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Signal transducer and activator of transcription

 A0A2K5KNY7_CERAT        Unreviewed;       787 AA.
A0A2K5KNY7;
28-MAR-2018, integrated into UniProtKB/TrEMBL.
28-MAR-2018, sequence version 1.
17-JUN-2020, entry version 16.
RecName: Full=Signal transducer and activator of transcription {ECO:0000256|RuleBase:RU046415};
Name=STAT5B {ECO:0000313|Ensembl:ENSCATP00000002403};
Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
Cercopithecidae; Cercopithecinae; Cercocebus.
NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000002403, ECO:0000313|Proteomes:UP000233060};
[1] {ECO:0000313|Ensembl:ENSCATP00000002403, ECO:0000313|Proteomes:UP000233060}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Liu Y., Hughes D.S., Murali S., Raveendran M., Korchina V., Wang M.,
Jhangiani S., Bandaranaike D., Bellair M., Blankenburg K., Chao H.,
Dahdouli M., Dinh H., Doddapaneni H., English A., Firestine M., Gross S.,
Hernandez B., Javaid M., Jayaseelan J., Jones J., Joshi V., Khan Z.,
Kovar C., Lee S., Newsham I., Nguyen L., Okwuonu G., Ongeri F., Osuji N.,
Pu L.-L., Puazo M., Qu C., Quiroz J., Raj R., Reid J.G., Santibanez J.,
Scheel M., Sexton D., Shah N., Skinner E., Vee V., Wu Y., Han Y.,
Muzny D.M., Richards S., Worley K.C., Rogers J., Gibbs R.A.;
"Sooty reference genome and diversity panel.";
Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSCATP00000002403}
IDENTIFICATION.
Ensembl;
Submitted (FEB-2018) to UniProtKB.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU046415}.
Nucleus {ECO:0000256|RuleBase:RU046415}.
-!- SIMILARITY: Belongs to the transcription factor STAT family.
{ECO:0000256|RuleBase:RU046415}.
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RefSeq; XP_011902081.1; XM_012046691.1.
RefSeq; XP_011902082.1; XM_012046692.1.
RefSeq; XP_011902083.1; XM_012046693.1.
RefSeq; XP_011902084.1; XM_012046694.1.
RefSeq; XP_011902085.1; XM_012046695.1.
Ensembl; ENSCATT00000011628; ENSCATP00000002403; ENSCATG00000009430.
GeneID; 105579668; -.
CTD; 6777; -.
GeneTree; ENSGT00990000203570; -.
OMA; IWLNRQQ; -.
OrthoDB; 327469at2759; -.
Proteomes; UP000233060; Whole Genome Shotgun Assembly.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
GO; GO:0035259; F:glucocorticoid receptor binding; IEA:Ensembl.
GO; GO:0046983; F:protein dimerization activity; IEA:Ensembl.
GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0071363; P:cellular response to growth factor stimulus; IEA:Ensembl.
GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
GO; GO:0046543; P:development of secondary female sexual characteristics; IEA:Ensembl.
GO; GO:0046544; P:development of secondary male sexual characteristics; IEA:Ensembl.
GO; GO:0007565; P:female pregnancy; IEA:Ensembl.
GO; GO:0060397; P:growth hormone receptor signaling pathway via JAK-STAT; IEA:Ensembl.
GO; GO:0007595; P:lactation; IEA:Ensembl.
GO; GO:0019915; P:lipid storage; IEA:Ensembl.
GO; GO:0001553; P:luteinization; IEA:Ensembl.
GO; GO:0097531; P:mast cell migration; IEA:Ensembl.
GO; GO:0001779; P:natural killer cell differentiation; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO; GO:0045647; P:negative regulation of erythrocyte differentiation; IEA:Ensembl.
GO; GO:0048541; P:Peyer's patch development; IEA:Ensembl.
GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
GO; GO:0045579; P:positive regulation of B cell differentiation; IEA:Ensembl.
GO; GO:0045648; P:positive regulation of erythrocyte differentiation; IEA:Ensembl.
GO; GO:0045588; P:positive regulation of gamma-delta T cell differentiation; IEA:Ensembl.
GO; GO:0050729; P:positive regulation of inflammatory response; IEA:Ensembl.
GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
GO; GO:0045931; P:positive regulation of mitotic cell cycle; IEA:Ensembl.
GO; GO:0040018; P:positive regulation of multicellular organism growth; IEA:Ensembl.
GO; GO:0032825; P:positive regulation of natural killer cell differentiation; IEA:Ensembl.
GO; GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IEA:Ensembl.
GO; GO:0032819; P:positive regulation of natural killer cell proliferation; IEA:Ensembl.
GO; GO:0042448; P:progesterone metabolic process; IEA:Ensembl.
GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; IEA:Ensembl.
GO; GO:0030856; P:regulation of epithelial cell differentiation; IEA:Ensembl.
GO; GO:0019218; P:regulation of steroid metabolic process; IEA:Ensembl.
GO; GO:0032355; P:response to estradiol; IEA:Ensembl.
GO; GO:0070672; P:response to interleukin-15; IEA:Ensembl.
GO; GO:0070669; P:response to interleukin-2; IEA:Ensembl.
GO; GO:0070670; P:response to interleukin-4; IEA:Ensembl.
GO; GO:0033077; P:T cell differentiation in thymus; IEA:Ensembl.
GO; GO:0043029; P:T cell homeostasis; IEA:Ensembl.
GO; GO:0019530; P:taurine metabolic process; IEA:Ensembl.
CDD; cd10420; SH2_STAT5b; 1.
Gene3D; 1.10.532.10; -; 1.
Gene3D; 2.60.40.630; -; 1.
Gene3D; 3.30.505.10; -; 1.
InterPro; IPR008967; p53-like_TF_DNA-bd.
InterPro; IPR000980; SH2.
InterPro; IPR036860; SH2_dom_sf.
InterPro; IPR001217; STAT.
InterPro; IPR035858; STAT5a/5b.
InterPro; IPR035886; STAT5b_SH2.
InterPro; IPR036535; STAT_N_sf.
InterPro; IPR013800; STAT_TF_alpha.
InterPro; IPR015988; STAT_TF_coiled-coil.
InterPro; IPR013801; STAT_TF_DNA-bd.
InterPro; IPR012345; STAT_TF_DNA-bd_N.
InterPro; IPR013799; STAT_TF_prot_interaction.
PANTHER; PTHR11801; PTHR11801; 1.
PANTHER; PTHR11801:SF47; PTHR11801:SF47; 1.
Pfam; PF00017; SH2; 1.
Pfam; PF01017; STAT_alpha; 1.
Pfam; PF02864; STAT_bind; 1.
Pfam; PF02865; STAT_int; 1.
SMART; SM00252; SH2; 1.
SMART; SM00964; STAT_int; 1.
SUPFAM; SSF47655; SSF47655; 1.
SUPFAM; SSF48092; SSF48092; 1.
SUPFAM; SSF49417; SSF49417; 1.
SUPFAM; SSF55550; SSF55550; 1.
PROSITE; PS50001; SH2; 1.
3: Inferred from homology;
Activator {ECO:0000256|RuleBase:RU046415};
Coiled coil {ECO:0000256|SAM:Coils};
Cytoplasm {ECO:0000256|RuleBase:RU046415};
DNA-binding {ECO:0000256|RuleBase:RU046415};
Nucleus {ECO:0000256|RuleBase:RU046415};
Phosphoprotein {ECO:0000256|RuleBase:RU046415};
Reference proteome {ECO:0000313|Proteomes:UP000233060};
SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191,
ECO:0000256|RuleBase:RU046415};
Transcription {ECO:0000256|RuleBase:RU046415};
Transcription regulation {ECO:0000256|RuleBase:RU046415}.
DOMAIN 589..686
/note="SH2"
/evidence="ECO:0000259|PROSITE:PS50001"
COILED 148..168
/evidence="ECO:0000256|SAM:Coils"
COILED 215..235
/evidence="ECO:0000256|SAM:Coils"
SEQUENCE 787 AA; 89942 MW; ADB0AABC2F5CBE37 CRC64;
MAVWIQAQQL QGEALHQMQA LYGQHFPIEV RHYLSQWIES QAWDSIDLDN PQENIKATQL
LEGLVQELQK KAEHQVGEDG FLLKIKLGHY ATQLQNTYDR CPMELVRCIR HILYNEQRLV
REANNGSSPA GSLADAMSQK HLQINQTFEE LRLVTQDTEN ELKKLQQTQE YFIIQYQESL
RIQAQFGPLA QLSPQERLSR ETALQQKQVS LEAWLQREAQ TLQQYRVELA EKHQKTLQLL
RKQQTIILDD ELIQWKRRQQ LAGNGGPPEG SLDMLQSWCE KLAEIIWQNR QQIRRAEHLC
QQLPIPGPVE EMLAEVNATI TDIISALVTS TFIIEKQPPQ VLKTQTKFAA TVRLLVGGKL
NVHMNPPQVK ATIISEQQAK SLLKNENTRN DYSGEILNNC CVMEYHQATG TLSAHFRNMS
LKRIKRSDRR GAESVTEEKF TILFESQFSV GGNELVFQVK TLSLPVVVIV HGSQDNNATA
TVLWDNAFAE PGRVPFAVPD KVLWPQLCEA LNMKFKAEVQ SNRGLTKENL VFLAQKLFNN
SSSHLEDYSG LSVSWSQFNR ENLPGRNYTF WQWFDGVMEV LKKHLKPHWN DGAILGFVNK
QQAHDLLINK PDGTFLLRFS DSEIGGITIA WKFDSQERMF WNLMPFTTRD FSIRSLADRL
GDLNYLIYVF PDRPKDEVYS KYYTPVPCES ATAKAVDGYV KPQIKQVVPE FVNASADAGS
GSATYMDQAP SPAVCPQAHY NMYPQNPDSV LDTDGDFDLE DTMDVARRVE ELLGRPMDSQ
WIPHAQS


Related products :

Catalog number Product name Quantity
18-661-15004 Signal transducer and activator of transcription 1-alpha_beta - Transcription factor ISGF-3 components p91_p84 Polyclonal 0.1 mg
15-288-22758 Signal transducer and activator of transcription 1-alpha_beta - Transcription factor ISGF-3 components p91_p84 Polyclonal 0.1 mg
15-288-22758 Signal transducer and activator of transcription 1-alpha_beta - Transcription factor ISGF-3 components p91_p84 Polyclonal 0.05 mg
18-003-44098 Signal transducer and activator of transcription 1-alpha_beta - Transcription factor ISGF-3 components p91_p84 Polyclonal 0.05 mg Aff Pur
15-288-22780 Signal transducer and activator of transcription 1-alpha_beta - Transcription factor ISGF-3 components p91_p84 Polyclonal 0.1 mg
15-288-22780 Signal transducer and activator of transcription 1-alpha_beta - Transcription factor ISGF-3 components p91_p84 Polyclonal 0.05 mg
18-003-43498 Signal transducer and activator of transcription 1-alpha_beta - Transcription factor ISGF-3 components p91_p84 Polyclonal 0.05 mg Aff Pur
18-003-43847 Signal transducer and activator of transcription 1-alpha_beta - Transcription factor ISGF-3 components p91_p84 Polyclonal 0.05 mg Aff Pur
FP-0102 Signal transducer and activator of transcription 4. 10 ug
FP-0101 Signal transducer and activator of transcription 3 10 ug
FP-0104 Signal transducer and activator of transcription 5B. 10ug
FP-0102 Signal transducer and activator of transcription 4. 10ug
FP-0101 Signal transducer and activator of transcription 3 10ug
FP-0103 Signal transducer and activator of transcription 5A. 10 ug
FP-0105 Signal transducer and activator of transcription 6 10ug
FP-0104 Signal transducer and activator of transcription 5B. 10 ug
FP-0105 Signal transducer and activator of transcription 6 10 ug
FP-0103 Signal transducer and activator of transcription 5A. 10ug
E02S0211 Rat Signal Transducer And Activator Of Transcription 5B ELISA 96T/kit
E02S0210 Rat Signal Transducer And Activator Of Transcription 5A ELISA 96T/kit
FP-0100 Signal transducer and activator of transcription 2 (p113). 10ug
E02S0206 Rat Signal Transducer And Activator Of Transcription 4 ELISA 96T/kit
pka-315 Recombinant Human Signal Transducer and Activator of Transcription 1 10
EM1378 Signal Transducer And Activator Of Transcription 2 Elisa Kit 96T
E02S0204 Rat Signal Transducer And Activator Of Transcription 3 ELISA 96T/kit
Pathways :
WP1965: VEGF-receptor Signal Transduction
WP1066: Eukaryotic Transcription Initiation
WP1198: Signal Transduction of S1P
WP405: Eukaryotic Transcription Initiation
WP518: Eukaryotic Transcription Initiation
WP1391: Signal Transduction of S1P
WP656: p53 signal pathway
WP177: Eukaryotic Transcription Initiation
WP948: Eukaryotic Transcription Initiation
WP1906: RNA Polymerase II Transcription
WP1930: Transcription
WP344: Eukaryotic Transcription Initiation
WP1182: Eukaryotic Transcription Initiation
WP1312: Signal Transduction of S1P
WP491: Eukaryotic Transcription Initiation
WP57: Signal Transduction of S1P Receptor
WP1546: Metapathway signal transduction
WP1905: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
WP842: Signal Transduction of S1P
WP962: Signal Transduction of S1P
WP1909: Signal regulatory protein (SIRP) family interactions
WP26: Signal Transduction of S1P Receptor
WP1081: Signal Transduction of S1P
WP1238: Eukaryotic Transcription Initiation
WP425: Eukaryotic Transcription Initiation

Related Genes :
[STAT1] Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84)
[STAT3 APRF] Signal transducer and activator of transcription 3 (Acute-phase response factor)
[STAT2] Signal transducer and activator of transcription 2 (p113)
[STAT5B] Signal transducer and activator of transcription 5B
[Stat3 Aprf] Signal transducer and activator of transcription 3 (Acute-phase response factor)
[STAT3] Signal transducer and activator of transcription 3
[STAT5A STAT5] Signal transducer and activator of transcription 5A
[Stat5b] Signal transducer and activator of transcription 5B
[Stat6] Signal transducer and transcription activator 6
[Stat1] Signal transducer and activator of transcription 1
[Stat3] Signal transducer and activator of transcription 3
[STAT3] Signal transducer and activator of transcription 3
[STAT1] Signal transducer and activator of transcription 1
[STAT6] Signal transducer and activator of transcription 6 (IL-4 Stat)
[Stat5a Mgf Mpf] Signal transducer and activator of transcription 5A (Mammary gland factor)
[Stat5b] Signal transducer and activator of transcription 5B
[Stat5a Mgf] Signal transducer and activator of transcription 5A (Mammary gland factor)
[Stat4] Signal transducer and activator of transcription 4
[Stat92E MARE mrL Stat CG4257] Signal transducer and transcription activator (d-STAT) (Protein marelle)
[STAT3 RCJMB04_38l20] Signal transducer and activator of transcription 3
[STAT4] Signal transducer and activator of transcription 4
[STAT5A MGF] Signal transducer and activator of transcription 5A (Mammary gland factor)
[STAT5A] Signal transducer and activator of transcription 5A
[STAT5B] Signal transducer and activator of transcription 5B
[STAT5B] Signal transducer and activator of transcription 5B
[STAT5A MGF STAT5] Signal transducer and activator of transcription 5A (Mammary gland factor)
[stat3.1 stat3] Signal transducer and activator of transcription 3.1 (Protein Stat3) (Xstat3)
[dstB statB DDB_G0268638] Signal transducer and activator of transcription B (Dd-STATb) (STAT5 homolog B)
[dstC statC DDB_G0293532] Signal transducer and activator of transcription C (Dd-STATc) (STAT5 homolog C)
[dstA stat5 statA DDB_G0281381] Signal transducer and activator of transcription A (Dd-STATa) (STAT5 homolog A)

Bibliography :
[32638565] MiR-1165-3p Suppresses Th2 Differentiation via Targeting IL-13 and PPM1A in a Mouse Model of Allergic Airway Inflammation.
[32637584] Dual Inhibition of MAPK and JAK2/STAT3 Pathways Is Critical for the Treatment of BRAF Mutant Melanoma.
[32636937] CagA orchestrates eEF1A1 and PKCĪ“ to induce interleukin-6 expression in -infected gastric epithelial cells.
[32636661] Promotion of Adropin Expression by Hyperglycemia Is Associated with STAT3 Activation in Diabetic Rats.
[32636362] The role of omega-3 fatty acids in preventing glucocorticoid-induced reduction in human hippocampal neurogenesis and increase in apoptosis.
[32636303] Interleukin-6-mediated epigenetic control of the VEGFR2 gene induces disorganized angiogenesis in human breast tumors.
[32634713] Bone interface modulates drug resistance in breast cancer bone metastasis.
[32634533] Lactate promotes reactive astrogliosis and confers axon guidance potential to astrocytes under oxygen-glucose deprivation.
[32633727] Essential role of STAT5a in DCIS formation and invasion following estrogen treatment.
[32633362] IGHG1 functions as an oncogene in tongue squamous cell carcinoma via JAK1/STAT5 signaling.