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Sodium-coupled neutral amino acid transporter 3 (N-system amino acid transporter 1) (Na( )-coupled neutral amino acid transporter 3) (Solute carrier family 38 member 3) (mNAT) (System N amino acid transporter 1)

 S38A3_MOUSE             Reviewed;         505 AA.
Q9DCP2; Q8BS53; Q9JLL8;
27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
01-JUN-2001, sequence version 1.
08-MAY-2019, entry version 131.
RecName: Full=Sodium-coupled neutral amino acid transporter 3;
AltName: Full=N-system amino acid transporter 1;
AltName: Full=Na(+)-coupled neutral amino acid transporter 3;
AltName: Full=Solute carrier family 38 member 3;
Short=mNAT;
AltName: Full=System N amino acid transporter 1;
Name=Slc38a3 {ECO:0000312|MGI:MGI:1923507}; Synonyms=Sn1, Snat3;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1] {ECO:0000305, ECO:0000312|EMBL:AAF61849.1}
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND TISSUE
SPECIFICITY.
TISSUE=Brain {ECO:0000269|PubMed:10716701},
Kidney {ECO:0000269|PubMed:10716701}, and
Liver {ECO:0000312|EMBL:AAF61849.1};
PubMed=10716701; DOI=10.1073/pnas.97.7.3230;
Gu S., Roderick H.L., Camacho P., Jiang J.X.;
"Identification and characterization of an amino acid transporter
expressed differentially in liver.";
Proc. Natl. Acad. Sci. U.S.A. 97:3230-3235(2000).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Embryo, and Kidney;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[3] {ECO:0000312|EMBL:AAH54846.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J {ECO:0000312|EMBL:AAH55339.1};
TISSUE=Brain {ECO:0000312|EMBL:AAH55339.1}, and
Retina {ECO:0000312|EMBL:AAH54846.1};
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain, Liver, and Pancreas;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Sodium-dependent amino acid/proton antiporter. Mediates
electrogenic cotransport of glutamine and sodium ions in exchange
for protons. Also recognizes histidine, asparagine and alanine.
May mediate amino acid transport in either direction under
physiological conditions. May play a role in nitrogen metabolism
and synaptic transmission. {ECO:0000250|UniProtKB:Q9JHZ9,
ECO:0000269|PubMed:10716701}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10716701};
Multi-pass membrane protein {ECO:0000269|PubMed:10716701}.
-!- TISSUE SPECIFICITY: Expressed predominantly in liver, moderately
expressed in kidney and brain, and barely detectable in heart and
muscle. Within liver, expressed in hepatocytes. Not detected in
testis. {ECO:0000269|PubMed:10716701}.
-!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2
family. {ECO:0000305}.
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EMBL; AF159856; AAF61849.1; -; mRNA.
EMBL; AK002607; BAB22226.1; -; mRNA.
EMBL; AK035155; BAC28963.1; -; mRNA.
EMBL; BC054846; AAH54846.1; -; mRNA.
EMBL; BC055339; AAH55339.1; -; mRNA.
CCDS; CCDS23503.1; -.
RefSeq; NP_001186146.1; NM_001199217.1.
RefSeq; NP_001186147.1; NM_001199218.1.
RefSeq; NP_076294.2; NM_023805.3.
RefSeq; XP_017169171.1; XM_017313682.1.
BioGrid; 218051; 1.
IntAct; Q9DCP2; 2.
MINT; Q9DCP2; -.
STRING; 10090.ENSMUSP00000130414; -.
TCDB; 2.A.18.6.2; the amino acid/auxin permease (aaap) family.
iPTMnet; Q9DCP2; -.
PhosphoSitePlus; Q9DCP2; -.
SwissPalm; Q9DCP2; -.
jPOST; Q9DCP2; -.
MaxQB; Q9DCP2; -.
PaxDb; Q9DCP2; -.
PeptideAtlas; Q9DCP2; -.
PRIDE; Q9DCP2; -.
Ensembl; ENSMUST00000010208; ENSMUSP00000010208; ENSMUSG00000010064.
Ensembl; ENSMUST00000167868; ENSMUSP00000130414; ENSMUSG00000010064.
Ensembl; ENSMUST00000177567; ENSMUSP00000137561; ENSMUSG00000010064.
Ensembl; ENSMUST00000193932; ENSMUSP00000142087; ENSMUSG00000010064.
GeneID; 76257; -.
KEGG; mmu:76257; -.
UCSC; uc009rmn.1; mouse.
CTD; 10991; -.
MGI; MGI:1923507; Slc38a3.
eggNOG; KOG1305; Eukaryota.
eggNOG; COG0814; LUCA.
GeneTree; ENSGT00940000157127; -.
HOGENOM; HOG000013088; -.
InParanoid; Q9DCP2; -.
KO; K13576; -.
OMA; TTGNFSH; -.
OrthoDB; 697331at2759; -.
PhylomeDB; Q9DCP2; -.
TreeFam; TF328787; -.
Reactome; R-MMU-352230; Amino acid transport across the plasma membrane.
PRO; PR:Q9DCP2; -.
Proteomes; UP000000589; Chromosome 9.
Bgee; ENSMUSG00000010064; Expressed in 163 organ(s), highest expression level in liver.
ExpressionAtlas; Q9DCP2; baseline and differential.
Genevisible; Q9DCP2; MM.
GO; GO:0016323; C:basolateral plasma membrane; ISO:MGI.
GO; GO:0005887; C:integral component of plasma membrane; IDA:MGI.
GO; GO:0016020; C:membrane; IDA:MGI.
GO; GO:0005886; C:plasma membrane; ISO:MGI.
GO; GO:0015171; F:amino acid transmembrane transporter activity; IBA:GO_Central.
GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
GO; GO:0015180; F:L-alanine transmembrane transporter activity; ISO:MGI.
GO; GO:0015182; F:L-asparagine transmembrane transporter activity; ISO:MGI.
GO; GO:0015186; F:L-glutamine transmembrane transporter activity; IDA:MGI.
GO; GO:0005290; F:L-histidine transmembrane transporter activity; IDA:MGI.
GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
GO; GO:0003333; P:amino acid transmembrane transport; IBA:GO_Central.
GO; GO:0006867; P:asparagine transport; ISO:MGI.
GO; GO:0007420; P:brain development; IEA:Ensembl.
GO; GO:0051365; P:cellular response to potassium ion starvation; IDA:MGI.
GO; GO:0007565; P:female pregnancy; IEA:Ensembl.
GO; GO:0006868; P:glutamine transport; IDA:MGI.
GO; GO:0015817; P:histidine transport; IDA:MGI.
GO; GO:0015808; P:L-alanine transport; ISO:MGI.
GO; GO:2000487; P:positive regulation of glutamine transport; ISO:MGI.
GO; GO:0061402; P:positive regulation of transcription from RNA polymerase II promoter in response to acidic pH; IDA:MGI.
GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
InterPro; IPR013057; AA_transpt_TM.
Pfam; PF01490; Aa_trans; 1.
1: Evidence at protein level;
Amino-acid transport; Antiport; Cell membrane; Complete proteome;
Disulfide bond; Glycoprotein; Ion transport; Membrane;
Reference proteome; Sodium; Sodium transport; Symport; Transmembrane;
Transmembrane helix; Transport.
CHAIN 1 505 Sodium-coupled neutral amino acid
transporter 3.
/FTId=PRO_0000093829.
TRANSMEM 82 102 Helical. {ECO:0000255}.
TRANSMEM 105 125 Helical. {ECO:0000255}.
TRANSMEM 143 163 Helical. {ECO:0000255}.
TRANSMEM 186 206 Helical. {ECO:0000255}.
TRANSMEM 212 232 Helical. {ECO:0000255}.
TRANSMEM 288 308 Helical. {ECO:0000255}.
TRANSMEM 325 345 Helical. {ECO:0000255}.
TRANSMEM 367 387 Helical. {ECO:0000255}.
TRANSMEM 409 429 Helical. {ECO:0000255}.
TRANSMEM 432 452 Helical. {ECO:0000255}.
TRANSMEM 472 492 Helical. {ECO:0000255}.
CARBOHYD 73 73 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 247 247 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 251 251 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 324 324 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 239 276 {ECO:0000255|PROSITE-ProRule:PRU00114}.
CONFLICT 110 110 S -> N (in Ref. 2; BAC28963).
{ECO:0000305}.
CONFLICT 130 130 Q -> R (in Ref. 2; BAC28963).
{ECO:0000305}.
CONFLICT 270 270 T -> A (in Ref. 1; AAF61849).
{ECO:0000305}.
SEQUENCE 505 AA; 55592 MW; 368DBB87F1BB248A CRC64;
MEIPRQTEMV ELVPNGKHLE GLLPVGVPTT DTQRTEDTQH CGEGKGFLQK SPSKEPHFTD
FEGKTSFGMS VFNLSNAIMG SGILGLAYAM ANTGIILFLF LLTAVALLSS YSIHLLLKSS
GIVGIRAYEQ LGYRAFGTPG KLAAALAITL QNIGAMSSYL YIIKSELPLV IQTFLNLEKP
ASVWYMDGNY LVILVSVTII LPLALMRQLG YLGYSSGFSL SCMVFFLIAV IYKKFQVPCP
LAHNLANATG NFSHMVVAEE KAQLQGEPDT AAEAFCTPSY FTLNSQTAYT IPIMAFAFVC
HPEVLPIYTE LKDPSKRKMQ HISNLSIAVM YVMYFLAALF GYLTFYDGVE SELLHTYSKV
DPFDVLILCV RVAVLIAVTL TVPIVLFPVR RAIQQMLFQN QEFSWLRHVL IATGLLTCIN
LLVIFAPNIL