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Solute carrier organic anion transporter family member 2B1 (Organic anion transporter B) (OATP-B) (Organic anion transporter polypeptide-related protein 2) (OATP-RP2) (OATPRP2) (Solute carrier family 21 member 9)

 SO2B1_HUMAN             Reviewed;         709 AA.
O94956; A8K2G9; B4DGA9; B4DTB0; E7ERN5; E9PPU8; Q9H2Z0; Q9UFU1;
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
30-NOV-2010, sequence version 2.
08-MAY-2019, entry version 162.
RecName: Full=Solute carrier organic anion transporter family member 2B1;
AltName: Full=Organic anion transporter B;
Short=OATP-B;
AltName: Full=Organic anion transporter polypeptide-related protein 2;
Short=OATP-RP2;
Short=OATPRP2;
AltName: Full=Solute carrier family 21 member 9;
Name=SLCO2B1; Synonyms=KIAA0880, OATP2B1, OATPB, SLC21A9;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT THR-392.
TISSUE=Brain;
PubMed=10873595; DOI=10.1006/bbrc.2000.2922;
Tamai I., Nezu J., Uchino H., Sai Y., Oku A., Shimane M., Tsuji A.;
"Molecular identification and characterization of novel members of the
human organic anion transporter (OATP) family.";
Biochem. Biophys. Res. Commun. 273:251-260(2000).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), AND VARIANT THR-392.
Wu Y., Hsiang B.H., Zhu Y., Yang W.-P., Kirchgessner T.G.;
"Identification and characterization of novel human OATP family
members.";
Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT
THR-392.
TISSUE=Brain;
PubMed=10048485; DOI=10.1093/dnares/5.6.355;
Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M.,
Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.;
"Prediction of the coding sequences of unidentified human genes. XII.
The complete sequences of 100 new cDNA clones from brain which code
for large proteins in vitro.";
DNA Res. 5:355-364(1998).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4), AND
VARIANTS THR-392 AND PHE-486.
TISSUE=Amygdala, and Thalamus;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT
THR-392.
TISSUE=Uterus;
PubMed=17974005; DOI=10.1186/1471-2164-8-399;
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
"The full-ORF clone resource of the German cDNA consortium.";
BMC Genomics 8:399-399(2007).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16554811; DOI=10.1038/nature04632;
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F.,
Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E.,
FitzGerald M.G., Jaffe D.B., LaButti K., Nicol R., Park H.-S.,
Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W.,
Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S.,
Sakaki Y.;
"Human chromosome 11 DNA sequence and analysis including novel gene
identification.";
Nature 440:497-500(2006).
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT
THR-392.
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[8]
PRESENCE OF DISULFIDE BONDS.
PubMed=16754786; DOI=10.1124/mol.105.019547;
Hanggi E., Grundschober A.F., Leuthold S., Meier P.J., St-Pierre M.V.;
"Functional analysis of the extracellular cysteine residues in the
human organic anion transporting polypeptide, OATP2B1.";
Mol. Pharmacol. 70:806-817(2006).
[9]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-320, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Erythroleukemia;
PubMed=23186163; DOI=10.1021/pr300630k;
Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
Mohammed S.;
"Toward a comprehensive characterization of a human cancer cell
phosphoproteome.";
J. Proteome Res. 12:260-271(2013).
[10]
ALTERNATIVE PROMOTER USAGE, AND TISSUE SPECIFICITY.
PubMed=23531488; DOI=10.1124/mol.112.083618;
Knauer M.J., Girdwood A.J., Kim R.B., Tirona R.G.;
"Transport function and transcriptional regulation of a liver-enriched
human organic anion transporting polypeptide 2B1 transcriptional start
site variant.";
Mol. Pharmacol. 83:1218-1228(2013).
[11]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-318 AND SER-320, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Liver;
PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
Wang L., Ye M., Zou H.;
"An enzyme assisted RP-RPLC approach for in-depth analysis of human
liver phosphoproteome.";
J. Proteomics 96:253-262(2014).
[12]
VARIANT [LARGE SCALE ANALYSIS] LYS-77.
PubMed=16959974; DOI=10.1126/science.1133427;
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S.,
Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J.,
Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C.,
Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N.,
Vogelstein B., Kinzler K.W., Velculescu V.E.;
"The consensus coding sequences of human breast and colorectal
cancers.";
Science 314:268-274(2006).
-!- FUNCTION: Mediates the Na(+)-independent transport of organic
anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2,
leukotriene C4, thromboxane B2 and iloprost. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative promoter usage, Alternative splicing; Named isoforms=4;
Name=1; Synonyms=1b, FL;
IsoId=O94956-1; Sequence=Displayed;
Name=2;
IsoId=O94956-2; Sequence=VSP_006147, VSP_006148;
Note=No experimental confirmation available.;
Name=3; Synonyms=1e, Short;
IsoId=O94956-3; Sequence=VSP_054109;
Note=Functional transporter. Predominant isoform in liver,
expression at promoter is regulated by HNF4alpha.;
Name=4;
IsoId=O94956-4; Sequence=VSP_054110;
Note=No experimental confirmation available.;
-!- TISSUE SPECIFICITY: Isoform 1 has it's highest expression in
brain, it is the major form expressed in duodenum, kidney,
placenta, and skeletal muscle. Isoform 3 predominates in liver.
{ECO:0000269|PubMed:23531488}.
-!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60)
family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=BAA74903.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
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EMBL; AB026256; BAA78638.1; -; mRNA.
EMBL; AF205073; AAG42205.1; -; mRNA.
EMBL; AB020687; BAA74903.2; ALT_INIT; mRNA.
EMBL; AK290234; BAF82923.1; -; mRNA.
EMBL; AK294503; BAG57720.1; -; mRNA.
EMBL; AK300134; BAG61922.1; -; mRNA.
EMBL; AL117465; CAB55940.1; -; mRNA.
EMBL; AP001972; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC041095; AAH41095.1; -; mRNA.
CCDS; CCDS44683.1; -. [O94956-3]
CCDS; CCDS53679.1; -. [O94956-4]
CCDS; CCDS8235.1; -. [O94956-1]
PIR; T17250; T17250.
RefSeq; NP_001138683.1; NM_001145211.2.
RefSeq; NP_001138684.1; NM_001145212.2.
RefSeq; NP_009187.1; NM_007256.4.
BioGrid; 116442; 1.
STRING; 9606.ENSP00000289575; -.
BindingDB; O94956; -.
ChEMBL; CHEMBL1743124; -.
DrugBank; DB03166; Acetic acid.
DrugBank; DB00770; Alprostadil.
DrugBank; DB01076; Atorvastatin.
DrugBank; DB03793; Benzoic Acid.
DrugBank; DB01053; Benzylpenicillin.
DrugBank; DB04272; Citric Acid.
DrugBank; DB00286; Conjugated Equine Estrogens.
DrugBank; DB05804; dehydroepiandrosterone sulfate.
DrugBank; DB00390; Digoxin.
DrugBank; DB00917; Dinoprostone.
DrugBank; DB01049; Ergoloid mesylate.
DrugBank; DB00783; Estradiol.
DrugBank; DB00655; Estrone.
DrugBank; DB00950; Fexofenadine.
DrugBank; DB01095; Fluvastatin.
DrugBank; DB01016; Glyburide.
DrugBank; DB01050; Ibuprofen.
DrugBank; DB01088; Iloprost.
DrugBank; DB04398; Lactic Acid.
DrugBank; DB00654; Latanoprost.
DrugBank; DB00471; Montelukast.
DrugBank; DB03467; Naringenin.
DrugBank; DB00627; Niacin.
DrugBank; DB03902; Oxalic Acid.
DrugBank; DB02746; Phthalic Acid.
DrugBank; DB08860; Pitavastatin.
DrugBank; DB00175; Pravastatin.
DrugBank; DB04216; Quercetin.
DrugBank; DB01045; Rifampicin.
DrugBank; DB01098; Rosuvastatin.
DrugBank; DB00936; Salicylic acid.
DrugBank; DB04348; Taurocholic Acid.
DrugBank; DB01124; Tolbutamide.
GuidetoPHARMACOLOGY; 1224; -.
TCDB; 2.A.60.1.20; the organo anion transporter (oat) family.
iPTMnet