GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

Steroid hormone receptor ERR2 (Estrogen receptor-like 2) (Estrogen-related receptor beta) (ERR-beta) (Nuclear receptor subfamily 3 group B member 2)

 ERR2_MOUSE              Reviewed;         433 AA.
Q61539; A2RTQ7; O09067; O09146; Q8C7A6;
15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
03-OCT-2012, sequence version 2.
11-DEC-2019, entry version 168.
RecName: Full=Steroid hormone receptor ERR2 {ECO:0000305};
AltName: Full=Estrogen receptor-like 2;
AltName: Full=Estrogen-related receptor beta {ECO:0000250|UniProtKB:O95718};
Short=ERR-beta;
AltName: Full=Nuclear receptor subfamily 3 group B member 2;
Name=Esrrb {ECO:0000312|MGI:MGI:1346832}; Synonyms=Err-2, Err2, Nr3b2;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=129;
PubMed=8652414; DOI=10.1016/0925-4773(95)00479-3;
Pettersson K., Svensson K., Mattsson R., Carlsson B., Ohlsson R.,
Berkenstam A.;
"Expression of a novel member of estrogen response element-binding nuclear
receptors is restricted to the early stages of chorion formation during
mouse embryogenesis.";
Mech. Dev. 54:211-223(1996).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Heart;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of the
mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
DISRUPTION PHENOTYPE, DEVELOPMENTAL STAGE, AND FUNCTION.
PubMed=9285590; DOI=10.1038/42022;
Luo J., Sladek R., Bader J.A., Matthyssen A., Rossant J., Giguere V.;
"Placental abnormalities in mouse embryos lacking the orphan nuclear
receptor ERR-beta.";
Nature 388:778-782(1997).
[6]
DISRUPTION PHENOTYPE, AND TISSUE SPECIFICITY.
PubMed=17765677; DOI=10.1016/j.devcel.2007.07.011;
Chen J., Nathans J.;
"Estrogen-related receptor beta/NR3B2 controls epithelial cell fate and
endolymph production by the stria vascularis.";
Dev. Cell 13:325-337(2007).
[7]
INTERACTION WITH POU5F1, AND FUNCTION.
PubMed=18662995; DOI=10.1128/mcb.00301-08;
van den Berg D.L., Zhang W., Yates A., Engelen E., Takacs K.,
Bezstarosti K., Demmers J., Chambers I., Poot R.A.;
"Estrogen-related receptor beta interacts with Oct4 to positively regulate
Nanog gene expression.";
Mol. Cell. Biol. 28:5986-5995(2008).
[8]
INTERACTION WITH NANOG, FUNCTION, AND REGION.
PubMed=18957414; DOI=10.1074/jbc.m803481200;
Zhang X., Zhang J., Wang T., Esteban M.A., Pei D.;
"Esrrb activates Oct4 transcription and sustains self-renewal and
pluripotency in embryonic stem cells.";
J. Biol. Chem. 283:35825-35833(2008).
[9]
SUBCELLULAR LOCATION.
PubMed=18472334; DOI=10.1016/j.neulet.2008.04.044;
Real M.A., Heredia R., Davila J.C., Guirado S.;
"Efferent retinal projections visualized by immunohistochemical detection
of the estrogen-related receptor beta in the postnatal and adult mouse
brain.";
Neurosci. Lett. 438:48-53(2008).
[10]
TISSUE SPECIFICITY, AND FUNCTION.
PubMed=20534447; DOI=10.1073/pnas.1000102107;
Onishi A., Peng G.H., Poth E.M., Lee D.A., Chen J., Alexis U., de Melo J.,
Chen S., Blackshaw S.;
"The orphan nuclear hormone receptor ERRbeta controls rod photoreceptor
survival.";
Proc. Natl. Acad. Sci. U.S.A. 107:11579-11584(2010).
[11]
INDUCTION, AND FUNCTION.
PubMed=23040477; DOI=10.1016/j.stem.2012.08.002;
Festuccia N., Osorno R., Halbritter F., Karwacki-Neisius V., Navarro P.,
Colby D., Wong F., Yates A., Tomlinson S.R., Chambers I.;
"Esrrb is a direct Nanog target gene that can substitute for Nanog function
in pluripotent cells.";
Cell Stem Cell 11:477-490(2012).
[12]
FUNCTION, AND INDUCTION.
PubMed=23040478; DOI=10.1016/j.stem.2012.06.008;
Martello G., Sugimoto T., Diamanti E., Joshi A., Hannah R., Ohtsuka S.,
Goettgens B., Niwa H., Smith A.;
"Esrrb is a pivotal target of the Gsk3/Tcf3 axis regulating embryonic stem
cell self-renewal.";
Cell Stem Cell 11:491-504(2012).
[13]
REGION, MUTAGENESIS OF LYS-259; LEU-424 AND PHE-425, FUNCTION, AND
INTERACTION WITH NCOA3.
PubMed=23019124; DOI=10.1101/gad.195545.112;
Percharde M., Lavial F., Ng J.H., Kumar V., Tomaz R.A., Martin N.,
Yeo J.C., Gil J., Prabhakar S., Ng H.H., Parker M.G., Azuara V.;
"Ncoa3 functions as an essential Esrrb coactivator to sustain embryonic
stem cell self-renewal and reprogramming.";
Genes Dev. 26:2286-2298(2012).
[14]
TISSUE SPECIFICITY, INDUCTION, INTERACTION WITH NR0B1, AND FUNCTION.
PubMed=23508100; DOI=10.1128/mcb.01520-12;
Uranishi K., Akagi T., Sun C., Koide H., Yokota T.;
"Dax1 associates with Esrrb and regulates its function in embryonic stem
cells.";
Mol. Cell. Biol. 33:2056-2066(2013).
[15]
FUNCTION.
PubMed=23169531; DOI=10.1002/stem.1279;
Hutchins A.P., Choo S.H., Mistri T.K., Rahmani M., Woon C.T., Ng C.K.,
Jauch R., Robson P.;
"Co-motif discovery identifies an Esrrb-Sox2-DNA ternary complex as a
mediator of transcriptional differences between mouse embryonic and
epiblast stem cells.";
Stem Cells 31:269-281(2013).
[16]
FUNCTION, AND INTERACTION WITH KDM1A AND INTEGRATOR COMPLEX.
PubMed=26206133; DOI=10.1038/ncomms8776;
Latos P.A., Goncalves A., Oxley D., Mohammed H., Turro E., Hemberger M.;
"Fgf and Esrrb integrate epigenetic and transcriptional networks that
regulate self-renewal of trophoblast stem cells.";
Nat. Commun. 6:7776-7776(2015).
[17]
INTERACTION WITH NR0B1, AND FUNCTION.
PubMed=27601327; DOI=10.1016/j.bbrc.2016.09.011;
Uranishi K., Akagi T., Koide H., Yokota T.;
"Esrrb directly binds to Gata6 promoter and regulates its expression with
Dax1 and Ncoa3.";
Biochem. Biophys. Res. Commun. 478:1720-1725(2016).
[18]
FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=27723719; DOI=10.1038/ncb3418;
Festuccia N., Dubois A., Vandormael-Pournin S., Gallego Tejeda E.,
Mouren A., Bessonnard S., Mueller F., Proux C., Cohen-Tannoudji M.,
Navarro P.;
"Mitotic binding of Esrrb marks key regulatory regions of the pluripotency
network.";
Nat. Cell Biol. 18:1139-1148(2016).
[19]
INTERACTION WITH JARID2.
PubMed=26523946; DOI=10.1002/stem.2243;
Iseki H., Nakachi Y., Hishida T., Yamashita-Sugahara Y., Hirasaki M.,
Ueda A., Tanimoto Y., Iijima S., Sugiyama F., Yagami K., Takahashi S.,
Okuda A., Okazaki Y.;
"Combined Overexpression of JARID2, PRDM14, ESRRB, and SALL4A Dramatically
Improves Efficiency and Kinetics of Reprogramming to Induced Pluripotent
Stem Cells.";
Stem Cells 34:322-333(2016).
-!- FUNCTION: Transcription factor that binds a canonical ESRRB recognition
(ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of
targets genes regulating their expression or their transcriptional
activity (PubMed:27601327, PubMed:23169531, PubMed:23508100,
PubMed:26206133, PubMed:20534447, PubMed:18662995, PubMed:18957414,
PubMed:27723719, PubMed:23019124). Plays a role, in a LIF-independent
manner, in maintainance of self-renewal and pluripotency of embryonic
and trophoblast stem cells through different signaling pathways
including FGF signaling pathway and Wnt signaling pathways
(PubMed:18957414, PubMed:26206133, PubMed:20534447, PubMed:23040478,
PubMed:23040477, PubMed:23019124, PubMed:23169531). Upon FGF signaling
pathway activation, interacts with KDM1A by directly binding to
enhancer site of ELF5 and EOMES and activating their transcription
leading to self-renewal of trophoblast stem cells (PubMed:26206133).
Also regulates expression of multiple rod-specific genes and is
required for survival of this cell type (PubMed:20534447). Plays a role
as transcription factor activator of GATA6, NR0B1, POU5F1 and PERM1
(PubMed:18662995, PubMed:23508100, PubMed:18957414). Plays a role as
transcription factor repressor of NFE2L2 transcriptional activity and
ESR1 transcriptional activity (By similarity). During mitosis remains
bound to a subset of interphase target genes, including pluripotency
regulators, through the canonical ESRRB recognition (ERRE) sequence,
leading to their transcriptional activation in early G1 phase
(PubMed:27723719). Can coassemble on structured DNA elements with other
transcription factors like SOX2, POU5F1, KDM1A and NCOA3 to trigger
ESRRB-dependent gene activation (PubMed:23019124, PubMed:23169531,
PubMed:18662995, PubMed:26206133). This mechanism, in the case of SOX2
corecruitment prevents the embryonic stem cells (ESCs) to epiblast stem
cells (EpiSC) transition through positive regulation of NR0B1 that
inhibits the EpiSC transcriptional program (PubMed:23169531). Also
plays a role inner ear development by controlling expression of ion
channels and transporters and in early placentation (PubMed:9285590,
PubMed:17765677). {ECO:0000250|UniProtKB:O95718,
ECO:0000269|PubMed:17765677, ECO:0000269|PubMed:18662995,
ECO:0000269|PubMed:18957414, ECO:0000269|PubMed:20534447,
ECO:0000269|PubMed:23019124, ECO:0000269|PubMed:23040477,
ECO:0000269|PubMed:23040478, ECO:0000269|PubMed:23169531,
ECO:0000269|PubMed:23508100, ECO:0000269|PubMed:26206133,
ECO:0000269|PubMed:27601327, ECO:0000269|PubMed:27723719,
ECO:0000269|PubMed:9285590}.
-!- SUBUNIT: Binds DNA as a monomer (By similarity). Interacts with NR0B1;
represses ESRRB activity at the GATA6 promoter (PubMed:27601327,
PubMed:23508100). Interacts with NANOG; reciprocally modulates their
transcriptional activities and activates POU5F1 expression
(PubMed:18957414). Interacts with NCOA3; mediates the interaction
between ESRRB and RNA polymerase II complexes and allows NCOA3
corecruitment to ESRRB, KLF4, NANOG, and SOX2 enhancer regions to
trigger ESRRB-dependent gene activation involved in self-renewal and
pluripotency (PubMed:23019124). Interacts with KDM1A; co-occupes the
core set of ESRRB targets including ELF5 and EOMES (PubMed:26206133).
Interacts with the multiprotein complex Integrator, at least composed
of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74,
INTS10, INTS11/CPSF3L and INTS12; ESRRB is probably not a core
component of the integrator complex and associates to integrator via
its interaction with INTS1 and INTS9; attracts the transcriptional
machinery (PubMed:26206133). Interacts with JARID2 (PubMed:26523946).
Interacts with POU5F1; recruits ESRRB near the POU5F1-SOX2 element in
the NANOG proximal promoter leading to activation of NANOG expression;
the interaction is DNA independent (PubMed:18662995).
{ECO:0000250|UniProtKB:O95718, ECO:0000269|PubMed:18662995,
ECO:0000269|PubMed:18957414, ECO:0000269|PubMed:23019124,
ECO:0000269|PubMed:23508100, ECO:0000269|PubMed:26206133,
ECO:0000269|PubMed:26523946, ECO:0000269|PubMed:27601327}.
-!- INTERACTION:
Q16665:HIF1A (xeno); NbExp=2; IntAct=EBI-2312731, EBI-447269;
Q9R190:Mta2; NbExp=2; IntAct=EBI-2312731, EBI-904134;
Q61066:Nr0b1; NbExp=2; IntAct=EBI-2312731, EBI-2312665;
Q3UNW5:Tfcp2l1; NbExp=4; IntAct=EBI-2312731, EBI-5691372;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18472334}. Cytoplasm
{ECO:0000269|PubMed:18472334}. Chromosome
{ECO:0000269|PubMed:27723719}.
-!- TISSUE SPECIFICITY: Highly expressed in undifferentiated ESCs
(PubMed:23508100). Expressed in immature horizontal cells and in rod
photoreceptors at intermediate and late stages of differentiation
(PubMed:20534447). Expressed in endolymph-producing epithelial cells
(PubMed:17765677). {ECO:0000269|PubMed:17765677,
ECO:0000269|PubMed:20534447, ECO:0000269|PubMed:23508100}.
-!- DEVELOPMENTAL STAGE: Found in the extra-embryonic ectoderm at 5.5 dpc,
6 dpc and 6.5 dpc. At 7.5 dpc, is exclusively detected in chorion, and
at 8.5 dpc is present only at its free margin. Expression is not
detected in the ectoplacental cone at any stage of development, nor is
placental expression detected after 8.5 dpc.
{ECO:0000269|PubMed:9285590}.
-!- INDUCTION: Induced by NANOG (PubMed:23040477). Induced by GSK3
inhibition through inhibition of TCF3 repression. Repressed by TCF3
(PubMed:23040478). Reduced upon differentiation induced by LIF
depletion (PubMed:23508100). {ECO:0000269|PubMed:23040477,
ECO:0000269|PubMed:23040478, ECO:0000269|PubMed:23508100}.
-!- PTM: Acetylated by PCAF/KAT2 (in vitro).
{ECO:0000250|UniProtKB:O95718}.
-!- DISRUPTION PHENOTYPE: Homozygote Esrrb mutant embryos die at 10.5 dpc.
They have severely impaired placental formation. The mutants display
abnormal chorion development associated with an overabundance of
trophoblast giant cells and a severe deficiency of diploid trophoblast
(PubMed:9285590). Conditional knockdown mice exhibit head bobbing and
spinning and running in circles and have hearing impairment
(PubMed:17765677). {ECO:0000269|PubMed:17765677,
ECO:0000269|PubMed:9285590}.
-!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR3
subfamily. {ECO:0000305}.
---------------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
---------------------------------------------------------------------------
EMBL; X89594; CAA61755.1; -; mRNA.
EMBL; S82458; AAB37687.1; -; mRNA.
EMBL; AK052256; BAC34898.1; -; mRNA.
EMBL; AC126685; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AC132189; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC132595; AAI32596.2; -; mRNA.
EMBL; BC132597; AAI32598.2; -; mRNA.
PIR; S58087; S58087.
RefSeq; NP_001152972.1; NM_001159500.1.
RefSeq; NP_036064.3; NM_011934.4.
SMR; Q61539; -.
BioGrid; 204938; 180.
DIP; DIP-46110N; -.
IntAct; Q61539; 29.
STRING; 10090.ENSMUSP00000105833; -.
iPTMnet; Q61539; -.
PhosphoSitePlus; Q61539; -.
MaxQB; Q61539; -.
PaxDb; Q61539; -.
PRIDE; Q61539; -.
Ensembl; ENSMUST00000021680; ENSMUSP00000021680; ENSMUSG00000021255.
Ensembl; ENSMUST00000167891; ENSMUSP00000131335; ENSMUSG00000021255.
GeneID; 26380; -.
KEGG; mmu:26380; -.
UCSC; uc007ohw.2; mouse.
CTD; 2103; -.
MGI; MGI:1346832; Esrrb.
eggNOG; KOG3575; Eukaryota.
eggNOG; ENOG410XRZC; LUCA.
GeneTree; ENSGT00940000153433; -.
HOGENOM; HOG000233467; -.
InParanoid; Q61539; -.
KO; K08553; -.
OrthoDB; 669799at2759; -.
Reactome; R-MMU-383280; Nuclear Receptor transcription pathway.
ChiTaRS; Esrrb; mouse.
PRO; PR:Q61539; -.
Proteomes; UP000000589; Chromosome 12.
RNAct; Q61539; protein.
Bgee; ENSMUSG00000021255; Expressed in 95 organ(s), highest expression level in retina.
ExpressionAtlas; Q61539; baseline and differential.
Genevisible; Q61539; MM.
GO; GO:0000793; C:condensed chromosome; IMP:UniProtKB.
GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO; GO:0005634; C:nucleus; IDA:UniProtKB.
GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:UniProtKB.
GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:UniProtKB.
GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IMP:UniProtKB.
GO; GO:0001158; F:enhancer sequence-specific DNA binding; IDA:UniProtKB.
GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:BHF-UCL.
GO; GO:0000993; F:RNA polymerase II complex binding; IDA:UniProtKB.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
GO; GO:0005496; F:steroid binding; IEA:InterPro.
GO; GO:0003707; F:steroid hormone receptor activity; IEA:InterPro.
GO; GO:0008134; F:transcription factor binding; IPI:UniProtKB.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0043697; P:cell dedifferentiation; IDA:UniProtKB.
GO; GO:0008283; P:cell population proliferation; ISS:UniProtKB.
GO; GO:0001892; P:embryonic placenta development; IMP:MGI.
GO; GO:0001701; P:in utero embryonic development; IMP:MGI.
GO; GO:0048839; P:inner ear development; IMP:UniProtKB.
GO; GO:2000737; P:negative regulation of stem cell differentiation; IMP:UniProtKB.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
GO; GO:0045494; P:photoreceptor cell maintenance; IMP:UniProtKB.
GO; GO:0045725; P:positive regulation of glycogen biosynthetic process; IDA:BHF-UCL.
GO; GO:0045821; P:positive regulation of glycolytic process; ISO:MGI.
GO; GO:1902459; P:positive regulation of stem cell population maintenance; IDA:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:BHF-UCL.
GO; GO:0071931; P:positive regulation of transcription involved in G1/S transition of mitotic cell cycle; IMP:UniProtKB.
GO; GO:0090282; P:positive regulation of transcription involved in G2/M transition of mitotic cell cycle; IMP:UniProtKB.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
GO; GO:2000035; P:regulation of stem cell division; IDA:UniProtKB.
GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0017145; P:stem cell division; IMP:UniProtKB.
GO; GO:0019827; P:stem cell population maintenance; IDA:UniProtKB.
GO; GO:0001834; P:trophectodermal cell proliferation; IMP:MGI.
GO; GO:0001831; P:trophectodermal cellular morphogenesis; IMP:MGI.
Gene3D; 1.10.565.10; -; 1.
Gene3D; 3.30.50.10; -; 1.
InterPro; IPR035500; NHR-like_dom_sf.
InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
InterPro; IPR001723; Nuclear_hrmn_rcpt.
InterPro; IPR027289; Oest-rel_rcp.
InterPro; IPR024178; Oest_rcpt/oest-rel_rcp.
InterPro; IPR001628; Znf_hrmn_rcpt.
InterPro; IPR013088; Znf_NHR/GATA.
Pfam; PF00104; Hormone_recep; 1.
Pfam; PF00105; zf-C4; 1.
PIRSF; PIRSF002527; ER-like_NR; 1.
PIRSF; PIRSF500939; ERR1-2-3; 1.
PRINTS; PR00398; STRDHORMONER.
PRINTS; PR00047; STROIDFINGER.
SMART; SM00430; HOLI; 1.
SMART; SM00399; ZnF_C4; 1.
SUPFAM; SSF48508; SSF48508; 1.
PROSITE; PS51843; NR_LBD; 1.
PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
1: Evidence at protein level;
Acetylation; Chromosome; Cytoplasm; DNA-binding; Metal-binding; Nucleus;
Receptor; Reference proteome; Transcription; Transcription regulation;
Zinc; Zinc-finger.
CHAIN 1..433
/note="Steroid hormone receptor ERR2"
/id="PRO_0000053663"
DOMAIN 208..432
/note="NR LBD"
/evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
DNA_BIND 100..186
/note="Nuclear receptor"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
ZN_FING 103..123
/note="NR C4-type"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
ZN_FING 139..163
/note="NR C4-type"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
REGION 93..211
/note="Interaction with NANOG"
/evidence="ECO:0000269|PubMed:18957414"
REGION 203..433
/note="Essential for ESRRB transcriptional activity and
interaction with NCOA3"
/evidence="ECO:0000269|PubMed:23019124"
SITE 185
/note="Important for stabilizing DNA-binding"
/evidence="ECO:0000250"
MUTAGEN 259
/note="K->A: Loss of self-renewal in embryonic stem cells
in absence of LIF. Does not interact with NCOA3."
/evidence="ECO:0000269|PubMed:23019124"
MUTAGEN 424
/note="L->A: Loss of self-renewal in embryonic stem cells
in absence of LIF; when associated with A-425. Does not
interact with NCOA3; when associated with A-425."
/evidence="ECO:0000269|PubMed:23019124"
MUTAGEN 425
/note="F->A: Loss of self-renewal in embryonic stem cells
in absence of LIF; when associated with A-424. Does not
interact with NCOA3; when associated with A-424."
/evidence="ECO:0000269|PubMed:23019124"
CONFLICT 394
/note="L -> W (in Ref. 1; CAA61755)"
/evidence="ECO:0000305"
SEQUENCE 433 AA; 48328 MW; 1A0383E7E2ED8BF3 CRC64;
MSSEDRHLGS SCGSFIKTEP SSPSSGIDAL SHHSPSGSSD ASGGFGIALS THANGLDSPP
MFAGAGLGGN PCRKSYEDCT SGIMEDSAIK CEYMLNAIPK RLCLVCGDIA SGYHYGVASC
EACKAFFKRT IQGNIEYNCP ATNECEITKR RRKSCQACRF MKCLKVGMLK EGVRLDRVRG
GRQKYKRRLD SENSPYLNLP ISPPAKKPLT KIVSNLLGVE QDKLYAMPPN DIPEGDIKAL
TTLCELADRE LVFLINWAKH IPGFPSLTLG DQMSLLQSAW MEILILGIVY RSLPYDDKLA
YAEDYIMDEE HSRLVGLLDL YRAILQLVRR YKKLKVEKEE FMILKALALA NSDSMYIENL
EAVQKLQDLL HEALQDYELS QRHEEPRRAG KLLLTLPLLR QTAAKAVQHF YSVKLQGKVP
MHKLFLEMLE AKV


Related products :

Catalog number Product name Quantity
EIAAB13286 Err2,ERR-beta,Esrl2,Esrrb,Estrogen receptor-like 2,Estrogen-related receptor beta,Nr3b2,Nuclear receptor subfamily 3 group B member 2,Rat,Rattus norvegicus,Steroid hormone receptor ERR2
EIAAB13285 Err2,Err-2,ERR-beta,Esrrb,Estrogen receptor-like 2,Estrogen-related receptor beta,Mouse,Mus musculus,Nr3b2,Nuclear receptor subfamily 3 group B member 2,Steroid hormone receptor ERR2
EIAAB13284 ERR beta-2,ERRB2,ERR-beta,ESRL2,ESRRB,Estrogen receptor-like 2,Estrogen-related receptor beta,Homo sapiens,Human,NR3B2,Nuclear receptor subfamily 3 group B member 2,Steroid hormone receptor ERR2
18-461-10247 Steroid hormone receptor ERR2 - Estrogen-related receptor. beta; ERR-beta; Estrogen receptor-like 2; ERR beta-2 Polyclonal 0.05 ml
18-461-10248 Steroid hormone receptor ERR2 - Estrogen-related receptor. beta; ERR-beta; Estrogen receptor-like 2; ERR beta-2 Polyclonal 0.05 ml
18-461-10249 Steroid hormone receptor ERR2 - Estrogen-related receptor. beta; ERR-beta; Estrogen receptor-like 2; ERR beta-2 Polyclonal 0.05 ml
18-003-42074 Steroid hormone receptor ERR2 - Estrogen-related receptor. beta; ERR-beta; Estrogen receptor-like 2; ERR beta-2 Polyclonal 0.05 mg Aff Pur
EIAAB13281 Err1,ERR-alpha,Esrra,Estrogen receptor-like 1,Estrogen-related receptor alpha,Estrra,Mouse,Mus musculus,Nr3b1,Nuclear receptor subfamily 3 group B member 1,Steroid hormone receptor ERR1
EIAAB13282 ERR1,ERR-alpha,ESRL1,ESRRA,Estrogen receptor-like 1,Estrogen-related receptor alpha,Homo sapiens,Human,NR3B1,Nuclear receptor subfamily 3 group B member 1,Steroid hormone receptor ERR1
EIAAB13280 ERR-alpha,Esrra,Estrogen-related receptor alpha,Nr3b1,Nuclear receptor subfamily 3 group B member 1,Rat,Rattus norvegicus,Steroid hormone receptor ERR1
EIAAB13287 Errg,Esrrg,Estrogen receptor-related protein 3,Estrogen-related receptor gamma,Nr3b3,Nuclear receptor subfamily 3 group B member 3,Rat,Rattus norvegicus
EIAAB13288 Err3,Esrrg,Estrogen receptor-related protein 3,Estrogen-related receptor gamma,Kiaa0832,Mouse,Mus musculus,Nr3b3,Nuclear receptor subfamily 3 group B member 3
EIAAB13283 Canis familiaris,Canis lupus familiaris,Dog,ERR-alpha,ESRRA,Estrogen-related receptor alpha,NR3B1,Nuclear receptor subfamily 3 group B member 1,Steroid hormone receptor ERR1
EIAAB13289 ERR gamma-2,ERR3,ERRG2,ESRRG,Estrogen receptor-related protein 3,Estrogen-related receptor gamma,Homo sapiens,Human,KIAA0832,NR3B3,Nuclear receptor subfamily 3 group B member 3
EIAAB35715 Homo sapiens,Human,NR1F2,Nuclear receptor ROR-beta,Nuclear receptor RZR-beta,Nuclear receptor subfamily 1 group F member 2,Retinoid-related orphan receptor-beta,RORB,RZRB
EIAAB35716 Nr1f2,Nuclear receptor ROR-beta,Nuclear receptor RZR-beta,Nuclear receptor subfamily 1 group F member 2,Rat,Rattus norvegicus,Retinoid-related orphan receptor-beta,Rorb,Rzrb
E2300p ER-beta,ESR2,Estrogen receptor beta,NR3A2,Nuclear receptor subfamily 3 group A member 2,Pig,Sus scrofa
E2300b Bos taurus,Bovine,ER-beta,ESR2,Estrogen receptor beta,NR3A2,Nuclear receptor subfamily 3 group A member 2
E2300p ELISA ER-beta,ESR2,Estrogen receptor beta,NR3A2,Nuclear receptor subfamily 3 group A member 2,Pig,Sus scrofa 96T
E2300p ELISA kit ER-beta,ESR2,Estrogen receptor beta,NR3A2,Nuclear receptor subfamily 3 group A member 2,Pig,Sus scrofa 96T
U2300p CLIA kit ER-beta,ESR2,Estrogen receptor beta,NR3A2,Nuclear receptor subfamily 3 group A member 2,Pig,Sus scrofa 96T
U2300p CLIA ER-beta,ESR2,Estrogen receptor beta,NR3A2,Nuclear receptor subfamily 3 group A member 2,Pig,Sus scrofa 96T
EIAAB35714 Mouse,Mus musculus,Nr1f2,Nuclear receptor ROR-beta,Nuclear receptor RZR-beta,Nuclear receptor subfamily 1 group F member 2,Retinoid-related orphan receptor-beta,Rorb
E2300r Erbeta,ER-beta,Esr2,Estrogen receptor beta,Nr3a2,Nuclear receptor subfamily 3 group A member 2,Rat,Rattus norvegicus
E2300b ELISA Bos taurus,Bovine,ER-beta,ESR2,Estrogen receptor beta,NR3A2,Nuclear receptor subfamily 3 group A member 2 96T
Pathways :
WP566: canonical wnt - zebrafish
WP926: TGF-beta Receptor Signaling Pathway
WP362: TGF-beta Receptor Signaling Pathway
WP1045: TGF-beta Receptor Signaling Pathway
WP258: TGF-beta Receptor Signaling Pathway
WP1367: TGF-beta Receptor Signaling Pathway
WP809: TGF-beta Receptor Signaling Pathway
WP1161: TGF-beta Receptor Signaling Pathway
WP474: Endochondral Ossification
WP2272: Pathogenic Escherichia coli infection
WP2355: Corticotropin-releasing hormone
WP732: Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
WP1271: Toll-like receptor signaling pathway
WP88: Toll Like Receptor signaling
WP1004: Kit Receptor Signaling Pathway
WP1183: Toll-like receptor signaling pathway
WP138: Androgen receptor signaling pathway
WP2328: Allograft rejection
WP780: T Cell Receptor Signaling Pathway
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP1913: Signaling by Insulin receptor
WP794: B Cell Receptor Signaling Pathway
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP996: EPO Receptor Signaling
WP75: Toll-like receptor signaling pathway

Related Genes :
[Esrrb Err-2 Err2 Nr3b2] Steroid hormone receptor ERR2 (Estrogen receptor-like 2) (Estrogen-related receptor beta) (ERR-beta) (Nuclear receptor subfamily 3 group B member 2)
[ESRRB ERRB2 ESRL2 NR3B2] Steroid hormone receptor ERR2 (ERR beta-2) (Estrogen receptor-like 2) (Estrogen-related receptor beta) (ERR-beta) (Nuclear receptor subfamily 3 group B member 2)
[Esrrb Err2 Esrl2 Nr3b2] Steroid hormone receptor ERR2 (Estrogen receptor-like 2) (Estrogen-related receptor beta) (ERR-beta) (Nuclear receptor subfamily 3 group B member 2)
[ESRRA ERR1 ESRL1 NR3B1] Steroid hormone receptor ERR1 (Estrogen receptor-like 1) (Estrogen-related receptor alpha) (ERR-alpha) (Nuclear receptor subfamily 3 group B member 1)
[Esrra Err1 Estrra Nr3b1] Steroid hormone receptor ERR1 (Estrogen receptor-like 1) (Estrogen-related receptor alpha) (ERR-alpha) (Nuclear receptor subfamily 3 group B member 1)
[Esrra Nr3b1] Steroid hormone receptor ERR1 (Estrogen-related receptor alpha) (ERR-alpha) (Nuclear receptor subfamily 3 group B member 1)
[Esrrg Err3 Kiaa0832 Nr3b3] Estrogen-related receptor gamma (Estrogen receptor-related protein 3) (Nuclear receptor subfamily 3 group B member 3)
[ESR2 ESTRB NR3A2] Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
[Esr2 Estrb Nr3a2] Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
[Esr2 Erbeta Nr3a2] Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
[NR1D2] Nuclear receptor subfamily 1 group D member 2 (Orphan nuclear hormone receptor BD73) (Rev-erb alpha-related receptor) (RVR) (Rev-erb-beta) (V-erbA-related protein 1-related) (EAR-1R)
[ESR1 ESR NR3A1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
[Esr1 Esr Estr Estra Nr3a1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
[Esr1 Esr Estr Nr3a1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
[ESR1 ESR NR3A1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
[ESR1 ESR NR3A1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
[ESR1 ESR NR3A1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
[ESR1 ESR NR3A1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
[ESR1 ESR NR3A1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
[THRB ERBA2 NR1A2 THR1] Thyroid hormone receptor beta (Nuclear receptor subfamily 1 group A member 2) (c-erbA-2) (c-erbA-beta)
[THRA EAR7 ERBA1 NR1A1 THRA1 THRA2] Thyroid hormone receptor alpha (Nuclear receptor subfamily 1 group A member 1) (V-erbA-related protein 7) (EAR-7) (c-erbA-1) (c-erbA-alpha)
[Rxrb Nr2b2] Retinoic acid receptor RXR-beta (MHC class I regulatory element-binding protein H-2RIIBP) (Nuclear receptor subfamily 2 group B member 2) (Retinoid X receptor beta)
[GPER1 CEPR CMKRL2 DRY12 GPER GPR30] G-protein coupled estrogen receptor 1 (Chemoattractant receptor-like 2) (Flow-induced endothelial G-protein coupled receptor 1) (FEG-1) (G protein-coupled estrogen receptor 1) (G-protein coupled receptor 30) (GPCR-Br) (IL8-related receptor DRY12) (Lymphocyte-derived G-protein coupled receptor) (LYGPR) (Membrane estrogen receptor) (mER)
[ESR1 ESR NR3A1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) (Fragment)
[ESR1 ESR NR3A1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
[Thrb Erba2 Nr1a2] Thyroid hormone receptor beta (Nuclear receptor subfamily 1 group A member 2) (c-erbA-2) (c-erbA-beta)
[nhr-6 cnr-8 nr4a5 C48D5.1] Nuclear hormone receptor family member nhr-6 (Nuclear receptor subfamily 4 group A member 5) (Steroid hormone receptor family member cnr8)
[Nr1h2 Lxrb] Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear receptor subfamily 1 group H member 2) (Orphan nuclear receptor OR-1) (Ubiquitously-expressed nuclear receptor) (UR)
[thrb nr1a2 trb si:ch211-264a6.2] Thyroid hormone receptor beta (TR-beta) (TRb) (Nuclear receptor subfamily 1 group A member 2) (Thyroid hormone receptor beta-1) (TRbeta1)
[Nr2c2 Mtr2r1 Tak1 Tr4] Nuclear receptor subfamily 2 group C member 2 (Orphan nuclear receptor TAK1) (Orphan nuclear receptor TR4) (Testicular receptor 4)

Bibliography :