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Signal transducer and activator of transcription 5A (Mammary gland factor)

 STA5A_SHEEP             Reviewed;         794 AA.
P42231;
01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
01-FEB-1996, sequence version 2.
13-FEB-2019, entry version 129.
RecName: Full=Signal transducer and activator of transcription 5A;
AltName: Full=Mammary gland factor;
Name=STAT5A; Synonyms=MGF, STAT5;
Ovis aries (Sheep).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Caprinae; Ovis.
NCBI_TaxID=9940;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Mammary gland;
PubMed=7514531;
Wakao H., Gouilleux F., Groner B.;
"Mammary gland factor (MGF) is a novel member of the cytokine
regulated transcription factor gene family and confers the prolactin
response.";
EMBO J. 13:2182-2191(1994).
[2]
ERRATUM, AND SEQUENCE REVISION.
PubMed=7882987;
Wakao H., Gouilleux F., Groner B.;
EMBO J. 14:854-855(1995).
[3]
PARTIAL PROTEIN SEQUENCE.
TISSUE=Mammary gland;
PubMed=7537213;
Azam M., Erdjument-Bromage H., Kreider B.L., Xia M., Quelle F.,
Basu R., Saris C., Tempst P., Ihle J.N., Schindler C.;
"Interleukin-3 signals through multiple isoforms of Stat5.";
EMBO J. 14:1402-1411(1995).
-!- FUNCTION: Carries out a dual function: signal transduction and
activation of transcription. Mediates cellular responses to the
cytokine KITLG/SCF and other growth factors. May mediate cellular
responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the
GAS element and activates PRL-induced transcription. Regulates the
expression of milk proteins during lactation.
-!- SUBUNIT: Forms a homodimer or a heterodimer with a related family
member. Binds NR3C1. Interacts with NCOA1 and SOCS7. Interacts
with ERBB4 (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocated into
the nucleus in response to phosphorylation.
-!- TISSUE SPECIFICITY: Found in mammary gland and, in lesser extent,
in ovary, thymus, spleen, kidney, lung, muscle and adrenal gland.
-!- INDUCTION: By prolactin.
-!- PTM: ISGylated. {ECO:0000250|UniProtKB:P42230}.
-!- PTM: Tyrosine phosphorylated in response to KITLG/SCF, IL2, IL3,
IL7, IL15, CSF2/GMCSF, GH1, PRL, EPO and THPO (By similarity).
Activated KIT promotes phosphorylation on tyrosine residues and
subsequent translocation to the nucleus (By similarity). Tyrosine
phosphorylated in response to constitutively activated FGFR1,
FGFR2, FGFR3 and FGFR4 (By similarity). Tyrosine phosphorylation
is required for DNA-binding activity and dimerization. Serine
phosphorylation is also required for maximal transcriptional
activity (By similarity). Tyrosine phosphorylated in response to
signaling via activated FLT3; wild-type FLT3 results in much
weaker phosphorylation than constitutively activated mutant FLT3.
Alternatively, can be phosphorylated by JAK2 at Tyr-694 (By
similarity). {ECO:0000250|UniProtKB:P40763,
ECO:0000250|UniProtKB:P42229, ECO:0000250|UniProtKB:P42230,
ECO:0000250|UniProtKB:Q62771}.
-!- SIMILARITY: Belongs to the transcription factor STAT family.
{ECO:0000305}.
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
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EMBL; X78428; CAA55191.1; -; mRNA.
PIR; S55527; S55527.
RefSeq; NP_001009402.1; NM_001009402.1.
UniGene; Oar.13291; -.
ProteinModelPortal; P42231; -.
SMR; P42231; -.
iPTMnet; P42231; -.
GeneID; 443419; -.
KEGG; oas:443419; -.
CTD; 6776; -.
HOVERGEN; HBG107486; -.
KO; K11223; -.
OrthoDB; 327469at2759; -.
Proteomes; UP000002356; Unplaced.
GO; GO:0005737; C:cytoplasm; ISS:AgBase.
GO; GO:0005634; C:nucleus; ISS:AgBase.
GO; GO:0003677; F:DNA binding; ISS:AgBase.
GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
GO; GO:0019221; P:cytokine-mediated signaling pathway; ISS:AgBase.
GO; GO:0046543; P:development of secondary female sexual characteristics; ISS:AgBase.
GO; GO:0007565; P:female pregnancy; ISS:AgBase.
GO; GO:0060397; P:growth hormone receptor signaling pathway via JAK-STAT; IEA:InterPro.
GO; GO:0007595; P:lactation; ISS:AgBase.
GO; GO:0019915; P:lipid storage; ISS:AgBase.
GO; GO:0001553; P:luteinization; ISS:AgBase.
GO; GO:0030879; P:mammary gland development; ISS:AgBase.
GO; GO:0001779; P:natural killer cell differentiation; ISS:AgBase.
GO; GO:0043066; P:negative regulation of apoptotic process; ISS:AgBase.
GO; GO:0045647; P:negative regulation of erythrocyte differentiation; ISS:AgBase.
GO; GO:0042104; P:positive regulation of activated T cell proliferation; ISS:AgBase.
GO; GO:0045579; P:positive regulation of B cell differentiation; ISS:AgBase.
GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:AgBase.
GO; GO:0050729; P:positive regulation of inflammatory response; ISS:AgBase.
GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; ISS:AgBase.
GO; GO:0045931; P:positive regulation of mitotic cell cycle; ISS:AgBase.
GO; GO:0040018; P:positive regulation of multicellular organism growth; ISS:AgBase.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:AgBase.
GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; ISS:AgBase.
GO; GO:0030155; P:regulation of cell adhesion; ISS:AgBase.
GO; GO:0030856; P:regulation of epithelial cell differentiation; ISS:AgBase.
GO; GO:0019218; P:regulation of steroid metabolic process; ISS:AgBase.
GO; GO:0043029; P:T cell homeostasis; ISS:AgBase.
Gene3D; 1.10.532.10; -; 1.
Gene3D; 2.60.40.630; -; 1.
Gene3D; 3.30.505.10; -; 1.
InterPro; IPR008967; p53-like_TF_DNA-bd.
InterPro; IPR000980; SH2.
InterPro; IPR036860; SH2_dom_sf.
InterPro; IPR001217; STAT.
InterPro; IPR035858; STAT5a/5b.
InterPro; IPR036535; STAT_N_sf.
InterPro; IPR013800; STAT_TF_alpha.
InterPro; IPR015988; STAT_TF_coiled-coil.
InterPro; IPR013801; STAT_TF_DNA-bd.
InterPro; IPR012345; STAT_TF_DNA-bd_N.
InterPro; IPR013799; STAT_TF_prot_interaction.
PANTHER; PTHR11801; PTHR11801; 1.
PANTHER; PTHR11801:SF47; PTHR11801:SF47; 1.
Pfam; PF00017; SH2; 1.
Pfam; PF01017; STAT_alpha; 1.
Pfam; PF02864; STAT_bind; 1.
Pfam; PF02865; STAT_int; 1.
SMART; SM00252; SH2; 1.
SMART; SM00964; STAT_int; 1.
SUPFAM; SSF47655; SSF47655; 1.
SUPFAM; SSF48092; SSF48092; 1.
SUPFAM; SSF49417; SSF49417; 1.
SUPFAM; SSF55550; SSF55550; 1.
PROSITE; PS50001; SH2; 1.
1: Evidence at protein level;
Activator; Complete proteome; Cytoplasm; Direct protein sequencing;
DNA-binding; Lactation; Nucleus; Phosphoprotein; Reference proteome;
SH2 domain; Transcription; Transcription regulation; Ubl conjugation.
CHAIN 1 794 Signal transducer and activator of
transcription 5A.
/FTId=PRO_0000182427.
DOMAIN 589 686 SH2. {ECO:0000255|PROSITE-
ProRule:PRU00191}.
MOD_RES 90 90 Phosphotyrosine.
{ECO:0000250|UniProtKB:P42229}.
MOD_RES 129 129 Phosphoserine.
{ECO:0000250|UniProtKB:P42229}.
MOD_RES 682 682 Phosphotyrosine.
{ECO:0000250|UniProtKB:P42229}.
MOD_RES 694 694 Phosphotyrosine; by JAK2.
{ECO:0000250|UniProtKB:P51692}.
SEQUENCE 794 AA; 90917 MW; E69A4EC826AF60BE CRC64;
MAGWIQAQQL QGDALRQMQV LYGQHFPIEV RHYLAQWIES QPWDAIDLDN PQDRAQVTQL
LEGLVQELQK KAEHQVGEDG FLLKIKLGHY VHVSSRTRTT AAPWSWLRCI RHILYNEQRL
VREATNGNSS AGILVDAMSQ KHLQINQTFE ELRLVTQDTE NELKKLQQTQ EYFIIQYQES
LRIQAQFAQL AQLNPQERLS RETALQQKQV SLEAWLQREA QTLQQYRVEL AEKHQKTLQL
LRKQQTIILD DELIQWKRRH DWRGMEAPPR SLDVLQSWCE KLAEIIWQNR QQIRRAEHLC
QQLPIPGPVE EMLAEVNATI TDIISALVTS TFIIEKQPPQ VLKTQTKFAA TVRLLVGGKL
NVHMNPPQVK ATIISEQQAK SLLKNENTRN ECSGEILNNC CVMEYHQRTG TLSAHFRNMS
LKRIKRADRR GAESVTEEKF TVLFESQFSV GSNELVFQVK TLSLPVVVIV HGSQDHNATA
TVLWDNAFAE PGRVPFAVPD KVLWPQLCEA LNMKFKAEVQ SNRGLTKENL LFLAQKLFNN
SSSHLEDYNG MSVSWSQFNR ENLPGWNYTF WQWFDGVMEV LKKHHKPHWN DGAILGFVNK
QQAHDLLINK PDGTFLLRFS DSEIGGITIA WKFDSPDRNL WNLKPFTTRE GSIRSLADRL
GDLNYLIYVF PDRPKDEVFS KYYTPVLAKA VDGYVKPQIK QVVPEFVSAS ADSAGSSATY
MDQAPSPAVC PQPHYNMYPQ NPDPVLDQDG EFDLDETMDV ARHVEELLRR PNGQSGPLSP
PPAGLFTPAR GSLS


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Pathways :
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1066: Eukaryotic Transcription Initiation
WP1081: Signal Transduction of S1P
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP1182: Eukaryotic Transcription Initiation
WP1198: Signal Transduction of S1P
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP1238: Eukaryotic Transcription Initiation
WP1312: Signal Transduction of S1P
WP1391: Signal Transduction of S1P
WP1541: Energy Metabolism
WP1546: Metapathway signal transduction
WP177: Eukaryotic Transcription Initiation
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP1822: Generic Transcription Pathway
WP1899: Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WP1905: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
WP1906: RNA Polymerase II Transcription
WP1908: Signal amplification
WP1909: Signal regulatory protein (SIRP) family interactions
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP1930: Transcription
WP1965: VEGF-receptor Signal Transduction
WP1983: Splicing factor NOVA regulated synpatic proteins

Related Genes :
[Stat5a Mgf Mpf] Signal transducer and activator of transcription 5A (Mammary gland factor)
[Stat5a Mgf] Signal transducer and activator of transcription 5A (Mammary gland factor)
[STAT5A MGF STAT5] Signal transducer and activator of transcription 5A (Mammary gland factor)
[STAT5A MGF] Signal transducer and activator of transcription 5A (Mammary gland factor)
[] Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); p7; Protease NS2-3 (p23) (EC 3.4.22.-); Serine protease NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3P) (p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[] Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); p7; Protease NS2-3 (p23) (EC 3.4.22.-); Serine protease NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3P) (p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[STAT5A STAT5] Signal transducer and activator of transcription 5A
[STAT5A] Signal transducer and activator of transcription 5A
[] Genome polyprotein [Cleaved into: N-terminal protease (N-pro) (EC 3.4.22.-) (Autoprotease p20); Capsid protein C; E(rns) glycoprotein (gp44/48); Envelope glycoprotein E1 (gp33); Envelope glycoprotein E2 (gp55); p7; Non-structural protein 2-3; Cysteine protease NS2 (EC 3.4.22.-) (Non-structural protein 2); Serine protease NS3 (EC 3.4.21.113) (EC 3.6.1.15) (EC 3.6.4.13) (Non-structural protein 3); Non-structural protein 4A (NS4A); Non-structural protein 4B (NS4B); Non-structural protein 5A (NS5A); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B)]
[icsA virG CP0182] Outer membrane protein IcsA autotransporter [Cleaved into: Outer membrane protein IcsA; Outer membrane protein IcsA translocator]
[Wnt5a Wnt-5a] Protein Wnt-5a
[PHF5A] PHD finger-like domain-containing protein 5A (PHD finger-like domain protein 5A) (Splicing factor 3B-associated 14 kDa protein) (SF3b14b)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[ospF mkaD CP0010 pWR501_0013 SFLP011] Phosphothreonine lyase OspF (EC 4.2.3.-) (Effector protein OspF)
[] Bradykinin-potentiating and C-type natriuretic peptides (Brain BPP-CNP) (bBPP-CNP) (Evasin-CNP) [Cleaved into: Bradykinin-potentiating peptide 13a+QQWA (BPP-13a+QQWA); Bradykinin-potentiating peptide 13a+QWA (BPP-13a+QWA); Bradykinin-potentiating peptide 13a (BPP-13a); Bradykinin-potentiating peptide 10c+QQWA (BPP-10c+QQWA); Bradykinin-potentiating peptide 10c (BPP-10c) (BPP-2) (Evasin-10c); Bradykinin-potentiating peptide 12b (BPP-12b) (Evasin-12b); Bradykinin-potentiating peptide AP; Bradykinin-potentiating peptide APL (BPP-APL); Bradykinin-potentiating peptide 11e (BPP-11e) (Evasin-11e); Bradykinin-potentiating peptide 5a (BPP-5a) (Bradykinin-potentiating peptide Va) (BPPVa) (Evasin-5a) (Proline-rich peptide 5a) (Bj-PRO-5a) (PRO-5a); Poly-His-poly-Gly peptide 1 (pHpG-1); C-type natriuretic peptide (Bj-CNP)]
[] Bradykinin-potentiating and C-type natriuretic peptides (BPP-CNP) [Cleaved into: Bradykinin-potentiating peptide 6a (BPP-6a); Bradykinin-potentiating peptide 10a (BPP-10a) (Bradykinin-potentiating peptide IV-1-A) (BPPIV-1-A) (Bradykinin-potentiating peptide V-8); Bradykinin-potentiating peptide 13a+QQWA (BPP-13a+QQWA); Bradykinin-potentiating peptide 13a+QWA (BPP-13a+QWA); Bradykinin-potentiating peptide 13a (BPP-13a) (Bradykinin-potentiating peptide III-1-A) (III-1-A) (Bradykinin-potentiating peptide V-9); Bradykinin-potentiating peptide 10c+QQWA (BPP-10c+QQWA); Bradykinin-potentiating peptide 10c (BPP-10c) (BPP-2) (Bradykinin-potentiating peptide IV-1-Bbeta) (BPP IV-1-Bbeta) (Bradykinin-potentiating peptide V-7); Bradykinin-potentiating peptide 10c-F (BPP-10c-F); Bradykinin-potentiating peptide 11b (BPP-11b) (Bradykinin-potentiating peptide IIa) (BPP-IIa); Bradykinin-potentiating peptide IIb (BPP-IIb); Bradykinin-potentiating peptide 5a (BPP-5a) (Bradykinin-potentiating peptide Va) (BPPVa) (Proline-rich peptide 5a) (Bj-PRO-5a) (PRO-5a); Poly-His-poly-Gly peptide 1 (pHpG-1); C-type natriuretic peptide (Bj-CNP)]
[WNT5A] Protein Wnt-5a
[] Bradykinin-potentiating and C-type natriuretic peptides (Angiotensin-converting enzyme inhibitor) (BPP-CNP homolog) [Cleaved into: Bradykinin-potentiating peptide 13a (BPP-13a) (Bradykinin-potentiating peptide S3,1); Bradykinin-potentiating peptide 10c (BPP-10c) (BPP-2) (Bradykinin-potentiating peptide S4,3,1); Bradykinin-potentiating peptide 12b (BPP-12b) (Bradykinin-potentiating peptide S4,3,2); Bradykinin-potentiating peptide 11e (BPP-11e); Bradykinin-potentiating peptide 5a (BPP-5a) (Bradykinin-potentiating peptide S5,2) (Bradykinin-potentiating peptide Va) (BPPVa) (Proline-rich peptide 5a) (PRO-5a); C-type natriuretic peptide (CNP)]
[] Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); p7; Protease NS2-3 (p23) (EC 3.4.22.-); Serine protease NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3P) (p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[ospG CP0227 pWR501_0237 SFLP087] Protein kinase OspG (EC 2.7.-.-) (Effector protein OspG)
[KMT5A PRSET7 SET07 SET8 SETD8] N-lysine methyltransferase KMT5A (EC 2.1.1.-) (H4-K20-HMTase KMT5A) (Histone-lysine N-methyltransferase KMT5A) (EC 2.1.1.43) (Lysine N-methyltransferase 5A) (Lysine-specific methylase 5A) (PR/SET domain-containing protein 07) (PR-Set7) (PR/SET07) (SET domain-containing protein 8)
[] Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); Viroporin p7; Protease NS2-3 (p23) (EC 3.4.22.-); Serine protease NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3P) (p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[] Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); p7; Protease NS2-3 (p23) (EC 3.4.22.-); Serine protease NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3P) (p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[KDM5A JARID1A RBBP2 RBP2] Lysine-specific demethylase 5A (EC 1.14.11.-) (Histone demethylase JARID1A) (Jumonji/ARID domain-containing protein 1A) (Retinoblastoma-binding protein 2) (RBBP-2)
[] Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); p7; Protease NS2-3 (p23) (EC 3.4.22.-); Serine protease NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3P) (p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[] Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); p7; Protease NS2-3 (p23) (EC 3.4.22.-); Serine protease NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3P) (p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[] Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); p7; Protease NS2-3 (p23) (EC 3.4.22.-); Serine protease NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3P) (p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[nnrE nnrD AT5A_14367] Multifunctional fusion protein [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)]
[] Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); p7; Protease NS2-3 (p23) (EC 3.4.22.-); Serine protease NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3P) (p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[] Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); p7; Protease NS2-3 (p23) (EC 3.4.22.-); Serine protease NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3P) (p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]

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