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Signal transducer and activator of transcription

 A0A4W2CDX1_BOBOX        Unreviewed;       787 AA.
A0A4W2CDX1;
18-SEP-2019, integrated into UniProtKB/TrEMBL.
18-SEP-2019, sequence version 1.
17-JUN-2020, entry version 7.
RecName: Full=Signal transducer and activator of transcription {ECO:0000256|RuleBase:RU046415};
Name=STAT5B {ECO:0000313|Ensembl:ENSBIXP00000011144};
Bos indicus x Bos taurus (Hybrid cattle).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
Bovinae; Bos.
NCBI_TaxID=30522 {ECO:0000313|Ensembl:ENSBIXP00000011144, ECO:0000313|Proteomes:UP000314981};
[1] {ECO:0000313|Ensembl:ENSBIXP00000011144, ECO:0000313|Proteomes:UP000314981}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Low W.Y., Tearle R., Bickhart D.M., Rosen B.D., Koren S., Rhie A.,
Hiendleder S., Phillippy A.M., Smith T.P.L., Williams J.L.;
"Haplotype-resolved cattle genomes.";
Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSBIXP00000011144}
IDENTIFICATION.
Ensembl;
Submitted (JUL-2019) to UniProtKB.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU046415}.
Nucleus {ECO:0000256|RuleBase:RU046415}.
-!- SIMILARITY: Belongs to the transcription factor STAT family.
{ECO:0000256|RuleBase:RU046415}.
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Ensembl; ENSBIXT00000044970; ENSBIXP00000011144; ENSBIXG00000016479.
Ensembl; ENSBIXT00005044013; ENSBIXP00005045702; ENSBIXG00005005263.
Proteomes; UP000314981; Chromosome 19.
Proteomes; UP000429181; Chromosome 19.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
GO; GO:0035259; F:glucocorticoid receptor binding; IEA:Ensembl.
GO; GO:0046983; F:protein dimerization activity; IEA:Ensembl.
GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0071363; P:cellular response to growth factor stimulus; IEA:Ensembl.
GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
GO; GO:0046543; P:development of secondary female sexual characteristics; IEA:Ensembl.
GO; GO:0046544; P:development of secondary male sexual characteristics; IEA:Ensembl.
GO; GO:0007565; P:female pregnancy; IEA:Ensembl.
GO; GO:0060397; P:growth hormone receptor signaling pathway via JAK-STAT; IEA:Ensembl.
GO; GO:0007595; P:lactation; IEA:Ensembl.
GO; GO:0019915; P:lipid storage; IEA:Ensembl.
GO; GO:0001553; P:luteinization; IEA:Ensembl.
GO; GO:0097531; P:mast cell migration; IEA:Ensembl.
GO; GO:0001779; P:natural killer cell differentiation; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO; GO:0045647; P:negative regulation of erythrocyte differentiation; IEA:Ensembl.
GO; GO:0048541; P:Peyer's patch development; IEA:Ensembl.
GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
GO; GO:0045579; P:positive regulation of B cell differentiation; IEA:Ensembl.
GO; GO:0045648; P:positive regulation of erythrocyte differentiation; IEA:Ensembl.
GO; GO:0045588; P:positive regulation of gamma-delta T cell differentiation; IEA:Ensembl.
GO; GO:0050729; P:positive regulation of inflammatory response; IEA:Ensembl.
GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
GO; GO:0045931; P:positive regulation of mitotic cell cycle; IEA:Ensembl.
GO; GO:0040018; P:positive regulation of multicellular organism growth; IEA:Ensembl.
GO; GO:0032825; P:positive regulation of natural killer cell differentiation; IEA:Ensembl.
GO; GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IEA:Ensembl.
GO; GO:0032819; P:positive regulation of natural killer cell proliferation; IEA:Ensembl.
GO; GO:0042448; P:progesterone metabolic process; IEA:Ensembl.
GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; IEA:Ensembl.
GO; GO:0030856; P:regulation of epithelial cell differentiation; IEA:Ensembl.
GO; GO:0019218; P:regulation of steroid metabolic process; IEA:Ensembl.
GO; GO:0032355; P:response to estradiol; IEA:Ensembl.
GO; GO:0070672; P:response to interleukin-15; IEA:Ensembl.
GO; GO:0070669; P:response to interleukin-2; IEA:Ensembl.
GO; GO:0070670; P:response to interleukin-4; IEA:Ensembl.
GO; GO:0033077; P:T cell differentiation in thymus; IEA:Ensembl.
GO; GO:0043029; P:T cell homeostasis; IEA:Ensembl.
GO; GO:0019530; P:taurine metabolic process; IEA:Ensembl.
CDD; cd10420; SH2_STAT5b; 1.
Gene3D; 1.10.532.10; -; 1.
Gene3D; 2.60.40.630; -; 1.
Gene3D; 3.30.505.10; -; 1.
InterPro; IPR008967; p53-like_TF_DNA-bd.
InterPro; IPR000980; SH2.
InterPro; IPR036860; SH2_dom_sf.
InterPro; IPR001217; STAT.
InterPro; IPR035858; STAT5a/5b.
InterPro; IPR035886; STAT5b_SH2.
InterPro; IPR036535; STAT_N_sf.
InterPro; IPR013800; STAT_TF_alpha.
InterPro; IPR015988; STAT_TF_coiled-coil.
InterPro; IPR013801; STAT_TF_DNA-bd.
InterPro; IPR012345; STAT_TF_DNA-bd_N.
InterPro; IPR013799; STAT_TF_prot_interaction.
PANTHER; PTHR11801; PTHR11801; 1.
PANTHER; PTHR11801:SF47; PTHR11801:SF47; 1.
Pfam; PF00017; SH2; 1.
Pfam; PF01017; STAT_alpha; 1.
Pfam; PF02864; STAT_bind; 1.
Pfam; PF02865; STAT_int; 1.
SMART; SM00252; SH2; 1.
SMART; SM00964; STAT_int; 1.
SUPFAM; SSF47655; SSF47655; 1.
SUPFAM; SSF48092; SSF48092; 1.
SUPFAM; SSF49417; SSF49417; 1.
SUPFAM; SSF55550; SSF55550; 1.
PROSITE; PS50001; SH2; 1.
3: Inferred from homology;
Activator {ECO:0000256|RuleBase:RU046415};
Coiled coil {ECO:0000256|SAM:Coils};
Cytoplasm {ECO:0000256|RuleBase:RU046415};
DNA-binding {ECO:0000256|RuleBase:RU046415};
Nucleus {ECO:0000256|RuleBase:RU046415};
Phosphoprotein {ECO:0000256|RuleBase:RU046415};
Reference proteome {ECO:0000313|Proteomes:UP000314981};
SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191,
ECO:0000256|RuleBase:RU046415};
Transcription {ECO:0000256|RuleBase:RU046415};
Transcription regulation {ECO:0000256|RuleBase:RU046415}.
DOMAIN 589..686
/note="SH2"
/evidence="ECO:0000259|PROSITE:PS50001"
COILED 148..168
/evidence="ECO:0000256|SAM:Coils"
COILED 215..235
/evidence="ECO:0000256|SAM:Coils"
SEQUENCE 787 AA; 89973 MW; FEAEC3B7E1267EDE CRC64;
MAVWIQAQQL QGDALHQMQA LYGQHFPIEV RHYLSQWIES QAWDSIDLDN PQENIKATQL
LEGLVQELQK KAEHQVGEDG FLLKIKLGHY ATQLQNTYDR CPMELVRCIR HILYNEQRLV
REANNGTSPA GSLADAMSQK HLQINQTFEE LRLVTQDTEN ELKKLQQTQE YFIIQYQESL
RIQAQFAQLA QLNPQERLSR ETALQQKQVS LEAWLQREAQ TLQQYRVELA EKHQKTLQLL
RKQQTIILDD ELIQWKRRQQ LAGNGGPPEG SLDVLQSWCE KLAEIIWQNR QQIRRAEHLC
QQLPIPGPVE EMLAEVNATI TDIISALVTS TFIIEKQPPQ VLKTQTKFAA TVRLLVGGKL
NVHMNPPQVK ATIISEQQAK SLLKNENTRN DYSGEILNNC CVMEYHQATG TLSAHFRNMS
LKRIKRSDRR GAESVTEEKF TILFESQFSV GGNELVFQVK TLSLPVVVIV HGSQDNNATA
TVLWDNAFAE PGRVPFAVPD KVLWPQLCEA LNMKFKAEVQ SNRGLTKENL VFLAQKLFNS
SSSHLEDYNG MSVSWSQFNR ENLPGRNYTF WQWFDGVMEV LKKHLKPHWN DGAILGFVNK
QQAHDLLINK PDGTFLLRFS DSEIGGITIA WKFDSQERMF WNLMPFTTRD FSIRSLADRL
GDLSYLIYVF PDRPKDEVYS KYYTPVPCEP ATAKAVDGYV KPQIKQVVPE FVSASADSAG
GSATYMDQAP SPAVCPQPHY NMYPQNPDPV LDNDGDFDLD DTIDVARRVE ELLGRPMDSQ
WIPHAQS


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Pathways :
WP1066: Eukaryotic Transcription Initiation
WP1965: VEGF-receptor Signal Transduction
WP405: Eukaryotic Transcription Initiation
WP1198: Signal Transduction of S1P
WP1391: Signal Transduction of S1P
WP518: Eukaryotic Transcription Initiation
WP656: p53 signal pathway
WP177: Eukaryotic Transcription Initiation
WP1906: RNA Polymerase II Transcription
WP948: Eukaryotic Transcription Initiation
WP1930: Transcription
WP344: Eukaryotic Transcription Initiation
WP1182: Eukaryotic Transcription Initiation
WP1312: Signal Transduction of S1P
WP491: Eukaryotic Transcription Initiation
WP57: Signal Transduction of S1P Receptor
WP1546: Metapathway signal transduction
WP1905: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
WP842: Signal Transduction of S1P
WP962: Signal Transduction of S1P
WP1909: Signal regulatory protein (SIRP) family interactions
WP26: Signal Transduction of S1P Receptor
WP1081: Signal Transduction of S1P
WP1238: Eukaryotic Transcription Initiation
WP425: Eukaryotic Transcription Initiation

Related Genes :
[STAT1] Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84)
[STAT3 APRF] Signal transducer and activator of transcription 3 (Acute-phase response factor)
[STAT2] Signal transducer and activator of transcription 2 (p113)
[STAT5B] Signal transducer and activator of transcription 5B
[Stat3 Aprf] Signal transducer and activator of transcription 3 (Acute-phase response factor)
[STAT3] Signal transducer and activator of transcription 3
[STAT5A STAT5] Signal transducer and activator of transcription 5A
[Stat5b] Signal transducer and activator of transcription 5B
[Stat6] Signal transducer and transcription activator 6
[Stat1] Signal transducer and activator of transcription 1
[Stat3] Signal transducer and activator of transcription 3
[STAT3] Signal transducer and activator of transcription 3
[STAT1] Signal transducer and activator of transcription 1
[STAT6] Signal transducer and activator of transcription 6 (IL-4 Stat)
[Stat5a Mgf Mpf] Signal transducer and activator of transcription 5A (Mammary gland factor)
[Stat5b] Signal transducer and activator of transcription 5B
[Stat5a Mgf] Signal transducer and activator of transcription 5A (Mammary gland factor)
[Stat4] Signal transducer and activator of transcription 4
[Stat92E MARE mrL Stat CG4257] Signal transducer and transcription activator (d-STAT) (Protein marelle)
[STAT3 RCJMB04_38l20] Signal transducer and activator of transcription 3
[STAT4] Signal transducer and activator of transcription 4
[STAT5A MGF] Signal transducer and activator of transcription 5A (Mammary gland factor)
[STAT5A] Signal transducer and activator of transcription 5A
[STAT5B] Signal transducer and activator of transcription 5B
[STAT5B] Signal transducer and activator of transcription 5B
[STAT5A MGF STAT5] Signal transducer and activator of transcription 5A (Mammary gland factor)
[stat3.1 stat3] Signal transducer and activator of transcription 3.1 (Protein Stat3) (Xstat3)
[dstB statB DDB_G0268638] Signal transducer and activator of transcription B (Dd-STATb) (STAT5 homolog B)
[dstC statC DDB_G0293532] Signal transducer and activator of transcription C (Dd-STATc) (STAT5 homolog C)
[dstA stat5 statA DDB_G0281381] Signal transducer and activator of transcription A (Dd-STATa) (STAT5 homolog A)

Bibliography :
[32657474] Metabolic signalling to somatotrophs: Transcriptional and post-transcriptional mediators.
[32655542] MicroRNA-200a Inhibits Inflammation and Atherosclerotic Lesion Formation by Disrupting EZH2-Mediated Methylation of STAT3.
[32655003] Prevention of tobacco carcinogen-induced lung tumor development by a novel STAT3 decoy inhibitor.
[32654696] Precision Therapy for the Treatment of Primary Immunodysregulatory Diseases.
[32653922] Liver microRNA-29b-3p positively correlates with relative enhancement values of magnetic resonance imaging and represses liver fibrosis.
[32652260] Iron promotes breast cancer cell migration via IL-6/JAK2/STAT3 signaling pathways in a paracrine or autocrine IL-6-rich inflammatory environment.
[32649972] Manipulating the function of tumor-associated macrophages by siRNA-loaded lipid nanoparticles for cancer immunotherapy.
[32648126] Kang-ai Injection () Inhibits Gastric Cancer Cells Proliferation through IL-6/STAT3 Pathway.
[32647323] Fedratinib, a newly approved treatment for patients with myeloproliferative neoplasm-associated myelofibrosis.
[32643603] Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment.