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Signal transducer and activator of transcription

 A0A2I3N366_PAPAN        Unreviewed;       791 AA.
A0A2I3N366;
28-FEB-2018, integrated into UniProtKB/TrEMBL.
28-FEB-2018, sequence version 1.
17-JUN-2020, entry version 15.
RecName: Full=Signal transducer and activator of transcription {ECO:0000256|RuleBase:RU046415};
Name=STAT5B {ECO:0000313|Ensembl:ENSPANP00000042459};
Papio anubis (Olive baboon).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
Cercopithecidae; Cercopithecinae; Papio.
NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000042459, ECO:0000313|Proteomes:UP000028761};
[1] {ECO:0000313|Ensembl:ENSPANP00000042459, ECO:0000313|Proteomes:UP000028761}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., Aqrawi P.A.,
Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., Bandaranaike D.B.,
Battles P.B., Bell A.B., Beltran B.B., Berhane-Mersha D.B., Bess C.B.,
Bickham C.B., Bolden T.B., Carter K.C., Chau D.C., Chavez A.C.,
Clerc-Blankenburg K.C., Coyle M.C., Dao M.D., Davila M.L.D.,
Davy-Carroll L.D., Denson S.D., Dinh H.D., Fernandez S.F., Fernando P.F.,
Forbes L.F., Francis C.F., Francisco L.F., Fu Q.F., Garcia-Iii R.G.,
Garrett T.G., Gross S.G., Gubbala S.G., Hirani K.H., Hogues M.H.,
Hollins B.H., Jackson L.J., Javaid M.J., Jhangiani S.J., Johnson A.J.,
Johnson B.J., Jones J.J., Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K.,
Kovar C.K., Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., Perez Y.P.,
Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., Rouhana J.R., Ruiz M.R.,
Ruiz S.-J.R., Saada N.S., Santibanez J.S., Scheel M.S., Schneider B.S.,
Simmons D.S., Sisson I.S., Tang L.-Y.T., Thornton R.T., Tisius J.T.,
Toledanes G.T., Trejos Z.T., Usmani K.U., Varghese R.V., Vattathil S.V.,
Vee V.V., Walker D.W., Weissenberger G.W., White C.W., Williams A.W.,
Woodworth J.W., Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N.,
Nazareth L.N., Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
"Whole Genome Assembly of Papio anubis.";
Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSPANP00000042459}
IDENTIFICATION.
Ensembl;
Submitted (JAN-2018) to UniProtKB.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU046415}.
Nucleus {ECO:0000256|RuleBase:RU046415}.
-!- SIMILARITY: Belongs to the transcription factor STAT family.
{ECO:0000256|RuleBase:RU046415}.
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EMBL; AHZZ02010382; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AHZZ02010383; -; NOT_ANNOTATED_CDS; Genomic_DNA.
Ensembl; ENSPANT00000058464; ENSPANP00000042459; ENSPANG00000021460.
GeneTree; ENSGT00990000203570; -.
Proteomes; UP000028761; Chromosome 16.
ExpressionAtlas; A0A2I3N366; baseline.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
GO; GO:0035259; F:glucocorticoid receptor binding; IEA:Ensembl.
GO; GO:0046983; F:protein dimerization activity; IEA:Ensembl.
GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0071363; P:cellular response to growth factor stimulus; IEA:Ensembl.
GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
GO; GO:0046543; P:development of secondary female sexual characteristics; IEA:Ensembl.
GO; GO:0046544; P:development of secondary male sexual characteristics; IEA:Ensembl.
GO; GO:0007565; P:female pregnancy; IEA:Ensembl.
GO; GO:0060397; P:growth hormone receptor signaling pathway via JAK-STAT; IEA:Ensembl.
GO; GO:0007595; P:lactation; IEA:Ensembl.
GO; GO:0019915; P:lipid storage; IEA:Ensembl.
GO; GO:0001553; P:luteinization; IEA:Ensembl.
GO; GO:0097531; P:mast cell migration; IEA:Ensembl.
GO; GO:0001779; P:natural killer cell differentiation; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO; GO:0045647; P:negative regulation of erythrocyte differentiation; IEA:Ensembl.
GO; GO:0048541; P:Peyer's patch development; IEA:Ensembl.
GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
GO; GO:0045579; P:positive regulation of B cell differentiation; IEA:Ensembl.
GO; GO:0045648; P:positive regulation of erythrocyte differentiation; IEA:Ensembl.
GO; GO:0045588; P:positive regulation of gamma-delta T cell differentiation; IEA:Ensembl.
GO; GO:0050729; P:positive regulation of inflammatory response; IEA:Ensembl.
GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
GO; GO:0045931; P:positive regulation of mitotic cell cycle; IEA:Ensembl.
GO; GO:0040018; P:positive regulation of multicellular organism growth; IEA:Ensembl.
GO; GO:0032825; P:positive regulation of natural killer cell differentiation; IEA:Ensembl.
GO; GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IEA:Ensembl.
GO; GO:0032819; P:positive regulation of natural killer cell proliferation; IEA:Ensembl.
GO; GO:0042448; P:progesterone metabolic process; IEA:Ensembl.
GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; IEA:Ensembl.
GO; GO:0030856; P:regulation of epithelial cell differentiation; IEA:Ensembl.
GO; GO:0019218; P:regulation of steroid metabolic process; IEA:Ensembl.
GO; GO:0032355; P:response to estradiol; IEA:Ensembl.
GO; GO:0070672; P:response to interleukin-15; IEA:Ensembl.
GO; GO:0070669; P:response to interleukin-2; IEA:Ensembl.
GO; GO:0070670; P:response to interleukin-4; IEA:Ensembl.
GO; GO:0033077; P:T cell differentiation in thymus; IEA:Ensembl.
GO; GO:0043029; P:T cell homeostasis; IEA:Ensembl.
GO; GO:0019530; P:taurine metabolic process; IEA:Ensembl.
CDD; cd10420; SH2_STAT5b; 1.
Gene3D; 1.10.532.10; -; 1.
Gene3D; 2.60.40.630; -; 1.
Gene3D; 3.30.505.10; -; 1.
InterPro; IPR008967; p53-like_TF_DNA-bd.
InterPro; IPR000980; SH2.
InterPro; IPR036860; SH2_dom_sf.
InterPro; IPR001217; STAT.
InterPro; IPR035858; STAT5a/5b.
InterPro; IPR035886; STAT5b_SH2.
InterPro; IPR036535; STAT_N_sf.
InterPro; IPR013800; STAT_TF_alpha.
InterPro; IPR015988; STAT_TF_coiled-coil.
InterPro; IPR013801; STAT_TF_DNA-bd.
InterPro; IPR012345; STAT_TF_DNA-bd_N.
InterPro; IPR013799; STAT_TF_prot_interaction.
PANTHER; PTHR11801; PTHR11801; 1.
PANTHER; PTHR11801:SF47; PTHR11801:SF47; 1.
Pfam; PF00017; SH2; 1.
Pfam; PF01017; STAT_alpha; 1.
Pfam; PF02864; STAT_bind; 1.
Pfam; PF02865; STAT_int; 1.
SMART; SM00252; SH2; 1.
SMART; SM00964; STAT_int; 1.
SUPFAM; SSF47655; SSF47655; 1.
SUPFAM; SSF48092; SSF48092; 1.
SUPFAM; SSF49417; SSF49417; 1.
SUPFAM; SSF55550; SSF55550; 1.
PROSITE; PS50001; SH2; 1.
3: Inferred from homology;
Activator {ECO:0000256|RuleBase:RU046415};
Coiled coil {ECO:0000256|SAM:Coils};
Cytoplasm {ECO:0000256|RuleBase:RU046415};
DNA-binding {ECO:0000256|RuleBase:RU046415};
Nucleus {ECO:0000256|RuleBase:RU046415};
Phosphoprotein {ECO:0000256|RuleBase:RU046415};
Reference proteome {ECO:0000313|Proteomes:UP000028761};
SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191,
ECO:0000256|RuleBase:RU046415};
Transcription {ECO:0000256|RuleBase:RU046415};
Transcription regulation {ECO:0000256|RuleBase:RU046415}.
DOMAIN 593..690
/note="SH2"
/evidence="ECO:0000259|PROSITE:PS50001"
COILED 148..168
/evidence="ECO:0000256|SAM:Coils"
COILED 215..235
/evidence="ECO:0000256|SAM:Coils"
SEQUENCE 791 AA; 90373 MW; A6A8865BD8021806 CRC64;
MAVWIQAQQL QGEALHQMQA LYGQHFPIEV RHYLSQWIES QAWDSIDLDN PQENIKATQL
LEGLVQELQK KAEHQVGEDG FLLKIKLGHY ATQLQNTYDR CPMELVRCIR HILYNEQRLV
REANNGSSPA GSLADAMSQK HLQINQTFEE LRLVTQDTEN ELKKLQQTQE YFIIQYQESL
RIQAQFGPLA QLSPQERLSR ETALQQKQVS LEAWLQREAQ TLQQYRVELA EKHQKTLQLL
RKQQTIILDD ELIQWKRRQQ LAGNGGPPEG SLDVLQSWCE KLAEIIWQNR QQIRRAEHLC
QQLPIPGPVE EMLAEVNATI TDIISALVTS TFIIEKQPPQ VLKTQTKFAA TVRLLVGGKL
NVHMNPPQVK ATIISEQQAK SLLKNENTRN FFSFPATCLI LNNCCVMEYH QATGTLSAHF
RNMSLKRIKR SDRRGAESVT EEKFTILFES QFSVGGNELV FQVKTLSLPV VVIVHGSQDN
NATATVLWDN AFAEPGRVPF AVPDKVLWPQ LCEALNMKFK AEVQSNRGLT KENLVFLAQK
LFNNSSSHLE DYSGLSVSWS QFNRENLPGR NYTFWQWFDG VMEVLKKHLK PHWNDGAILG
FVNKQQAHDL LINKPDGTFL LRFSDSEIGG ITIAWKFDSQ ERMFWNLMPF TTRDFSIRSL
ADRLGDLNYL IYVFPDRPKD EVYSKYYTPV PCESATAKAV DGYVKPQIKQ VVPEFVNASA
DAGSGSATYM DQAPSPAVCP QAHYNMYPQN PDSVLDTDGD FDLEDTMDVA RRVEELLGRP
MDSQWIPHAQ S


Related products :

Catalog number Product name Quantity
18-661-15004 Signal transducer and activator of transcription 1-alpha_beta - Transcription factor ISGF-3 components p91_p84 Polyclonal 0.1 mg
15-288-22758 Signal transducer and activator of transcription 1-alpha_beta - Transcription factor ISGF-3 components p91_p84 Polyclonal 0.1 mg
15-288-22758 Signal transducer and activator of transcription 1-alpha_beta - Transcription factor ISGF-3 components p91_p84 Polyclonal 0.05 mg
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15-288-22780 Signal transducer and activator of transcription 1-alpha_beta - Transcription factor ISGF-3 components p91_p84 Polyclonal 0.1 mg
15-288-22780 Signal transducer and activator of transcription 1-alpha_beta - Transcription factor ISGF-3 components p91_p84 Polyclonal 0.05 mg
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18-003-43847 Signal transducer and activator of transcription 1-alpha_beta - Transcription factor ISGF-3 components p91_p84 Polyclonal 0.05 mg Aff Pur
FP-0102 Signal transducer and activator of transcription 4. 10 ug
FP-0101 Signal transducer and activator of transcription 3 10 ug
FP-0104 Signal transducer and activator of transcription 5B. 10ug
FP-0102 Signal transducer and activator of transcription 4. 10ug
FP-0101 Signal transducer and activator of transcription 3 10ug
FP-0103 Signal transducer and activator of transcription 5A. 10 ug
FP-0105 Signal transducer and activator of transcription 6 10ug
FP-0104 Signal transducer and activator of transcription 5B. 10 ug
FP-0105 Signal transducer and activator of transcription 6 10 ug
FP-0103 Signal transducer and activator of transcription 5A. 10ug
E02S0211 Rat Signal Transducer And Activator Of Transcription 5B ELISA 96T/kit
E02S0210 Rat Signal Transducer And Activator Of Transcription 5A ELISA 96T/kit
FP-0100 Signal transducer and activator of transcription 2 (p113). 10ug
E02S0206 Rat Signal Transducer And Activator Of Transcription 4 ELISA 96T/kit
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EM1378 Signal Transducer And Activator Of Transcription 2 Elisa Kit 96T
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Pathways :
WP1965: VEGF-receptor Signal Transduction
WP1066: Eukaryotic Transcription Initiation
WP1198: Signal Transduction of S1P
WP405: Eukaryotic Transcription Initiation
WP518: Eukaryotic Transcription Initiation
WP1391: Signal Transduction of S1P
WP177: Eukaryotic Transcription Initiation
WP656: p53 signal pathway
WP948: Eukaryotic Transcription Initiation
WP1906: RNA Polymerase II Transcription
WP1930: Transcription
WP1182: Eukaryotic Transcription Initiation
WP344: Eukaryotic Transcription Initiation
WP491: Eukaryotic Transcription Initiation
WP1312: Signal Transduction of S1P
WP1546: Metapathway signal transduction
WP57: Signal Transduction of S1P Receptor
WP842: Signal Transduction of S1P
WP1905: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
WP1909: Signal regulatory protein (SIRP) family interactions
WP962: Signal Transduction of S1P
WP1081: Signal Transduction of S1P
WP26: Signal Transduction of S1P Receptor
WP425: Eukaryotic Transcription Initiation
WP1238: Eukaryotic Transcription Initiation

Related Genes :
[STAT1] Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84)
[STAT3 APRF] Signal transducer and activator of transcription 3 (Acute-phase response factor)
[STAT2] Signal transducer and activator of transcription 2 (p113)
[STAT5B] Signal transducer and activator of transcription 5B
[Stat3 Aprf] Signal transducer and activator of transcription 3 (Acute-phase response factor)
[STAT3] Signal transducer and activator of transcription 3
[STAT5A STAT5] Signal transducer and activator of transcription 5A
[Stat5b] Signal transducer and activator of transcription 5B
[Stat6] Signal transducer and transcription activator 6
[Stat1] Signal transducer and activator of transcription 1
[Stat3] Signal transducer and activator of transcription 3
[STAT3] Signal transducer and activator of transcription 3
[STAT1] Signal transducer and activator of transcription 1
[STAT6] Signal transducer and activator of transcription 6 (IL-4 Stat)
[Stat5a Mgf Mpf] Signal transducer and activator of transcription 5A (Mammary gland factor)
[Stat5b] Signal transducer and activator of transcription 5B
[Stat5a Mgf] Signal transducer and activator of transcription 5A (Mammary gland factor)
[Stat4] Signal transducer and activator of transcription 4
[Stat92E MARE mrL Stat CG4257] Signal transducer and transcription activator (d-STAT) (Protein marelle)
[STAT3 RCJMB04_38l20] Signal transducer and activator of transcription 3
[STAT4] Signal transducer and activator of transcription 4
[STAT5A MGF] Signal transducer and activator of transcription 5A (Mammary gland factor)
[STAT5A] Signal transducer and activator of transcription 5A
[STAT5B] Signal transducer and activator of transcription 5B
[STAT5B] Signal transducer and activator of transcription 5B
[STAT5A MGF STAT5] Signal transducer and activator of transcription 5A (Mammary gland factor)
[stat3.1 stat3] Signal transducer and activator of transcription 3.1 (Protein Stat3) (Xstat3)
[dstB statB DDB_G0268638] Signal transducer and activator of transcription B (Dd-STATb) (STAT5 homolog B)
[dstC statC DDB_G0293532] Signal transducer and activator of transcription C (Dd-STATc) (STAT5 homolog C)
[dstA stat5 statA DDB_G0281381] Signal transducer and activator of transcription A (Dd-STATa) (STAT5 homolog A)

Bibliography :
[32614965] Inflammation-driven activation of JAK/STAT signaling reversibly accelerates acute myeloid leukemia in vitro.
[32606809] Targeting IFN/STAT1 Pathway as a Promising Strategy to Overcome Radioresistance.
[32606591] Gastro-Protective Effects of Calycosin Against Precancerous Lesions of Gastric Carcinoma in Rats.
[32605912] Radiation with STAT3 blockade triggers dendritic cell-T cell interactions in the glioma microenvironment and therapeutic efficacy.
[32605129] Rounding up the Usual Suspects: Assessing Yorkie, AP-1, and Stat Coactivation in Tumorigenesis.
[32604799] HNG, A Humanin Analogue, Promotes Hair Growth by Inhibiting Anagen-to-Catagen Transition.
[32603980] Design, synthesis and biological evaluation of novel potent STAT3 inhibitors based on BBI608 for cancer therapy.
[32603894] Counteracting role of nuclear factor erythroid 2-related factor 2 pathway in Alzheimer's disease.
[32603428] Autosomal recessive complete STAT1 deficiency caused by compound heterozygous intronic mutations.
[32602014] IL-6 induces tumor suppressor protein tyrosine phosphatase receptor type D by inhibiting miR-34a to prevent IL-6 signaling overactivation.