc_finger_PHD-type_CS.
InterPro; IPR011011; Znf_FYVE_PHD.
InterPro; IPR001965; Znf_PHD.
InterPro; IPR019787; Znf_PHD-finger.
InterPro; IPR013083; Znf_RING/FYVE/PHD.
PANTHER; PTHR46174; PTHR46174; 2.
Pfam; PF00628; PHD; 1.
SMART; SM00249; PHD; 1.
SUPFAM; SSF57903; SSF57903; 1.
PROSITE; PS01359; ZF_PHD_1; 1.
PROSITE; PS50016; ZF_PHD_2; 1.
4: Predicted;
Metal-binding; Nucleus; Reference proteome; Zinc; Zinc-finger.
CHAIN 1..424
/note="Set1 complex component spp1"
/id="PRO_0000059337"
ZN_FING 118..168
/note="PHD-type"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00146"
SEQUENCE 424 AA; 48683 MW; 2963605C3DFCC0B9 CRC64;
MELTQENTEE NEKTHVESIV KFEDSNRGTI TDFHIETANN EEEKDANVIL NKSVKMEVEE
VNGHVDSSST ETDIEMQVIQ QPTIPKKPPV SAHRRGPRKH RGNANSQLNL STADHQRPLY
CICQKPDDGS WMLGCDGCED WFHGTCVNIP ESYNDLTVQY FCPKCTEEGK GITTWKRKCR
LRECSNPTRP NSNYCSDKHG VDFFREKVKL STVEPSAIKN LVLFAKKREE FQNLGTVGPT
LPSQVPPEVV YNFEIEEANR LNAEIVQLNK EKEVASNKKI FLQLIKDSSR RAVLAYKERE
GIKKDLCGFD SRLLFNQQQM NELWEKVSNG APLSLDMSID PSPESTCFTE KRRCAKHTSW
QVIFTEDFEL QESNILQKLN MKQTAKDVML EHQKQRCLPG IQYDGYARFC HEQLSPEKMA
NLLK


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Related Genes :
[ash2 SPBC13G1.08c] Set1 complex component ash2 (Set1C component ash2) (COMPASS component ash2) (Complex proteins associated with set1 protein ash2) (Lid2 complex component ash2) (Lid2C component ash2)
[SGPP1 SPP1] Sphingosine-1-phosphate phosphatase 1 (SPPase1) (Spp1) (hSPP1) (hSPPase1) (EC 3.1.3.-) (Sphingosine-1-phosphatase 1) (Sphingosine-1-phosphate phosphohydrolase 1) (SPP-1)
[SPP1 BNSP OPN PSEC0156] Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin)
[Sgpp1 Spp1 Spph1] Sphingosine-1-phosphate phosphatase 1 (SPP) (SPPase1) (mSPP1) (EC 3.1.3.-) (Sphingosine-1-phosphatase 1)
[SETD1A KIAA0339 KMT2F SET1 SET1A] Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.354) (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1)
[ash2 CG6677] Set1/Ash2 histone methyltransferase complex subunit ASH2 (Absent, small, or homeotic discs protein 2)
[ASH2L ASH2L1] Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein)
[Ash2l] Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein)
[Sgpp1] Sphingosine-1-phosphate phosphatase 1 (SPPase1) (Spp1) (EC 3.1.3.-) (Sphingosine-1-phosphatase 1)
[SETD1B KIAA1076 KMT2G SET1B] Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.354) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B)
[CXXC1 CFP1 CGBP PCCX1 PHF18] CXXC-type zinc finger protein 1 (CpG-binding protein) (PHD finger and CXXC domain-containing protein 1)
[Cxxc1 Cgbp Pccx1] CXXC-type zinc finger protein 1 (CpG-binding protein) (PHD finger and CXXC domain-containing protein 1)
[1] Terminase small subunit (G1P) (Terminase, small subunit gp1)
[yueB BSU31860] ESX secretion system protein YueB (Bacteriophage SPP1 adsorption protein YueB) (Bacteriophage SPP1 receptor protein YueB)
[Setd1b Kiaa1076 Set1b] Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.354) (SET domain-containing protein 1B)
[CLF ICU1 PIF1 PIF2 SDG1 SET1 At2g23380 F26B6.3] Histone-lysine N-methyltransferase CLF (EC 2.1.1.-) (Polycomb group protein CURLY LEAF) (Protein INCURVATA 1) (Protein SET DOMAIN GROUP 1) (Protein photoperiod insensitive flowering)
[set-1 T26A5.7] Histone-lysine N-methyltransferase set-1 (EC 2.1.1.361)
[set-1 18F11.100 NCU01206] Histone-lysine N-methyltransferase, H3 lysine-4 specific (EC 2.1.1.354) (COMPASS component set-1) (SET domain-containing protein 1)
[lid2 SPBP19A11.06 SPBP4H10.01] Lid2 complex component lid2 (Lid2C component lid2)
[SUDS3 SAP45 SDS3] Sin3 histone deacetylase corepressor complex component SDS3 (45 kDa Sin3-associated polypeptide) (Suppressor of defective silencing 3 protein homolog)
[cytb] Cytochrome b
[HCFC1 HCF1 HFC1] Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6]
[WDR5A At3g49660 T16K5.10] COMPASS-like H3K4 histone methylase component WDR5A (AtWDR5A)
[kgd Rv1248c] Multifunctional 2-oxoglutarate metabolism enzyme (2-hydroxy-3-oxoadipate synthase) (HOA synthase) (HOAS) (EC 2.2.1.5) (2-oxoglutarate carboxy-lyase) (2-oxoglutarate decarboxylase) (Alpha-ketoglutarate decarboxylase) (KG decarboxylase) (KGD) (EC 4.1.1.71) (Alpha-ketoglutarate-glyoxylate carboligase) [Includes: 2-oxoglutarate dehydrogenase E1 component (ODH E1 component) (EC 1.2.4.2) (Alpha-ketoglutarate dehydrogenase E1 component) (KDH E1 component); Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex E2 component) (ODH E2 component) (OGDC-E2) (Dihydrolipoamide succinyltransferase)]
[FAM20C DMP4] Extracellular serine/threonine protein kinase FAM20C (EC 2.7.11.1) (Dentin matrix protein 4) (DMP-4) (Golgi casein kinase) (Golgi-enriched fraction casein kinase) (GEF-CK)
[RBBP5 RBQ3] Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3)
[WDR5 BIG3] WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein)
[CXXC1] CXXC-type zinc finger protein 1 (CpG-binding protein) (PHD finger and CXXC domain-containing protein 1)
[Wdr5 Big Big3] WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein) (WD repeat-containing protein BIG-3)
[wdr-5.1 swd-3.1 tag-125 C14B1.4] WD repeat-containing protein wdr-5.1

Bibliography :