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Solute carrier organic anion transporter family member 1B3 (Liver-specific organic anion transporter 2) (LST-2) (Organic anion transporter 8) (Organic anion-transporting polypeptide 8) (OATP-8) (Solute carrier family 21 member 8)

 SO1B3_HUMAN             Reviewed;         702 AA.
Q9NPD5; E7EMT8; Q5JAR4;
10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
18-SEP-2019, entry version 164.
RecName: Full=Solute carrier organic anion transporter family member 1B3;
AltName: Full=Liver-specific organic anion transporter 2;
Short=LST-2;
AltName: Full=Organic anion transporter 8;
AltName: Full=Organic anion-transporting polypeptide 8;
Short=OATP-8;
AltName: Full=Solute carrier family 21 member 8;
Name=SLCO1B3; Synonyms=LST2, OATP1B3, OATP8, SLC21A8;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), AND
GLYCOSYLATION.
TISSUE=Liver;
PubMed=10779507; DOI=10.1074/jbc.m001448200;
Koenig J., Cui Y., Nies A.T., Keppler D.;
"Localization and genomic organization of a new hepatocellular organic
anion transporting polypeptide.";
J. Biol. Chem. 275:23161-23168(2000).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Liver;
PubMed=11375950; DOI=10.1053/gast.2001.24804;
Abe T., Unno M., Onogawa T., Tokui T., Kondo T.N., Nakagomi R.,
Adachi H., Fujiwara K., Okabe M., Suzuki T., Nunoki K., Sato E.,
Kakyo M., Nishio T., Sugita J., Asano N., Tanemoto M., Seki M.,
Date F., Ono K., Kondo Y., Shiiba K., Suzuki M., Ohtani H.,
Shimosegawa T., Iinuma K., Nagura H., Ito S., Matsuno S.;
"LST-2, a human liver-specific organic anion transporter, determines
methotrexate sensitivity in gastrointestinal cancers.";
Gastroenterology 120:1689-1699(2001).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Mizutamari H., Abe T.;
"Molecular identification of LST-3 subtype.";
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16541075; DOI=10.1038/nature04569;
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M.,
Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B.,
Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D.,
Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z.,
Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H.,
Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H.,
Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V.,
Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J.,
Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A.,
Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M.,
Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E.,
Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M.,
Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R.,
Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J.,
Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C.,
Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M.,
Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M.,
Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P.,
Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L.,
Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E.,
Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C.,
Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F.,
Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M.,
Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S.,
Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D.,
Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I.,
Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T.,
Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S.,
Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D.,
Kucherlapati R., Weinstock G., Gibbs R.A.;
"The finished DNA sequence of human chromosome 12.";
Nature 440:346-351(2006).
[5]
FUNCTION, AND INVOLVEMENT IN HBLRR.
PubMed=22232210; DOI=10.1172/jci59526;
van de Steeg E., Stranecky V., Hartmannova H., Noskova L.,
Hrebicek M., Wagenaar E., van Esch A., de Waart D.R.,
Oude Elferink R.P., Kenworthy K.E., Sticova E., al-Edreesi M.,
Knisely A.S., Kmoch S., Jirsa M., Schinkel A.H.;
"Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome
by interrupting conjugated bilirubin reuptake into the liver.";
J. Clin. Invest. 122:519-528(2012).
[6]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Liver;
PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
Wang L., Ye M., Zou H.;
"An enzyme assisted RP-RPLC approach for in-depth analysis of human
liver phosphoproteome.";
J. Proteomics 96:253-262(2014).
[7]
VARIANTS [LARGE SCALE ANALYSIS] MET-292 AND LEU-647.
PubMed=16959974; DOI=10.1126/science.1133427;
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S.,
Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J.,
Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C.,
Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N.,
Vogelstein B., Kinzler K.W., Velculescu V.E.;
"The consensus coding sequences of human breast and colorectal
cancers.";
Science 314:268-274(2006).
-!- FUNCTION: Mediates the Na(+)-independent uptake of organic anions
such as 17-beta-glucuronosyl estradiol, taurocholate,
triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone
sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP).
Involved in the clearance of bile acids and organic anions from
the liver. {ECO:0000269|PubMed:22232210}.
-!- SUBCELLULAR LOCATION: Basolateral cell membrane; Multi-pass
membrane protein.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q9NPD5-1; Sequence=Displayed;
Name=2;
IsoId=Q9NPD5-2; Sequence=VSP_056615, VSP_056616, VSP_056617;
-!- TISSUE SPECIFICITY: Highly expressed in liver, in particular at
the basolateral membrane of hepatocytes near the central vein. Not
detected in other tissues. Highly expressed in some cancer cell
lines derived from colon, pancreas, liver and gall bladder.
-!- PTM: N-glycosylated. {ECO:0000269|PubMed:10779507}.
-!- DISEASE: Hyperbilirubinemia, Rotor type (HBLRR) [MIM:237450]: An
autosomal recessive form of primary conjugated hyperbilirubinemia.
Affected individuals develop mild jaundice not associated with
hemolysis shortly after birth or in childhood. They have delayed
plasma clearance of the unconjugated anionic dye bromsulphthalein
and prominent urinary excretion of coproporphyrin I. Hepatic
pigmentation is normal. {ECO:0000269|PubMed:22232210}. Note=The
disease is caused by mutations affecting the gene represented in
this entry.
-!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60)
family. {ECO:0000305}.
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EMBL; AJ400763; CAB97008.1; -; Genomic_DNA.
EMBL; AJ400764; CAB97008.1; JOINED; Genomic_DNA.
EMBL; AJ400765; CAB97008.1; JOINED; Genomic_DNA.
EMBL; AJ400766; CAB97008.1; JOINED; Genomic_DNA.
EMBL; AJ400767; CAB97008.1; JOINED; Genomic_DNA.
EMBL; AJ400768; CAB97008.1; JOINED; Genomic_DNA.
EMBL; AJ400769; CAB97008.1; JOINED; Genomic_DNA.
EMBL; AJ400770; CAB97008.1; JOINED; Genomic_DNA.
EMBL; AJ400771; CAB97008.1; JOINED; Genomic_DNA.
EMBL; AJ400772; CAB97008.1; JOINED; Genomic_DNA.
EMBL; AJ400773; CAB97008.1; JOINED; Genomic_DNA.
EMBL; AJ400774; CAB97008.1; JOINED; Genomic_DNA.
EMBL; AJ400775; CAB97008.1; JOINED; Genomic_DNA.
EMBL; AJ400776; CAB97008.1; JOINED; Genomic_DNA.
EMBL; AJ251506; CAB96997.1; -; mRNA.
EMBL; AF187815; AAG43445.1; -; mRNA.
EMBL; AY257471; AAP81212.1; -; mRNA.
EMBL; AY442326; AAS01768.1; -; mRNA.
EMBL; AC011604; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AC087309; -; NOT_ANNOTATED_CDS; Genomic_DNA.
CCDS; CCDS8684.1; -. [Q9NPD5-1]
RefSeq; NP_062818.1; NM_019844.3. [Q9NPD5-1]
STRING; 9606.ENSP00000261196; -.
BindingDB; Q9NPD5; -.
ChEMBL; CHEMBL1743121; -.
DrugBank; DB06403; Ambrisentan.
DrugBank; DB11586; Asunaprevir.
DrugBank; DB05016; Ataluren.
DrugBank; DB01072; Atazanavir.
DrugBank; DB01076; Atorvastatin.
DrugBank; DB11817; Baricitinib.
DrugBank; DB06772; Cabazitaxel.
DrugBank; DB00520; Caspofungin.
DrugBank; DB08862; Cholecystokinin.
DrugBank; DB02659; Cholic Acid.
DrugBank; DB00091; Ciclosporin.
DrugBank; DB01211; Clarithromycin.
DrugBank; DB00257; Clotrimazole.
DrugBank; DB09065; Cobicistat.
DrugBank; DB05239; Cobimetinib.
DrugBank; DB00286; Conjugated estrogens.
DrugBank; DB08912; Dabrafenib.
DrugBank; DB09102; Daclatasvir.
DrugBank; DB00975; Dipyridamole.
DrugBank; DB01248; Docetaxel.
DrugBank; DB05928; Dovitinib.
DrugBank; DB08861; DPDPE.
DrugBank; DB13874; Enasidenib.
DrugBank; DB00199; Erythromycin.
DrugBank; DB00783; Estradiol.
DrugBank; DB13952; Estradiol acetate.
DrugBank; DB13953; Estradiol benzoate.
DrugBank; DB13954; Estradiol cypionate.
DrugBank; DB13955; Estradiol dienanthate.
DrugBank; DB13956; Estradiol valerate.
DrugBank; DB01590; Everolimus.
DrugBank; DB00950; Fexofenadine.
DrugBank; DB01095; Fluvastatin.
DrugBank; DB08884; Gadoxetic acid.
DrugBank; DB06749; Ginsenoside Rb1.
DrugBank; DB06750; Ginsenoside Rg1.
DrugBank; DB13879; Glecaprevir.
DrugBank; DB02691; Glycocholic acid.
DrugBank; DB11575; Grazoprevir.
DrugBank; DB09054;