GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

Solute carrier family 52, riboflavin transporter, member 3 (Riboflavin transporter 2) (rRFT2)

 S52A3_RAT               Reviewed;         463 AA.
Q4FZU9;
05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
30-AUG-2005, sequence version 1.
12-AUG-2020, entry version 73.
RecName: Full=Solute carrier family 52, riboflavin transporter, member 3;
AltName: Full=Riboflavin transporter 2;
Short=rRFT2;
Name=Slc52a3; Synonyms=Rft2;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Placenta;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[2]
FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND BIOPHYSICOCHEMICAL
PROPERTIES.
PubMed=19122205; DOI=10.1093/jb/mvn181;
Yamamoto S., Inoue K., Ohta K.Y., Fukatsu R., Maeda J.Y., Yoshida Y.,
Yuasa H.;
"Identification and functional characterization of rat riboflavin
transporter 2.";
J. Biochem. 145:437-443(2009).
[3]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-245 AND SER-269, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22673903; DOI=10.1038/ncomms1871;
Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
Olsen J.V.;
"Quantitative maps of protein phosphorylation sites across 14 different rat
organs and tissues.";
Nat. Commun. 3:876-876(2012).
-!- FUNCTION: Plasma membrane transporter mediating the uptake by cells of
the water soluble vitamin B2/riboflavin that plays a key role in
biochemical oxidation-reduction reactions of the carbohydrate, lipid,
and amino acid metabolism. {ECO:0000250|UniProtKB:Q9NQ40}.
-!- CATALYTIC ACTIVITY:
Reaction=riboflavin(in) = riboflavin(out); Xref=Rhea:RHEA:35015,
ChEBI:CHEBI:57986; Evidence={ECO:0000250|UniProtKB:Q9NQ40};
-!- BIOPHYSICOCHEMICAL PROPERTIES:
Kinetic parameters:
KM=0.21 uM for riboflavin {ECO:0000269|PubMed:19122205};
Vmax=11 pmol/min/mg enzyme {ECO:0000269|PubMed:19122205};
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19122205};
Multi-pass membrane protein {ECO:0000269|PubMed:19122205}.
-!- TISSUE SPECIFICITY: Predominantly expressed in small intestine. Highly
expressed in jejunum and ileum. Also expressed in testis and at lower
level in lung, kidney, stomach and colon.
{ECO:0000269|PubMed:19122205}.
-!- SIMILARITY: Belongs to the riboflavin transporter family.
{ECO:0000305}.
---------------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
---------------------------------------------------------------------------
EMBL; BC099097; AAH99097.1; -; mRNA.
RefSeq; NP_001032275.1; NM_001037198.1.
STRING; 10116.ENSRNOP00000006828; -.
GlyGen; Q4FZU9; 1 site.
iPTMnet; Q4FZU9; -.
PhosphoSitePlus; Q4FZU9; -.
PaxDb; Q4FZU9; -.
PRIDE; Q4FZU9; -.
GeneID; 311536; -.
KEGG; rno:311536; -.
UCSC; RGD:1304644; rat.
CTD; 113278; -.
RGD; 1304644; Slc52a3.
eggNOG; KOG4255; Eukaryota.
InParanoid; Q4FZU9; -.
KO; K14620; -.
PhylomeDB; Q4FZU9; -.
Reactome; R-RNO-196843; Vitamin B2 (riboflavin) metabolism.
PRO; PR:Q4FZU9; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0005737; C:cytoplasm; ISO:RGD.
GO; GO:0005887; C:integral component of plasma membrane; IDA:UniProtKB.
GO; GO:0005634; C:nucleus; ISO:RGD.
GO; GO:0005886; C:plasma membrane; ISO:RGD.
GO; GO:0032217; F:riboflavin transmembrane transporter activity; IDA:UniProtKB.
GO; GO:0034605; P:cellular response to heat; ISO:RGD.
GO; GO:0032218; P:riboflavin transport; IDA:UniProtKB.
GO; GO:0007605; P:sensory perception of sound; ISS:UniProtKB.
InterPro; IPR009357; Riboflavin_transptr.
PANTHER; PTHR12929; PTHR12929; 1.
Pfam; PF06237; DUF1011; 1.
1: Evidence at protein level;
Cell membrane; Glycoprotein; Membrane; Phosphoprotein; Reference proteome;
Transmembrane; Transmembrane helix; Transport.
CHAIN 1..463
/note="Solute carrier family 52, riboflavin transporter,
member 3"
/id="PRO_0000399792"
TOPO_DOM 1..6
/note="Cytoplasmic"
/evidence="ECO:0000305"
TRANSMEM 7..27
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 28..37
/note="Extracellular"
/evidence="ECO:0000305"
TRANSMEM 38..58
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 59..71
/note="Cytoplasmic"
/evidence="ECO:0000305"
TRANSMEM 72..92
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 93..105
/note="Extracellular"
/evidence="ECO:0000305"
TRANSMEM 106..126
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 127..137
/note="Cytoplasmic"
/evidence="ECO:0000305"
TRANSMEM 138..158
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 159..214
/note="Extracellular"
/evidence="ECO:0000305"
TRANSMEM 215..235
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 236..294
/note="Cytoplasmic"
/evidence="ECO:0000305"
TRANSMEM 295..315
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 316..329
/note="Extracellular"
/evidence="ECO:0000305"
TRANSMEM 330..350
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 351..353
/note="Cytoplasmic"
/evidence="ECO:0000305"
TRANSMEM 354..374
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 375..390
/note="Extracellular"
/evidence="ECO:0000305"
TRANSMEM 391..411
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 412..421
/note="Cytoplasmic"
/evidence="ECO:0000305"
TRANSMEM 422..442
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 443..463
/note="Extracellular"
/evidence="ECO:0000305"
MOD_RES 245
/note="Phosphoserine"
/evidence="ECO:0000244|PubMed:22673903"
MOD_RES 269
/note="Phosphoserine"
/evidence="ECO:0000244|PubMed:22673903"
CARBOHYD 168
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
SEQUENCE 463 AA; 50130 MW; 3D513AD8339D4B15 CRC64;
MAFLTHLLVC VFGMGSWVAI NGLWVELPLL VTKLPEGWYL PSYLTVVIQL ANTGPLLVTL
MHRFRPGCLS EVPVIFLILC VGTTACILLA FLWSMTSWIQ GRQHSVAFIV LTFFLALVDC
TSSVTFLPFM SQLPTYYLTT FFIGEGLSGL LPALVALVQG SGITTCVNVT ETPGTTLNPV
TTMETSITQR TLSPSLTPLT WHLESRYLAP RFSPLLFFLL LSFLMGCCLV AFFLLQRQPW
GRQGSIEDLL HSQVTLHSIK PRDTEDTGSV GAPVSSPGKG SVEVSVASLR PAQLAFIYSV
VAFVNALTNG VLPSVQTYSC LPYGPVAYHL SATLSSVASP LACFLPIFLP NRSLLFLGVL
TVLGTGFGTY NMAMAAMSPC PILQGHWGGE VLIVLSWMLF VACLSYVKVM LGVILRDRSR
SALLWCGAAV QLGSLIGALL MFPLVNVLKL FSSADYCSLD CSA


Related products :

Catalog number Product name Quantity
E1198m Rat ELISA Kit FOR Solute carrier family 52, riboflavin transporter, member 3 96T
E1209b Pig ELISA Kit FOR Solute carrier family 52, riboflavin transporter, member 2 96T
E1253h Human ELISA Kit FOR Solute carrier family 52, riboflavin transporter, member 3 96T
EIAAB34413 Rat,Rattus norvegicus,Rft2,Riboflavin transporter 2,rRFT2
EIAAB39157 Matr1,Matrin F_G 1,PGT,Prostaglandin transporter,Rat,Rattus norvegicus,Slc21a2,Slco2a1,Solute carrier family 21 member 2,Solute carrier organic anion transporter family member 2A1
EIAAB39156 Homo sapiens,Human,OATP2A1,PGT,Prostaglandin transporter,SLC21A2,SLCO2A1,Solute carrier family 21 member 2,Solute carrier organic anion transporter family member 2A1
EIAAB39155 Mouse,Mus musculus,Oatp2a1,PGT,Prostaglandin transporter,Slc21a2,Slco2a1,Solute carrier family 21 member 2,Solute carrier organic anion transporter family member 2A1
EIAAB36707 Ergothioneine transporter,ET transporter,ETT,Homo sapiens,Human,OCTN1,Organic cation_carnitine transporter 1,SLC22A4,Solute carrier family 22 member 4,UT2H
EIAAB39150 Liver-specific organic anion transporter 1,LST-1,Mouse,Mus musculus,Oatp1b2,Slc21a10,SLC21A6,Slco1b2,Solute carrier family 21 member 10,Solute carrier organic anion transporter family member 1B2
EIAAB36639 Homo sapiens,Human,OCTP,Osteoclast transporter,Peptide transporter 3,Peptide_histidine transporter 2,PHT2,PTR3,SLC15A3,Solute carrier family 15 member 3
EIAAB39158 Oatp2b1,Organic anion transporter moatp1,Rat,Rattus norvegicus,Slc21a9,Slco2b1,Solute carrier family 21 member 9,Solute carrier organic anion transporter family member 2B1
EIAAB39171 Homo sapiens,Human,OATP5A1,OATPRP4,OATP-RP4,Organic anion transporter polypeptide-related protein 4,SLC21A15,SLCO5A1,Solute carrier family 21 member 15,Solute carrier organic anion transporter family
EIAAB12295 Eaat1,Excitatory amino acid transporter 1,GLAST-1,Glial glutamate transporter,Rat,Rattus norvegicus,Slc1a3,Sodium-dependent glutamate_aspartate transporter 1,Solute carrier family 1 member 3
EIAAB39141 OAT-K1,OAT-K2,Oatp1a3,Rat,Rattus norvegicus,rOAT-K,Slc21a4,Slco1a3,Sodium-independent organic anion transporter K1,Solute carrier family 21 member 4,Solute carrier organic anion transporter family mem
EIAAB12307 Eaat4,Excitatory amino acid transporter 4,High-affinity neuronal glutamate transporter,Mouse,Mus musculus,Slc1a6,Sodium-dependent glutamate_aspartate transporter,Solute carrier family 1 member 6
EIAAB12308 Eaat4,Excitatory amino acid transporter 4,High-affinity neuronal glutamate transporter,Rat,Rattus norvegicus,Slc1a6,Sodium-dependent glutamate_aspartate transporter,Solute carrier family 1 member 6
EIAAB39168 Homo sapiens,Human,OATP4C1,OATP-H,OATP-M1,OATPX,Organic anion transporter M1,SLC21A20,SLCO4C1,Solute carrier family 21 member 20,Solute carrier organic anion transporter family member 4C1
EIAAB25211 Homo sapiens,Human,MCT 7,MCT 8,MCT8,Monocarboxylate transporter 7,Monocarboxylate transporter 8,SLC16A2,Solute carrier family 16 member 2,X-linked PEST-containing transporter,XPCT
EIAAB37153 Rat,Rattus norvegicus,Sit1,Slc6a20,Sodium- and chloride-dependent transporter XTRP3,Sodium_imino-acid transporter 1,Solute carrier family 6 member 20,Transporter rB21A,Xtrp3
EIAAB12297 EAAT2,Excitatory amino acid transporter 2,GLT1,Glutamate_aspartate transporter II,Homo sapiens,Human,SLC1A2,Sodium-dependent glutamate_aspartate transporter 2,Solute carrier family 1 member 2
EIAAB39170 Mouse,Mus musculus,Oatp4c1,Oatp-R,Slc21a20,Slco4c1,Solute carrier family 21 member 20,Solute carrier organic anion transporter family member 4C1
EIAAB39169 Oatp4c1,Rat,Rattus norvegicus,Slc21a20,Slco4c1,Solute carrier family 21 member 20,Solute carrier organic anion transporter family member 4C1
EIAAB36752 Mouse,Mus musculus,Octn3,Organic cation_carnitine transporter 3,Slc22a21,Slc22a9,Solute carrier family 22 member 21,Solute carrier family 22 member 9
EIAAB39160 Mouse,Mus musculus,Oatp2b1,Slc21a9,Slco2b1,Solute carrier family 21 member 9,Solute carrier organic anion transporter family member 2B1
EIAAB37152 Homo sapiens,Human,SIT1,SLC6A20,Sodium- and chloride-dependent transporter XTRP3,Sodium_imino-acid transporter 1,Solute carrier family 6 member 20,Transporter rB21A homolog,XT3,XTRP3
Pathways :
WP2347: vitamin B5 (pantothenate) and CoA biosynthesis Pathway
WP2344: vitamin B6 (pyridoxine, pyridoxal, pyridoxamine) biosynthesis and salvage pathway
WP1455: Serotonin Transporter Activity
WP2349: vitamin B3 (niacin), NAD and NADP biosynthesis pathway
WP1689: Porphyrin and chlorophyll metabolism
WP2339: vitamin B2 (riboflavin) biosynthesis and conversion to FMN and FAD pathway
WP1493: Carbon assimilation C4 pathway
WP1680: Oxidative phosphorylation
WP1713: Two-component system
WP2345: vitamin B7 (biotin) biosynthesis pathway
WP381: Riboflavin, FMN, and FAD Biosynthesis
WP1616: ABC transporters
WP1696: Riboflavin metabolism
WP1502: Mitochondrial biogenesis
WP1780: ABC-family proteins mediated transport
WP1909: Signal regulatory protein (SIRP) family interactions
WP1834: Interactions of the immunoglobulin superfamily (IgSF) member proteins
WP2199: Seed Development
WP1485: Interactions between CFTR and other ion channels
WP1799: Costimulation by the CD28 family
WP211: BMP signaling pathway

Related Genes :
[SLC52A3 C20orf54 RFT2 RFVT3] Solute carrier family 52, riboflavin transporter, member 3 (Riboflavin transporter 2) (hRFT2)
[SLC52A1 GPR172B PAR2 RFT1] Solute carrier family 52, riboflavin transporter, member 1 (Porcine endogenous retrovirus A receptor 2) (PERV-A receptor 2) (huPAR-2) (Protein GPR172B) (Riboflavin transporter 1) (hRFT1)
[SLCO1B3 LST2 OATP1B3 OATP8 SLC21A8] Solute carrier organic anion transporter family member 1B3 (Liver-specific organic anion transporter 2) (LST-2) (Organic anion transporter 8) (Organic anion-transporting polypeptide 8) (OATP-8) (Solute carrier family 21 member 8)
[Slco1a3 Oatp1a3 Slc21a4] Solute carrier organic anion transporter family member 1A3 (OAT-K2) (Sodium-independent organic anion transporter K1) (OAT-K1) (Solute carrier family 21 member 4) (rOAT-K)
[SLC2A1 GLUT1] Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1) (HepG2 glucose transporter)
[SLC22A18 BWR1A BWSCR1A HET IMPT1 ITM ORCTL2 SLC22A1L TSSC5] Solute carrier family 22 member 18 (Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein) (Efflux transporter-like protein) (Imprinted multi-membrane-spanning polyspecific transporter-related protein 1) (Organic cation transporter-like protein 2) (ORCTL-2) (Solute carrier family 22 member 1-like) (Tumor-suppressing STF cDNA 5 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein) (p45-Beckwith-Wiedemann region 1 A) (p45-BWR1A)
[Slco1b2 Oatp1b2 Slc21a10] Solute carrier organic anion transporter family member 1B2 (Liver-specific organic anion transporter 1) (rLST-1) (Sodium-independent organic anion-transporting polypeptide 4) (OATP-4) (Solute carrier family 21 member 10)
[SLCO1B1 LST1 OATP1B1 OATP2 OATPC SLC21A6] Solute carrier organic anion transporter family member 1B1 (Liver-specific organic anion transporter 1) (LST-1) (OATP-C) (Sodium-independent organic anion-transporting polypeptide 2) (OATP-2) (Solute carrier family 21 member 6)
[SLC6A18 XTRP2] Inactive sodium-dependent neutral amino acid transporter B(0)AT3 (Sodium- and chloride-dependent transporter XTRP2) (Solute carrier family 6 member 18) (System B(0) neutral amino acid transporter AT3)
[SLC35B2 PAPST1 PSEC0149] Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (PAPS transporter 1) (Putative MAPK-activating protein PM15) (Putative NF-kappa-B-activating protein 48) (Solute carrier family 35 member B2)
[SLC40A1 FPN1 IREG1 SLC11A3 MSTP079] Solute carrier family 40 member 1 (Ferroportin-1) (Iron-regulated transporter 1)
[rft-1 Y47D7A.16] Riboflavin transporter rft-1 (Solute carrier family 52, riboflavin transporter rft-1)
[SLC23A2 KIAA0238 NBTL1 SLC23A1 SVCT2 YSPL2] Solute carrier family 23 member 2 (Na(+)/L-ascorbic acid transporter 2) (Nucleobase transporter-like 1 protein) (Sodium-dependent vitamin C transporter 2) (hSVCT2) (Yolk sac permease-like molecule 2)
[SLC2A9 GLUT9] Solute carrier family 2, facilitated glucose transporter member 9 (Glucose transporter type 9) (GLUT-9) (Urate transporter)
[SLCO4C1 OATP4C1 OATPX SLC21A20] Solute carrier organic anion transporter family member 4C1 (OATP-H) (Organic anion transporter M1) (OATP-M1) (Solute carrier family 21 member 20)
[Slc2a5 Glut5] Solute carrier family 2, facilitated glucose transporter member 5 (Fructose transporter) (Glucose transporter type 5, small intestine) (GLUT-5)
[SLC2A6 GLUT6] Solute carrier family 2, facilitated glucose transporter member 6 (Glucose transporter type 6) (GLUT-6)
[SLC2A11 GLUT11] Solute carrier family 2, facilitated glucose transporter member 11 (Glucose transporter type 11) (GLUT-11)
[Slc2a9 Glut9] Solute carrier family 2, facilitated glucose transporter member 9 (Glucose transporter type 9) (GLUT-9) (Urate transporter)
[Slc2a1 Glut1] Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1) (GT1)
[SLC16A12 MCT12] Monocarboxylate transporter 12 (MCT 12) (Creatine transporter 2) (CRT2) (Solute carrier family 16 member 12)
[SLC23A1 SVCT1 YSPL3] Solute carrier family 23 member 1 (Na(+)/L-ascorbic acid transporter 1) (Sodium-dependent vitamin C transporter 1) (hSVCT1) (Yolk sac permease-like molecule 3)
[Slc2a1 Glut1] Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1)
[SLC2A4 GLUT4] Solute carrier family 2, facilitated glucose transporter member 4 (Glucose transporter type 4, insulin-responsive) (GLUT-4)
[Slc2a4 Glut4] Solute carrier family 2, facilitated glucose transporter member 4 (Glucose transporter type 4, insulin-responsive) (GLUT-4)
[SLC19A3] Thiamine transporter 2 (ThTr-2) (ThTr2) (Solute carrier family 19 member 3)
[SLC22A5 OCTN2] Solute carrier family 22 member 5 (High-affinity sodium-dependent carnitine cotransporter) (Organic cation/carnitine transporter 2)
[Slc15a2 Pept2] Solute carrier family 15 member 2 (Kidney H(+)/peptide cotransporter) (Oligopeptide transporter, kidney isoform) (Peptide transporter 2)
[Slc40a1 Fpn1 Ireg1 Slc11a3 Slc39a1] Solute carrier family 40 member 1 (Ferroportin-1) (Iron-regulated transporter 1) (Metal transporter protein 1) (MTP1)
[SLC25A23 APC2 MCSC2 SCAMC3] Calcium-binding mitochondrial carrier protein SCaMC-3 (Mitochondrial ATP-Mg/Pi carrier protein 2) (Mitochondrial Ca(2+)-dependent solute carrier protein 2) (Small calcium-binding mitochondrial carrier protein 3) (Solute carrier family 25 member 23)

Bibliography :