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Signal transducer and activator of transcription

 M3YGJ3_MUSPF            Unreviewed;       691 AA.
M3YGJ3;
01-MAY-2013, integrated into UniProtKB/TrEMBL.
01-MAY-2013, sequence version 1.
17-JUN-2020, entry version 46.
RecName: Full=Signal transducer and activator of transcription {ECO:0000256|RuleBase:RU046415};
Name=STAT5B {ECO:0000313|Ensembl:ENSMPUP00000010450};
Mustela putorius furo (European domestic ferret) (Mustela furo).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae; Mustelinae;
Mustela.
NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000010450, ECO:0000313|Proteomes:UP000000715};
[1] {ECO:0000313|Ensembl:ENSMPUP00000010450, ECO:0000313|Proteomes:UP000000715}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ID#1420 {ECO:0000313|Ensembl:ENSMPUP00000010450,
ECO:0000313|Proteomes:UP000000715};
Di Palma F., Alfoldi J., Johnson J., Jaffe D., Berlin A., Gnerre S.,
Grabherr M., Hall G., Lara M., MacCallum I., Mauceli E., Przyblyski D.,
Ribeiro F., Russell P., Sharpe T., Turner-Maier J., Walker B.J., Young S.,
Birren B., Lindblad-Toh K.;
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSMPUP00000010450}
IDENTIFICATION.
Ensembl;
Submitted (MAR-2013) to UniProtKB.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU046415}.
Nucleus {ECO:0000256|RuleBase:RU046415}.
-!- SIMILARITY: Belongs to the transcription factor STAT family.
{ECO:0000256|RuleBase:RU046415}.
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EMBL; AEYP01079467; -; NOT_ANNOTATED_CDS; Genomic_DNA.
STRING; 9668.ENSMPUP00000010450; -.
Ensembl; ENSMPUT00000010619; ENSMPUP00000010450; ENSMPUG00000010528.
eggNOG; KOG3667; Eukaryota.
eggNOG; ENOG410XPN8; LUCA.
GeneTree; ENSGT00990000203570; -.
HOGENOM; CLU_014189_2_2_1; -.
InParanoid; M3YGJ3; -.
OMA; IWLNRQQ; -.
Proteomes; UP000000715; Unassembled WGS sequence.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
GO; GO:0035259; F:glucocorticoid receptor binding; IEA:Ensembl.
GO; GO:0046983; F:protein dimerization activity; IEA:Ensembl.
GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0071363; P:cellular response to growth factor stimulus; IEA:Ensembl.
GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
GO; GO:0046543; P:development of secondary female sexual characteristics; IEA:Ensembl.
GO; GO:0046544; P:development of secondary male sexual characteristics; IEA:Ensembl.
GO; GO:0007565; P:female pregnancy; IEA:Ensembl.
GO; GO:0060397; P:growth hormone receptor signaling pathway via JAK-STAT; IEA:Ensembl.
GO; GO:0007595; P:lactation; IEA:Ensembl.
GO; GO:0019915; P:lipid storage; IEA:Ensembl.
GO; GO:0001553; P:luteinization; IEA:Ensembl.
GO; GO:0097531; P:mast cell migration; IEA:Ensembl.
GO; GO:0001779; P:natural killer cell differentiation; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO; GO:0045647; P:negative regulation of erythrocyte differentiation; IEA:Ensembl.
GO; GO:0048541; P:Peyer's patch development; IEA:Ensembl.
GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
GO; GO:0045579; P:positive regulation of B cell differentiation; IEA:Ensembl.
GO; GO:0045648; P:positive regulation of erythrocyte differentiation; IEA:Ensembl.
GO; GO:0045588; P:positive regulation of gamma-delta T cell differentiation; IEA:Ensembl.
GO; GO:0050729; P:positive regulation of inflammatory response; IEA:Ensembl.
GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
GO; GO:0045931; P:positive regulation of mitotic cell cycle; IEA:Ensembl.
GO; GO:0040018; P:positive regulation of multicellular organism growth; IEA:Ensembl.
GO; GO:0032825; P:positive regulation of natural killer cell differentiation; IEA:Ensembl.
GO; GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IEA:Ensembl.
GO; GO:0032819; P:positive regulation of natural killer cell proliferation; IEA:Ensembl.
GO; GO:0042448; P:progesterone metabolic process; IEA:Ensembl.
GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; IEA:Ensembl.
GO; GO:0030856; P:regulation of epithelial cell differentiation; IEA:Ensembl.
GO; GO:0019218; P:regulation of steroid metabolic process; IEA:Ensembl.
GO; GO:0032355; P:response to estradiol; IEA:Ensembl.
GO; GO:0070672; P:response to interleukin-15; IEA:Ensembl.
GO; GO:0070669; P:response to interleukin-2; IEA:Ensembl.
GO; GO:0070670; P:response to interleukin-4; IEA:Ensembl.
GO; GO:0033077; P:T cell differentiation in thymus; IEA:Ensembl.
GO; GO:0043029; P:T cell homeostasis; IEA:Ensembl.
GO; GO:0019530; P:taurine metabolic process; IEA:Ensembl.
CDD; cd10420; SH2_STAT5b; 1.
Gene3D; 2.60.40.630; -; 1.
Gene3D; 3.30.505.10; -; 1.
InterPro; IPR008967; p53-like_TF_DNA-bd.
InterPro; IPR000980; SH2.
InterPro; IPR036860; SH2_dom_sf.
InterPro; IPR001217; STAT.
InterPro; IPR035858; STAT5a/5b.
InterPro; IPR035886; STAT5b_SH2.
InterPro; IPR013800; STAT_TF_alpha.
InterPro; IPR015988; STAT_TF_coiled-coil.
InterPro; IPR013801; STAT_TF_DNA-bd.
InterPro; IPR012345; STAT_TF_DNA-bd_N.
PANTHER; PTHR11801; PTHR11801; 1.
PANTHER; PTHR11801:SF47; PTHR11801:SF47; 1.
Pfam; PF00017; SH2; 1.
Pfam; PF01017; STAT_alpha; 1.
Pfam; PF02864; STAT_bind; 1.
SMART; SM00252; SH2; 1.
SUPFAM; SSF47655; SSF47655; 1.
SUPFAM; SSF49417; SSF49417; 1.
SUPFAM; SSF55550; SSF55550; 1.
PROSITE; PS50001; SH2; 1.
3: Inferred from homology;
Activator {ECO:0000256|RuleBase:RU046415};
Coiled coil {ECO:0000256|SAM:Coils};
Cytoplasm {ECO:0000256|RuleBase:RU046415};
DNA-binding {ECO:0000256|RuleBase:RU046415};
Nucleus {ECO:0000256|RuleBase:RU046415};
Phosphoprotein {ECO:0000256|RuleBase:RU046415};
Reference proteome {ECO:0000313|Proteomes:UP000000715};
SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191,
ECO:0000256|RuleBase:RU046415};
Transcription {ECO:0000256|RuleBase:RU046415};
Transcription regulation {ECO:0000256|RuleBase:RU046415}.
DOMAIN 487..584
/note="SH2"
/evidence="ECO:0000259|PROSITE:PS50001"
REGION 672..691
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COILED 46..66
/evidence="ECO:0000256|SAM:Coils"
SEQUENCE 691 AA; 78815 MW; 27D724C14342585A CRC64;
MELVRCIRHI LYNEQRLVRE ANNGTSPVGS LADTMSQKHL QINQTFEELR LVTQDTENEL
KKLQQTQEYF IIQYQESLRI QAQFAGLNQL SPQERLSRET ALQQKQVSLE AWLQHEAQTL
QQYRVELAEK HQKTLQLLRK QQTIILDDEL IQWKRRQQLA GNGGPPEGSL DVLQSWCEKL
AEIIWQNRQQ IRRAEHLCQQ LPIPGPVEEM LAEVNATITD IISALVTSTF IIEKQPPQVL
KTQTKFAATV RLLVGGKLNV HMNPPQVKAT IISEQQAKSL LKNENTRNDY SGEILNNCCV
MEYHQATGTL SAHFRNMSLK RIKRSDRRGA ESVTEEKFTI LFESQFSVGG NELVFQVKTL
SLPVVVIVHG SQDNNATATV LWDNAFAEPG RVPFAVPDKV LWPQLCEALN MKFKAEVQSN
RGLTKENLVF LAQKLFNSSS SHLEDYNGMS VSWSQFNREN LPGRNYTFWQ WFDGVMEVLK
KHLKPHWNDG AILGFVNKQQ AHDLLINKPD GTFLLRFSDS EIGGITIAWK FDSQERMFWN
LMPFTTRDFS IRSLADRLGD LNYLIYVFPD RPKDEVYSRY YTPVPCEPAT AKAVDGYVKP
QIKQVVPEFV NASADSAGAS ATYMDQAPSP AVCPPAHYNM YPQNPDPVLD NDGDFDLDDT
MDVARRVEEL LGRPMDSSRL SLPLRSRPTP P


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FP-0103 Signal transducer and activator of transcription 5A. 10 ug
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Pathways :
WP1965: VEGF-receptor Signal Transduction
WP1066: Eukaryotic Transcription Initiation
WP1198: Signal Transduction of S1P
WP405: Eukaryotic Transcription Initiation
WP518: Eukaryotic Transcription Initiation
WP1391: Signal Transduction of S1P
WP656: p53 signal pathway
WP177: Eukaryotic Transcription Initiation
WP948: Eukaryotic Transcription Initiation
WP1906: RNA Polymerase II Transcription
WP1930: Transcription
WP344: Eukaryotic Transcription Initiation
WP1182: Eukaryotic Transcription Initiation
WP1312: Signal Transduction of S1P
WP491: Eukaryotic Transcription Initiation
WP57: Signal Transduction of S1P Receptor
WP1546: Metapathway signal transduction
WP1905: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
WP842: Signal Transduction of S1P
WP962: Signal Transduction of S1P
WP1909: Signal regulatory protein (SIRP) family interactions
WP26: Signal Transduction of S1P Receptor
WP1081: Signal Transduction of S1P
WP1238: Eukaryotic Transcription Initiation
WP425: Eukaryotic Transcription Initiation

Related Genes :
[STAT1] Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84)
[STAT3 APRF] Signal transducer and activator of transcription 3 (Acute-phase response factor)
[STAT2] Signal transducer and activator of transcription 2 (p113)
[STAT5B] Signal transducer and activator of transcription 5B
[Stat3 Aprf] Signal transducer and activator of transcription 3 (Acute-phase response factor)
[STAT3] Signal transducer and activator of transcription 3
[STAT5A STAT5] Signal transducer and activator of transcription 5A
[Stat5b] Signal transducer and activator of transcription 5B
[Stat6] Signal transducer and transcription activator 6
[Stat1] Signal transducer and activator of transcription 1
[Stat3] Signal transducer and activator of transcription 3
[STAT3] Signal transducer and activator of transcription 3
[STAT1] Signal transducer and activator of transcription 1
[STAT6] Signal transducer and activator of transcription 6 (IL-4 Stat)
[Stat5a Mgf Mpf] Signal transducer and activator of transcription 5A (Mammary gland factor)
[Stat5b] Signal transducer and activator of transcription 5B
[Stat5a Mgf] Signal transducer and activator of transcription 5A (Mammary gland factor)
[Stat4] Signal transducer and activator of transcription 4
[Stat92E MARE mrL Stat CG4257] Signal transducer and transcription activator (d-STAT) (Protein marelle)
[STAT3 RCJMB04_38l20] Signal transducer and activator of transcription 3
[STAT4] Signal transducer and activator of transcription 4
[STAT5A MGF] Signal transducer and activator of transcription 5A (Mammary gland factor)
[STAT5A] Signal transducer and activator of transcription 5A
[STAT5B] Signal transducer and activator of transcription 5B
[STAT5B] Signal transducer and activator of transcription 5B
[STAT5A MGF STAT5] Signal transducer and activator of transcription 5A (Mammary gland factor)
[stat3.1 stat3] Signal transducer and activator of transcription 3.1 (Protein Stat3) (Xstat3)
[dstB statB DDB_G0268638] Signal transducer and activator of transcription B (Dd-STATb) (STAT5 homolog B)
[dstC statC DDB_G0293532] Signal transducer and activator of transcription C (Dd-STATc) (STAT5 homolog C)
[dstA stat5 statA DDB_G0281381] Signal transducer and activator of transcription A (Dd-STATa) (STAT5 homolog A)

Bibliography :
[32638565] MiR-1165-3p Suppresses Th2 Differentiation via Targeting IL-13 and PPM1A in a Mouse Model of Allergic Airway Inflammation.
[32637584] Dual Inhibition of MAPK and JAK2/STAT3 Pathways Is Critical for the Treatment of BRAF Mutant Melanoma.
[32636937] CagA orchestrates eEF1A1 and PKCĪ“ to induce interleukin-6 expression in -infected gastric epithelial cells.
[32636661] Promotion of Adropin Expression by Hyperglycemia Is Associated with STAT3 Activation in Diabetic Rats.
[32636362] The role of omega-3 fatty acids in preventing glucocorticoid-induced reduction in human hippocampal neurogenesis and increase in apoptosis.
[32636303] Interleukin-6-mediated epigenetic control of the VEGFR2 gene induces disorganized angiogenesis in human breast tumors.
[32634713] Bone interface modulates drug resistance in breast cancer bone metastasis.
[32634533] Lactate promotes reactive astrogliosis and confers axon guidance potential to astrocytes under oxygen-glucose deprivation.
[32633727] Essential role of STAT5a in DCIS formation and invasion following estrogen treatment.
[32633362] IGHG1 functions as an oncogene in tongue squamous cell carcinoma via JAK1/STAT5 signaling.