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Src-like-adapter 2 (Modulator of antigen receptor signaling) (MARS) (Src-like adapter protein 2) (SLAP-2)

 SLAP2_HUMAN             Reviewed;         261 AA.
Q9H6Q3; A8K648; E1P5U1; E1P5U2; Q5TH27; Q5TH28; Q8WY18; Q96QI4;
Q9H135;
23-APR-2003, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 3.
13-NOV-2019, entry version 163.
RecName: Full=Src-like-adapter 2;
AltName: Full=Modulator of antigen receptor signaling;
Short=MARS;
AltName: Full=Src-like adapter protein 2;
Short=SLAP-2;
Name=SLA2; Synonyms=C20orf156, SLAP2;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE (ISOFORM 1), CHARACTERIZATION, FUNCTION,
MYRISTOYLATION AT GLY-2, INTERACTION WITH CBL, AND MUTAGENESIS OF
GLY-2.
PubMed=11696592; DOI=10.1084/jem.194.9.1263;
Holland S.J., Liao X.C., Mendenhall M.K., Zhou X., Pardo J., Chu P.,
Spencer C., Fu A.C., Sheng N., Yu P., Pali E., Nagin A., Shen M.,
Yu S., Chan E., Wu X., Li C., Woisetschlager M., Aversa G.,
Kolbinger F., Bennett M.K., Molineaux S., Luo Y., Payan D.G.,
Mancebo H.S.Y., Wu J.;
"Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel
inhibitor of antigen receptor signaling.";
J. Exp. Med. 194:1263-1276(2001).
[2]
NUCLEOTIDE SEQUENCE (ISOFORMS 1; 2; 3 AND 4), AND ALTERNATIVE
INITIATION.
TISSUE=Thymus;
PubMed=12527895; DOI=10.1038/sj.onc.1206114;
Loreto M.P., McGlade C.J.;
"Cloning and characterization of human Src-like adaptor protein 2 and
a novel splice isoform, SLAP-2-v.";
Oncogene 22:266-273(2003).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Hepatoma;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=11780052; DOI=10.1038/414865a;
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M.,
Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J.,
Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P.,
Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M.,
Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R.,
Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M.,
Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H.,
Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S.,
Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E.,
Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A.,
Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M.,
Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A.,
Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S.,
Rogers J.;
"The DNA sequence and comparative analysis of human chromosome 20.";
Nature 414:865-871(2001).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Prostate;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
CHARACTERIZATION.
PubMed=11891219; DOI=10.1074/jbc.m110318200;
Pandey A., Ibarrola N., Kratchmarova I., Fernandez M.M.,
Constantinescu S.N., Ohara O., Sawasdikosol S., Lodish H.F., Mann M.;
"A novel Src homology 2 domain-containing molecule, Src-like adapter
protein-2 (SLAP-2), which negatively regulates T cell receptor
signaling.";
J. Biol. Chem. 277:19131-19138(2002).
-!- FUNCTION: Adapter protein, which negatively regulates T-cell
receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced
activation of nuclear factor of activated T-cells. May act by
linking signaling proteins such as ZAP70 with CBL, leading to a
CBL dependent degradation of signaling proteins.
{ECO:0000269|PubMed:11696592}.
-!- SUBUNIT: Interacts (via SH2 domain) with ZAP70 (phosphorylated)
and CD3Z (phosphorylated). Interacts (via SH2 domain) with CSF1R
(phosphorylated) (By similarity). Interacts (via its C-terminal
domain) with CBL (phosphorylated). {ECO:0000250,
ECO:0000269|PubMed:11696592}.
-!- INTERACTION:
P04626:ERBB2; NbExp=2; IntAct=EBI-1222854, EBI-641062;
Q13480:GAB1; NbExp=4; IntAct=EBI-1222854, EBI-517684;
P10721:KIT; NbExp=2; IntAct=EBI-1222854, EBI-1379503;
P08581:MET; NbExp=4; IntAct=EBI-1222854, EBI-1039152;
-!- SUBCELLULAR LOCATION: Cytoplasm.
-!- SUBCELLULAR LOCATION: Isoform 1: Cell membrane. Cytoplasmic
vesicle. Note=Localized to the plasma membrane and intracellular
vesicles, including late endosomal vesicles.
-!- SUBCELLULAR LOCATION: Isoform 2: Cytoplasm {ECO:0000305}. Note=May
be cytoplasmic and is not localized to membranes.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing, Alternative initiation; Named isoforms=4;
Name=1; Synonyms=p28;
IsoId=Q9H6Q3-1; Sequence=Displayed;
Name=2; Synonyms=p23, SLAP-2-v, MARS-v;
IsoId=Q9H6Q3-2; Sequence=VSP_007240, VSP_007241;
Name=3; Synonyms=p25;
IsoId=Q9H6Q3-3; Sequence=VSP_018794;
Note=Produced by alternative initiation at Met-28 of isoform 1.;
Name=4; Synonyms=p20;
IsoId=Q9H6Q3-4; Sequence=VSP_018794, VSP_007240, VSP_007241;
Note=Produced by alternative initiation at Met-28 of isoform 2.;
-!- TISSUE SPECIFICITY: Predominantly expressed in immune system, with
highest levels in peripheral blood leukocytes. Expressed in
spleen, thymus and lymph nodes. Expressed in T-cells as well as in
monocytes, and at low level in B-cells. Also detected in placenta,
prostate, skin, retina and colon.
-!- DOMAIN: The loss of the C-terminal domain partially abolishes the
inhibitory function, but can be partially compensated by higher
level of protein expression.
-!- PTM: Phosphorylated by CSF1R. {ECO:0000250}.
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EMBL; AF326353; AAL29204.1; -; mRNA.
EMBL; AF290985; AAL38197.1; -; mRNA.
EMBL; AF290986; AAL38198.1; -; mRNA.
EMBL; AK025645; BAB15201.1; -; mRNA.
EMBL; AK291513; BAF84202.1; -; mRNA.
EMBL; AL031662; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AL050318; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH471077; EAW76116.1; -; Genomic_DNA.
EMBL; CH471077; EAW76117.1; -; Genomic_DNA.
EMBL; CH471077; EAW76118.1; -; Genomic_DNA.
EMBL; CH471077; EAW76119.1; -; Genomic_DNA.
EMBL; BC042041; AAH42041.1; -; mRNA.
CCDS; CCDS13282.1; -. [Q9H6Q3-1]
CCDS; CCDS13283.1; -. [Q9H6Q3-2]
RefSeq; NP_115590.1; NM_032214.3. [Q9H6Q3-1]
RefSeq; NP_778252.1; NM_175077.2. [Q9H6Q3-2]
PDB; 4M4Z; X-ray; 2.10 A; A=29-193.
PDBsum; 4M4Z; -.
SMR; Q9H6Q3; -.
BioGrid; 123928; 14.
ELM; Q9H6Q3; -.
IntAct; Q9H6Q3; 8.
MINT; Q9H6Q3; -.
STRING; 9606.ENSP00000262866; -.
iPTMnet; Q9H6Q3; -.
PhosphoSitePlus; Q9H6Q3; -.
BioMuta; SLA2; -.
DMDM; 30173374; -.
jPOST; Q9H6Q3; -.
MassIVE; Q9H6Q3; -.
MaxQB; Q9H6Q3; -.
PaxDb; Q9H6Q3; -.
PeptideAtlas; Q9H6Q3; -.
PRIDE; Q9H6Q3; -.
ProteomicsDB; 81005; -. [Q9H6Q3-1]
ProteomicsDB; 81006; -. [Q9H6Q3-2]
ProteomicsDB; 81007; -. [Q9H6Q3-3]
ProteomicsDB; 81008; -. [Q9H6Q3-4]
Ensembl; ENST00000262866; ENSP00000262866; ENSG00000101082. [Q9H6Q3-1]
Ensembl; ENST00000360672; ENSP00000353890; ENSG00000101082. [Q9H6Q3-2]
GeneID; 84174; -.
KEGG; hsa:84174; -.
UCSC; uc002xfu.4; human. [Q9H6Q3-1]
CTD; 84174; -.
GeneCards; SLA2; -.
HGNC; HGNC:17329; SLA2.
HPA; HPA053746; -.
HPA; HPA058217; -.
MIM; 606577; gene.
neXtProt; NX_Q9H6Q3; -.
OpenTargets; ENSG00000101082; -.
PharmGKB; PA38231; -.
eggNOG; ENOG410IKI6; Eukaryota.
eggNOG; ENOG4111GMN; LUCA.
GeneTree; ENSGT00940000160331; -.
InParanoid; Q9H6Q3; -.
KO; K23698; -.
OMA; KEPCALR; -.
OrthoDB; 1051480at2759; -.
PhylomeDB; Q9H6Q3; -.
TreeFam; TF354288; -.
SignaLink; Q9H6Q3; -.
SIGNOR; Q9H6Q3; -.
ChiTaRS; SLA2; human.
GeneWiki; SLA2; -.
GenomeRNAi; 84174; -.
Pharos; Q9H6Q3; -.
PRO; PR:Q9H6Q3; -.
Proteomes; UP000005640; Chromosome 20.
Bgee; ENSG00000101082; Expressed in 107 organ(s), highest expression level in blood.
Genevisible; Q9H6Q3; HS.
GO; GO:0005737; C:cytoplasm; TAS:UniProtKB.
GO; GO:0010008; C:endosome membrane; NAS:UniProtKB.
GO; GO:0005794; C:Golgi apparatus; IDA:HPA.
GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
GO; GO:0005770; C:late endosome; IEA:Ensembl.
GO; GO:0005654; C:nucleoplasm; IDA:HPA.
GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; TAS:UniProtKB.
GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IBA:GO_Central.
GO; GO:0047485; F:protein N-terminus binding; IPI:UniProtKB.
GO; GO:0005070; F:SH3/SH2 adaptor activity; IDA:UniProtKB.
GO; GO:0050851; P:antigen receptor-mediated signaling pathway; TAS:UniProtKB.
GO; GO:0019724; P:B cell mediated immunity; TAS:UniProtKB.
GO; GO:0030522; P:intracellular receptor signaling pathway; TAS:UniProtKB.
GO; GO:0050869; P:negative regulation of B cell activation; TAS:UniProtKB.
GO; GO:0050849; P:negative regulation of calcium-mediated signaling; IDA:UniProtKB.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:UniProtKB.
GO; GO:0046854; P:phosphatidylinositol phosphorylation; IBA:GO_Central.
GO; GO:0050776; P:regulation of immune response; NAS:UniProtKB.
GO; GO:0042110; P:T cell activation; TAS:UniProtKB.
CDD; cd10344; SH2_SLAP; 1.
Gene3D; 3.30.505.10; -; 1.
InterPro; IPR000980; SH2.
InterPro; IPR036860; SH2_dom_sf.
InterPro; IPR036028; SH3-like_dom_sf.
InterPro; IPR001452; SH3_domain.
InterPro; IPR035054; SLAP2.
InterPro; IPR035052; SLAP_SH2.
PANTHER; PTHR10155:SF6; PTHR10155:SF6; 1.
Pfam; PF00017; SH2; 1.
Pfam; PF00018; SH3_1; 1.
PRINTS; PR00401; SH2DOMAIN.
SMART; SM00252; SH2; 1.
SMART; SM00326; SH3; 1.
SUPFAM; SSF50044; SSF50044; 1.
SUPFAM; SSF55550; SSF55550; 1.
PROSITE; PS50001; SH2; 1.
PROSITE; PS50002; SH3; 1.
1: Evidence at protein level;
3D-structure; Alternative initiation; Alternative splicing;
Cell membrane; Complete proteome; Cytoplasm; Cytoplasmic vesicle;
Lipoprotein; Membrane; Myristate; Phosphoprotein; Polymorphism;
Reference proteome; SH2 domain; SH3 domain.
INIT_MET 1 1 Removed.
CHAIN 2 261 Src-like-adapter 2.
/FTId=PRO_0000022351.
DOMAIN 32 92 SH3. {ECO:0000255|PROSITE-
ProRule:PRU00192}.
DOMAIN 94 191 SH2. {ECO:0000255|PROSITE-
ProRule:PRU00191}.
REGION 195 261 SLA C-terminal.
LIPID 2 2 N-myristoyl glycine.
{ECO:0000269|PubMed:11696592}.
VAR_SEQ 1 27 Missing (in isoform 3 and isoform 4).
{ECO:0000305}.
/FTId=VSP_018794.
VAR_SEQ 179 210 LADDICCLLKEPCVLQRAGPLPGKDIPLPVTV -> GWPAP
WQGYTPTCDCAEDTTQLERAGQLPPVF (in isoform 2
and isoform 4). {ECO:0000305}.
/FTId=VSP_007240.
VAR_SEQ 211 261 Missing (in isoform 2 and isoform 4).
{ECO:0000305}.
/FTId=VSP_007241.
VARIANT 210 210 V -> M (in dbSNP:rs34834764).
/FTId=VAR_051361.
MUTAGEN 2 2 G->A: Abolishes localization to
membranes. {ECO:0000269|PubMed:11696592}.
STRAND 37 39 {ECO:0000244|PDB:4M4Z}.
STRAND 58 65 {ECO:0000244|PDB:4M4Z}.
STRAND 68 73 {ECO:0000244|PDB:4M4Z}.
TURN 74 76 {ECO:0000244|PDB:4M4Z}.
STRAND 79 83 {ECO:0000244|PDB:4M4Z}.
HELIX 84 86 {ECO:0000244|PDB:4M4Z}.
STRAND 87 91 {ECO:0000244|PDB:4M4Z}.
TURN 92 94 {ECO:0000244|PDB:4M4Z}.
STRAND 95 98 {ECO:0000244|PDB:4M4Z}.
HELIX 101 108 {ECO:0000244|PDB:4M4Z}.
STRAND 118 122 {ECO:0000244|PDB:4M4Z}.
STRAND 124 128 {ECO:0000244|PDB:4M4Z}.
STRAND 130 135 {ECO:0000244|PDB:4M4Z}.
STRAND 145 152 {ECO:0000244|PDB:4M4Z}.
STRAND 158 161 {ECO:0000244|PDB:4M4Z}.
STRAND 164 168 {ECO:0000244|PDB:4M4Z}.
HELIX 169 176 {ECO:0000244|PDB:4M4Z}.
SEQUENCE 261 AA; 28585 MW; 858AF03451672B3D CRC64;
MGSLPSRRKS LPSPSLSSSV QGQGPVTMEA ERSKATAVAL GSFPAGGPAE LSLRLGEPLT
IVSEDGDWWT VLSEVSGREY NIPSVHVAKV SHGWLYEGLS REKAEELLLL PGNPGGAFLI
RESQTRRGSY SLSVRLSRPA SWDRIRHYRI HCLDNGWLYI SPRLTFPSLQ ALVDHYSELA
DDICCLLKEP CVLQRAGPLP GKDIPLPVTV QRTPLNWKEL DSSLLFSEAA TGEESLLSEG
LRESLSFYIS LNDEAVSLDD A


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EIAAB38194 Adapter protein with pleckstrin homology and Src homology 2 domains,Aps,Mouse,Mus musculus,SH2 and PH domain-containing adapter protein APS,SH2B adapter protein 2,Sh2b2
EIAAB38193 Adapter protein with pleckstrin homology and Src homology 2 domains,Aps,Rat,Rattus norvegicus,SH2 and PH domain-containing adapter protein APS,SH2B adapter protein 2,Sh2b2
EIAAB38196 Lnk,Lymphocyte adapter protein,Lymphocyte-specific adapter protein Lnk,Mouse,Mus musculus,SH2B adapter protein 3,Sh2b3,Signal transduction protein Lnk
EIAAB38198 Lnk,Lymphocyte adapter protein,Lymphocyte-specific adapter protein Lnk,Rat,Rattus norvegicus,SH2B adapter protein 3,Sh2b3,Signal transduction protein Lnk
Pathways :
WP2272: Pathogenic Escherichia coli infection
WP2328: Allograft rejection
WP2292: Chemokine signaling pathway
WP931: G Protein Signaling Pathways
WP590: Cardiovascular Signaling
WP894: T Cell Receptor Signaling Pathway
WP94: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP1913: Signaling by Insulin receptor
WP1011: T Cell Receptor Signaling Pathway
WP1121: Kit Receptor Signaling Pathway
WP1130: T Cell Receptor Signaling Pathway
WP949: Toll-like receptor signaling pathway
WP908: B Cell Receptor Signaling Pathway
WP1165: G Protein Signaling Pathways
WP211: BMP signaling pathway
WP1367: TGF-beta Receptor Signaling Pathway
WP73: G Protein Signaling Pathways
WP810: Signaling of Hepatocyte Growth Factor Receptor
WP1336: EPO Receptor Signaling
WP147: Kit Receptor Signaling Pathway
WP1025: B Cell Receptor Signaling Pathway
WP1271: Toll-like receptor signaling pathway
WP193: Signaling of Hepatocyte Growth Factor Receptor

Related Genes :
[Blnk Bash Ly57 Slp65] B-cell linker protein (B-cell adapter containing a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain protein) (Cytoplasmic adapter protein) (Lymphocyte antigen 57) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65)
[BLNK BASH SLP65] B-cell linker protein (B-cell adapter containing a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain protein) (Cytoplasmic adapter protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65)
[SRC SRC1] Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
[shc-1 F54A5.3] SHC-transforming protein homolog 1 (Src homology 2 domain adapter homolog 1)
[SKAP1 SCAP1 SKAP55] Src kinase-associated phosphoprotein 1 (Src family-associated phosphoprotein 1) (Src kinase-associated phosphoprotein of 55 kDa) (SKAP-55) (pp55)
[Frs2 Frs2a] Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (FRS2-alpha) (Suc1-associated neurotrophic factor target 1) (SNT-1)
[FRS2] Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (Suc1-associated neurotrophic factor target 1) (SNT-1)
[GRB2 ASH] Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
[src-1 Y92H12A.1] Tyrosine protein-kinase src-1 (EC 2.7.10.2) (SRC oncogene related protein 1)
[Grb2] Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)
[LCK] Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
[SH3KBP1 CIN85] SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)
[Sh2b1 Sh2bpsm1] SH2B adapter protein 1 (Pro-rich, PH and SH2 domain-containing signaling mediator) (PSM) (SH2 domain-containing protein 1B) (SH2-B PH domain-containing signaling mediator 1)
[Lck Lsk-t] Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (p56-LCK)
[Grb2 Ash] Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
[MAVS IPS1 KIAA1271 VISA] Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA)
[SRC] Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
[SHC1 SHC SHCA] SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
[CSK] Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase CYL)
[AP2B1 ADTB2 CLAPB1] AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit)
[Csk] Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase MPK-2) (p50CSK)
[Khdrbs1] KH domain-containing, RNA-binding, signal transduction-associated protein 1 (GAP-associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p21 Ras GTPase-activating protein-associated p62) (p68)
[NCK2 GRB4] Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
[csk-1 Y48G1C.2] Tyrosine-protein kinase csk-1 (EC 2.7.10.2) (C-terminal src kinase)
[Shc1 Shc ShcA] SHC-transforming protein 1 (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
[Csk] Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase)
[Src] Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
[Src] Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
[SH2D2A SCAP TSAD VRAP] SH2 domain-containing protein 2A (SH2 domain-containing adapter protein) (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein)
[src] Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)

Bibliography :